Neuroprotection in neonatal hypoxic-ischemic encephalopathy: Literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v13i5.45695

Keywords:

Encephalopathy; Neonatal; Neuroprotection; Hypoxia.

Abstract

Hypoxic-ischemic encephalopathy (HIE) is a neurological syndrome that varies in severity due to ischemia in the newborn. Symptoms include loss of consciousness, decreased movement, muscle tone and reflexes, and in severe cases, seizures. Therapeutic hypothermia (TH) is a treatment strategy now widely adopted in high-income countries, demonstrating that improving neurodevelopment is possible through clinical practices. The present article aims to analyze the intrinsic characteristics of hypoxic-ischemic encephalopathy, as well as pathophysiology and therapeutic measures. The study methodology consists of an integrative review. Therefore, the development of research on the pathophysiology and treatment of the disease to determine new therapies is essential, bringing fewer future sequelae and a better neurological prognosis for patients with this condition.

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Published

04/05/2024

How to Cite

PIGNATARI, V. T. .; MOURA, G. F. .; TSUJIGUSHI, G. K. .; MORETO, B. F. .; SUGUI, T. M. B. .; VALOTTO, M. E.; RAMOS, L. V. .; SERPA, P. G. S. .; FONSECA, K. C. L. .; COSTA SEGUNDO, J. C. .; SOARES, I. M. .; ALMEIDA, D. dos S. .; TURRA, E. A. N. .; KOPTIAN, T.; PAULETTI, C. L. . Neuroprotection in neonatal hypoxic-ischemic encephalopathy: Literature review. Research, Society and Development, [S. l.], v. 13, n. 5, p. e0713545695, 2024. DOI: 10.33448/rsd-v13i5.45695. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/45695. Acesso em: 5 jan. 2025.

Issue

Vol. 13 No. 5

Section

Health Sciences

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Copyright (c) 2024 Vinícius Thomaz Pignatari; Giulia Figueira Moura; Guilherme Kazama Tsujigushi; Bruna Farinelli Moreto; Tiffany Mie Botelho Sugui; Maria Eduarda Valotto; Luiza Vasconcelos Ramos; Priscila Gomes Silva Serpa; Kennia Carreiro Lima Fonseca; Jadivardi Coelho Costa Segundo; Isabella Melo Soares; Douglas dos Santos Almeida; Enayle Amanda Nascimento Turra; Thifany Koptian; Carolina Laperuta Pauletti

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