Microbiological profile of respiratory tract infections in children with neurological impairment

Authors

DOI:

https://doi.org/10.33448/rsd-v13i9.46824

Keywords:

Child; Microbiology; Pneumonia, Bacterial; Nervous system diseases.

Abstract

The microbiological profile of respiratory infections in children with neurological impairment (CNI) may differ from that of the general population, which is why this study is interested in investigating the main bacterial agents that affect the respiratory tract of CNI compared to the general compared to the general pediatric population. To this end, the aim of this article is to present a systematic review of the microbiological profile of respiratory tract infections in children with neurological impairment. Initially found 34 articles in the Pubmed, Cochrane and BvSalud databases, published between 2014 and 2024. Of these, articles covering bacterial pneumonia were included, and review articles without meta-analysis were excluded, master's dissertations and doctoral theses that did not contain an observational study; a total of 5 articles were used. The The main causative agents of bacterial pneumonia vary according to the child's age and condition of the child, with Pseudomonas aeruginosa and Staphylococcus aureus predominate in CNI, unlike other children, in whom commonly develop pneumonia due to Streptococcus pneumoniae and, less commonly, Staphylococcus aureus. The microbiological profile of respiratory infections in children with neurological syndromes differs from that of the general population due to their susceptibility to atypical and sometimes more severe infections. However, more studies are needed on this subject clarification is needed in the current literature.

Author Biographies

Dalila Morais Vilela, Universidade José do Rosário Vellano

 

 

Mariana Sanches de Carvalho, Universidade José do Rosário Vellano

 

 

References

Bodey, G. P., Jadeja, L., & Elting, L. (1985). Pseudomonas bacteremia: retrospective analysis of 410 episodes. Archives of internal medicine, 145(9), 1621-1629.

Broughton, R. A. (1986). Infections due toMycoplasma pneumoniaein childhood. The Pediatric infectious disease journal, 5(1), 71-85.

Banerjee, R., Barnett, E. D., Lynfield, R., Sawyer, M. H. (2024). Streptococcus pneumoniae (pneumococcal) infections. American Academy of Pediatrics & Committee on Infectious Diseases. Red book: 2024-2027 report of the Committee on Infectious Diseases, 33ª Ed. American Academy of Pediatrics, p. 810.

Carter, M. J., Gurung, M., Pokhrel, B., Bijukchhe, S. M., Karmacharya, S., Khadka, B., & Pollard, A. J. (2022). Childhood Invasive Bacterial Disease in Kathmandu, Nepal (2005–2013). The Pediatric infectious disease journal, 41(3), 192-198.

Crabtree, T. D., Gleason, T. G., Pruett, T. L., & Sawyer, R. G. (1999). Trends in nosocomial pneumonia in surgical patients as we approach the 21st century: a prospective analysis. The American Surgeon, 65(8), 706-710.

Estrela, C. (2018). Metodologia científica: ciência, ensino, pesquisa. Artes médicas.

Green, E. W., Ndiaye, M., Hossain, I. M., Olatunji, Y. A., Sahito, S. M., Salaudeen, R., & Mackenzie, G. A. (2023). Pneumonia, meningitis, and Septicemia in adults and older children in rural Gambia: 8 years of population-based surveillance. Clinical Infectious Diseases, 76(4), 694-703.

Harris, M., Clark, J., Coote, N., Fletcher, P., Harnden, A., McKean, M., & Thomson, A. (2002). British Thoracic Society guidelines for the management of community acquired pneumonia in children. Thorax, 57(Suppl 1), i1-e24.

Jain, S., Self, W. H., Wunderink, R. G., Fakhran, S., Balk, R., Bramley, A. M., & Finelli, L. (2015). Community-acquired pneumonia requiring hospitalization among US adults. New England Journal of Medicine, 373(5), 415-427.

Mpabalwani, E. M., Lukwesa-Musyani, C., Imamba, A., Nakazwe, R., Matapo, B., Muzongwe, C. M., ... & Lessa, F. C. (2019). Declines in pneumonia and meningitis hospitalizations in children under 5 years of age after introduction of 10-valent pneumococcal conjugate vaccine in Zambia, 2010–2016. Clinical Infectious Diseases, 69(Supplement_2), S58-S65.

McIntosh, K. (2002). Community-acquired pneumonia in children. New England Journal of Medicine, 346(6), 429-437.

Moore, M. R., Link-Gelles, R., Schaffner, W., Lynfield, R., Lexau, C., Bennett, N. M., & Whitney, C. G. (2015). Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: analysis of multisite, population-based surveillance. The Lancet Infectious Diseases, 15(3), 301-309.

Moise, P. A., Gonzalez, M., Alekseeva, I., Lopez, D., Akrich, B., DeRyke, C. A., & Motyl, M. (2021). Collective assessment of antimicrobial susceptibility among the most common Gram-negative respiratory pathogens driving therapy in the ICU. JAC-Antimicrobial Resistance, 3(1), dlaa129.

Olarte, L., Barson, W. J., Barson, R. M., Romero, J. R., Bradley, J. S., Tan, T. Q., & Kaplan, S. L. (2017). Pneumococcal pneumonia requiring hospitalization in US children in the 13-valent pneumococcal conjugate vaccine era. Clinical Infectious Diseases, 64(12), 1699-1704.

Organização Mundial Da Saúde (2024). Base de dados de mortalidade da OMS: infecções respiratórias inferiores de 2020 a 2022. https://platform.who.int/mortality/themes/theme-details/topics/indicator-groups/indicator-group-details/MDB/lower-respiratory-infections

Ouldali, N., Levy, C., Minodier, P., Morin, L., Biscardi, S., Aurel, M., & Cohen, R. (2019). Long-term association of 13-valent pneumococcal conjugate vaccine implementation with rates of community-acquired pneumonia in children. JAMA pediatrics, 173(4), 362-370.

Pfaller, M. A., Jones, R. N., Doern, G. V., Kugler, K., & Group, T. S. P. (1998). Bacterial pathogens isolated from patients with bloodstream infection: frequencies of occurrence and antimicrobial susceptibility patterns from the SENTRY antimicrobial surveillance program (United States and Canada, 1997). Antimicrobial agents and chemotherapy, 42(7), 1762-1770.

Richards, M. J., Edwards, J. R., Culver, D. H., & Gaynes, R. P. (1999). Nosocomial infections in medical intensive care units in the United States. Critical care medicine, 27(5), 887-892.

Slekovec, C., Robert, J., van der Mee-Marquet, N., Berthelot, P., Rogues, A. M., Derouin, V., & Bertrand, X. (2019). Molecular epidemiology of Pseudomonas aeruginosa isolated from infected ICU patients: a French multicenter 2012–2013 study. European Journal of Clinical Microbiology & Infectious Diseases, 38, 921-926.

Thomson, J., Hall, M., Ambroggio, L., Berry, J. G., Stone, B., Srivastava, R., & Shah, S. S. (2020). Antibiotics for aspiration pneumonia in neurologically impaired children. Journal of Hospital Medicine, 15(7), 395-402.

Tipple, M. A., Beem, M. O., & Saxon, E. M. (1979). Clinical characteristics of the afebrile pneumonia associated with Chlamydia trachomatis infection in infants less than 6 months of age. Pediatrics, 63(2), 192-197.

Warniment, A., Steuart, R., Rodean, J., Hall, M., Chinchilla, S., Shah, S. S., & Thomson, J. (2021). Variation in bacterial respiratory culture results in children with neurologic impairment. Hospital Pediatrics, 11(11), e326-e333.

Published

16/09/2024

How to Cite

ROMERO, R. B. .; COSTA, A. L. R. .; VILELA, D. M. .; CARVALHO, M. S. de .; NUNES, R. A. . Microbiological profile of respiratory tract infections in children with neurological impairment. Research, Society and Development, [S. l.], v. 13, n. 9, p. e4713946824, 2024. DOI: 10.33448/rsd-v13i9.46824. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/46824. Acesso em: 27 sep. 2024.

Issue

Section

Health Sciences