Pulmonary cryptococcosis due to Cryptococcus gattii in an immunocompetent patient: A case report
DOI:
https://doi.org/10.33448/rsd-v13i12.47827Keywords:
Cryptococcosis; Mycosis fungoides; Cryptococcus gattii; Pneumonia; Case reports.Abstract
Introduction: Cryptococcosis is a fungal infection that can affect humans, primarily causing infections in the central nervous system and lungs. Cryptococcus gattii is more prevalent in immunocompetent hosts, with pulmonary infections. Objective: To describe the case of an immunocompetent patient with pneumonia caused by Cryptococcus gattii. Methods: Data collection through a review of the medical records of a patient admitted to the Hospital Maria Aparecida Pedrossian, Campo Grande, Mato Grosso do Sul. Results: A case is reported of a 55-year-old male, immunocompetent patient, presenting with extensive pulmonary infection due to cryptococcosis, in which Cryptococcus gattii was isolated from a lung biopsy, sputum, and serology. The outcome was unfavorable despite multiple treatment attempts. Conclusion: In patients with pulmonary infection, fungal infections should be considered as a diagnostic possibility, depending on the patient, signs, and symptoms, even though they are less common than bacterial infections. Delayed diagnosis can lead to unfavorable outcomes. Therefore, studies and case reports are necessary to optimize diagnosis and treatment.
References
Beardsley, J., Dao, A., Keighley, C., Garnham, K., Halliday, C., Chen, S. C., & Sorrell, T. C. (2022). What's New in Cryptococcus gattii: From Bench to Bedside and Beyond. Journal of fungi (Basel, Switzerland), 9(1), 41. https://doi.org/10.3390/jof9010041
Chen, S. C., Meyer, W., & Sorrell, T. C. (2014). Cryptococcus gattii infections. Clinical microbiology reviews, 27(4), 980–1024. https://doi.org/10.1128/CMR.00126-13
Harris, J., Lockhart, S., & Chiller, T. (2012). Cryptococcus gattii: where do we go from here?. Medical mycology, 50(2), 113–129. https://doi.org/10.3109/13693786.2011.607854
Howard-Jones, A. R., Sparks, R., Pham, D., Halliday, C., Beardsley, J., & Chen, S. C. (2022). Pulmonary Cryptococcosis. Journal of fungi (Basel, Switzerland), 8(11), 1156. https://doi.org/10.3390/jof8111156
Hsueh, Y.-P., Metin, B., Findley, K., Rodriguez-Carres, M., & Heitman, J. (2011). The Mating-Type Locus of Cryptococcus: Evolution of Gene Clusters Governing Sex Determination and Sexual Reproduction from the Phylogenomic Perspective. In Cryptococcus: from human pathogen to model yeast (pp. 139–149).
Huston, S. M., & Mody, C. H. (2009). Cryptococcosis: an emerging respiratory mycosis. Clinics in chest medicine, 30(2), 253–vi. https://doi.org/10.1016/j.ccm.2009.02.006
Kishi, K., Homma, S., Kurosaki, A., Kohno, T., Motoi, N., & Yoshimura, K. (2006). Clinical features and high-resolution CT findings of pulmonary cryptococcosis in non-AIDS patients. Respiratory medicine, 100(5), 807–812. https://doi.org/10.1016/j.rmed.2005.09.017
Kohno, S., Kakeya, H., Izumikawa, K., Miyazaki, T., Yamamoto, Y., Yanagihara, K., Mitsutake, K., Miyazaki, Y., Maesaki, S., Yasuoka, A., Tashiro, T., Mine, M., Uetani, M., & Ashizawa, K. (2015). Clinical features of pulmonary cryptococcosis in non-HIV patients in Japan. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 21(1), 23–30. https://doi.org/10.1016/j.jiac.2014.08.025
Kwon-Chung, K. J., Bennett, J. E., Wickes, B. L., Meyer, W., Cuomo, C. A., Wollenburg, K. R., Bicanic, T. A., Castañeda, E., Chang, Y. C., Chen, J., Cogliati, M., Dromer, F., Ellis, D., Filler, S. G., Fisher, M. C., Harrison, T. S., Holland, S. M., Kohno, S., Kronstad, J. W., Lazera, M., … Casadevall, A. (2017). The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis. mSphere, 2(1), e00357-16. https://doi.org/10.1128/mSphere.00357-16
MacDougall, L., Kidd, S. E., Galanis, E., Mak, S., Leslie, M. J., Cieslak, P. R., Kronstad, J. W., Morshed, M. G., & Bartlett, K. H. (2007). Spread of Cryptococcus gattii in British Columbia, Canada, and detection in the Pacific Northwest, USA. Emerging infectious diseases, 13(1), 42–50. https://doi.org/10.3201/eid1301.060827
Maziarz, E. K., & Perfect, J. R. (2016). Cryptococcosis. Infectious disease clinics of North America, 30(1), 179–206. https://doi.org/10.1016/j.idc.2015.10.006
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM. Toassi, R. F. C. & Petry, P. C. (2021). Metodologia científica aplicada à área da Saúde. 2. ed. – Porto Alegre: Editora da UFRGS.
Perfect, J. R., Dismukes, W. E., Dromer, F., Goldman, D. L., Graybill, J. R., Hamill, R. J., Harrison, T. S., Larsen, R. A., Lortholary, O., Nguyen, M. H., Pappas, P. G., Powderly, W. G., Singh, N., Sobel, J. D., & Sorrell, T. C. (2010). Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 50(3), 291–322. https://doi.org/10.1086/649858
Perfect, JR; Dismukes, WE; Dromer, F.; Goldman, DL; Graybill, JR; Hamill, RJ; Harrison, TS; Larsen, RA; Lortholary, O.; Nguyen, M.-H.; et al. Diretrizes de prática clínica para o tratamento da doença criptocócica: atualização de 2010 pela sociedade de doenças infecciosas da América. Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. 2010 , 50 , 291–322.
Sasaki, M.; Reyes, L. A. Y.; COSTA, D. A.; Yamaguti, A. ; Moura, S. C. de; Guimarães, T. ; Paula, A. I.C. de; Badenas, C. C.; Galvão, L. de L.; Barros, R. C. Criptococose disseminada por Cryptococcus gatti com perfil de resistência intermediário a fluconazol em imunocompetente - Manejo e tratamento de caso. The Brazilian Journal Of Infectious Diseases, [S.L.], v. 26, p. 102477, set. 2022. Elsevier BV. http://dx.doi.org/10.1016/j.bjid.2022.102477.
Setianingrum, F., Rautemaa-Richardson, R., & Denning, D. W. (2019). Pulmonary cryptococcosis: A review of pathobiology and clinical aspects. Medical mycology, 57(2), 133–150. https://doi.org/10.1093/mmy/myy086
Skolnik, K., Huston, S., & Mody, C. H. (2017). Cryptococcal Lung Infections. Clinics in chest medicine, 38(3), 451–464. https://doi.org/10.1016/j.ccm.2017.04.007
Song, K. D., Lee, K. S., Chung, M. P., Kwon, O. J., Kim, T. S., Yi, C. A., & Chung, M. J. (2010). Pulmonary cryptococcosis: imaging findings in 23 non-AIDS patients. Korean journal of radiology, 11(4), 407–416. https://doi.org/10.3348/kjr.2010.11.4.407
Springer, D. J., & Chaturvedi, V. (2010). Projecting global occurrence of Cryptococcus gattii. Emerging infectious diseases, 16(1), 14–20. https://doi.org/10.3201/eid1601.090369
Tu, A., & Byard, R. W. (2021). Cryptococcosis and unexpected death. Forensic science, medicine, and pathology, 17(4), 742–745. https://doi.org/10.1007/s12024-021-00400-1
Yang, D. H., England, M. R., Salvator, H., Anjum, S., Park, Y. D., Marr, K. A., Chu, L. A., Govender, N. P., Lockhart, S. R., Desnos-Ollivier, M., Chen, S., Halliday, C., Kan, A., Chen, J., Wollenberg, K. R., Zelazny, A., Perfect, J. R., Chang, Y. C., Bennett, J. E., Holland, S. M., … Kwon-Chung, K. J. (2021). Cryptococcus gattii Species Complex as an Opportunistic Pathogen: Underlying Medical Conditions Associated with the Infection. mBio, 12(5), e0270821. https://doi.org/10.1128/mBio.02708-21
Ye, F., Xie, J. X., Zeng, Q. S., Chen, G. Q., Zhong, S. Q., & Zhong, N. S. (2012). Retrospective analysis of 76 immunocompetent patients with primary pulmonary cryptococcosis. Lung, 190(3), 339–346. https://doi.org/10.1007/s00408-011-9362-8
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Maria Luiza Fucuta de Moraes; Andrea Marcia Cunha Acosta
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.