Aortic stenosis: factors that interfere with the evaluation of severity by the Doppler echocardiographic method - review article

Authors

DOI:

https://doi.org/10.33448/rsd-v14i2.48347

Keywords:

Heart Valves; Aortic Valve Stenosis; Echocardiography; Diagnostic Techniques, Cardiovascular; Heart Valve Diseases.

Abstract

The importance of timely diagnosis and treatment of Aortic Stenosis (AS) is consensual in cardiology, seeking to prevent the high morbidity and mortality of this disease. Although diagnostic tests are widely available, several factors can interfere with the correct classification of the severity of the disease. Therefore, echocardiographic parameters are part of a critical step to ensure optimal results. Objective: To describe the main factors that interfere in the assessment of the severity of aortic stenosis by diagnostic methods, mainly echocardiography. Methodology: Data processing was performed by gathering the main journals related to the health area, with keywords related to the main theme (aortic stenosis) and subsequent selection of 80 articles for analysis and construction of this review article. Results: The review exposes the various limitations in the assessment of the severity of aortic stenosis, namely: factors related to anatomy, technical issues, hemodynamic variables and/or patient comorbidities.Conclusions: Knowledge of possible diagnostic limitations is essential for specialists in the field, thus allowing a more critical analysis of echocardiogram results, as well as providing the physician with the opportunity to extend the investigation in cases of complementary exams that disagree with the history and clinical examination.

References

Abbas, A. E., Mando, R., Hanzel, G., Goldstein, J., Shannon, F., & Pibarot, P. (2020). Hemodynamic principles of prosthetic aortic valve evaluation in the era of transcatheter aortic valve replacement. Echocardiography, 37(7), 738–757. https://doi.org/10.1111/echo.14663

Abbas, A. E., Mando, R., Kadri, A., et al. (2021). Comparison of transvalvular aortic mean gradients obtained by intraprocedural echocardiography and invasive measurement in balloon and self-expanding transcatheter valves. Journal of the American Heart Association, 10(19). https://doi.org/10.1161/JAHA.120.021014

Akhobekov, A. A., Zeynalova, P. A., Ryabukhina, Y. E., & Chekini, D. A. (2023). Próteses transcateter na estenose aórtica pós-radiação: uma revisão da literatura. MD-Onco, 3(4), 35–40. https://doi.org/10.17650/2782-3202-2023-3-4-35-40

Alizadeh, L., Peters, F., Vainrib, A. F., Freedberg, R. S., & Saric, M. (2024). Rheumatic heart disease: A rare cause of very severe valvular aortic stenosis. Journal of Clinical Medicine, 8(5), 320–324. https://doi.org/10.1016/j.case.2024.02.005

Bach, D. (2010). Echo/Doppler evaluation of hemodynamics after aortic valve replacement: Principles of interrogation and assessment of high gradients. Journal of the American College of Cardiology: Imaging, 3(3), 296–304. https://doi.org/10.1016/j.jcmg.2009.11.009

Banovic, M., Mileva, N., Moya, A., Paolisso, P., Beles, M., Boskovic, N., et al. (2023). Myocardial work predicts outcome in asymptomatic severe aortic stenosis: Subanalysis of the randomized AVATAR trial. JACC: Cardiovascular Imaging, 16(5), 708–710. https://doi.org/10.1016/j.jcmg.2022.10.019

Baumgartner, H. (2019). Should we forget about valve area when assessing aortic stenosis? Heart, 105(2), 92–93. https://doi.org/10.1136/heartjnl-2018-313666

Baumgartner, H., Hung, J., Bermejo, J., Chambers, J. B., Evangelista, A., Griffin, B. P., et al. (2009). Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice. Journal of the American Society of Echocardiography, 22(1), 1–23. https://doi.org/10.1016/j.echo.2008.11.029

Beck, A. L. de S., & Ribeiro, L. C. M. (2022). Como eu faço: Avaliação da estenose aórtica com discordância em sua quantificação. Arquivos Brasileiros de Cardiologia: Imagem Cardiovascular, 35(1). https://doi.org/10.47593/2675-312X/20223501ecom21

Canciello, G., Pate, S., Sannino, A., Borrelli, F., Todde, G., Grayburn, P., et al. (2023). Pitfalls and tips in the assessment of aortic stenosis by transthoracic echocardiography. Diagnostics, 13(14), 2414. https://doi.org/10.3390/diagnostics13142414

Cavaca, R., Teixeira, R., Vieira, M. J., & Gonçalves, L. (2017). Estenose aórtica paradoxal – revisão sistemática. Revista Portuguesa de Cardiologia, 36(4), 287-305. https://doi.org/10.1016/j.repc.2016.09.010

Casarin, S. T., et al. (2020). Tipos de revisão de literatura: considerações das editoras do Journal of Nursing and Health. Journal of Nursing and Health, 10(5). https://periodicos.ufpel.edu.br/index.php/enfermagem/article/view/19924

Cavalcante, L. T. C., & Oliveira, A. A. S. (2020). Métodos de revisão bibliográfica nos estudos científicos. Psicol. Rev, 26(1), 82-100. https://doi.org/10.5752/P.1678-9563.2020v26n1p82-100

Chen, M. C., Chiang, C. W., Shern, M. S., Fang, B. R., Kuo, C. T., Lin, F. C., et al. (1992). Simplified continuity equation: A simple, accurate, and noninvasive method in the evaluation of aortic stenosis. Changgeng Yi Xue Za Zhi, 15(1), 1-8. https://pubmed.ncbi.nlm.nih.gov/1581834

Clavel, M. A., Bruwash, I. G., Mundigler, G., Dumesnil, J. G., Baumgartner, H., Klein, J. B., et al. (2010). Validation of conventional and simplified methods to calculate projected valve area at normal flow rate in patients with low flow, low gradient aortic stenosis: The multicenter TOPAS (True or Pseudo Severe Aortic Stenosis) study. JASE, 23(4), 380-386. https://doi.org/10.1016/j.echo.2010.02.002

Clavel, M. A., Bruwash, I. G., & Pibarot, P. (2017). Cardiac imaging for assessing low-gradient severe aortic stenosis. JACC: Cardiovascular Imaging, 10(2), 185-202. https://doi.org/10.1016/j.jcmg.2017.01.002

Clavel, M. A., Dumesnil, J. G., Mathieu, P., Senechal, M., & Pibarot, P. (2010). Outcome of patients presenting with small aortic valve area and low gradient despite preserved LV ejection fraction. Circulation, 122(21). https://www.ahajournals.org/doi/abs/10.1161/circ.122.suppl_21.A10411

Clavel, M. A., Malouf, J., Zeitoun, D. M., Araoz, P. A., Mechelena, H. I., & Sarano, M. E. (2015). Aortic valve area calculation in aortic stenosis by CT and Doppler echocardiography. JACC: Cardiovascular Imaging, 8(3), 248-257. https://doi.org/10.1016/j.jcmg.2015.01.009

Czarny, M. J., & Resar, J. R. (2014). Diagnosis and management of valvular aortic stenosis. Clinical Medicine Insights: Cardiology, 8(1), 15–24. https://doi.org/10.4137/CMC.S15716

Dahl, J. S., Julanki, R., Ali, M., Scott, C. G., Padang, R., & Pellikk, P. A. (2024). Cardiac damage in early aortic stenosis: Is the valve to blame? JACC: Cardiovascular Imaging, 17(9), 1031-1040. https://doi.org/10.1016/j.jcmg.2024.05.003

Davies, S. W., Gershlick, A. H., & Balcon, R. (1991). Progression of valvular aortic stenosis: A long-term retrospective study. European Heart Journal, 12(1), 10–14. https://doi.org/10.1093/oxfordjournals.eurheartj.a059815

Deeprasertkul, P., & Ahmad, M. (2017). Evolving new concepts in the assessment of aortic stenosis. Echocardiography – A Journal of Multimodality Cardiovascular Imaging, 34(5), 731-745. https://doi.org/10.1111/echo.13501

Donal, E., Novaro, G. M., Deserrano, D., Popovic, Z. B., Greenberg, N. L., Richards, K. E., et al. (2005). Planimetric assessment of anatomic valve area overestimates effective orifice area in bicuspid aortic stenosis. Journal of the American Society of Echocardiography, 18(12), 1392-1398. https://doi.org/10.1016/j.echo.2005.04.005

Dumont, Y., & Arsenault, M. (2003). An alternative to standard continuity equation for the calculation of aortic valve area by echocardiography. Journal of the American Society of Echocardiography, 16(12), 1309–1315. https://doi.org/10.1067/j.echo.2003.07.004

Everett, R. J., Tastet, L., Clavel, M. A., Chin, C. W. L., Capoulade, R., Vassiliou, V. S., et al. (2018). Progression of myocardial hypertrophy and fibrosis in aortic stenosis: A multicenter cardiac magnetic resonance imaging study. Circulation: Cardiovascular Imaging, 11(6), e007451. https://doi.org/10.1161/CIRCIMAGING.117.007451

Feigenbaum, A. W. F., & Ryan, T. (2012). Stenosis aórtica. In Feigenbaum’s Echocardiography (pp. 1-22). Guanabara Koogan.

Flachskampf, F. A. (2015). Stenotic aortic valve area: Should it be calculated from CT instead of echocardiographic data? JACC: Cardiovascular Imaging, 8(3), 258–260. https://doi.org/10.1016/j.jcmg.2014.12.012

Firstenberg, M. S., Abel, E. E., Papadimos, T. J., & Tripathi, R. S. (2012). Nonconvective forces: A critical and often ignored component in the echocardiographic assessment of transvalvular pressure gradients. Cardiology Research and Practice. https://doi.org/10.1155/2012/383217

Franke, B., Brüning, J., Yevtushenko, P., Dreger, H., Brand, A., & Juri, B. (2021). Computed tomography-based assessment of transvalvular pressure gradient in aortic stenosis. Frontiers in Cardiovascular Medicine, 8, 706628. https://doi.org/10.3389/fcvm.2021.706628

Freeman, R. V., Crittenden, G., & Otto, C. (2014). Acquired aortic stenosis. Expert Review of Cardiovascular Therapy, 2(1), 107-116. https://doi.org/10.1586/14779072.2.1.107

Généreux, P., Pibarot, P., Redfors, B., Mack, R. R., Jaber, W. A., Svensson, L. G., et al. (2016). Natural history, diagnostic approaches, and therapeutic strategies for patients with asymptomatic severe aortic stenosis. Journal of the American College of Cardiology, 67(19), 2263-2288. https://doi.org/10.1016/j.jacc.2016.02.057

Grando, T. A., Leite, R. S., Prates, P. R. L., Gomes, C. R., Specht, F., Gheller, A. S., et al. (2013). Anesthetic management and complications of percutaneous aortic valve implantation. Revista Brasileira de Anestesiologia, 63(3). https://doi.org/10.1590/S0034-70942013000300009

Grodecki, C., Warniello, M., Spiewak, M., & Kwiecinski, J. (2023). Advanced cardiac imaging in the assessment of aortic stenosis. Journal of Cardiovascular Development and Disease, 10(5), 216. https://doi.org/10.3390/jcdd10050216

Gulino, S., Di Landro, A., & Indelicato, A. (2017). Aortic stenosis: Epidemiology and pathogenesis. In Percutaneous Treatment of Left-Sided Heart Valves (pp. 245-252). Springer Nature. https://doi.org/10.1007/978-3-319-59620-4_14

Halpern, E. J., Mallya, R., Sewell, M., Shulman, M., & Zwas, D. R. (2009). Differences in aortic valve area measured with CT planimetry and echocardiography (continuity equation) are related to divergent estimates of left ventricular outflow tract area. AJR American Journal of Roentgenology, 192(6), 1668–1673. https://doi.org/10.2214/AJR.08.1986

Hirasawa, K., Izumo, M., & Akashi, Y. J. (2023). Stress echocardiography in valvular heart disease. Frontiers in Cardiovascular Medicine, 10, 1233924. https://doi.org/10.3389/fcvm.2023.1233924

Hung, J., Klassen, S. L., Bermejo, J., & Chambers, J. B. (2018). Take home messages with cases from focused update on echocardiographic assessment of aortic stenosis. Heart, 104(16), 1317–1322. https://doi.org/10.1136/heartjnl-2017-312917

Islas, F., Gonzalez, P. O. N., Quevedo, P. J., Franco, L. M., Abizanda, S. G., Casado, P. M., et al. (2024). Aortic stenosis and the evolution of cardiac damage after transcatheter aortic valve replacement. Journal of Clinical Medicine, 13(12), 3539. https://doi.org/10.3390/jcm13123539

Ito, S., Pislaru, C., Miranda, W. R., Nkomo, V. T., Connolly, H. M., Pislaru, S. V., et al. (2020). Left ventricular contractility and wall stress in patients with aortic stenosis with preserved or reduced ejection fraction. JACC: Cardiovascular Imaging, 13, 357–369. https://doi.org/10.1016/j.jcmg.2019.06.013

Kardos, A., Rusinaru, D., Maréchaux, S., Maréchaux, S., Alskaf, E., Prendergast, B., & Tribouilloy, C. (2022). Implementation of a CT-derived correction factor to refine the measurement of aortic valve area and stroke volume using Doppler echocardiography improves grading of severity and prediction of prognosis in patients with severe aortic stenosis. International Journal of Cardiology, 363, 129–137. https://doi.org/10.1016/j.ijcard.2022.01.028

Kebed, K., Sun, D., Addetia, K., Avi, V. M., Markuzon, N., & Lang, R. M. (2020). Measurement errors in serial echocardiographic assessments of aortic valve stenosis severity. The International Journal of Cardiovascular Imaging, 36, 471–479. https://doi.org/10.1007/s10554-019-01680-0

Kim, H. J., Choe, Y. H., Kim, S. M., Kim, E. K., Lee, M., & Park, S. J. (2021). A new method for aortic valve planimetry with high-resolution 3-dimensional MRI and its comparison with conventional cine MRI and echocardiography for assessing the severity of aortic valvular stenosis. Korean Journal of Radiology, 22(8), 1266–1278. https://doi.org/10.3348/kjr.2021.0106

Lester, S. J., McElhinney, D. B., Miller, J. P., Lutz, J. T., Otto, C. M., & Redberg, R. F. (2000). Rate of change in aortic valve area during a cardiac cycle can predict the rate of hemodynamic progression of aortic stenosis. Circulation, 101(16), 1774–1779. https://doi.org/10.1161/01.CIR.101.16.1774

Luft, F. C. (2015). Aortic stenosis is largely a boney affair. Journal of Molecular Medicine, 93, 357–359. https://doi.org/10.1007/s00109-015-1333-2

Madanat, J. C., Schott, J., Mando, R., Shannon, H. K., Cabau, J. R., Wood, D., et al. (2023). Discordance vs pressure recovery in aortic stenosis and post-TAVR. JACC: Cardiovascular Imaging, 16(7), 985–987. https://doi.org/10.1016/j.jcmg.2023.02.006

Mansilla, A. G., Legazpi, P. M., Prieto, A., Goma, E., Haurigot, P., & Del Villar, C. P. (2019). Valve area and the risk of overestimating aortic stenosis. Heart, 105(12), 911–919. https://doi.org/10.1136/heartjnl-2018-314396

Manzo, R., Ilardi, F., Nappa, D., Mariani, A., Angellotti, D., Molaro, M. I., et al. (2023). Echocardiographic evaluation of aortic stenosis: A comprehensive review. Diagnostic, 13(15), 2527. https://doi.org/10.3390/diagnostics13152527

Mǎrgulescu, A. D. (2017). Assessment of aortic valve disease - a clinician-oriented review. World Journal of Cardiology, 9(6), 481–495. https://doi.org/10.4330/wjc.v9.i6.481

Maznyczka, A., Prendergast, B., Dweck, M., Windecker, S., Généreux, P., Smith, D. H., et al. (2024). Timing of aortic valve intervention in the management of aortic stenosis. JACC: Cardiovascular Imaging, 17, 2502–2514. https://doi.org/10.1016/j.jcmg.2024.01.006

Minners, J., Allgeier, M., Baerwolf, C. G., Kienzle, R. P., Neumann, F. J., & Jander, N. (2008). Inconsistencies of echocardiographic criteria for the grading of aortic valve stenosis. European Heart Journal, 29, 1043–1048. https://doi.org/10.1093/eurheartj/ehn090

Mitchell, C., Rahko, P. S., Blauwet, L. A., Canaday, B., Finstuen, J. A., Foster, M. C., et al. (2019). Guidelines for performing a comprehensive transthoracic echocardiographic examination in adults: Recommendations from the American Society of Echocardiography. Journal of the American Society of Echocardiography, 32(1), 1–64. https://doi.org/10.1016/j.echo.2018.11.017

Moss, R. R. (2013). Echocardiographic evaluation of aortic stenosis. In Multimodality Imaging for Transcatheter Aortic Valve Replacement (pp. 157–169). Springer Nature. https://doi.org/10.1007/978-1-4471-2798-7_12

Movahed, M. Z., Timmerman, B., & Hashemzadeh, M. (2023). Independent association of aortic stenosis with many known cardiovascular risk factors and many inflammatory diseases. Archives of Cardiovascular Diseases, 116(10), 467–473. https://doi.org/10.1016/j.acvd.2023.01.013

Nanea, I. T. (2018). Echocardiography in aortic valve stenosis. In New Approaches to Aortic Diseases from the Abdominal Valve to the Bifurcation (pp. 133–143). Springer. https://doi.org/10.1007/978-3-319-68144-7_12

Otto, C. M. (2013). Textbook of clinical echocardiography (5th ed.). Elsevier Saunders.

Otto, C. M., Pearlman, A. S., Comess, K. A., Reamer, R. P., Janko, C. L., & Huntsman, L. L. (1986). Determination of the stenotic aortic valve area in adults using Doppler echocardiography. Journal of the American College of Cardiology, 7(3), 509–517. https://doi.org/10.1016/S0735-1097(86)80460-0

Pan, X., Hijazi, Z. M., & Sievert, H. (2020). Echocardiography-guided percutaneous interventions for aortic valve stenosis. In Percutaneous and Non-fluoroscopical (PAN) Procedure for Structural Heart Disease (pp. 85–90).

Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM. Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paul. Enferm. 20 (2). https://doi.org/10.1590/S0103-21002007000200001.

Poh, K. K., Levine, R. A., Solis, J., Shen, L., Flaherty, M., Kang, Y. J., et al. (2008). Assessing aortic valve area in aortic stenosis by continuity equation: A novel approach using real-time three-dimensional echocardiography. European Heart Journal, 29(20), 2526–2535. https://doi.org/10.1093/eurheartj/ehn022

Prasad, Y., & Bhalodkar, N. C. (2004). Aortic sclerosis—A marker of coronary atherosclerosis. Clinical Cardiology, 27(12), 671–673. https://doi.org/10.1002/clc.4960271202

Puche, A. J. R., Cayuelas, J. M. A., Sanchez, F. C., Sanchez, M. C., Escribano, I. G., & Vera, T. V. (2022). Accuracy of continuity equation in aortic stenosis and irregular heart rhythm (5–10 beats average). European Heart Journal, 43(Suppl. 2), ehac544.128. https://doi.org/10.1093/eurheartj/ehac544.128

Pujari, S. H., & Agasthi, P. (2023, April 16). Aortic stenosis. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK557628

Richards, K. L., Cannon, S. R., Miller, J. F., & Crawford, M. H. (1986). Calculation of aortic valve area by Doppler echocardiography: A direct application of the continuity equation. Circulation, 73(5), 964–969. https://doi.org/10.1161/01.CIR.73.5.964

Rosa, V. E. E., Fernandes, J. R. C., Lopes, A. S., Sampaio, R. O., & Tarasoutchi, F. (2018). Paradoxical aortic stenosis: Simplifying the diagnostic process. Arquivos Brasileiros de Cardiologia, 110(5). https://doi.org/10.5935/abc.20180075

Rother, E. D. (2007). Revisão sistemática X revisão narrativa. Acta Paulista de Enfermagem, 20(2), 158-163. https://doi.org/10.1590/S0103-21002007000200001

Santangelo, G., Rossi, A., Toriello, F., Badano, L. P., Zeitoun, D. M., & Faggiano, P. (2021). Diagnosis and management of aortic valve stenosis: The role of non-invasive imaging. Journal of Clinical Medicine, 10(16), 3745. https://doi.org/10.3390/jcm10163745

Sen, J., Huynh, Q., Stub, D., Neil, C., & Marwick, T. H. (2021). Prognosis of severe low-flow, low-gradient aortic stenosis by stroke volume index and transvalvular flow rate. JACC Cardiovascular Imaging, 14(5), 915–927. https://doi.org/10.1016/j.jcmg.2020.12.029

Solomon, S. D., Wu, J. C., & Gillam, L. D. (2019). Essential echocardiography: A companion to Braunwald’s heart disease (10th ed.). Elsevier.

Stassen, J., Ewe, V. J., Singh, K., Butcher, S. C., Hirasawa, K., Amanullah, M. R., et al. (2022). Prevalence and prognostic implications of discordant grading and flow-gradient patterns in moderate aortic stenosis. Journal of the American College of Cardiology, 80(7), 666–676. https://doi.org/10.1016/j.jacc.2022.05.036

Thaden, J. J., Nkomo, V. T., Lee, K. J., & Oh, J. K. (2015). Doppler imaging in aortic stenosis: The importance of the nonapical imaging windows to determine severity in a contemporary cohort. Journal of the American Society of Echocardiography, 28(7), 780–785. https://doi.org/10.1016/j.echo.2015.02.016

Takamatsu, K., Yamano, T., Zen, K., Takahara, M., Tani, R., Nakamura, S., et al. (2023). Doppler underestimates transvalvular gradient measured by catheterization in patients with severe aortic stenosis. American Journal of Cardiology, 195, 28–36. https://doi.org/10.1016/j.amjcard.2023.02.025

Tarasoutchi, F., Montera, M. W., Ramos, A. I., Sampaio, R. O., Rosa, V. E., Accorsi, T. A., et al. (2020). Atualização das Diretrizes Brasileiras de Valvopatias – 2020. Arquivos Brasileiros de Cardiologia, 115(4). https://doi.org/10.36660/abc.20201047

Teixeira, P. T., Ramos, R., Rio, P., Moura Branco, L., Portugal, G., Abreu, A., et al. (2017). Modified continuity equation using left ventricular outflow tract three-dimensional imaging for aortic valve area estimation. Echocardiography, 34(7), 978–985. https://doi.org/10.1111/echo.13589

Treibel, T. A., Lopez, B., Gonzalez, A., Menacho, K., Schofield, R. S., Ravassa, S., et al. (2018). Reappraising myocardial fibrosis in severe aortic stenosis: An invasive and noninvasive study in 133 patients. European Heart Journal, 39(8), 699–709. https://doi.org/10.1093/eurheartj/ehx353

Utsunomiya, H., Yamamoto, H., Horiguchi, J., Kunita, E., Okada, T., & Yamazato, R. (2012). Underestimation of aortic valve area in calcified aortic valve disease: Effects of left ventricular outflow tract ellipticity. International Journal of Cardiology, 157(3), 347–353. https://doi.org/10.1016/j.ijcard.2010.12.071

Vahanian, A., Beyersdorf, F., Praz, F., Milojevic, M., Baldus, S., Bauersachs, J., et al. (2022). 2021 ESC/EACTS guidelines for the management of valvular heart disease. EuroIntervention, 17, e1126–e1196. https://eurointervention.pcronline.com/article/2021-esc-eacts-guidelines-for-the-management-of-valvular-heart-disease

Veloso, M. L. A. (2012). Perfil ecocardiográfico do doente com estenose aórtica degenerativa (Master’s thesis, Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa).

Visby, L., Kristensen, C. B., Pedersen, F. H. G., Sigvardsen, P. E., Kofoed, K. F., & Hassager, C. (2019). Assessment of left ventricular outflow tract and aortic root: Comparison of 2D and 3D transthoracic echocardiography with multidetector computed tomography. European Heart Journal - Cardiovascular Imaging, 20(10). https://doi.org/10.1093/ehjci/jez045

Zoghbi, W. A. (2015). Velocity acceleration in aortic stenosis revisited. JACC Cardiovascular Imaging, 8(7), 776–778. https://doi.org/10.1016/j.jcmg.2015.04.005

Zhou, Y. Q., Faerestrand, S., & Matre, K. (1995). Velocity distributions in the left ventricular outflow tract in patients with valvular aortic stenosis: Effect on the measurement of aortic valve area by using the continuity equation. European Heart Journal, 16(3), 383–393. https://doi.org/10.1093/oxfordjournals.eurheartj.a060922

Published

27/02/2025

How to Cite

LEPRE, V. B. N.; RODRIGUES, G. D. Aortic stenosis: factors that interfere with the evaluation of severity by the Doppler echocardiographic method - review article. Research, Society and Development, [S. l.], v. 14, n. 2, p. e13114248347, 2025. DOI: 10.33448/rsd-v14i2.48347. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/48347. Acesso em: 30 mar. 2025.

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Health Sciences