Epidemiological profile of hospitalizations related to Crohn's Disease and Ulcerative Colitis in the state of Minas Gerais
DOI:
https://doi.org/10.33448/rsd-v13i12.47826Keywords:
Ulcerative Colitis; Crohn's Disease; Epidemiological Profile.Abstract
Crohn's Disease (CD) and Ulcerative Colitis (UC) are Inflammatory Bowel Diseases (IBD), chronic conditions with multiple causes, including genetic, immunological, and environmental factors. In Brazil, there has been an increase in IBD, especially in industrialized areas; however, few studies address the epidemiological profile of these conditions. This study aims to analyze hospitalizations and deaths due to CD and UC. The research used a cross-sectional quantitative methodology with data from DATASUS, analyzing 5,103 hospitalizations for IBD in Minas Gerais between 2014 and 2024. The variables included number of deaths and hospitalizations and hospitalizations by: sex, age group, color/race, type of care, total value, average number of days. There was a predominance of emergency hospitalizations (95%), with a higher incidence in women (56.6%) and brown people (51.9%), concentrated mainly among the age group of 20 to 49 years. The average length of hospital stay was 6.9 days, with peak mortality rates recorded in 2020 and 2023. The discussion highlighted the influence of environmental factors on the progression of IBD. The higher incidence in women may be related to hormonal differences. Cases in young adults indicate an impact on the economically active population. The higher number of cases among brown individuals reflects the demographics of the region. Emergency hospitalizations and their high costs highlight the need for prevention and early diagnosis, while peak mortality rates highlight challenges in clinical management. Identifying the epidemiological profile of these diseases directs efforts to optimize resources and improve quality of life, promoting a more effective approach to managing these conditions.
References
Afzali, A., & Cross, R. K. (2016). Racial and Ethnic Minorities with Inflammatory Bowel Disease in the United States: A Systematic Review of Disease Characteristics and Differences. Inflammatory bowel diseases, 22(8), 2023–2040. https://doi.org/10.1097/MIB.0000000000000835
Aziz, S., Akhlaq, A., Owings, A., Gurz, S., Zafar, Y., Ali, B., & Tang, S. J. (2024). Mortality Trends in Inflammatory Bowel Disease by Age, Sex, and Race in the United States from 1999 to 2020. Inflammatory bowel diseases, izae184. Advance online publication. https://doi.org/10.1093/ibd/izae184
Barnes, E. L., Nowell, W. B., Venkatachalam, S., Dobes, A., & Kappelman, M. D. (2022). Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States. Inflammatory bowel diseases, 28(7), 983–987. https://doi.org/10.1093/ibd/izab219
Blumenstein, I., & Sonnenberg, E. (2023). Sex- and gender-related differences in inflammatory bowel diseases. Frontiers in Gastroenterology, 2. https://doi.org/10.3389/fgstr.2023.1199687
Brito, R. C. V. D., Peres, C. L., Silveira, K. A. F., Arruda, E. L., & Júnior, M. P. d. A. (2020). Doenças inflamatórias intestinais no Brasil: perfil das internações, entre os anos de 2009 a 2019. Revista Educação em Saúde, 8(1), 127–135. https://doi.org/10.29237/2358-9868.2020v8i1.p127-135
Caron, B., Honap, S., & Peyrin-Biroulet, L. (2024). Epidemiology of Inflammatory Bowel Disease across the Ages in the Era of Advanced Therapies. Journal of Crohn's and Colitis, 18(Supplement_2), ii3—ii15. https://doi.org/10.1093/ecco-jcc/jjae082
Costa, G. A., Carvalho, G. S., Pereira, L. C., Costa, S. G. V. B. S., & Brasil, C. A. (2022). Epidemiological Profile of Patients with Crohn's Disease and Ulcerative Colitis in the Last 6 Years. Journal of Health Sciences, 24(1), 63–66. https://doi.org/10.17921/2447-8938.2022v24n1p63-66
Danpanichkul, P., Suparan, K., Arayakarnkul, S., Jaroenlapnopparat, A., Polpichai, N., Fangsaard, P., Kongarin, S., Srisurapanont, K., Sukphutanan, B., Wanchaitanawong, W., Kanjanakot, Y., Pupaibool, J., Duangsonk, K., Kochhar, G. S., & Wijarnpreecha, K. (2023). Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review. Journal of clinical medicine, 12(15), 5142. https://doi.org/10.3390/jcm12155142
Elia, P. P., Fogaça, H. S., Barros, R. G. G. R., Zaltman, C., & Elia, C. S. C. (2007). Análise descritiva dos perfis social, clínico, laboratorial e antropométrico de pacientes com doenças inflamatórias intestinais, internados no Hospital Universitário Clementino Fraga Filho, Rio de Janeiro. Arquivos de Gastroenterologia, 44(4), 332–339. https://doi.org/10.1590/s0004-28032007000400010
Faro, C. C. P. de., Nascimento Filho, T. B. do., Lisboa, B. B. S. S., Soares, M. C. T., Torres, L. V. F., Silveira, V. F. C., & Cruz, D. C. da. (2024). Análise das características epidemiológicas, hospitalares e clínicas das doenças inflamatórias intestinais no Brasil. Research, Society and Development, 13(3), e7913344837. https://doi.org/10.33448/rsd-v13i3.44837
Follin-Arbelet, B., Cvancarova Småstuen, M., Hovde, Ø., Jelsness-Jørgensen, L. P., & Moum, B. (2023). Mortality in Patients with Inflammatory Bowel Disease: Results from 30 Years of Follow-up in a Norwegian Inception Cohort (the IBSEN study). Journal of Crohn's & colitis, 17(4), 497–503. https://doi.org/10.1093/ecco-jcc/jjac156
Huh, G., Yoon, H., Choi, Y. J., Shin, C. M., Park, Y. S., Kim, N., Lee, D. H., & Kim, J. S. (2019). Trends in emergency department visits and hospitalization rates for inflammatory bowel disease in the era of biologics. PloS one, 14(1), e0210703. https://doi.org/10.1371/journal.pone.0210703
Kaplan, G. G., & Windsor, J. W. (2021). The four epidemiological stages in the global evolution of inflammatory bowel disease. Nature reviews. Gastroenterology & hepatology, 18(1), 56–66. https://doi.org/10.1038/s41575-020-00360-x
King, J. A., Underwood, F. E., Panaccione, N., Quan, J., Windsor, J. W., Kotze, P. G., Ng, S. C., Ghosh, S., Lakatos, P. L., Jess, T., Panaccione, R., Seow, C. H., Ben-Horin, S., Burisch, J., Colombel, J. F., Loftus, E. V., Jr, Gearry, R., Halfvarson, J., & Kaplan, G. G. (2019). Trends in hospitalisation rates for inflammatory bowel disease in western versus newly industrialised countries: a population-based study of countries in the Organisation for Economic Co-operation and Development. The lancet. Gastroenterology & hepatology, 4(4), 287–295. https://doi.org/10.1016/S2468-1253(19)30013-5
Kotze, P. G., Underwood, F. E., Damião, A. O. M. C., Ferraz, J. G. P., Saad-Hossne, R., Toro, M., Iade, B., Bosques-Padilla, F., Teixeira, F. V., Juliao-Banos, F., Simian, D., Ghosh, S., Panaccione, R., Ng, S. C., & Kaplan, G. G. (2020). Progression of Inflammatory Bowel Diseases Throughout Latin America and the Caribbean: A Systematic Review. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association, 18(2), 304–312. https://doi.org/10.1016/j.cgh.2019.06.030
Loscalzo, J., Fauci, A. S, Kasper, D. L et al. (2024). Medicina Interna de Harrison (21ª ed.). Grupo A. https://integrada.minhabiblioteca.com.br/books/9786558040231
Mahadea, D., Kotecki P., Miechowicz I., Dobrowolska A., & Eder P. (2024). 1138 Long-term Epidemiological Trends in Emergency Hospital Admissions and Hospitalizations of Patients with Inflammatory Bowel Diseases in one of the biggest metropolises in western Poland in years 2010 to 2021. Journal of Crohn's and Colitis, 18(1), i2037–i2038. https://doi.org/10.1093/ecco-jcc/jjad212.1268
Martins, K. R., Araújo, J. M., Cruz, Á. C., & Luiz-Ferreira, A. (2021). Epidemiologic aspects of inflammatory bowel disease in the western region of Minas Gerais State. Arquivos de gastroenterologia, 58(3), 377–383. https://doi.org/10.1590/S0004-2803.202100000-63
Moura Rodrigues, P. V., Voss, L., Goudinho Silva, Y., Barbosa Mota, S. M., Pereira Alves Coelho, V., Lima Freitas, M. W., Feronatto, C., Lara Botelho Ferreira, G., Carvalho Saraiva, V. A., & Peccini, V. A. (2024). Perfil de mortalidade por Doença de Crohn no Brasil, 2013-2022: retrato de uma década. Brazilian Journal of Implantology and Health Sciences, 6(2), 45–55. https://doi.org/10.36557/2674-8169.2024v6n2p45-55
Oliveira, F. M., Emerick, A. P. do C., & Soares, E. G. (2010). Aspectos epidemiológicos das doenças intestinais inflamatórias na macrorregião de saúde leste do Estado de Minas Gerais. Ciência & Saúde Coletiva, 15, 1031–1037. https://doi.org/10.1590/S1413-81232010000700009
Paiva, V. V., Sousa, D. C. da S. de, Lima, C. A. N., Damascena, A. F. L., Silva, T. V. C. da, Silva, M. C. S. da, Costa, D. D. de M., Campigotto, R. S., Nery, M. D., & Costa, L. S. G. (2023). A Doença de Crohn e Colite Ulcerativa: Uma análise de dados epidemiológicos da morbidade hospitalar do SUS. Brazilian Journal of Implantology and Health Sciences, 5(5), 598–609. https://doi.org/10.36557/2674-8169.2023v5n5p598-609
Panorama do Censo 2022. (s.d.). Panorama do Censo 2022. https://censo2022.ibge.gov.br/panorama/
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Editora UAB/NTE/UFSM.
Quaresma, A. B., Damiao, A. O. M. C., Coy, C. S. R., Magro, D. O., Hino, A. A. F., Valverde, D. A., Panaccione, R., Coward, S. B., Ng, S. C., Kaplan, G. G., & Kotze, P. G. (2022). Temporal trends in the epidemiology of inflammatory bowel diseases in the public healthcare system in Brazil: A large population-based study. Lancet regional health. Americas, 13, 100298. https://doi.org/10.1016/j.lana.2022.100298
Quaresma, A. B., Kaplan, G. G., & Kotze, P. G. (2019). The globalization of inflammatory bowel disease: the incidence and prevalence of inflammatory bowel disease in Brazil. Current opinion in gastroenterology, 35(4), 259–264. https://doi.org/10.1097/MOG.0000000000000534
Shah, S. C., Khalili, H., Gower-Rousseau, C., Olen, O., Benchimol, E. I., Lynge, E., Nielsen, K. R., Brassard, P., Vutcovici, M., Bitton, A., Bernstein, C. N., Leddin, D., Tamim, H., Stefansson, T., Loftus, E. V., Jr, Moum, B., Tang, W., Ng, S. C., Gearry, R., Sincic, B., & Colombel, J. F. (2018). Sex-Based Differences in Incidence of Inflammatory Bowel Diseases-Pooled Analysis of Population-Based Studies From Western Countries. Gastroenterology, 155(4), 1079–1089.e3. https://doi.org/10.1053/j.gastro.2018.06.043
Shitsuka, R. et al. (2014). Matemática fundamental para tecnologia. (2.ed.). Editora Erica.
Silva, D. C. B. da, & Tanaka, T. M. (2023). Perfil clínico e epidemiológico da Doença Inflamatória Intestinal em um centro de referência em gastroenterologia no oeste do Paraná. E-Acadêmica, 4(2), e2442486. https://doi.org/10.52076/eacad-v4i2.486
Souza, M. M. de., Belasco, A. G. S., & Aguilar-Nascimento, J. E. de. (2008). Perfil epidemiológico dos pacientes portadores de doença inflamatória intestinal do estado de Mato Grosso. Revista Brasileira De Coloproctologia, 28(3), 324–328. https://doi.org/10.1590/S0101-98802008000300009
Wang, R., Li, Z., Liu, S., & Zhang, D. (2023). Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019. BMJ open, 13(3), e065186. https://doi.org/10.1136/bmjopen-2022-065186
Xu, L., Huang, G., Cong, Y., Yu, Y., & Li, Y. (2022). Sex-related Differences in Inflammatory Bowel Diseases: The Potential Role of Sex Hormones. Inflammatory bowel diseases, 28(11), 1766–1775. https://doi.org/10.1093/ibd/izac094
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Beatriz Rodrigues Pinheiro; Gabriela Luiza Nogueira Camargos; Ravena Telles Queiroz; Édson Freire Fonseca
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
