Endometriosis and infertility: Updates on the pathophysiological aspects and treatment of the association

Authors

DOI:

https://doi.org/10.33448/rsd-v13i8.46696

Keywords:

Endometriosis; Infertility; Treatment.

Abstract

Introduction: Endometriosis is a benign gynecological disorder that mainly affects women of childbearing age. As a multisystem disease, in addition to the female reproductive system, intestinal portions and structures of the urinary system can also be affected. Its pathophysiology is complex and multifactorial, as is establishing the diagnosis. Treatment is multidisciplinary and multimodal. Objective: The aim of this study was to evaluate the clinical, epidemiological and pathophysiological aspects of the association between infertility and endometriosis. Materials and Methods: This is an integrative literature review on the general clinical characteristics of the association between endometriosis and infertility. The PICO strategy was used to develop the guiding question. In addition, the descriptors "Endometriosis"; "Infertility"; "Treatment" were cross-referenced in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), Ebscohost, Google Scholar and Virtual Health Library (VHL) databases. Results and Discussion: The studies show that the association between endometriosis and infertility involves specific nuances within medicine, including pathophysiological, clinical, epidemiological and therapeutic aspects. Conclusion: The association between infertility and endometriosis is already well established in the literature and involves the interaction of multiple pathophysiological factors. In order to deal with it correctly, there are now drug and surgical techniques as well as assisted reproduction techniques, and the doctor must analyze and select the most appropriate treatment for each patient.

References

Coccia, M. E., Nardone, L., & Rizzello, F. (2022). Endometriosis and Infertility: A Long-Life Approach to Preserve Reproductive Integrity. International Journal of Environmental Research and Public Health, 19(10), 6162. https://doi.org/10.3390/ijerph19106162

Almeida, R. V. de, Guimarães, V. de P. R., Kurosawa, J. A. A., Mileo, A. B. V., & Yasojima, E. Y. (2022). Tratamento cirúrgico da Endometriose Pélvica - revisão de literatura / Surgical treatment of Pelvic Endometriosis - literature review. Brazilian Journal of Health Review, 5(3), 11920–11934. https://doi.org/10.34119/bjhrv5n3-323

Apolinário, P. A., Pinheiro, L. E. G., & Sousa, M. N. A. de. (2023). O papel da cirurgia na endometriose. Revista Eletrônica Acervo Saúde, 23(1), e11772. https://doi.org/10.25248/reas.e11772.2023

Bonavina, G., & Taylor, H. S. (2022). Endometriosis-associated infertility: From pathophysiology to tailored treatment. Frontiers in Endocrinology, 13. https://doi.org/10.3389/fendo.2022.1020827

Broi, M. G. D., Ferriani, R. A., & Navarro, P. A. (2019). Ethiopathogenic mechanisms of endometriosis-related infertility. JBRA Assisted Reproduction. https://doi.org/10.5935/1518-0557.20190029

Carneiro, H. L., Figueiredo, B. Q. de, Machado, K. S., Cunha, L. L. P. da, Pereira, R. M. P., Naves, P. G. R., Silva, J. L. A., Lage, L. T., Sousa, J. M. de, & Souza, R. L. de. (2023). O papel da endometriose na infertilidade feminina: uma revisão integrativa de literatura. Research, Society and Development, 12(3), e6612340529–e6612340529. https://doi.org/10.33448/rsd-v12i3.40529

Didziokaite, G., Biliute, G., Gudaite, J., & Kvedariene, V. (2023). Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility. International Journal of Molecular Sciences, 24(4), 3809. https://doi.org/10.3390/ijms24043809

Federação Brasileira das Associações de Ginecologia e Obstetrícia (FEBRASGO). Endometriose. São Paulo: FEBRASGO, 2021 (Protocolo FEBRASGO-Ginecologia, n. 78/Comissão Nacional Especializada em Endometriose).

Filip, L., Duică, F., Prădatu, A., Crețoiu, D., Suciu, N., Crețoiu, S. M., Predescu, D.-V., Varlas, V. N., & Voinea, S.-C. (2020). Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches. Medicina, 56(9), 460. https://doi.org/10.3390/medicina56090460

Flávia, M., Ferreira, S., Adriane Farias Patriota, Girliane, A., Inaia Mackert Pascoal, Luiz Gonçalves Filho, Vieira, I., Silva, & Silva. (2022). Endometriose e seus desafios no diagnóstico e tratamento: revisão integrativa da literatura. 15(9), e10979–e10979. https://doi.org/10.25248/reas.e10979.2022

Gama, A. V., Crystina, M., Júlia, M., Pereira, K., Maillany Amorim Gomes, Gabriela Moreira Lima, Costa, S., Catarina, A., & Carolinne Lisboa Silva. (2023). A endometriose e sua abordagem cirúrgica. Brazilian Journal of Development, 9(6), 19151–19161. https://doi.org/10.34117/bjdv9n6-030

Hodgson, R. M., Lee, H. L., Wang, R., Mol, B. W., & Johnson, N. (2020). Interventions for endometriosis-related infertility: a systematic review and network meta-analysis. Fertility and Sterility, 113(2), 374-382.e2. https://doi.org/10.1016/j.fertnstert.2019.09.031

Horne, A. W., & Missmer, S. A. (2022). Pathophysiology, diagnosis, and management of endometriosis. BMJ, 379(379), e070750. https://doi.org/10.1136/bmj-2022-070750

Pinto, L. V. R. C. P., Saleh, K. W., Barbosa, L. de A., Pinto, A. C. A., Sagrillo, I. F., Araujo, H. L. O. de, Lucindo, I. M. T., & Roza, T. C. B. N. (2022). Endometriose e infertilidade: relação e tratamento / Endometriosis and infertility: relationship and treatment. Brazilian Journal of Health Review, 5(2), 5889–5898. https://doi.org/10.34119/bjhrv5n2-165

Shan, J., Da Jin Li, & Wang, X. (2023). Towards a Better Understanding of Endometriosis-Related Infertility: A Review on How Endometriosis Affects Endometrial Receptivity. Biomolecules, 13(3), 430–430. https://doi.org/10.3390/biom13030430

Smolarz, B., Szyłło, K., & Romanowicz, H. (2021). Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature). International Journal of Molecular Sciences, 22(19), 10554. https://doi.org/10.3390/ijms221910554

Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8(1), 102–106. https://doi.org/10.1590/s1679-45082010rw1134.

Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of business research, 104, 333-339.

Vercellini, P., Viganò, P., Bandini, V., Buggio, L., Berlanda, N., & Somigliana, E. (2023). Association of endometriosis and adenomyosis with pregnancy and infertility. Fertility and Sterility, 119(5), 727–740. https://doi.org/10.1016/j.fertnstert.2023.03.018

Vieira, G. C. D., Silva, J. A. C. da, Padilha, R. T., & Padilha, D. de M. M. (2020). Endometriose: causas, implicações e tratamento da infertilidade feminina através das técnicas de reprodução assistida. Research, Society and Development, 9(10), e6859109128. https://doi.org/10.33448/rsd-v9i10.9128

Published

31/08/2024

How to Cite

NUNES, L. M. R. .; TOLEDO, M. P. .; NUNES, L. M. R. .; ALTIVO, Y. L. .; VELOSO, B. C. . Endometriosis and infertility: Updates on the pathophysiological aspects and treatment of the association. Research, Society and Development, [S. l.], v. 13, n. 8, p. e12913846696, 2024. DOI: 10.33448/rsd-v13i8.46696. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/46696. Acesso em: 6 sep. 2024.

Issue

Section

Health Sciences