Reference values for domestic felines (Felis catus) of prothrombin time and activated partial thromboplastin time

Authors

DOI:

https://doi.org/10.33448/rsd-v9i7.4819

Keywords:

Cats; Coagulation; Clinical laboratory; Hemostasis.

Abstract

Blood coagulation tests are used to check hemostasis in all its phases and to investigate the presence of hemostatic diseases in small animals. In view of the scarcity and the high acquisition value of specific reagents for the evaluation of hemostasis in felines, human reagents are used in most veterinary clinical laboratories, which compromises the sensitivity of the results. The present study had as objective to determine reference values for prothrombin time (PT) and activated partial thromboplastin time (aPTT) for domestic felines (Felis catus)  using standardized Wiener reagents for humans. Blood samples from 50 clinically healthy adult cats were used. The results obtained were 3.9 ± 1.52 seconds for the PT, with minimum and maximum values of 3.52 and 4.34; and 27.94 ± 1.77 seconds for aPTT, with minimum and maximum values of 27.50 and 28.48, respectively. It is concluded that the values obtained in this experiment can be used as a reference for felines, in manual tests with a human kit from the Wiener Lab brand.

Author Biography

Carolina Zorzo, Universidade Federal do Mato Grosso

Médica Veterinária

Patologista Clínica Veterinária

References

Benvenuto SL, Sanches OC (2014). O seu laboratório clínico: metodologia aplicada em diagnóstico laboratorial veterinário (3.ed). Presidente Prudente-SP: Impress.

Biermann K, Hungerbühler S, Mischke R, Kästner SB (2012). Sedative, cardiovascular, haematologic and biochemical effects of four different drug combinations administered intramuscularly in cats. Veterinary Anaesthesia and Analgesia, 39(2):137–50.

Bittencourt NC, Santos PNP (2016). Avaliação das provas da hemostasia primária em indivíduos atendidos nas clínicas odontológicas da Universidade Estadual de Feira de Santana. Revista Brasileira de Análises Clínicas, 48(2):144-8.

Ferreira CN, Sousa MO, Dusse LMS, Carvalho MG (2010). O novo modelo da cascata de coagulação baseado nas superfícies celulares e suas implicações. Revista Brasileira de Hematologia e Hemoterapia, 32(5):416-21.

Garcia-Navarro CEK (2005). Manual de hematologia Veterinária (2.ed). SP: Varela Ltda.

Gottlieb DL, Prittie J, Buriko Y, Lamb KE (2017). Evaluation of acut traumatic coagulopathy in dogs and cats following blunt force trauma. Journal of Veterinary Emergency and Critical Care, 27(1):35-43.

Lopes STA, Emanuelli MP, Schmidt S, Raiser AG, Mazzanti A, Alves AS (2005). Valores de referência do tempo de protrombina (TP) e tempo de tromboplastina parcial ativada (TTPa) em cães. Ciência Rural, 35(2):381-4.

Oliveira BR, Cruz BR, Moss MF, Borato DCK (2019). Influência do tempo de centrifugação em testes de coagulação: tempo de protrombina e tempo de tromboplastina parcial. Revista Brasileira de Análises Clínicas, 51(1):52-7.

Reynolds, B. S.; Geffre, N. H.; Bourges-Abella, S.; Vaucoret, S.; Mourot, M.; Braun, J. D.; Trumel C (2012). Effects of intravenous, low-dose ketamine-diazepam sedation on the results of hematologic, plasma biochemical, and coagulation analyses in cats. Journal of the American Veterinary Medical Association, 240(3):287-93.

Rezende S M (2010). Distúrbios da hemostasia: doenças hemorrágicas. Revista Médica de Minas Gerais. 20(4):534-53.

Solbak S, Epstein SE, Hopper K (2019). Influence of needle gauge used for venipuncture on measures of hemostasis in cat. Journal of Feline Medicine and Surgery, 21(2):143-7.

Stockham SL & Scott MA (2011). Fundamentos de patologia clínica veterinária (2.ed). Rio de Janeiro: Guanabara Koogan.

Thrall MA, Weiser G, Allison RW, Campbell TW. (2015). Hematologia e Bioquímica Clínica Veterinária (2.ed). São Paulo: Roca.

Vine AK (2009). Recent Advances in Haemostasis and Thrombosis. Retina, 29(1):1-7.

Volpato J (2013). Efeitos da contenção física e química sobre as variáveis hematológicas e hemostáticas em gatos. Dissertação de Mestrado, Universidade do Estado de Santa Catarina- UDESC, Lages, SC, Brasil. 59p.

Downloads

Published

09/06/2020

How to Cite

ZORZO, C.; BARROS, M. A. de; SOUZA, T. G. de; BORGES, J. C.; PEREIRA, N. A.; SILVA, D. W. da; BORTOLINI, J.; MENDONÇA, A. J. Reference values for domestic felines (Felis catus) of prothrombin time and activated partial thromboplastin time. Research, Society and Development, [S. l.], v. 9, n. 7, p. e744974819, 2020. DOI: 10.33448/rsd-v9i7.4819. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/4819. Acesso em: 20 apr. 2024.

Issue

Vol. 9 No. 7

Section

Agrarian and Biological Sciences

License

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.