The development of Metabolic Syndrome in patients with late onset Hypogonadism
DOI:
https://doi.org/10.33448/rsd-v13i6.45954Keywords:
Metabolic Syndrome; Late Onset Hypogonadismo; Gonadal Disorders.Abstract
Introduction: The reduction in serum testosterone levels with age can be associated with an increase in body fat and a worsening of endocrine-metabolic parameters, culminating in metabolic syndrome and hypogonadism. Objective: The aim of this study was to evaluate the clinical, epidemiological and pathophysiological aspects of metabolic syndrome resulting from late onset hypogonadism, building on knowledge based on case reports and knowledge based on the literature. Materials and Methods: This is an integrative literature review on the general clinical characteristics of metabolic syndrome induced by reduced testosterone levels. The PICO strategy was used to develop the guiding question. In addition, the descriptors "Metabolic Syndrome"; "Late Hypogonadism"; "Gonadal Disorders" were cross-referenced in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), Ebscohost, Google Scholar and Virtual Health Library (VHL) databases. Results and Discussion: A significant proportion of the articles showed that there is an association between low testosterone levels, characteristic of late-onset hypogonadism, and the development of metabolic syndrome, especially in patients aged between 30 and 50. The management of the combination of these endocrine conditions must be planned and individualized in order to offer the best prognosis for the patient. Conclusion: The bidirectionality between the pathophysiological mechanisms of the diseases is extremely important for an integrative understanding of them, as well as the aspects that involve therapy, and is fundamental for patients to receive the best care.
References
Abe, S. Y., Dos Santos, K. S., Barbosa, B. F. B., Biondo, C. M. P., Takito, D., Hayashi, S. K., ... & Boguszewski, C. L. (2020). Metabolic syndrome and its components in adult hypopituitary patients. Pituitary, 23, 409-416.
Ahlstrand, H. (2022). Functional hypogonadism in prediabetes and metabolic syndrome: the role of testosterone replacement therapy (Doctoral dissertation, Faculty of Medicine; Department of Medicine, Helsinki University).
Armeni, E. (2023). Male hypogonadism in overweight and obesity. Metab Target Organ Damage, 3(2), 9.
Barber, T. M., Kyrou, I., Kaltsas, G., Grossman, A. B., Randeva, H. S., & Weickert, M. O. (2021). Mechanisms of central hypogonadism. International Journal of Molecular Sciences, 22(15), 8217.
Braga, P. C., Pereira, S. C., Ribeiro, J. C., Sousa, M., Monteiro, M. P., Oliveira, P. F., & Alves, M. G. (2020). Late‐onset hypogonadism and lifestyle‐related metabolic disorders. Andrology, 8(6), 1530-1538.
Crisóstomo, L., Pereira, S. C., Monteiro, M. P., Raposo, J. F., Oliveira, P. F., & Alves, M. G. (2020). Lifestyle, metabolic disorders and male hypogonadism–A one-way ticket?. Molecular and Cellular Endocrinology, 516, 110945.
Gleicher, S., Daugherty, M., Ferry, E., & Byler, T. (2020). Looking beyond hypogonadism: association between low testosterone and metabolic syndrome in men 20–59 years. International Urology and Nephrology, 52, 2237-2244.
Grossmann, M., Ng Tang Fui, M., & Cheung, A. S. (2020). Late‐onset hypogonadism: metabolic impact. Andrology, 8(6), 1519-1529.
Hermoso, D. A. M., Bizerra, P. F. V., Constantin, R. P., Ishii-Iwamoto, E. L., & Gilglioni, E. H. (2020). Association between metabolic syndrome, hepatic steatosis, and testosterone deficiency: evidences from studies with men and rodents. The Aging Male, 23(5), 1296-1315.
Kirlangic, O. F., Yilmaz-Oral, D., Kaya-Sezginer, E., Toktanis, G., Tezgelen, A. S., Sen, E., ... & Gur, S. (2020). The effects of androgens on cardiometabolic syndrome: current therapeutic concepts. Sexual Medicine, 8(2), 132-155.
Leisegang, K., Roychoudhury, S., Slama, P., & Finelli, R. (2021). The mechanisms and management of age-related oxidative stress in male hypogonadism associated with non-communicable chronic disease. Antioxidants, 10(11), 1834.
Lisco, G., Triggiani, V., Bartolomeo, N., Ramunni, M. I., Pelusi, C., De Pergola, G., ... & Giagulli, V. A. (2023). The role of male hypogonadism, aging, and chronic diseases in characterizing adult and elderly men with erectile dysfunction: a cross-sectional study. Basic and Clinical Andrology, 33(1), 5.
Marcelli, M., & Mediwala, S. N. (2020). Male hypogonadism: a review. Journal of Investigative Medicine, 68(2), 335-356.
Munari, E. V., Amer, M., Amodeo, A., Bollino, R., Federici, S., Goggi, G., ... & Bonomi, M. (2023). The complications of male hypogonadism: is it just a matter of low testosterone?. Frontiers in Endocrinology, 14, 1201313.
Naeem, M., Shehzad, S., Khan, R. A., & Khan, R. (2022). Male Hypogonadism and Obesity: An Insight. Pakistan Journal of Medical & Health Sciences, 16(08), 597-600.
Nunes, D. C., Ribeiro, J. C., Alves, M. G., Oliveira, P. F., & Bernardino, R. L. (2023). Male Sex Hormones, Metabolic Syndrome, and Aquaporins: A Triad of Players in Male (in) Fertility. International Journal of Molecular Sciences, 24(3), 1960.
Pinto, J., & Lima da Costa, R. S. (2024). Hipogonadismo masculino e sua relação com a sindrome metabólica. Revista Foco (Interdisciplinary Studies Journal), 17(1).
Salvio, G., Ciarloni, A., Cutini, M., Delli Muti, N., Finocchi, F., Perrone, M., ... & Balercia, G. (2022). Metabolic syndrome and male fertility: beyond heart consequences of a complex cardiometabolic endocrinopathy. International Journal of Molecular Sciences, 23(10), 5497.
Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8(1), 102–106. https://doi.org/10.1590/s1679-45082010rw1134
Winters, S. J. (2020). SHBG and total testosterone levels in men with adult onset hypogonadism: what are we overlooking?. Clinical Diabetes and Endocrinology, 6, 1-6.
Xu, Z., Ke, X., Yuan, X., Wang, L., Duan, L., Yao, Y., ... & Zhu, H. (2022). Metabolic syndrome as a common comorbidity in adults with hypothalamic dysfunction. Frontiers in Endocrinology, 13, 973299.
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Copyright (c) 2024 Júlia Paiva Lounine; Julia Alvim Aguiar; Noeme Rocha Pereira Campos; Larissa Ferreira Carvalho Silva ; Thiago Barroso Ferreira Lima Brito Campos; Hugo Nacif da Costa Valle; Laura Rodrigues Haddad; José Pedro Gomes de Faria Tavares; Luiz Eduardo Alencar de Souza; Diogo Almeida Martins
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