The relationship between Rheumatoid Arthritis and the intestinal microbiota: A literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v13i4.45662

Keywords:

Dysbiosis; Intestinal microbiota; Rheumatoid arthritis.

Abstract

This literature review aims to discuss in detail the possible connection between the pathogenesis of Rheumatoid Arthritis and intestinal dysbiosis. Rheumatoid Arthritis is an autoimmune condition that affects the joints, generating inflammation and chronic pain, as well as having extra-articular repercussions. Lately, there has been a growing interest in the role of the intestinal microbiota in the origin and evolution of these diseases. In this study, we analyzed a compilation of scientific articles that investigate the composition of this microbiome in patients with Rheumatoid Arthritis, in addition to also investigating the mechanisms by which the microbiota can influence the immune response and the pathogenesis of Arthritis. The results highlight the complexity of this interaction, indicating that changes in the microbiome may play a crucial role in the emergence and progression of Rheumatoid Arthritis.

References

Cheng, M., Zhao, Y., Cui, Y., Zhong, C., Zha, Y., Li, S., et al. (2022). Stage-specific roles of microbial dysbiosis and metabolic disorders in rheumatoid arthritis. Annals of the Rheumatic Diseases, 81(12), 1669–1677. 10.1136/ard-2022-222871

Chiang, H. I., Li, J. R., Liu, C. C., Liu, P. Y., Chen, H. H., Chen, Y. M., et al. (2019). An association of gut microbiota with different phenotypes in Chinese patients with rheumatoid arthritis. Journal of Clinical Medicine, 8(11), 1770. 10.3390/jcm8111770

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Fan, Z., Yang, B., Ross, R. P., Stanton, C., Shi, G., Zhao, J., et al. (2020). Protective effects of Bifidobacterium adolescentis on collagen-induced arthritis in rats depend on timing of administration. Food & Function, 11(5), 4499–4511. 10.1039/d0fo00077a

Fasano, A. (2011). Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiological Reviews, 91(1), 151-175.

Lamprecht, M., Bogner, S., Schippinger, G., Steinbauer, K., Fankhauser, F., Hallstroem, S., et al. (2012). Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. Journal of the International Society of Sports Nutrition, 9(1), 45.

Larsen, J. M. (2017). The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology, 151(4), 363–374. 10.1111/imm.12760

Li, H., Yu, L., Zhang, X., Shang, J., & Duan, X. (2022). Exploring the molecular mechanisms and shared gene signatures between rheumatoid arthritis and diffuse large B-cell lymphoma. Frontiers in Immunology, 13. 10.3389/fimmu.2022.1036239

Litvak, Y., Byndloss, M. X., & Baumler, A. J. (2018). Colonocyte metabolism shapes the gut microbiota. Science, 362(6418), eaat9076. 10.1126/science.aat9076

Liu, X., Zeng, B., Zhang, J., Li, W., Mou, F., Wang, H., et al. (2016). Role of the gut microbiome in modulating arthritis progression in mice. Scientific Reports, 6, 30594. 10.1038/srep30594

Louis, P., & Flint, H. J. (2017). Formation of propionate and butyrate by the human colonic microbiota. Environmental Microbiology, 19(1), 29-41.

Opoku, Y. K., Asare, K. K., Ghartey-Quansah, G., Afrifa, J., Bentsi-Enchill, F., Ofori, E. G., et al. (2022). Intestinal microbiome-rheumatoid arthritis crosstalk: The therapeutic role of probiotics. Frontiers in Microbiology, 13. 10.3389/fmicb.2022.996031

Parantainen, J., Barreto, G., Koivuniemi, R., Kautiainen, H., Nordstrom, D., Moilanen, E., et al. (2022). The biological activity of serum bacterial lipopolysaccharides associates with disease activity and likelihood of achieving remission in patients with rheumatoid arthritis. Arthritis Research & Therapy, 24(1), 256. 10.1186/s13075-022-02946-z

Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. Santa Maria/RS. Ed. UAB/NTE/UFSM.

Reichert, S., Haffner, M., Keysser, G., Schafer, C., Stein, J. M., Schaller, H. G., et al. (2013). Detection of oral bacterial DNA in synovial fluid. Journal of Clinical Periodontology, 40(6), 591–598. 10.1111/jcpe.12102

Smolen, J. S., Aletaha, D., & McInnes, I. B. (2016). Rheumatoid arthritis. The Lancet, 388(10055), 2023-2038.

Turner, J. R. (2009). Intestinal mucosal barrier function in health and disease. Nature Reviews Immunology, 9(11), 799-809.

Van der Heijden, I. M., Wilbrink, B., Tchetverikov, I., Schrijver, I. A., Schouls, L. M., Hazenberg, M. P., et al. (2000). Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arthritis & Rheumatism, 43(3), 593–598. 10.1002/1529-0131(200003)43:3<593::AID-ANR16>3.0.CO;2-1

Wang, X., Yang, C., Xu, F., Qi, L., Wang, J., & Yang, P. (2019). Imbalance of circulating Tfr/Tfh ratio in patients with rheumatoid arthritis. Clinical and Experimental Medicine, 19(1), 55–64. 10.1007/s10238-018-0530-5

Zhang, X., Chen, B. D., Zhao, L. D., & Li, H. (2020). The gut microbiota: Emerging evidence in autoimmune diseases. Trends in Molecular Medicine, 26(9), 862–873. 10.1016/j.molmed.2020.04.001

Zhang, X., Zhang, D., Jia, H., Feng, Q., Wang, D., Liang, D., et al. (2015). The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nature Medicine, 21(8), 895–905. 10.1038/nm.3914

Zhao, Y., Chen, B., Li, S., Yang, L., Zhu, D., Wang, Y., et al. (2018). Detection and characterization of bacterial nucleic acids in culture-negative synovial tissue and fluid samples from rheumatoid arthritis or osteoarthritis patients. Scientific Reports, 8(1), 14305. 10.1038/s41598-018-32675-w

Published

30/04/2024

How to Cite

MELO, M. A. F. de .; COSTA, T. V. S. .; NOGUEIRA, M. A. L. da P. .; PEREIRA NETO, J. de A. .; COSTA, J. A. F. .; OLIVEIRA, G. L. R. de .; TAVARES, M. F. .; ASSIS, M. Q. de .; SOUZA, M. M. de L. .; GREGO, M. Ângelo R. .; BARROS, L. B. . The relationship between Rheumatoid Arthritis and the intestinal microbiota: A literature review . Research, Society and Development, [S. l.], v. 13, n. 4, p. e11913445662, 2024. DOI: 10.33448/rsd-v13i4.45662. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/45662. Acesso em: 22 dec. 2024.

Issue

Section

Health Sciences