Trichloroacetic acid in skin texturization: A narrative literature review
DOI:
https://doi.org/10.33448/rsd-v14i2.48289Keywords:
Face; Trichloroacetic Acid; Skin Abnormalities.Abstract
Trichloroacetic acid (TCA) is widely used in orofacial harmonization for skin texturization. Its application in chemical peels promotes deep exfoliation, improving wrinkles, acne scars, and hyperpigmentation. The aim of this narrative literature review is to present the use of TCA in skin texturization. This research is a narrative literature review, following the specifications of Rother (2007). Data collection was conducted in the PubMed, LILACS, and Scielo databases, using the following search terms: "Face," "Trichloroacetic Acid," and "Skin Abnormalities." Concentrations range from 10-35%, selected according to the patient's skin condition. TCA offers a short recovery time and can be combined with other treatments for more comprehensive results. However, it is essential to follow specific care guidelines, such as avoiding sun exposure and using sunscreen, to ensure safety and effectiveness.
References
Ansary, T. M., Hossain, M. R., Kamiya, K., Komine, M., & Ohtsuki, M. (2021). Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging. International journal of molecular sciences, 22(8), 3974.
Baldissera, R. L., Yang, E. J., Schmitt, J. V., Lin, E., Emanuel de Jesus, F., Simões E Silva Enokihara, M. M., Wambier, C. G., & Bagatin, E. (2022). Trichloroacetic acid peels for the treatment of acanthosis nigricans. Journal of the American Academy of Dermatology, 86(1), 203–204.
Barańska-Rybak, W., & Merholtz, D. (2020). Trichloroacetic acid peel complicated with impetigo contagious infection. Dermatologic therapy, 33(3), e13450.
Boismal, F., Serror, K., Dobos, G., Zuelgaray, E., Bensussan, A., & Michel, L. (2020). Vieillissement cutané - Physiopathologie et thérapies innovantes [Skin aging: Pathophysiology and innovative therapies]. Medecine sciences : M/S, 36(12), 1163–1172.
Butler, P. E., Gonzalez, S., Randolph, M. A., Kim, J., Kollias, N., & Yaremchuk, M. J. (2001). Quantitative and qualitative effects of chemical peeling on photo-aged skin: an experimental study. Plastic and reconstructive surgery, 107(1), 222–228.
Collins P. S. (1989). Trichloroacetic acid peels revisited. The Journal of dermatologic surgery and oncology, 15(9), 933–940.
Csekes, E., & Račková, L. (2021). Skin Aging, Cellular Senescence and Natural Polyphenols. International journal of molecular sciences, 22(23), 12641.
Fanous, N., & Zari, S. (2017). Universal Trichloroacetic Acid Peel Technique for Light and Dark Skin. JAMA facial plastic surgery, 19(3), 212–219.
Khavkin, J., & Ellis, D. A. (2011). Aging skin: histology, physiology, and pathology. Facial plastic surgery clinics of North America, 19(2), 229–234.
Koontz L. (2014). TCA precipitation. Methods in enzymology, 541, 3–10.
Lee, K. C., Wambier, C. G., Soon, S. L., Sterling, J. B., Landau, M., Rullan, P., Brody, H. J., & International Peeling Society (2019). Basic chemical peeling: Superficial and medium-depth peels. Journal of the American Academy of Dermatology, 81(2), 313–324.
Puizina-Ivić N. (2008). Skin aging. Acta dermatovenerologica Alpina, Pannonica, et Adriatica, 17(2), 47–54.
Rorteau, J., Chevalier, F. P., Fromy, B., & Lamartine, J. (2020). Vieillissement et intégrité de la peau - De la biologie cutanée aux stratégies anti-âge [Functional integrity of aging skin, from cutaneous biology to anti-aging strategies]. Medecine sciences: M/S, 36(12), 1155–1162.
Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paul. Enferm, 20(2).
Rullan P. (2022). Commentary on Trichloroacetic Acid Paint. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 48(2), 219.
Sarkar, R., & Katoch, S. (2024). Chemical Peels in Treatment of Melasma. Dermatologic clinics, 42(1), 21–32.
Truchuelo, M., Cerdá, P., & Fernández, L. F. (2017). Chemical Peeling: A Useful Tool in the Office. Peeling químico, una herramienta útil en la consulta. Actas dermo-sifiliograficas, 108(4), 315–322.
Zenjari, L., Hali, F., & Chiheb, S. (2021). Trichloroacetic acid (50%) in the treatment of venous leg ulcers. Journal de medecine vasculaire, 46(3), 139–143.
Zhang, S., & Duan, E. (2018). Fighting against Skin Aging: The Way from Bench to Bedside. Cell transplantation, 27(5), 729–738.
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Copyright (c) 2025 Gabriele de Souza Trindade; Nicola Felipe Lopez Bempensante; Rafael Pioltine; Regina Ranieri; Raphaella Guimarães; Daniella Pilon Muknicka

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