Defining aspects of Mesenteric Lymphadenitis: A rare and underexplored condition
DOI:
https://doi.org/10.33448/rsd-v13i8.46716Keywords:
Propaedeutics; Mesenteric lymphadenitis; Clinical manifestations.Abstract
Introduction: Mesenteric lymphadenitis (ML) is a syndrome characterized by right lower quadrant abdominal pain resulting from an inflammatory condition of the mesenteric lymph nodes. It is a rare and self-limiting condition that generally does not present complications, but it mimics other conditions such as acute appendicitis. Objective: To define general information about mesenteric lymphadenitis. Materials and Methods: This study is an integrative literature review on the general clinical characteristics of mesenteric lymphadenitis and its approaches. The PICO strategy was used to formulate a guiding question. Moreover, a search was conducted using the keywords "Mesenteric Lymphadenitis"; "Clinical Manifestations"; "Propaedeutics," across databases including the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), Ebscohost, Google Scholar, and Virtual Health Library (BVS). Results and Discussion: Evidence on ML is extremely limited, making it difficult to identify the epidemiological pattern and other defining characteristics of the disease. The peak incidence appears to be between 5 and 8 years old. Abdominal pain, nausea, vomiting, and fever constitute the clinical picture. Lymphocytosis is frequently observed. Complications have not been documented, and the prognosis is generally favorable, with resolution in an average of four weeks. Conclusion: Due to the rarity of mesenteric lymphadenitis, its self-limiting nature, and the scarcity of publications dedicated exclusively to the topic, it is still challenging to precisely delineate the clinical and laboratory patterns that define this condition. Rigorous studies are essential to improve understanding and treatment of mesenteric lymphadenitis.
References
Alshoaibi, N. M., Alsaedi, W. H., Alsulaimani, R. W., Althagafi, K. A., Alhemaid, M. K., & Hazzaa, I. (2019). Clinical, Laboratory, and Radiological Differentiation between Acute Appendicitis and Acute Mesenteric Adenitis in Paediatrics: A Literature Review. EC Microbiology, 15, 1082-7.
Benetti, C., Conficconi, E., Hamitaga, F., Wyttenbach, M., Lava, S. A. G., Milani, G. P., Bianchetti, M. G., Simonetti, G. D., & Helbling, R. (2018). Course of acute nonspecific mesenteric lymphadenitis: single-center experience. European Journal of Pediatrics, 177(2), 243–246. https://doi.org/10.1007/s00431-017-3010-0
Chanchlani, R. (2015). Clinical profile and management of mesenteric lymphadenitis in children-our experience. Int J Orthop Traumatol Surg Sci, 1(1), 1-4.
El-Reshaid, K., Al-Bader, S., & Markova, Z. (2021). Mesenteric lymphadenitis; a common diagnostic mimic to acute appendicitis. With radiology it is no more a diagnosis of exclusion, laparoscopy or surgery. Journal of Drug Delivery and Therapeutics, 11(2), 55–57. https://doi.org/10.22270/jddt.v11i2.4590
Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8(1), 102–106. https://doi.org/10.1590/s1679-45082010rw1134.
Gawad, A., Abu, F., & Aliaa Mohammed Talat. (2016). The utility of multi-detector CT in detection and characterization of mesenteric lymphadenopathy with histopathological confirmation. The Egyptian Journal of Radiology and Nuclear Medicine, 47(3), 757–764. https://doi.org/10.1016/j.ejrnm.2016.06.020
Gross, I., Siedner-Weintraub, Y., Stibbe, S., Rekhtman, D., Weiss, D., Simanovsky, N., Arbell, D., & Hashavya, S. (2017). Characteristics of mesenteric lymphadenitis in comparison with those of acute appendicitis in children. European Journal of Pediatrics, 176(2), 199–205. https://doi.org/10.1007/s00431-016-2822-7
Helbling, R., Conficconi, E., Wyttenbach, M., Benetti, C., Simonetti, G. D., Bianchetti, M. G., Hamitaga, F., Lava, S. A. G., Fossali, E. F., & Milani, G. P. (2017). Acute Nonspecific Mesenteric Lymphadenitis: More Than “No Need for Surgery.” BioMed Research International, 2017. https://doi.org/10.1155/2017/9784565
Kurian, B., Philip, P., & Kommu, P. P. K. (2024). Association of mesenteric lymphadenitis with abdominal pain in children–A case–control study. Asian Journal of Medical Sciences, 15(2), 104-107.
Lahel, R. S., & Chail, A. (2023). Relevance of Mesenteric Lymphadenopathy in Children Detected on Sonography. Journal of Marine Medical Society, 25(1), 78-80.
Mota, A., & Schraiber, L. B. (2014). Medicina sob as lentes da História: reflexões teórico-metodológicas. Ciência & Saúde Coletiva, 19, 1085-1094.
Özdamar, M. Y., & Karavaş, E. (2018). Acute mesenteric lymphadenitis in children: findings related to differential diagnosis and hospitalization. Archives of Medical Science, 16(2), 313-320.
Otto, M., & Nagalli, S. (2020). Mesenteric Adenitis. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK560822/
Pavlovic, M., Rokvic, Z., & Berenji, K. (2020). Prednisone for the treatment of acute nonspecific mesenteric lymphadenitis. Open Access Macedonian Journal of Medical Sciences, 8(C), 82-85.
Shahba, L., Parizi, M. K., & Shafie, M. (2024). Comparison of Clinical and Laboratory Manifestations Between Acute Appendicitis and Mesenteric Lymphadenitis in Children. Cureus, 16(6).
Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8, 102-106.
Tobcu, E., Tobcu, Z. (2024). Relationship Between Mesenteric Lymphadenitis and SIRS. Advanced Radiology and Imaging, 1(1), 13-16. doi:10.4274/AdvRadiolImaging.galenos.2024.35220.
Watanabe, K., Watanabe, N., Jin, M., Tamotsu Matsuhashi, Koizumi, S., Kengo Onochi, Masayuki Sawaguchi, Tawaraya, S., Miyazawa, H., Hiroshi Uchinami, Yamamoto, Y., Hiroshi Nanjo, Hirohide Ohnishi, & Hirosato Mashima. (2014). Mesenteric lymph node abscess due to Yersinia enterocolitica: case report and review of the literature. Clinical Journal of Gastroenterology, 7(1), 41–47. https://doi.org/10.1007/s12328-013-0452-4
Zhu, Y. C., Zhou, L., Zu, D. M., Deng, S. H., Zhang, Y., Shan, J., & Jiang, Q. Clinical applications of superb microvascular imaging and virtual touch imaging quantification in pediatric mesenteric lymphadenitis diagnosis: A promising pathway to enhanced precision. Clinical Hemorheology and Microcirculation, 1-12.
Zviedre, A., Engelis, A., Tretjakovs, P., Jurka, A., Zile, I., & Petersons, A. (2016). Role of serum cytokines in acute appendicitis and acute mesenteric lymphadenitis among children. Medicina (Kaunas, Lithuania), 52(5), 291–297. https://doi.org/10.1016/j.medici.2016.10.002
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