Mesosphaerum suaveolens (Lamiacae): Source of antimicrobial and antioxidant compounds

Authors

DOI:

https://doi.org/10.33448/rsd-v9i8.6161

Keywords:

Hyptis suaveolens; Essential oil; Modulation; Medicinal plant; DIP’s; Caatinga.

Abstract

The use in folk medicine of leaves of Mesosphaerum suaveolens for the treatment of diseases of the digestive system and respiratory system, raised the hypothesis that its volatile oil has biological properties against pathogenic microorganisms. To evaluate this hypothesis, the antibacterial, antifungal activity against Candida yeast strains, which modifies the action of antibiotics and antioxidants (DPPH) was evaluated in vitro. In addition, it was determined by means of Gas Chromatography (GC-FID), the constituents present in the essential oil. The results show that M. suaveolens oil has antibacterial activity against standard and multidrug-resistant strains of Staphylococcus aureus, with a MIC of 64 and 256 μg/mL respectively, however it does not have the capacity to enhance the action of commercial antibacterials. Regarding the anti-Candida activity, it was possible to observe that there was biological action, since they presented IC50 de 18.15 µg/mL for Candida albicans URM and 40.4 for Candida tropicalis INCQS 40042. In addition, the oil was able to modulate fluconazole for all strains analyzed. As for the antioxidant action, the oil demonstrated that even in low percentages, there is an action in the reduction of free radicals (IC50> 200 µg/mL). Such activities may be related to the major constituent of the oil, the sesquiterpene β-caryophyllene (C17H28O2). Thus, M. suaveolens oil is a natural source with antimicrobial and antioxidant properties.

References

Albuquerque, U. P., Medeiros, P. M., Almeida, A. L. S., Monteiro, J. M., Neto, E. M. D. F. L., Melo, J. G. & Santos, J. P. (2007). Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: a quantitative approach. Journal of Ethnopharmacology, 114 (3), 325-54.

Bezerra, J. W. A., Costa, A. R., Freitas, M. A., Rodrigues, F. C., Souza, M. A., Silva, A. R. P., Santos, A. T. L., Linhares, K. V., Coutinho, H. D. M., Silva, J. R. L. & Morais-Braga, M. F. B. (2019). Chemical composition, antimicrobial, modulator and antioxidant activity of essential oil of Dysphania ambrosioides (L.) Mosyakin & Clemants. Comparative Immunology, Microbiology & Infectious Diseases, 65 (s/n), 58-64.

Bezerra, J. W. A., Costa, A. R., Rodrigues, F. C., Cunha, F. A. B., Silva, V. B., Boligon, A. A. & Anraku, M. M. (2018). Mesosphaerum suaveolens (L.) Kuntze (bamburral): planta medicinal com potencial antioxidante e rica em polifenóis. Revista Cubana de Plantas Medicinales, 24 (1), 1-14.

Bezerra, J. W. A., Costa, A. R., Silva, M. A. P., Rocha, M. I., Boligon, A. A., Rocha, J. B. T., Barros, L. M. & Kamdem, J. P. (2017). Chemical composition and toxicological evaluation of Hyptis suaveolens (L.) Poiteau (LAMIACEAE) in Drosophila melanogaster and Artemia salina. South African Journal of Botany, 113 (s/n), 437-442.

Costa, A. R., Silva, J. L., Lima, K. R. R., Rocha, M. I., Barros, L. M., Costa, J. G. M., Menezes, I. R. A. & Duarte, A. E. (2017). Rhaphiodon echinus (Nees & Mart.) Schauer: Chemical, toxicological activity and increased antibiotic activity of antifungal drug activity and antibacterial. Microbial Pathogenesis, 107 (s/n), 280-286.

Costa, A. R., Bezerra, J. W. A., Cruz, R. P., Freitas, M. A., Silva, V. B., Neto, J. C. & Kamdem, J. P. (2020). In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains. Antibiotics, 9 (s/n), 46-59.

Coutinho, H. D., Costa, J. G., Lima, E. O., Falcão-Silva, V. S. & Siqueira-Júnior, J. P. (2008). Enhancement of the antibiotic activity against a multiresistant Escherichia coli by Mentha arvensis L. and chlorpromazine. Chemotherapy, 54 (4), 328-330.

Duarte, A. E., Menezes, I. R. A., Morais-Braga, M. F. B., Leite, N. F., Barros, L. M., Waczuk, E. P. & Kamdem, J. P. (2016). Antimicrobial activity and Modulatory effect of essential oil from the leaf of Rhaphiodon echinus (Nees & Mart) Schauer on some antimicrobial drugs. Molecules, 21 (6), 743.

Ferreira, H. & Eliane, R. P. L. Pseudomonas aeruginosa: An alert to the professionals of health. Revista Panamericana De Infectología, 12 (s/n), 44-50.

Garcia-Cuesta, C., Sarrion-Pérez, M. G. & Bagán, J. V. (2014). Current treatment of oral candidiasis: A literature review. Journal of Clinical and Experimental dentistry, 6 (5), 576-582.

Martins, M., Henriques, M., Ribeiro, A. P., Fernandes, R., Gonçalves, V., Seabra, Á. & Oliveira, R. (2010). Oral Candida carriage of patients attending a dental clinic in Braga, Portugal. Revista Iberoamericana De Micologia, 27 (3), 119-124.

Navarro-Arias, M. J., Hernández-Chávez, M. J., Garcia-Carnero, L. C., Amezcua-Hernández, D. G., Lozoya-Pérez, N. E., Martínez-Duncker, I. & Mora-Montes, H. M. (2019). Differential recognition of Candida tropicalis, Candida guilliermondii, Candida krusei, and Candida auris by human innate immune cells. Infection And Drug Resistance, 12 (s/n), 783-794.

Raja, R. R. (2012). Medicinally potential plants of Labiatae (Lamiaceae) family: an overview. Research Journal of Medicinal Plant, 6 (3), 203-213.

Ramachandhiran, D., Sankaranarayanan, C., Murali, R., Babukumar, S. & Vinothkumar, V. (2019). β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway–An in-vitro and in-silico study. Archives of Physiology and Biochemistry, s/v (s/n),1-15.

Rodrigues, F. C., Santos, A. T. L., Machado, A. J. T., Bezerra, C. F., Freitas, T. S., Coutinho, H. D. M. & Boligon, A. A. (2019). Chemical composition and anti-Candida potencial of the extracts of Tarenaya spinosa (Jacq.) Raf. (Cleomaceae). Comparative Immunology, Microbiology And Infectious Diseases, 64 (s/n), 14-19.

Santos, F. S. M., Bezerra, J. W. A., Kamdem, J. P., Boligon, A. A., Anraku, M. M., Silva, A. R. P. & dos Santos, J. E. G. (2019). Polyphenolic composition, antibacterial, modulator and neuroprotective activity of Tarenaya spinosa (Jacq.) Raf. (Cleomaceae). Asian Pacific Journal of Tropical Biomedicine, 9 (1), 12-17.

Selestino-Neta, M. C., Vittorazzi, C., Guimarães, A. C., Martins, J. D. L., Fronza, M., Endringer, D. C. & Scherer, R. (2017). Effects of β-caryophyllene and Murraya paniculata essential oil in the murine hepatoma cells and in the bacteria and fungi 24-h time–kill curve studies. Pharmaceutical biology, 55 (1), 190-197.

Uritu, C. M., Mihai, C. T., Stanciu, G. D., Dodi, G., Alexa-Stratulat, T., Luca, A. & Tamba, B. I. (2018). Medicinal plants of the family Lamiaceae in pain therapy: A review. Pain Research and Management, s/v (s/n), 1-44.

Veras, H. N., Rodrigues, F. F., Botelho, M. A., Menezes, I. R., Coutinho, H. D. & Costa, J. G. (2017). Enhancement of aminoglycosides and β-lactams antibiotic activity by essential oil of Lippia sidoides Cham. and the Thymol. Arabian Journal of Chemistry, 10 (2), 2790-2795.

Downloads

Published

17/07/2020

How to Cite

BEZERRA, J. W. A.; RODRIGUES, F. C.; COSTA, A. R.; PEREIRA, K. S.; VIEIRA, N. R.; LÔBO, G. de O.; DE MENEZES, S. A.; GRANGEIRO NETO, F. A.; PEREIRA FILHO, J. T.; BOMTEMPO, P. H. S.; PEREIRA, T. da C.; TAVARES, H. C.; RIBEIRO, T. G.; COSTA, A. R. de S.; SOUSA, S. M. de; SANTOS, J. F. S. dos; COUTINHO, H. D. M.; MORAIS BRAGA, M. F. B. Mesosphaerum suaveolens (Lamiacae): Source of antimicrobial and antioxidant compounds. Research, Society and Development, [S. l.], v. 9, n. 8, p. e575986161, 2020. DOI: 10.33448/rsd-v9i8.6161. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/6161. Acesso em: 22 nov. 2024.

Issue

Vol. 9 No. 8

Section

Agrarian and Biological Sciences

License

Copyright (c) 2020 José Weverton Almeida Bezerra, Felicidade Caroline Rodrigues, Adrielle Rodrigues Costa, Kyhara Soares Pereira, Natália Rodrigues Vieira, Gabriel de Oliveira Lôbo, Saulo Almeida de Menezes, Francisco Alves Grangeiro Neto, Jacques Tavares Pereira Filho, Paulo Heinrich Soares Bomtempo, Thaís da Conceição Pereira, Helder Cardoso Tavares, Talina Guedes Ribeiro, Angélica Rodrigues de Souza Costa, Samara Mendes de Sousa, Joycy Francely Sampaio dos Santos, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais Braga

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.