Strategies to combat antimicrobial resistance in hospital infections: A literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v13i8.46545

Keywords:

Antimicrobial resistance; Hospital infections; Antimicrobial stewardship; Surveillance; Infection control.

Abstract

Antimicrobial resistance (AMR) in hospital infections represents a critical challenge for global public health, compromising treatment efficacy and increasing morbidity and mortality. This article reviews existing literature on strategies to combat AMR in hospital settings. Key approaches include the implementation of antimicrobial stewardship programs, which promote the rational use of antibiotics, and the continuous education of healthcare professionals on appropriate prescribing practices. Rigorous surveillance and infection control are essential to identify and contain outbreaks of resistant pathogens. The development of new therapies, including antibiotics and non-antibiotic alternatives, is crucial to address AMR. Research in rapid diagnostics is also vital to ensure appropriate and timely treatment. Collaboration among healthcare institutions, governments, and international organizations is fundamental to effectively monitor and respond to AMR. This study highlights the need for a multifaceted and coordinated approach to combat antimicrobial resistance in hospital infections, integrating education, surveillance, therapeutic innovation, and global cooperation.

References

Baur, D., Gladstone, B. P., Burkert, F., Carrara, E., Foschi, F., Döbele, S., & Tacconelli, E. (2017). Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis. The Lancet Infectious Diseases, 17(9), 990-1001. 10.1016/S1473-3099(17)30325-0.

Cassini, A., Högberg, L. D., Plachouras, D., Quattrocchi, A., Hoxha, A., Simonsen, G. S., & Suetens, C. (2019). Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. The Lancet Infectious Diseases, 19(1), 56-66. 10.1016/S1473-3099(18)30605-4.

Centers for Disease Control and Prevention. (2019). Antibiotic resistance threats in the United States, 2019. U.S. Department of Health and Human Services, CDC.

Dyar, O. J., Huttner, B., Schouten, J., & Pulcini, C. (2017). What is antimicrobial stewardship? Clinical Microbiology and Infection, 23(11), 793-798

Holmes, A. H., Moore, L. S., Sundsfjord, A., Steinbakk, M., Regmi, S., Karkey, A., & Piddock, L. J. V. (2016). Understanding the mechanisms and drivers of antimicrobial resistance. The Lancet, 387(10014), 176-187.

Howard, P., Pulcini, C., Hara, G. L., West, R. M., Gould, I. M., Harbarth, S., & Nathwani, D. (2018). An international cross-sectional survey of antimicrobial stewardship programmes in hospitals. Journal of Antimicrobial Chemotherapy, 73(4), 1121-1130. 10.1093/jac/dkx503.

Klein, E. Y., Van Boeckel, T. P., Martinez, E. M., Pant, S., Gandra, S., Levin, S. A., & Laxminarayan, R. (2018). Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proceedings of the National Academy of Sciences, 115(15), E3463-E3470.

Laxminarayan, R., Duse, A., Wattal, C., Zaidi, A. K., Wertheim, H. F., Sumpradit, N., & Cars, O. (2013). Antibiotic resistance—the need for global solutions. The Lancet Infectious Diseases, 13(12), 1057-1098.

Llor, C., & Bjerrum, L. (2018). Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Therapeutic Advances in Drug Safety, 9(9), 559-574. 10.1177/2042098618782785.

Mendes, K. D., Silveira, R. C., & Galvão, C. M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto - Enfermagem, 17(4), 758-764.

O'Neill, J. (2016). Tackling drug-resistant infections globally: final report and recommendations. Review on Antimicrobial Resistance.

Parker, H. M., & Mattick, J. S. (2019). The role of antimicrobial stewardship programmes in reducing antibiotic resistance. British Medical Bulletin, 131(1), 81-91. 10.1093/bmb/ldz032.

Pittet, D., Hugonnet, S., Harbarth, S., Mourouga, P., Sauvan, V., Touveneau, S., & Perneger, T. V. (2000). Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. The Lancet, 356(9238), 1307-1312.

Rutala, W. A., & Weber, D. J. (2019). Disinfection and sterilization in health care facilities: An overview and current issues. Infection Control & Hospital Epidemiology, 40(1), 1-10.

Schuts, E. C., Hulscher, M. E., Mouton, J. W., Verduin, C. M., Stuart, J. W., Overdiek, H. W., & Prins, J. M. (2018). Current evidence on hospital antimicrobial stewardship objectives: a systematic review and meta-analysis. The Lancet Infectious Diseases, 18(9), e627-e644. 10.1016/S1473-3099(18)30201-0.

Siegel, J. D., Rhinehart, E., Jackson, M., Chiarello, L., & Healthcare Infection Control Practices Advisory Committee. (2007). 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings. American Journal of Infection Control, 35(10).

Tacconelli, E., Carrara, E., Savoldi, A., Harbarth, S., Mendelson, M., Monnet, D. L., & Magrini, N. (2018). Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. The Lancet Infectious Diseases, 18(3), 318-327. 10.1016/S1473-3099(17)30753-3

Tamma, P. D., Miller, M. A., & Cosgrove, S. E. (2019). Rethinking how antibiotics are prescribed: incorporating the 4 moments of antibiotic decision making into clinical practice. JAMA, 321(2), 139-140. 10.1001/jama.2018.19509.

Ventola, C. L. (2015). The antibiotic resistance crisis: part 1: causes and threats. P & T, 40(4), 277-283.

World Health Organization. (2020). Antimicrobial resistance. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance.

Published

10/08/2024

How to Cite

MENDES, L. M. C. .; LINO, L. A. .; DEUS FILHO , A. L. de .; SILVA, P. H. B. da .; ROCHA, S. M. S. .; MONTINO, M. C. .; TOMAZ, M. E. G. .; LIMA, A. C. P. de .; GOMES, C. V. C. .; CASTRO , P. A. de .; SANTOS , N. O. .; FERNANDES , J. R. P. de C. . Strategies to combat antimicrobial resistance in hospital infections: A literature review. Research, Society and Development, [S. l.], v. 13, n. 8, p. e3713846545, 2024. DOI: 10.33448/rsd-v13i8.46545. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/46545. Acesso em: 6 sep. 2024.

Issue

Section

Health Sciences