Advances in the diagnosis and treatment of Wernicke-Korsakoff Syndrome: An integrative literature analysis
DOI:
https://doi.org/10.33448/rsd-v13i5.45878Keywords:
Wernicke-Korsakoff Syndrome; Diagnosis; Treatment; Therapeutics.Abstract
Wernicke-Korsakoff Syndrome (WKS) is a debilitating neuropsychiatric condition, characterized by a classical triad of symptoms: Wernicke's encephalopathy, which includes mental confusion, ataxia, and ophthalmoplegia; and Korsakoff's syndrome, which involves deficits in both anterograde and retrograde memory, confabulation, and mood alterations. This syndrome is commonly associated with chronic alcohol consumption and thiamine deficiency, although it can also occur in cases of malnutrition, gastrointestinal disorders, bariatric surgery, among others. To initiate the review process, a search was conducted in the PubMed electronic database with the aim of identifying studies published in the last 10 years (2014 to 2024) that addressed advances in the diagnosis and treatment of WKS. The specific MESH descriptors used were "Wernicke-Korsakoff Syndrome", "Diagnosis", "Treatment", "Therapeutics". These terms were selected to ensure the inclusion of studies addressing different aspects related to the diagnosis and treatment of WKS, from new diagnostic techniques to emerging therapeutic strategies. After the initial search, the results were filtered to include only studies relevant to the theme of the review. The inclusion criteria required that studies specifically addressed advances in the diagnosis and treatment of Wernicke-Korsakoff Syndrome and provided insights into current and future perspectives in this area. Studies that did not meet these criteria were excluded from the review. The conclusion of this analysis on the treatment of Wernicke-Korsakoff Syndrome highlights the importance of multidisciplinary and evidence-based approaches for the effective management of this complex neuropsychiatric condition. Recent advances in early diagnosis, thiamine therapy, and cognitive rehabilitation represent significant progress in the treatment of WKS, providing improvements in the quality of life of affected patients.
References
Crossetti, M. G. O. (2012). Revisión integrativa de la investigación en enfermería, el rigor científico que se le exige. Revista Gaúcha de Enfermagem, 33, 10- 11
Educação, Grupo Anima. (2014). Manual Revisão Bibliográfica Sistemática Integrativa: a pesquisa baseada em evidências. Grupo Anima Educação.
Pompeo, D. A., Rossi, L. A., & Galvão, C. M. (2009). Revisão integrativa: etapa inicial do processo de validação de diagnóstico de enfermagem. Acta paulista de enfermagem, 22, 434-438. https://doi.org/10.1590/S0103-21002009000400014
Soares, C. B. et al. (2014). Revisão integrativa: conceitos e métodos utilizados na enfermagem. Revista da Escola de Enfermagem da USP, 48, 335-345.
Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8, 102-106.
Mateos-Díaz, A. M., Marcos, M., & Chamorro, A. J. (2022) Wernicke-Korsakoff syndrome and other diseases associated with thyamine deficiency. Med Clin (Barc). 158(9), 431-436.
Chandrakumar, A., Bhardwaj, A., & 't Jong, G. W. (2018) Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. J Basic Clin Physiol Pharmacol. 30(2), 153-162. 10.1515/jbcpp-2018-0075.
Cohen, S. M., Alexander, R. S., & Holt, S. R. (2022) The Spectrum of Alcohol Use: Epidemiology, Diagnosis, and Treatment. Med Clin North Am. 106(1):43-60. 10.1016/j.mcna.2021.08.003.
Dervaux A, & Laqueille X. (2017) Le traitement par thiamine (vitamine B1) dans l’alcoolodépendance [Thiamine (vitamin B1) treatment in patients with alcohol dependence]. Presse Med. 46(2):165-171.
Yoon, C., Gedzior, J., & DePry, D. (2019) Wernicke-Korsakoff syndrome: Focus on low-threshold diagnosis and prompt treatment in the primary care setting. Int J Psychiatry Med. 54(3), 172-180.
Lin, S., Leppla, I. E., Yan, H., Probert, J. M., Randhawa, P. A., Leoutsakos, J. S., Probasco, J. C., & Neufeld, K. J. (2020) Prevalence and Improvement of Caine-Positive Wernicke-Korsakoff Syndrome in Psychiatric Inpatient Admissions. Psychosomatics. 61(1), 31-38.
Infante, M. T., Fancellu, R., Murialdo, A., Barletta, L., Castellan, L., & Serrati, C. (2016) Challenges in Diagnosis and Treatment of Wernicke Encephalopathy: Report of 2 Cases. Nutr Clin Pract. 31(2), 186-90. 10.1177/0884533615621753.
Fiorentini M, Nedu B, Dapoto F, Brunelli E, Pilu G, & Youssef A. (2023) When time is brain: a systematic review about Wernicke encephalopathy as a dramatic consequence of thiamin deficiency in hyperemesis gravidarum. J Matern Fetal Neonatal Med. 36(2):2223678.
Narasimha V. L, Ganesh S, Reddy S, Shukla L, Mukherjee D, Kandasamy A, Chand P. K, Benegal V, & Murthy P. (2019) Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India. Alcohol Alcohol. 54(2):148-151.
Oudman E, Wijnia J. W, Severs D, Oey M. J, van Dam M, van Dorp M, & Postma A. (2024) Wernicke's Encephalopathy in Acute and Chronic Kidney Disease: A Systematic Review. J Ren Nutr. (2):105-114.
Pang, D., Duffield, P., & Day, E. (2019) A view from the acute hospital: managing patients with alcohol problems. Br J Hosp Med (Lond). 80(9):500-506.
Sirkeci, O., & Sirkeci, E. E. (2021) Wernicke-Korsakoff syndrome in a patient with tuberculous peritonitis. Eur Rev Med Pharmacol Sci.25(21):6716-6718.
Di Marco, S., Pilati, L., Brighina, F., Fierro, B., & Cosentino, G. (2018) Wernicke-Korsakoff syndrome complicated by subacute beriberi neuropathy in an alcoholic patient. Clin Neurol Neurosurg. 164:1-4.
Isenberg-Grzeda, E., Alici, Y., Hatzoglou, V., Nelson, C., & Breitbart, W. (2016) Nonalcoholic Thiamine-Related Encephalopathy (Wernicke-Korsakoff Syndrome) Among Inpatients With Cancer: A Series of 18 Cases. Psychosomatics. 57(1):71-81.
Onishi, H., Uchida, N., Itami, K., Sato, M., Tamura, S., Kurosaki, A., & Ishida, M. (2020) Subclinical thiamine deficiency: What is the most appropriate method of diagnosis and treatment? Palliat Support Care. 18(5):614-616.
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Copyright (c) 2024 Rafael Leituga de Carvalho Cavalcante; Enzzo Cavalcante Pereira; Guilherme Protázio Oliveira Pires de Sá; Rhaira Fernanda Ayoub Casalvara; Sophya Bezerra Silva Rocha; Julia Cordeiro Schneider Ferreira; Fernando Rodrigues Dias; Fillipe Eduardo Amorim Mesquita; Thúlio Willen Siqueira Neder
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