Aspects of OMICs sciences in the neurobiology of aggressive human behavior
DOI:
https://doi.org/10.33448/rsd-v13i12.47808Keywords:
Genetics and aggression; Genetics and social behavior; Genes and personality.Abstract
The understanding of human behavior is based on pathogenetic concepts, empirical therapies and neuropsychopharmacological approaches, involving neurotransmitters such as norepinephrine, dopamine, serotonin, and the treatment of underlying pathologies includes psychotropic drugs, antipsychotics and selective inhibitors, whose effectiveness has been limited, denoting the involvement of other pathways in the pathogenetic process. Studies based on omic sciences (molecular biology, metabolism, transcriptional factors, genetics and epigenetics) demonstrate several genes and genetic processes of DNA methylation and repair involved in the pathogenesis of these diseases. The aim of this article is to present a systematic review study on the main aspects of omics sciences that can contribute to the understanding of the molecular mechanisms of human aggressive behavior, given its presence in most psychiatric disorders. The molecular knowledge of these processes reveals an overlap of genetic and epigenetic foundations that can provide useful information for the study, diagnosis, prediction and therapeutic research of the mechanisms of human aggressive behavior.
References
Abou Al Hassan, S., Cutinha, D., & Mattar, L. (2021). The impact of COMT, BDNF and 5-HTT brain-genes on the development of anorexia nervosa: a systematic review. Eating and weight disorders: EWD, 26(5), 1323–1344. https://doi.org/10.1007/s40519-020-00978-5
Achenbach, T. M., Ivanova, M. Y., & Rescorla, L. A. (2017). Empirically based assessment and taxonomy of psychopathology for ages 1½-90+ years: Developmental, multi-informant, and multicultural findings. Comprehensive psychiatry, 79, 4–18. https://doi.org/10.1016/j.comppsych.2017.03.006
Ai, Y., Liu, Y., Yin, M., Zhang, L., Luo, J., Zhang, S., Huang, L., Zhang, C., Liu, G., Fang, J., Zheng, H., Li, L., & Hu, X. (2024). Interactions between tDCS treatment and COMT Val158Met in poststroke cognitive impairment. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 158, 43–55. https://doi.org/10.1016/j.clinph.2023.12.011
Al-Eitan, L. N., Rababa'h, D. M., & Alghamdi, M. A. (2021). Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study. BMC psychiatry, 21(1), 5. https://doi.org/10.1186/s12888-020-03006-z
Alachkar, A., Phan, A., Dabbous, T., Alhassen, S., Alhassen, W., Reynolds, B., Rubinstein, M., Ferré, S., & Civelli, O. (2024). Humanized dopamine D4.7 receptor male mice display risk-taking behavior and deficits of social recognition and working memory in light/dark-dependent manner. Journal of neuroscience research, 102(2), e25299. https://doi.org/10.1002/jnr.25299
Alekseyenko, O. V., Chan, Y. B., Okaty, B. W., Chang, Y., Dymecki, S. M., & Kravitz, E. A. (2019). Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways. Current biology : CB, 29(13), 2145–2156.e5. https://doi.org/10.1016/j.cub.2019.05.070
American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (5th ed., text rev.). https://doi.org/10.1176/appi.books.9780890425787
Anderson, C. A., & Bushman, B. J. (2002). Human aggression. Annual review of psychology, 53, 27–51. https://doi.org/10.1146/annurev.psych.53.100901.135231
Bacqué-Cazenave, J., Bharatiya, R., Barrière, G., Delbecque, J. P., Bouguiyoud, N., Di Giovanni, G., Cattaert, D., & De Deurwaerdère, P. (2020). Serotonin in Animal Cognition and Behavior. International journal of molecular sciences, 21(5), 1649. https://doi.org/10.3390/ijms21051649
Bai, F., Huang, L., Deng, J., Long, Z., Hao, X., Chen, P., Wu, G., Wen, H., Deng, Q., Bao, X., Huang, J., Yang, M., Li, D., Ren, Y., Zhang, M., Xiong, Y., & Li, H. (2023). Prelimbic area to lateral hypothalamus circuit drives social aggression. iScience, 26(10), 107718. https://doi.org/10.1016/j.isci.2023.107718
Barnes, J.C., Beaver, K. M., & Boutwell, B. B. (2011). Examining the genetic underpinnings to Moffitt's developmental taxonomy: A behavioral genetic analysis. Criminology: An Interdisciplinary Journal, 49(4), 923–954. https://doi.org/10.1111/j.1745-9125.2011.00243.x
Barnes, J. C., & Beaver, K. M. (2012). Extending research on the victim-offender overlap: evidence from a genetically informative analysis. Journal of interpersonal violence, 27(16), 3299–3321. https://doi.org/10.1177/0886260512441259
Bayerl, D. S., & Bosch, O. J. (2019). Brain vasopressin signaling modulates aspects of maternal behavior in lactating rats. Genes, brain, and behavior, 18(1), e12517. https://doi.org/10.1111/gbb.12517
Bernardo, P., Cuccurullo, C., Rubino, M., De Vita, G., Terrone, G., Bilo, L., & Coppola, A. (2024). X-Linked Epilepsies: A Narrative Review. International journal of molecular sciences, 25(7), 4110. https://doi.org/10.3390/ijms25074110
Besemer, S., Ahmad, S.I., Hinshaw, S.P., & Farrington, D.P. (2017). A systematic review and meta-analysis of the intergenerational transmission of criminal behavior. Aggression and Violent Behavior, 37, 161-178.
Bhandari, R., Paliwal, J. K., & Kuhad, A. (2020). Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors. Advances in neurobiology, 24, 97–141. https://doi.org/10.1007/978-3-030-30402-7_4
Bilen, E., & Elioz, M. (2023). The relationship between the SLC6A4 gene polymorphism (rs 5-HTTLPR) and aggression in combat athletes. Journal of ROL Sport Sciences, 4(4), 1423–1436. https://doi.org/10.5281/zenodo.10377634
Black DW. Update on Antisocial Personality Disorder. Curr Psychiatry Rep. 2024 Oct;26(10):543-549. doi: 10.1007/s11920-024-01528-x. Epub 2024 Sep 4. PMID:39230801.
Blokhin, I. O., Khorkova, O., Saveanu, R. V., & Wahlestedt, C. (2020). Molecular mechanisms of psychiatric diseases. Neurobiology of disease, 146, 105136. https://doi.org/10.1016/j.nbd.2020.105136
Bolat, H., Ercan, E. S., Ünsel-Bolat, G., Tahillioğlu, A., Yazici, K. U., Bacanli, A., Pariltay, E., Aygüneş Jafari, D., Kosova, B., Özgül, S., Rohde, L. A., & Akin, H. (2020). DRD4 genotyping may differentiate symptoms of attention-deficit/hyperactivity disorder and sluggish cognitive tempo. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 42(6), 630–637. https://doi.org/10.1590/1516-4446-2019-0630
Bonder, M. J., Luijk, R., Zhernakova, D. V., Moed, M., Deelen, P., Vermaat, M., van Iterson, M., van Dijk, F., van Galen, M., Bot, J., Slieker, R. C., Jhamai, P. M., Verbiest, M., Suchiman, H. E., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Arindrarto, W., Kielbasa, S. M., … Heijmans, B. T. (2017). Disease variants alter transcription factor levels and methylation of their binding sites. Nature genetics, 49(1), 131–138. https://doi.org/10.1038/ng.3721
Broniarczyk-Czarniak, M., Szemraj, J., Śmigielski, J., & Gałecki, P. (2022). The Role of OXT, OXTR, AVP, and AVPR1a Gene Expression in the Course of Schizophrenia. Current issues in molecular biology, 44(1), 336–349. https://doi.org/10.3390/cimb44010025
Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993). Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science (New York, N.Y.), 262(5133), 578–580. https://doi.org/10.1126/science.8211186
Burt S. A. (2022). The Genetic, Environmental, and Cultural Forces Influencing Youth Antisocial Behavior Are Tightly Intertwined. Annual review of clinical psychology, 18, 155–178. https://doi.org/10.1146/annurev-clinpsy-072220-015507
Buss, A. H., & Durkee, A. (1957). An inventory for assessing different kinds of hostility. Journal of Consulting Psychology, 21(4), 343–349. https://doi.org/10.1037/h0046900
Cadet, J. L., & Jayanthi, S. (2021). Epigenetics of addiction. Neurochemistry international, 147, 105069. https://doi.org/10.1016/j.neuint.2021.105069
Carrico, A. W., Cherenack, E. M., Flentje, A., Moskowitz, J. T., Asam, K., Ghanooni, D., Chavez, J. V., Neilands, T. B., Dilworth, S. E., Rubin, L. H., Gouse, H., Fuchs, D., Paul, R. H., & Aouizerat, B. E. (2024). A positive affect intervention alters leukocyte DNA methylation in sexual minority men with HIV who use methamphetamine. Brain, behavior, and immunity, 120, 151–158. https://doi.org/10.1016/j.bbi.2024.05.025
Chaibi, I., Bennis, M., & Ba-M'Hamed, S. (2021). GABA-A receptor signaling in the anterior cingulate cortex modulates aggression and anxiety-related behaviors in socially isolated mice. Brain research, 1762, 147440. https://doi.org/10.1016/j.brainres.2021.147440
Chaibi, I., Bouchatta, O., Bennis, M., & Ba-M'hamed, S. (2023). The role of the anterior cingulate cortex in aggression and impulsivity. Behavioral neuroscience, 137(3), 155–169. https://doi.org/10.1037/bne0000552
Chen, X., Xu, J., Wang, H., Luo, J., Wang, Z., Chen, G., Jiang, D., Cao, R., Huang, H., Luo, D., Xiao, X., & Hu, J. (2021). Profiling the differences of gut microbial structure between schizophrenia patients with and without violent behaviors based on 16S rRNA gene sequencing. International journal of legal medicine, 135(1), 131–141. https://doi.org/10.1007/s00414-020-02439-1
Cheng, J., He, Z., Chen, Q., Lin, J., Peng, Y., Zhang, J., Yan, X., Yan, J., & Niu, S. (2023). Histone modifications in cocaine, methamphetamine and opioids. Heliyon, 9(6), e16407. https://doi.org/10.1016/j.heliyon.2023.e16407
Cooke, E. M., Connolly, E. J., Boisvert, D. L., & Hayes, B. E. (2023). A Systematic Review of the Biological Correlates and Consequences of Childhood Maltreatment and Adverse Childhood Experiences. Trauma, violence & abuse, 24(1), 156–173. https://doi.org/10.1177/15248380211021613
Colijn M. A. (2020). The characterization of psychotic symptoms in succinic semialdehyde dehydrogenase deficiency: a review. Psychiatric genetics, 30(6), 153–161. https://doi.org/10.1097/YPG.0000000000000264
Cunha-Bang, S., & Knudsen, G. M. (2021). The Modulatory Role of Serotonin on Human Impulsive Aggression. Biological psychiatry, 90(7), 447–457. https://doi.org/10.1016/j.biopsych.2021.05.016
Cupaioli, F. A., Zucca, F. A., Caporale, C., Lesch, K. P., Passamonti, L., & Zecca, L. (2021). The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects. Progress in neuro-psychopharmacology & biological psychiatry, 106, 110059. https://doi.org/10.1016/j.pnpbp.2020.110059
Dawson, M., Terstege, D. J., Jamani, N., Tsutsui, M., Pavlov, D., Bugescu, R., Epp, J. R., Leinninger, G. M., & Sargin, D. (2023). Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction. Cell reports, 42(7), 112815. https://doi.org/10.1016/j.celrep.2023.112815
Degtyareva, A. O., Antontseva, E. V., & Merkulova, T. I. (2021). Regulatory SNPs: Altered Transcription Factor Binding Sites Implicated in Complex Traits and Diseases. International journal of molecular sciences, 22(12), 6454. https://doi.org/10.3390/ijms22126454
Dragovich, A., & Borinskaya, S.A. (2019). Genetic and Genomic Basis of Aggressive Behavior. Russian Journal of Genetics, 55, 1445 - 1459.
Dresp-Langley, B., & Hutt, A. (2022). Digital Addiction and Sleep. International journal of environmental research and public health, 19(11), 6910. https://doi.org/10.3390/ijerph19116910
Duclot, F., & Kabbaj, M. (2022). Epigenetics of Aggression. Current topics in behavioral neurosciences, 54, 283–310. https://doi.org/10.1007/7854_2021_252
Eichelsheim, V.I., & van de Weijer, S.G.A. (Eds.). (2018). Intergenerational Continuity of Criminal and Antisocial Behaviour: An International Overview of Studies (1st ed.). Routledge. https://doi.org/10.4324/9781315102788
Elvir, L., Duclot, F., Wang, Z., & Kabbaj, M. (2019). Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors. Neuroscience and biobehavioral reviews, 105, 305–317. https://doi.org/10.1016/j.neubiorev.2017.09.030
Fageera, W., Chaumette, B., Fortier, M. È., Grizenko, N., Labbe, A., Sengupta, S. M., & Joober, R. (2021). Association between COMT methylation and response to treatment in children with ADHD. Journal of psychiatric research, 135, 86–93. https://doi.org/10.1016/j.jpsychires.2021.01.008
Faure, P., Fayad, S. L., Solié, C., & Reynolds, L. M. (2022). Social Determinants of Inter-Individual Variability and Vulnerability: The Role of Dopamine. Frontiers in behavioral neuroscience, 16, 836343. https://doi.org/10.3389/fnbeh.2022.836343
Ferguson C. J. (2010). Genetic contributions to antisocial personality and behavior: a meta-analytic review from an evolutionary perspective. The Journal of social psychology, 150(2), 160–180. https://doi.org/10.1080/00224540903366503
François, M., Delgado, I. C., Lafond, A., Lewis, E. M., Kuromaru, M., Hassouna, R., Deng, S., Thaker, V. V., Dölen, G., & Zeltser, L. M. (2023). Amygdala AVPR1A mediates susceptibility to chronic social isolation in females. bioRxiv : the preprint server for biology, 2023.02.15.528679. https://doi.org/10.1101/2023.02.15.528679
Fernàndez-Castillo, N., Gan, G., van Donkelaar, M. M. J., Vaht, M., Weber, H., Retz, W., Meyer-Lindenberg, A., Franke, B., Harro, J., Reif, A., Faraone, S. V., & Cormand, B. (2020). RBFOX1, encoding a splicing regulator, is a candidate gene for aggressive behavior. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 30, 44–55. https://doi.org/10.1016/j.euroneuro.2017.11.012
Fernàndez-Castillo, N., Cabana-Domínguez, J., Corominas, R., & Cormand, B. (2022). Molecular genetics of cocaine use disorders in humans. Molecular psychiatry, 27(1), 624–639. https://doi.org/10.1038/s41380-021-01256-1
Fleming, T., Kikuchi, Y., Nakajo, M., Tachizawa, M., Inazumi, T., Tsuchiya, S., Sugimoto, Y., Saito, D., Suyama, M., Ohkawa, Y., Baba, T., Morohashi, K. I., & Okubo, K. (2022). Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka. Communications biology, 5(1), 1215. https://doi.org/10.1038/s42003-022-04195-x
Fico, G., Anmella, G., Pacchiarotti, I., Verdolini, N., Sagué-Vilavella, M., Corponi, F., Manchia, M., Vieta, E., & Murru, A. (2020). The biology of aggressive behavior in bipolar disorder: A systematic review. Neuroscience and biobehavioral reviews, 119, 9–20. https://doi.org/10.1016/j.neubiorev.2020.09.015
França, T. F. A., & Pompeia, S. (2023). Reappraising the role of dopamine in adolescent risk-taking behavior. Neuroscience and biobehavioral reviews, 147, 105085. https://doi.org/10.1016/j.neubiorev.2023.105085
Fritz, M., Soravia, S. M., Dudeck, M., Malli, L., & Fakhoury, M. (2023). Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma. Biology, 12(3), 469. https://doi.org/10.3390/biology12030469
Gard, A. M., Dotterer, H. L., & Hyde, L. W. (2019). Genetic influences on antisocial behavior: recent advances and future directions. Current opinion in psychology, 27, 46–55. https://doi.org/10.1016/j.copsyc.2018.07.013
Gao, X. B., & Horvath, T. L. (2022). From Molecule to Behavior: Hypocretin/orexin Revisited From a Sex-dependent Perspective. Endocrine reviews, 43(4), 743–760. https://doi.org/10.1210/endrev/bnab042
Gegenhuber, B., & Tollkuhn, J. (2022). Epigenetic Mechanisms of Brain Sexual Differentiation. Cold Spring Harbor perspectives in biology, 14(11), a039099. https://doi.org/10.1101/cshperspect.a039099
Goodman, A., Lamping, D. L., & Ploubidis, G. B. (2010). When to use broader internalising and externalising subscales instead of the hypothesised five subscales on the Strengths and Difficulties Questionnaire (SDQ): data from British parents, teachers and children. Journal of abnormal child psychology, 38(8), 1179–1191. https://doi.org/10.1007/s10802-010-9434-x
Grieb, Z. A., & Lonstein, J. S. (2022). Oxytocin interactions with central dopamine and serotonin systems regulate different components of motherhood. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 377(1858), 20210062. https://doi.org/10.1098/rstb.2021.0062
Hande, S. H., Krishna, S. M., Sahote, K. K., Dev, N., Erl, T. P., Ramakrishna, K., Ravidhran, R., & Das, R. (2021). Population genetic variation of SLC6A4 gene, associated with neurophysiological development. Journal of genetics, 100, 16.
Harden K. P. (2021). "Reports of My Death Were Greatly Exaggerated": Behavior Genetics in the Postgenomic Era. Annual review of psychology, 72, 37–60. https://doi.org/10.1146/annurev-psych-052220-103822
Harro, J., Laas, K., Eensoo, D., Kurrikoff, T., Sakala, K., Vaht, M., Parik, J., Mäestu, J., & Veidebaum, T. (2019). Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour. Neuropharmacology, 156, 107527. https://doi.org/10.1016/j.neuropharm.2019.02.009
Homberg, J. R., & Jagiellowicz, J. (2022). A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility. Molecular psychiatry, 27(1), 514–524. https://doi.org/10.1038/s41380-021-01047-8
Hagenbeek, F. A., van Dongen, J., Pool, R., Roetman, P. J., Harms, A. C., Hottenga, J. J., Kluft, C., Colins, O. F., van Beijsterveldt, C. E. M., Fanos, V., Ehli, E. A., Hankemeier, T., Vermeiren, R. R. J. M., Bartels, M., Déjean, S., & Boomsma, D. I. (2023). Integrative Multi-omics Analysis of Childhood Aggressive Behavior. Behavior genetics, 53(2), 101–117. https://doi.org/10.1007/s10519-022-10126-7
Hawley P. H. (2003). Strategies of control, aggression, and morality in preschoolers: an evolutionary perspective. Journal of experimental child psychology, 85(3), 213–235. https://doi.org/10.1016/s0022-0965(03)00073-0
Hung, C. C., Ko, Y. C., Chen, P. H., & Chung, C. M. (2024). Impact of MAOA Gene Polymorphism on the Efficacy of Antidepressant Treatment and Craving Severity for Betel Quid Use Disorder. International journal of molecular sciences, 25(17), 9221. https://doi.org/10.3390/ijms25179221
Iamjan, S. A., Thanoi, S., Watiktinkorn, P., Reynolds, G. P., & Nudmamud-Thanoi, S. (2018). Genetic variation of GRIA3 gene is associated with vulnerability to methamphetamine dependence and its associated psychosis. Journal of psychopharmacology (Oxford, England), 32(3), 309–315. https://doi.org/10.1177/0269881117750153
IItis, A. S., Lewis, A., Neely, S., Seaton, S. W., & Jeong, S. H. (2023). Applying Genetic and Genomic Tools to Psychiatric Disorders: A Scoping Review. HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues, 35(3), 293–308. https://doi.org/10.1007/s10730-021-09465-5
Jacob T. C. (2019). Neurobiology and Therapeutic Potential of α5-GABA Type A Receptors. Frontiers in molecular neuroscience, 12, 179. https://doi.org/10.3389/fnmol.2019.00179
Jager, A., Amiri, H., Bielczyk, N., van Heukelum, S., Heerschap, A., Aschrafi, A., Poelmans, G., Buitelaar, J. K., Kozicz, T., & Glennon, J. C. (2020). Cortical control of aggression: GABA signalling in the anterior cingulate cortex. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 30, 5–16. https://doi.org/10.1016/j.euroneuro.2017.12.007
Kolla, N. J., & Bortolato, M. (2020). The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men. Progress in neurobiology, 194, 101875. https://doi.org/10.1016/j.pneurobio.2020.101875
Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024). Genetics of child aggression, a systematic review. Translational psychiatry, 14(1), 252. https://doi.org/10.1038/s41398-024-02870-7
Krassowski, M., Das, V., Sahu, S. K., & Misra, B. B. (2020). State of the Field in Multi-Omics Research: From Computational Needs to Data Mining and Sharing. Frontiers in genetics, 11, 610798. https://doi.org/10.3389/fgene.2020.610798
Landoni, M., Di Tella, S., Ciuffo, G., & Ionio, C. (2024). The Association between Post-Traumatic Stress Disorder, 5HTTLPR, and the Role of Ethnicity: A Meta-Analysis. Genes, 15(10), 1270. https://doi.org/10.3390/genes15101270
Li, C. Y., Lawrence, K., Merlo-Coyne, J., & Juntti, S. A. (2023). Prostaglandin F2α drives female pheromone signaling in cichlids, revealing a basis for evolutionary divergence in olfactory signaling. Proceedings of the National Academy of Sciences of the United States of America, 120(1), e2214418120. https://doi.org/10.1073/pnas.2214418120
López-Echeverri, Y. P., Cardona-Londoño, K. J., Garcia-Aguirre, J. F., & Orrego-Cardozo, M. (2023). Effects of serotonin transporter and receptor polymorphisms on depression. Revista Colombiana de psiquiatria (English ed.), 52(2), 130–138. https://doi.org/10.1016/j.rcpeng.2021.07.003
Lu, Q., & Hu, S. (2021). Sex differences of oxytocin and vasopressin in social behaviors. Handbook of clinical neurology, 180, 65–88. https://doi.org/10.1016/B978-0-12-820107-7.00005-7
Magwai, T., & Xulu, K. R. (2022). Physiological Genomics Plays a Crucial Role in Response to Stressful Life Events, the Development of Aggressive Behaviours, and Post-Traumatic Stress Disorder (PTSD). Genes, 13(2), 300. https://doi.org/10.3390/genes13020300
Maini, K., Hollier, J. W., Gould, H., Bollich, V., John LaForge, J., Cornett, E. M., Edinoff, A. N., Kaye, A. M., & Kaye, A. D. (2021). Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia. Health psychology research, 9(1), 24932. https://doi.org/10.52965/001c.24932
Martinez-Esteve Melnikova, A., Pijuan, J., Aparicio, J., Ramírez, A., Altisent-Huguet, A., Vilanova-Adell, A., Arzimanoglou, A., Armstrong, J., Palau, F., Hoenicka, J., & San Antonio-Arce, V. (2022). The p.Glu787Lys variant in the GRIA3 gene causes developmental and epileptic encephalopathy mimicking structural epilepsy in a female patient. European journal of medical genetics, 65(3), 104442. https://doi.org/10.1016/j.ejmg.2022.104442
McCarthy M. M. (2023). Neural Control of Sexually Dimorphic Social Behavior: Connecting Development to Adulthood. Annual review of neuroscience, 46, 321–339. https://doi.org/10.1146/annurev-neuro-121522-110856
McKusick V. A. (2007). Mendelian Inheritance in Man and its online version, OMIM. American journal of human genetics, 80(4), 588–604. https://doi.org/10.1086/514346
Meijer, M., Franke, B., Sandi, C., & Klein, M. (2023). Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis. Neuroscience and biobehavioral reviews, 145, 104997. https://doi.org/10.1016/j.neubiorev.2022.104997
Meier, I. M., van Honk, J., Bos, P. A., & Terburg, D. (2021). A mu-opioid feedback model of human social behavior. Neuroscience and biobehavioral reviews, 121, 250–258. https://doi.org/10.1016/j.neubiorev.2020.12.013
Meldrum, R. C., & Barnes, J. C. (2017). Unstructured Socializing with Peers and Delinquent Behavior: A Genetically Informed Analysis. Journal of youth and adolescence, 46(9), 1968–1981. https://doi.org/10.1007/s10964-017-0680-x
Mentis, A. A., Dardiotis, E., Katsouni, E., & Chrousos, G. P. (2021). From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression. Translational psychiatry, 11(1), 130. https://doi.org/10.1038/s41398-021-01257-2
Mishra, A. K., & Varma, A. R. (2023). A Comprehensive Review of the Generalized Anxiety Disorder. Cureus, 15(9), e46115. https://doi.org/10.7759/cureus.46115
Moffat, J. J., Jung, E. M., Ka, M., Smith, A. L., Jeon, B. T., Santen, G. W. E., & Kim, W. Y. (2019). The role of ARID1B, a BAF chromatin remodeling complex subunit, in neural development and behavior. Progress in neuro-psychopharmacology & biological psychiatry, 89, 30–38. https://doi.org/10.1016/j.pnpbp.2018.08.021
Mohammadi, N. A., Ahring, P. K., Yu Liao, V. W., Chua, H. C., Ortiz de la Rosa, S., Johannesen, K. M., Michaeli-Yossef, Y., Vincent-Devulder, A., Meridda, C., Bruel, A. L., Rossi, A., Patel, C., Klepper, J., Bonanni, P., Minghetti, S., Trivisano, M., Specchio, N., Amor, D., Auvin, S., Baer, S., … Møller, R. S. (2024). Distinct neurodevelopmental and epileptic phenotypes associated with gain- and loss-of-function GABRB2 variants. EBioMedicine, 106, 105236. https://doi.org/10.1016/j.ebiom.2024.105236
Mountoufaris, G., Nair, A., Yang, B., Kim, D. W., Vinograd, A., Kim, S., Linderman, S. W., & Anderson, D. J. (2024). A line attractor encoding a persistent internal state requires neuropeptide signaling. Cell, 187(21), 5998–6015.e18. https://doi.org/10.1016/j.cell.2024.08.015
Mulligan, C. J., Clukay, C. J., Matarazzo, A., Hadfield, K., Nevell, L., Dajani, R., & Panter-Brick, C. (2022). Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth. PloS one, 17(4), e0266509. https://doi.org/10.1371/journal.pone.0266509
Murray, S. L., & Holton, K. F. (2021). Post-traumatic stress disorder may set the neurobiological stage for eating disorders: A focus on glutamatergic dysfunction. Appetite, 167, 105599. https://doi.org/10.1016/j.appet.2021.105599
Năstase, M. G., Vlaicu, I., & Trifu, S. C. (2022). Genetic polymorphism and neuroanatomical changes in schizophrenia. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 63(2), 307–322. https://doi.org/10.47162/RJME.63.2.03
Nakamura, T., & Takata, A. (2023). The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research. Molecular psychiatry, 28(5), 1868–1889. https://doi.org/10.1038/s41380-023-02005-2
Nazari, S., Pourmand, S. M., Makki, S. M., Brand, S., & Vousooghi, N. (2022). Potential biomarkers of addiction identified by real-time PCR in human peripheral blood lymphocytes: a narrative review. Biomarkers in medicine, 16(9), 739–758. https://doi.org/10.2217/bmm-2021-0291
Neri, L., Marziani, B., Sebastiani, P., Del Beato, T., Colanardi, A., Legge, M. P., & Aureli, A. (2024). Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement. Diseases (Basel, Switzerland), 12(4), 70. https://doi.org/10.3390/diseases12040070
Odintsova, V. V., Roetman, P. J., Ip, H. F., Pool, R., Van der Laan, C. M., Tona, K. D., Vermeiren, R. R. J. M., & Boomsma, D. I. (2019). Genomics of human aggression: current state of genome-wide studies and an automated systematic review tool. Psychiatric genetics, 29(5), 170–190. https://doi.org/10.1097/YPG.0000000000000239
Odintsova, V. V., Hagenbeek, F. A., van der Laan, C. M., van de Weijer, S., & Boomsma, D. I. (2023). Genetics and epigenetics of human aggression. Handbook of clinical neurology, 197, 13–44. https://doi.org/10.1016/B978-0-12-821375-9.00005-0
Ouaidat, S., Amaral, I. M., Monteiro, D. G., Harati, H., Hofer, A., & El Rawas, R. (2024). Orexins/Hypocretins: Gatekeepers of Social Interaction and Motivation. International journal of molecular sciences, 25(5), 2609. https://doi.org/10.3390/ijms25052609
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., McGuinness, L. A., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. International journal of surgery (London, England), 88, 105906. https://doi.org/10.1016/j.ijsu.2021.105906
Pinna G. (2019). Animal Models of PTSD: The Socially Isolated Mouse and the Biomarker Role of Allopregnanolone. Frontiers in behavioral neuroscience, 13, 114. https://doi.org/10.3389/fnbeh.2019.00114
Popova, N. K., Tsybko, A. S., & Naumenko, V. S. (2022). The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference. International journal of molecular sciences, 23(15), 8814. https://doi.org/10.3390/ijms23158814
Pigoni, A., Lazzaretti, M., Mandolini, G. M., Delvecchio, G., Altamura, A. C., Soares, J. C., & Brambilla, P. (2019). The impact of COMT polymorphisms on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders. Journal of affective disorders, 243, 545–551. https://doi.org/10.1016/j.jad.2018.08.009
Qadeer, M. I., Amar, A., Huang, Y. Y., Min, E., Galfalvy, H., Hasnain, S., & Mann, J. J. (2021). Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin. Scientific reports, 11(1), 1670. https://doi.org/10.1038/s41598-021-81198-4
Quintero, J., Gutiérrez-Casares, J. R., & Álamo, C. (2022). Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review. Neurology and therapy, 11(4), 1489–1517. https://doi.org/10.1007/s40120-022-00392-2
Rae, M., Lemos Duarte, M., Gomes, I., Camarini, R., & Devi, L. A. (2022). Oxytocin and vasopressin: Signalling, behavioural modulation and potential therapeutic effects. British journal of pharmacology, 179(8), 1544–1564. https://doi.org/10.1111/bph.15481
Rhee, S. H., & Waldman, I. D. (2011). Genetic and environmental influences on aggression. In P. R. Shaver & M. Mikulincer (Eds.), Human aggression and violence: Causes, manifestations, and consequences (pp. 143–163). American Psychological Association. https://doi.org/10.1037/12346-008
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022). Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities. Endocrinology, 163(9), bqac111. https://doi.org/10.1210/endocr/bqac111
Rodnyy, A. Y., Kondaurova, E. M., Tsybko, A. S., Popova, N. K., Kudlay, D. A., & Naumenko, V. S. (2023). The brain serotonin system in autism. Reviews in the neurosciences, 35(1), 1–20. https://doi.org/10.1515/revneuro-2023-0055
Santoft, F., Hedman-Lagerlöf, E., Salomonsson, S., Lindsäter, E., Ljótsson, B., Kecklund, G., Lekander, M., & Andreasson, A. (2020). Inflammatory cytokines in patients with common mental disorders treated with cognitive behavior therapy. Brain, behavior, & immunity - health, 3, 100045. https://doi.org/10.1016/j.bbih.2020.100045
Santoft, F., Hedman-Lagerlöf, E., Salomonsson, S., Lindsäter, E., Ljótsson, B., Kecklund, G., Lekander, M., & Andreasson, A. (2020). Inflammatory cytokines in patients with common mental disorders treated with cognitive behavior therapy. Brain, behavior, & immunity - health, 3, 100045. https://doi.org/10.1016/j.bbih.2020.100045
Sarkar, P., Mozumder, S., Bej, A., Mukherjee, S., Sengupta, J., & Chattopadhyay, A. (2020). Structure, dynamics and lipid interactions of serotonin receptors: excitements and challenges. Biophysical reviews, 13(1), 101–122. Advance online publication. https://doi.org/10.1007/s12551-020-00772-8
Sontate, K. V., Rahim Kamaluddin, M., Naina Mohamed, I., Mohamed, R. M. P., Shaikh, M. F., Kamal, H., & Kumar, J. (2021). Alcohol, Aggression, and Violence: From Public Health to Neuroscience. Frontiers in psychology, 12, 699726. https://doi.org/10.3389/fpsyg.2021.699726
Strac, D. S., Erjavec, G. N., Perkovic, M. N., Sviglin, K. N., Borovecki, F., & Pivac, N. (2015). Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior. Progress in neuro-psychopharmacology & biological psychiatry, 63, 119–125. https://doi.org/10.1016/j.pnpbp.2015.06.010
Summers, C. H., Yaeger, J. D. W., Staton, C. D., Arendt, D. H., & Summers, T. R. (2020). Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy. Brain research, 1731, 146085. https://doi.org/10.1016/j.brainres.2018.12.036
Tchalova, K., Lydon, J. E., Atkinson, L., Fleming, A. S., Kennedy, J., Lecompte, V., Meaney, M. J., Moss, E., O'Donnell, K. A., O'Donnell, K. J., Silveira, P. P., Sokolowski, M. B., Steiner, M., & Bartz, J. A. (2024). Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment. Translational psychiatry, 14(1), 181. https://doi.org/10.1038/s41398-024-02888-x
Thomas, S. D., Jha, N. K., Ojha, S., & Sadek, B. (2023). mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder. Molecules (Basel, Switzerland), 28(4), 1889. https://doi.org/10.3390/molecules28041889
Tobore T. O. (2019). On the Neurobiological Role of Oxidative Stress in Alcohol-Induced Impulsive, Aggressive and Suicidal Behavior. Substance use & misuse, 54(14), 2290–2303. https://doi.org/10.1080/10826084.2019.1645179
Toddes, C., Lefevre, E. M., Brandner, D. D., Zugschwert, L., & Rothwell, P. E. (2021). μ-Opioid Receptor (Oprm1) Copy Number Influences Nucleus Accumbens Microcircuitry and Reciprocal Social Behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(38), 7965–7977. https://doi.org/10.1523/JNEUROSCI.2440-20.2021
van Andel, D. M., Sprengers, J. J., Oranje, B., Scheepers, F. E., Jansen, F. E., & Bruining, H. (2020). Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: an open-label pilot study. Molecular autism, 11(1), 30. https://doi.org/10.1186/s13229-020-00335-4
van der Laan, C. M., Morosoli-García, J. J., van de Weijer, S. G. A., Colodro-Conde, L., ACTION Consortium, Lupton, M. K., Mitchell, B. L., McAloney, K., Parker, R., Burns, J. M., Hickie, I. B., Pool, R., Hottenga, J. J., Martin, N. G., Medland, S. E., Nivard, M. G., & Boomsma, D. I. (2021). Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course. Behavior genetics, 51(5), 592–606. https://doi.org/10.1007/s10519-021-10076-6
van Dongen, J., Hagenbeek, F. A., Suderman, M., Roetman, P. J., Sugden, K., Chiocchetti, A. G., Ismail, K., Mulder, R. H., Hafferty, J. D., Adams, M. J., Walker, R. M., Morris, S. W., Lahti, J., Küpers, L. K., Escaramis, G., Alemany, S., Jan Bonder, M., Meijer, M., Ip, H. F., Jansen, R., … Boomsma, D. I. (2021). DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan. Molecular psychiatry, 26(6), 2148–2162. https://doi.org/10.1038/s41380-020-00987-x
VanElzakker, M. B., Tillman, E. M., Yonker, L. M., Ratai, E. M., & Georgiopoulos, A. M. (2023). Neuropsychiatric adverse effects from CFTR modulators deserve a serious research effort. Current opinion in pulmonary medicine, 29(6), 603–609. https://doi.org/10.1097/MCP.0000000000001014
Vázquez-León, P., Miranda-Páez, A., Valencia-Flores, K., & Sánchez-Castillo, H. (2023). Defensive and Emotional Behavior Modulation by Serotonin in the Periaqueductal Gray. Cellular and molecular neurobiology, 43(4), 1453–1468. https://doi.org/10.1007/s10571-022-01262-z
Veroude, K., Zhang-James, Y., Fernàndez-Castillo, N., Bakker, M. J., Cormand, B., & Faraone, S. V. (2016). Genetics of aggressive behavior: An overview. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 171B(1), 3–43. https://doi.org/10.1002/ajmg.b.32364
Vollebregt, O., Koyama, E., Zai, C. C., Shaikh, S. A., Lisoway, A. J., Kennedy, J. L., & Beitchman, J. H. (2021). Evidence for association of vasopressin receptor 1A promoter region repeat with childhood onset aggression. Journal of psychiatric research, 140, 522–528. https://doi.org/10.1016/j.jpsychires.2021.05.062
Villafuerte, S., Trucco, E. M., Heitzeg, M. M., Burmeister, M., & Zucker, R. A. (2014). Genetic variation in GABRA2 moderates peer influence on externalizing behavior in adolescents. Brain and behavior, 4(6), 833–840. https://doi.org/10.1002/brb3.291
Visscher, P. M., Wray, N. R., Zhang, Q., Sklar, P., McCarthy, M. I., Brown, M. A., & Yang, J. (2017). 10 Years of GWAS Discovery: Biology, Function, and Translation. American journal of human genetics, 101(1), 5–22. https://doi.org/10.1016/j.ajhg.2017.06.005
Wang, L., Chen, Y., Wang, M., Zhao, C., & Qiao, D. (2023). Relationship between gene-environment interaction and obsessive-compulsive disorder: A systematic review. Journal of psychiatric research, 164, 281–290. https://doi.org/10.1016/j.jpsychires.2023.06.004
Wink, L. K., Reisinger, D. L., Horn, P., Shaffer, R. C., O'Brien, K., Schmitt, L., Dominick, K. R., Pedapati, E. V., & Erickson, C. A. (2021). Brief Report: Intranasal Ketamine in Adolescents and Young Adults with Autism Spectrum Disorder-Initial Results of a Randomized, Controlled, Crossover, Pilot Study. Journal of autism and developmental disorders, 51(4), 1392–1399. https://doi.org/10.1007/s10803-020-04542-z
Wood, E. K., Baron, Z., Schwandt, M. L., Lindell, S. G., Barr, C. S., Suomi, S. J., & Higley, J. D. (2022). Variation in the Mu-Opioid Receptor (OPRM1) and Offspring Sex Are Associated With Maternal Behavior in Rhesus Macaques (Macaca mulatta). Frontiers in behavioral neuroscience, 16, 721958. https://doi.org/10.3389/fnbeh.2022.721958
Wronikowska-Denysiuk, O., Mrozek, W., & Budzyńska, B. (2023). The Role of Oxytocin and Vasopressin in Drug-Induced Reward-Implications for Social and Non-Social Factors. Biomolecules, 13(3), 405. https://doi.org/10.3390/biom13030405
Zhang-James, Y., & Faraone, S. V. (2016). Genetic architecture for human aggression: A study of gene-phenotype relationship in OMIM. American journal of medical genetics. Part B, Neuropsychiatric genetics: the official publication of the International Society of Psychiatric Genetics, 171(5), 641–649. https://doi.org/10.1002/ajmg.b.32363
Zhang-James, Y., Fernàndez-Castillo, N., Hess, J. L., Malki, K., Glatt, S. J., Cormand, B., & Faraone, S. V. (2019). An integrated analysis of genes and functional pathways for aggression in human and rodent models. Molecular psychiatry, 24(11), 1655–1667. https://doi.org/10.1038/s41380-018-0068-7
Zhao, L., Han, G., Zhao, Y., Jin, Y., Ge, T., Yang, W., Cui, R., Xu, S., & Li, B. (2020). Gender Differences in Depression: Evidence From Genetics. Frontiers in genetics, 11, 562316. https://doi.org/10.3389/fgene.2020.562316
Zoicas, I., & Kornhuber, J. (2019). The Role of Metabotropic Glutamate Receptors in Social Behavior in Rodents. International journal of molecular sciences, 20(6), 1412. https://doi.org/10.3390/ijms20061412
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Gutemberg Delfino de Sousa; Marcia Silva de Oliveira
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
