Nanomagnetism in early diagnosis and treatment of cancer: A narrative review
DOI:
https://doi.org/10.33448/rsd-v13i6.45983Keywords:
Hyperthermia; Nanoparticles; Magnetic therapy; Cancer treatment.Abstract
This review presents an analysis of nanomagnetism in the treatment and cure of cancer. The primary objective of this study was to investigate how magnetic nanoparticles can be optimized to maximize efficiency and safety in tumor treatment, while minimizing the side effects associated with conventional therapies. To achieve this, the study set forth the following detailed objectives: to discuss cancer, nanotechnology, and nanomagnetism; to examine nanomagnetism in cancer diagnosis; to investigate the mechanism of action of nanoparticles; to analyze advancements and challenges in clinical research; and to compare the efficacy and safety of these therapies with conventional ones. The methodology employed included a review of relevant literature and an evaluation of data from secondary sources. The study's findings indicated effective concentration of treatments in tumor tissue with minimized damage to healthy cells, concluding that magnetic nanoparticles hold significant promise for revolutionizing oncological treatments. The final considerations emphasize the importance of continuing research on long-term safety, multidisciplinary collaboration, and clinical regulation, which are crucial for expanding understanding and fostering future advances in clinical application.
References
Abbas, A. K., Lichtman, A. H., & Pober, J. S. (2000). Imunologia Celular e Molecular. Revinter.
Araújo, L. H., Baldotto, C., Castro Jr, G. de., Katz, A., Ferreira, C. G., Mathias, C., Mascarenhas, E., et al.. (2018). Lung câncer in Brazil. Jornal Brasileiro de Pneumologia, 44(1), 55–64.
Belizário, J. E. (2002). O próximo desafio, reverter o câncer. Ciência Hoje, 31(184), 51-57.
Brasil. (2004). Lei n.º 10.973, de 2 de dezembro de 2004. Dispõe sobre incentivos à inovação e à pesquisa científica e tecnológica no ambiente produtivo e dá outras providências. https://planalto.gov.br/ccivil_03/_Ato2004-2006/2004/Lei/L10.973.htm
Brasil. (2016). Lei n.º 13.243, de 11 de janeiro de 2016. Dispõe sobre estímulos ao desenvolvimento científico, à pesquisa, à capacitação científica e tecnológica e à inovação e dá outras providências. https://www.planalto.gov.br/ccivil_03/_Ato2015-2018/2016/Lei/L13243.htm
Bulte, J. W., Duncan, I. D., & Frank, J. A. (2002). In vivo magnetic resonance tracking of magnetically labeled cells after transplantation. Journal of cerebral blood flow and metabolism: official journal of the international society of cerebral blood flow and metabolism, 22(8), 899–907.
Caizer, C., & Rai, M. (2021). Magnetic nanoparticles in human health and medicine: current medical applications and alternative therapy of cancer. John Wiley & Sons.
Cancino, J., Marangoni, V. S., & Zucolotto, V.. (2014). Nanotecnologia em medicina: aspectos fundamentais e principais preocupações. Química Nova, 37(3), 521–526.
Caro, C., Guzzi, C., Moral-Sánchez, I., Urbano-Gámez, J. D., Beltrán, A. M., & García-Martín, M. L. (2024). Smart design of znfe and znfe@fe nanoparticles for mri-tracked magnetic hyperthermia therapy: challenging classical theories of nanoparticles growth and nanomagnetism. Advanced Healthcare Materials, 13(12). https://doi.org/10.1002/adhm.202304044.
Costa, A. M., & Silva, V. V. (2017). Estratégias nanotecnológicas para diagnóstico e tratamento do câncer. Revista Saúde e Meio Ambiente, 5(2), 1–13.
Dias, B. de P., Ribeiro, E. M. de C., Gonçalves, R. L., Oliveira, D. S., Ferreira, T. H., & Silva, B. de M.. (2021). A nanotecnologia no Brasil e o desenvolvimento de produtos com atividade antimicrobiana. Química Nova, 44(8), 1084–1092.
Falleiros, J. P. B., Brandl, A. L., & Fonseca, A. R. A. (2011). Aplicações da nanotecnologia no diagnóstico e tratamento de câncer. Nucleus, 8(1), 1–20.
Faria, Rubens N., & Lima, L. F. C.P. (2005). Introdução ao magnetismo dos materiais. Livraria da Física.
Hermes, E. G. C., & Bastos, P. R. H. de O. (2014). Nanotecnologia: progresso científico, material, global e ético. Persona Y Bioética, 18(2), 107–118.
Instituto Nacional de Câncer. (2022). O que é câncer?. Instituto Nacional de Câncer – INCA. https://www.gov.br/inca/pt-br/assuntos/cancer/o-que-e-cancer.
Instituto Nacional de Câncer. (2023). Estimativa 2023 – Incidência de Câncer no Brasil. Instituo Nacional de Câncer - INCA.
https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//estimativa-2023.pdf
Jesus, M. C. (2002). Imunologia do câncer. Centro Universitário de Brasília. https://repositorio.uniceub.br/jspui/handle/123456789/2487
Joanitti, G. A., Morais, P. C., & Azevedo, R. B. (2022). Nanotecnologia: considerações em materiais, saúde e meio ambiente. Editora UnB,186 (1), 220-256.
Johnson, G. A., Benveniste, H., Black, R. D., Hedlund, L. W., Maronpot, R. R., & Smith, B. R. (1993). Histology by magnetic resonance microscopy. Magnetic Resonance Quarterly, 9(1), 1–30.
Khan, A. U., Chen, L., & Ge, G. (2021). Recent development for biomedical applications of magnetic nanoparticles. Inorganic Chemistry Communications. https://doi.org/10.1016/j.inoche.2021.108995
Konwar, K., & Deb, P. (2021). Review of soft computing techniques and nanomagnetism: Impact on biomedical applications. Soft Computing Techniques and Applications in Mechanical Engineering (pp. 53-72) https://doi.org/10.1201/9781003161707-3
Lanier, O. L., Korotych, O. I., Monsalve, A. G., Wable, D., Savliwala, S., Grooms, N. W. F., Nacea, C., Tuitt, O. R., & Dobson, J. (2019). Evaluation of magnetic nanoparticles for magnetic fluid hyperthermia. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 36(1), 687–701. https://doi.org/10.1080/02656736.2019.1628313
Lewis, G. (2023). Understanding nanomagnetism from all angles: Developments in magnetic electron tomography. Apollo - University of Cambridge Repository. https://doi.org/10.17863/CAM.97030
Makridis, A. (2019). Magnetic nanostructures and nanomagnetism for modern biomedical applications. Aristotle University Of Thessaloniki.
Martins, M. A., & Trindade, T.. (2012). Os nanomateriais e a descoberta de novos mundos na bancada do químico. Química Nova, 35(7), 1434–1446. https://doi.org/10.1590/S0100-40422012000700026
Mattos, P. C. (2015). Tipos de revisão de literatura. Unesp, 1-9. Recuperado de https://www.fca.unesp.br/Home/Biblioteca/tipos-de-evisao-de-literatura.pdf
Ministério da Ciência, Tecnologia e Inovação. (2024). Sistema Nacional de Laboratórios de Nanotecnologias (SisNano). https://antigo.mctic.gov.br/mctic/opencms/tecnologia/incentivo_desenvolvimento/sisnano/sisnano.html
Organização Pan-Americana da Saúde (2020). Câncer. Organização Mundial da Saúde. https://www.paho.org/pt/topicos/câncer
Pereira, N.M.S. (2012). Desenvolvimento de nanopartículas para apliacações biomédicas. Escola Superior de Tecnologia e Gestão Instituto Politécnico de Bragança. Recuperado de https://bibliotecadigital.ipb.pt/bitstream/10198/8218/1/Pereira_Nuno.pdf
Rajan, A., & Sahu, N. K. (2020). Review on magnetic nanoparticle-mediated hyperthermia for cancer therapy. Journal of Nanoparticle Research, 22(11). https://doi.org/10.1007/s11051-020-05045-9
Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta paulista de enfermagem. 20 (2). https://doi.org/10.1590/S0103-21002007000200001
Rodrigues, F. V. P. (2019). Desmistificando a neutralidade da ciência e da tecnologia: uma proposta sobre nanociência. Instituto de Física da Universidade de Brasília. Recuperado de http://icts.unb.br/jspui/bitstream/10482/39276/1/2019_FranciscaVaniaPereiraRodrigues.pdf
Sabença, C. C.S. (2023). Avaliação da influência da força iônica na síntese de nanopartículas de fe3o4 para aplicação de hipertermia magnética. Universidade Federal Fluminense.
Silva, V. & Costa, I. & Barros, R. & Almeida, C. & Gonzaga, M. (2021). Nanotecnologia aplicada ao tratamento do câncer. Revista Saúde em Foco, 13, 95-107.
Tong, S., Zhu, H., & Bao, G. (2019). Magnetic iron oxide nanoparticles for disease detection and therapy. Materials Today (Kidlington, England), 31, 86–99. https://doi.org/10.1016/j.mattod.2019.06.003
Verma, J., Warsame, C., Seenivasagam, R. K., Katiyar, N. K., Aleem, E., & Goel, S. (2023). Nanoparticle-mediated cancer cell therapy: basic science to clinical applications. Cancer Metastasis Reviews, 42(3), 601–627. https://doi.org/10.1007/s10555-023-10086-2
Veronez, L., Salomão, K., das Chagas, P., Barbieri, M., Scrideli, C., & Tone, L. (2019). Genética e imunologia do câncer para alunos do ensino básico: relato de uma experiência. Revista Brasileira de Extensão Universitária, 10(2), 63-70. https://doi.org/10.24317/2358-0399.2019v10i2.10625
Yigit, M. V., Moore, A., & Medarova, Z. (2012). Magnetic nanoparticles for cancer diagnosis and therapy. Pharmaceutical Research, 29(5), 1180–1188. https://doi.org/10.1007/s11095-012-0679-7
Zhang, X. and Webb, A. (2005). Design of a four-coil surface array for in vivo magnetic resonance microscopy at 600 MHz. Concepts in Magnetic Resonance. 24B: 6-14. https://doi.org/10.1002/cmr.b.20022
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Carolina Cardoso Santos; Gustavo José Vasco Pereira; Isabelle Almeida de Sousa Cunha; Jaqueline Lopes; Mirella Silva Rocha
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
