Impact of deep brain stimulation on cognition in Alzheimer's patients
DOI:
https://doi.org/10.33448/rsd-v13i8.46624Keywords:
Alzheimer disease; Deep brain stimulation; Social cognition.Abstract
Alzheimer's disease (AD) is a progressive and chronic disorder, characterized by the destruction of cholinergic neurons, and is one of the main causes of dementia in the world. Deep brain stimulation (DBS) is effective in treating symptoms and features of various disorders, including Parkinson's disease, essential tremor, dystonia, epilepsy, and obsessive-compulsive disorder, and is currently being explored for use in other disorders, including Alzheimer's disease, obesity, anorexia nervosa, among others. In addition to altering local and network-wide circuitry, there is growing evidence that DBS may also have neuroprotective effects. The present work is constituted under the format of a Systematic Review, which is used as a tool to summarize, evaluate and communicate the results and implications of a large amount of research and information. The promising results of some studies highlight the urgent need for larger-scale RCTs with larger sample sizes and more standardized stimulation parameters to understand whether PES can become an innovative treatment for AD. This study aims to describe the occurrence of cases in which DBS, in patients with Alzheimer´s, had an impact on the social cognition and quality of life of this population group.
References
Barcia, J. A., Viloria, M. A., Yubero, R., Sanchez-Sanchez-Rojas, L., López, A., Strange, B. A., Cabrera, M., Canuet, L., Gil, P., & Nombela, C. (2022). Directional DBS of the Fornix in Alzheimer's Disease Achieves Long-Term Benefits: A Case Report. Frontiers in aging neuroscience, 14, 809972. https://doi.org/10.3389/fnagi.2022.809972
Bateman, R. J., Xiong, C., Benzinger, T. L., Fagan, A. M., Goate, A., Fox, N. C., et al. (2012). Alterações clínicas e de biomarcadores na doença de Alzheimer predominantemente hereditária.N. Engl. J. Med. 367, 795–804. 10.1056/NEJMoa1202753
Bauab, J. P., & Emmel, M. L. G.. (2014). Mudanças no cotidiano de cuidadores de idosos em processo demencial. Revista Brasileira De Geriatria E Gerontologia, 17(2), 339–352. https://doi.org/10.1590/S1809-98232014000200011
Cheyuo, C., Germann, J., Yamamoto, K., Vetkas, A., Loh, A., Sarica, C., Milano, V., Zemmar, A., Flouty, O., Harmsen, I. E., Hodaie, M., Kalia, S. K., Tang-Wai, D., & Lozano, A. M. (2022). Connectomic neuromodulation for Alzheimer's disease: A systematic review and meta-analysis of invasive and non-invasive techniques. Translational psychiatry, 12(1), 490. https://doi.org/10.1038/s41398-022-02246-9
Deeb, W., Salvato, B., Almeida, L., Foote, K. D., Amaral, R., Germann, J., Rosenberg, P. B., Tang-Wai, D. F., Wolk, D. A., Burke, A. D., Salloway, S., Sabbagh, M. N., Chakravarty, M. M., Smith, G. S., Lyketsos, C. G., Lozano, A. M., & Okun, M. S. (2019). Fornix-Region Deep Brain Stimulation-Induced Memory Flashbacks in Alzheimer's Disease. The New England journal of medicine, 381(8), 783–785. https://doi.org/10.1056/NEJMc1905240
Falco, A. D., Cukierman, D. S., Hauser-Davis, R. A., & Rey, N. A.. (2016). Doença de Alzheimer: hipóteses etiológicas e perspectivas de tratamento. Química Nova, 39(1), 63–80. https://doi.org/10.5935/0100-4042.20150152.
Forlenza, O. V.. (2005). Tratamento farmacológico da doença de Alzheimer. Archives of Clinical Psychiatry, 32(3), 137–148. https://doi.org/10.1590/S0101-60832005000300006
Fox, M. D., Buckner, R. L., Liu, H., Chakravarty, M. M., Lozano, A. M., Pascual-Leone, A. (2014). Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases. Proc Natl Acad Sci. 111, E4367–75. https://doi.org/10.1073/pnas.1405003111
Frota, N. A. F., Nitrini, R., Damasceno, B. P., Forlenza, O. V., Dias-Tosta, E., Silva, A. B., et al. (2022). Diagnóstico da doença de Alzheimer: Recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia. Dementia & Neuropsychologia, 16(3 Suppl. 1), 25-39. https://doi.org/10.1590/1980-57642011DN05030002
Goard, M., & Dan, Y. (2009). Basal forebrain activation enhances cortical coding of natural scenes. Nature neuroscience, 12(11), 1444–1449. https://doi.org/10.1038/nn.2402
Holtzman, D. M., John, C. M. & Goate, A. (2011). Alzheimer’s disease: The challenge of the second century. SciTransl Med. 3(77):77. https://doi.org/10.1126/scitranslmed.3002369.
Huang, P., Lin, L., Zhang, J., Cheng, Y., & Pan, X. (2024). Efficacy analysis of three brain stimulation techniques for Alzheimer's disease: a meta-analysis of repeated transcranial magnetic stimulation, transcranial direct current stimulation, and deep brain stimulation. Expert review of neurotherapeutics, 24(1), 117–127. https://doi.org/10.1080/14737175.2023.2293225
Jafari, Z., Kolb, B. E., & Mohajerani, M. H. (2020). Neural oscillations and brain stimulation in Alzheimer's disease. Progress in neurobiology, 194, 101878. https://doi.org/10.1016/j.pneurobio.2020.101878
Jiao, L., Kang, H., Geng, Y., Liu, X., Wang, M., & Shu, K. (2024). The role of the nucleus basalis of Meynert in neuromodulation therapy: a systematic review from the perspective of neural network oscillations. Frontiers in aging neuroscience, 16, 1376764. https://doi.org/10.3389/fnagi.2024.1376764
Ledig, C., Schuh, A., Guerrero, R., Heckemann, R. A., e Rueckert, D. (2018). Imagem estrutural cerebral na doença de Alzheimer e comprometimento cognitivo leve: análise de biomarcadores e banco de dados de morfometria compartilhados. Rep. 8, 11258. DOI: 10.1038/s41598-018-29295-9
Lozano, A. M., Fosdick, L., Chakravarty, M. M., Leoutsakos, J. M., Munro, C., Oh, E., Drake, K. E., Lyman, C. H., Rosenberg, P. B., Anderson, W. S., Tang-Wai, D. F., Pendergrass, J. C., Salloway, S., Asaad, W. F., Ponce, F. A., Burke, A., Sabbagh, M., Wolk, D. A., Baltuch, G., Okun, M. S., & Smith, G. S. (2016). A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 54(2), 777–787. https://doi.org/10.3233/JAD-160017
Luo, Y., Sun, Y., Tian, X., Zheng, X., Wang, X., Li, W., et al. Estimulação cerebral profunda para a doença de alzheimer: parâmetros de estimulação e potenciais mecanismos de ação. Neurosci do Envelhecimento. 13, 619543. 10.3389/fnagi.2021.619543
Majdi, A., Deng, Z., Sadigh-Eteghad, S., De Vloo, P., Nuttin, B., & Mc Laughlin, M. (2023). Deep brain stimulation for the treatment of Alzheimer's disease: A systematic review and meta-analysis. Frontiers in neuroscience, 17, 1154180. https://doi.org/10.3389/fnins.2023.1154180
Marques, Y., Casarin, F., Huppes, B., Maziero, B., Gehlen, M., & Ilha, S. (2022). Doença de Alzheimer na pessoa idosa/família: potencialidades, fragilidades e estratégias. Cogitare Enfermagem, 27. Recuperado de https://revistas.ufpr.br/cogitare/article/view/80169
McKinnon, C., Gros, P., Lee, D. J., Hamani, C., Lozano, A. M., Kalia, L. V., & Kalia, S. K. (2018). Deep brain stimulation: potential for neuroprotection. Annals of Clinical and Translational Neurology, 6(1), 174–185. https://doi.org/10.1002/acn3.682
Moreta, M. P., Burgos-Alonso, N., Torrecilla, M., Marco-Contelles, J., & Bruzos-Cidón, C. (2021). Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer's Disease. Review of Reviews. Biomedicines, 9(11), 1689. https://doi.org/10.3390/biomedicines9111689
Nardone, R., Höller, Y., Tezzon, F., Christova, M., Schwenker, K., Golaszewski, S., Trinka, E., & Brigo, F. (2015). Neurostimulation in Alzheimer's disease: from basic research to clinical applications. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 36(5), 689–700. https://doi.org/10.1007/s10072-015-2120-6
Nardone, R., Sebastianelli, L., Versace, V., Ferrazzoli, D., Saltuari, L., & Trinka, E. (2021). TMS-EEG Co-Registration in Patients with Mild Cognitive Impairment, Alzheimer's Disease and Other Dementias: A Systematic Review. Brain sciences, 11(3), 303. https://doi.org/10.3390/brainsci11030303
Nazmuddin, M., Philippens, I. H. C. H. M., & van Laar, T. (2021). Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data. Scientific reports, 11(1), 11751. https://doi.org/10.1038/s41598-021-91391-0
Neto, H. A. (Org.). (2017). A Disease Called Alzheimer. Mirabilia Medicinæ, 9, V UNESC Medical Humanities Seminar, V Seminário UNESC de Humanidades Médicas, Jul-Dez 2017. ISSN 1676-5818.
Page, M. J., Moher, D., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., & McGuinness, L. A. (2021). PRISMA 2020 Explanation and elaboration: Updated Guidance and Exemplars for Reporting Systematic Reviews. BMJ, 372(160). NCBI. https://doi.org/10.1136/bmj.n160
Palop, J. J., & Mucke, L. (2010). Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nature neuroscience, 13(7), 812–818. https://doi.org/10.1038/nn.2583
Picton, B., Wong, J., Lopez, A. M., Solomon, S. S., Andalib, S., Brown, N. J., Dutta, R. R., Paff, M. R., Hsu, F. P., & Oh, M. Y. (2024). Deep Brain Stimulation as an Emerging Therapy for Cognitive Decline in Alzheimer Disease: Systematic Review of Evidence and Current Targets. World neurosurgery, 184, 253–266.e2. https://doi.org/10.1016/j.wneu.2023.12.083
Ponce, F. A., Asaad, W. F., Foote, K. D., Anderson, W. S., Rees Cosgrove, G., Baltuch, G. H., Beasley, K., Reymers, D. E., Oh, E. S., Targum, S. D., Smith, G. S., Lyketsos, C. G., Lozano, A. M., & ADvance Research Group (2016). Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial. Journal of neurosurgery, 125(1), 75–84. https://doi.org/10.3171/2015.6.JNS15716
Remoli, G., Tariciotti, L., Remore, L. G., Palmisciano, P., Sciancalepore, F., Canevelli, M., Lacorte, E., Da Re, F., Bruno, G., Ferrarese, C., Appollonio, I., Locatelli, M., & Vanacore, N. (2023). An updated overview of recent and ongoing deep brain stimulation (DBS) trials in patients with dementia: a systematic review. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 44(10), 3395–3427. https://doi.org/10.1007/s10072-023-06821-w
Sampaio, R., & Mancini, M. (2007). Estudos de revisão sistemática: um guia para síntese criteriosa da evidência científica. Revista Brasileira de Fisioterapia, 11(1), 83–89. https://doi.org/10.1590/s1413-35552007000100013
Segtnan, E. A., Majdi, A., Constantinescu, C., Grupe, P., Gerke, O., Dali, H., et al. Manifestações diagnósticas da razão do metabolismo da glicose hemisférica total na diásquise da rede neuronal: implicações diagnósticas na doença de Alzheimer e comprometimento cognitivo leve. Eur. J. Nucl. 46, 1164–1174. 10.1007/s00259-018-4248-0
Silva, M. V. F., Loures, C. M. G., Alves, L. C. V., de Souza, L. C., Borges, K. B. G., Carvalho, M. D. G., et al. Doença de Alzheimer: fatores de risco e medidas potencialmente protetoras. J. Biomed. Ciência. 26, 33. 10.1186/s12929-019-0524-y
Williams, M. M., Storandt, M., Roe, C. M., & Morris, J. C. (2013). Progression of Alzheimer's disease as measured by Clinical Dementia Rating Sum of Boxes scores. Alzheimer's & dementia : the journal of the Alzheimer's Association, 9(1), S39–S44. https://doi.org/10.1016/j.jalz.2012.01.005
Yi, H. A., Möller, C., Dieleman, N., Bouwman, F. H., Barkhof, F., Scheltens, P., et al. Relação entre atrofia da substância cinzenta subcortical e conversão de comprometimento cognitivo leve para doença de Alzheimer. J. Neurol. Neurossurg. Psiquiatria. 87, 425–432. 10.1136/jnnp-2014-309105
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Lavínia Pessoa de Melo Albuquerque Cavalcanti; Letícia Bezerra de Almeida; Maria Eduarda Notaro Cavalvanti; Maria Júlia Tenório Oliveira da Silva; Roberta Gomes Barros; Wagner Gonçalves Horta
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
