Intestinal microbiota and mental health: A comprehensive literature review and therapeutic perspectives

Authors

DOI:

https://doi.org/10.33448/rsd-v13i4.45472

Keywords:

Intestinal microbiota; Mental health; Anxiety; Depression; Probiotic therapy.

Abstract

This study aims to understand the complex relationship between intestinal microbiota and mental health, exploring the mechanism by which this interaction may occur, the major neuropsychological disorders involved, and potential therapeutic implications. Methodologically, a comprehensive literature review was conducted, focusing on studies from the past 20 years obtained from the National Library of Medicine database (PubMed). The results and discussion section revealed significant correlations between intestinal microbiota and various mental health disorders, including anxiety, depression, stress, schizophrenia, and psychosis. The gut-brain axis emerged as a crucial mediator, influencing neurotransmitter production, immune responses, and emotional behaviors. Probiotic supplementation and dietary interventions have shown promise as complementary therapeutic approaches, potentially alleviating symptoms associated with mental health conditions. In conclusion, this review highlights the complex interplay between intestinal microbiota and mental well-being, underscoring the need for further research to elucidate underlying mechanisms and translate findings into clinical practice. By advancing our understanding of this relationship, we can pave the way for comprehensive approaches to mental health care, shaping the future of medicine.

References

Aizawa, E., Tsuji, H., Asahara, T., Takahashi, T., Teraishi, T., Yoshida, S., & Kunugi, H. (2016). Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder. Journal of Affective Disorders, 202, 254-257. doi:10.1016/j.jad.2016.05.038

Cryan, J. F., & Dinan, T. G. (2012). Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci, 13(10), 701-12. doi:10.1038/nrn3346.

Cussotto, S., Strain, C. R., Fouhy, F., Strain, R. G., Peterson, V. L., Clarke, G., & Cryan, J. F. (2019). Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function. Psychopharmacology, 236(5), 1671-1685. doi:10.1007/s00213-019-05187-4

Dash, S., Clarke, G., Berk, M., & Jacka, F. N. (2015). The gut microbiome and diet in psychiatry: focus on depression. Current Opinion in Psychiatry, 28(1), 1-6.

Dickerson, F., Severance, E., Yolken, R., & Adamos, M. (2014). Prenatal exposure to maternal infection and risk of schizophrenia. Schizophrenia Bulletin, 40(3), 542-547. doi:10.1093/schbul/sbu001

Dinan, T. G., Borre, Y. E., & Cryan, J. F. (2014). Genomics of schizophrenia: time to consider the gut microbiome? Molecular Psychiatry, 19(12), 1252-1257. doi:10.1038/mp.2014.93

Eckburg, P. B., Bik, E. M., Bernstein, C. N., et al. (2005). Diversity of the human intestinal microbial flora. Science, 308(5728), 1635-8. doi:10.1126/science.1110591.

Foster, J. A., & McVey Neufeld, K. A. (2013). Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci, 36(5), 305-12. doi:10.1016/j.tins.2013.01.005.

Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., & Ruan, B. (2015). Altered fecal microbiota composition in patients with major depressive disorder. Brain, Behavior, and Immunity, 48, 186-194. doi:10.1016/j.bbi.2015.03.016

Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., & Dinan, T. G. (2016). Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research, 82, 109-118. doi:10.1016/j.jpsychires.2016.07.019

Lynch, S. V., & Pedersen, O. (2016). The human intestinal microbiome in health and disease. New England Journal of Medicine, 375(24), 2369-2379. doi:10.1056/NEJMra1600266.

Mayer, E. A. (2011). Gut feelings: the emerging biology of gut-brain communication. Nature Reviews Neuroscience, 12(8), 453-466. https://doi.org/10.1038/nrn3071

Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., & Cazaubiel, J. M. (2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition, 105(5), 755-764.

Minichino, A., Brondino, N., Solmi, M., Del Giovane, C., Fusar-Poli, P., Burnet, P., Cipriani, A., & Lennox, B. R. (2020). The gut-microbiome as a target for the treatment of schizophrenia: A systematic review and meta-analysis of randomised controlled trials of add-on strategies. Schizophrenia Research. https://doi.org/10.1016/j.schres.2020.02.012

Murray, N., Al Khalaf, S., Bastiaanssen, T. F. S., Kaulmann, D., Lonergan, E., Cryan, J. F., Clarke, G., Khashan, A. S., & O'Connor, K. (2024). Compositional and Functional Alterations in Intestinal Microbiota in Patients with Psychosis or Schizophrenia: A Systematic Review and Meta-analysis. Schizophrenia Bulletin. Advance online publication. https://doi.org/10.1093/schbul/sbad049

Ng, Q. X., Peters, C., Ho, C. Y. X., Lim, D. Y., & Yeo, W. S. (2018). A meta-analysis of the use of probiotics to alleviate depressive symptoms. Journal of Affective Disorders, 228, 13-19. https://doi.org/10.1016/j.jad.2017.11.063

Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014). Correlation between the human fecal microbiota and depression. Neurogastroenterology & Motility, 26(8), 1155-1162. doi:10.1111/nmo.12378

Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. (2016). Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals. Trends in Neurosciences, 39(11), 763-781. doi:10.1016/j.tins.2016.09.002

Schéle, E., Grahnemo, L., Anesten, F., Hallén, A., Bäckhed, F., & Jansson, J. (2018). Microbiota–gut–brain axis: Modulator of host metabolism and appetite. Human Genetics, 137(11-12), 959-971. https://doi.org/10.1007/s00439-018-1968-3

Severance, E. G., Gressitt, K. L., Stallings, C. R., Katsafanas, E., Schweinfurth, L. A. B., Savage, C. L. G., & Yolken, R. H. (2016). Probiotic normalization of Candida albicans in schizophrenia: a randomized, placebo-controlled, longitudinal pilot study. Brain, Behavior, and Immunity, 62, 41-45. doi:10.1016/j.bbi.2016.11.019

Singh, R. K., Chang, H. W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., & Liao, W. (2017). Influence of diet on the gut microbiome and implications for human health. Journal of translational medicine, 15(1), 73. 10.1186/s12967-017-1175-y

Wallace, C. J. K., & Milev, R. (2017). The effects of probiotics on depressive symptoms in humans: a systematic review. Annals of general psychiatry, 16(1), 14. doi:10.1186/s12991-017-0138-2

Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., & Xie, P. (2016). Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism. Molecular Psychiatry, 21(6), 786-796. doi:10.1038/mp.2016.44

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Published

05/04/2024

How to Cite

SANTOS, L. H. C. dos .; SILVA, M. C. S. .; COSTA, J. A. F. .; SILVA JUNIOR, M. A. L.; RÊGO, L. V. R. do; MENDONÇA, L. A. de; BECKER FILHO, R.; FALCÃO, D. W. A. .; SILVA, A. K. de A. .; LINS, M. A. B. .; ALVES, M. J. de C. . Intestinal microbiota and mental health: A comprehensive literature review and therapeutic perspectives. Research, Society and Development, [S. l.], v. 13, n. 4, p. e0413445472, 2024. DOI: 10.33448/rsd-v13i4.45472. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/45472. Acesso em: 5 nov. 2024.

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Vol. 13 No. 4

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Health Sciences

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Copyright (c) 2024 Luiz Henrique Cunha dos Santos; Matheus Claizoni Santos Silva; Juliana Albuquerque Freyre Costa; Marcus Antonio Lessa Silva Junior; Luma Vitória Rios do Rêgo; Larissa Andrade de Mendonça; Ramiro Becker Filho; Débora Wanderley Albanez Falcão; Ayana Kalina de Araujo Silva; Manoela Alves Bezerra Lins; Matheus José de Carvalho Alves

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