Enterococcus spp. resistant to vancomycin and its spread in infections in the hospital environment
DOI:
https://doi.org/10.33448/rsd-v9i8.6404Keywords:
Enterococcus; Bacterial resistance; Vancomycin.Abstract
Objective: Describe the main virulence factors associated with this pathogen, with an emphasis on E. faecium and E. faecalis, demonstrating the main resistance genes involved in the mentioned species, as well as reporting the form of dissemination of these in hospital settings. Methodology: This article was prepared through Literature Review, based on materials indexed in the databases: PubMed, SciELO and Google Scholar, published between the years 2010 to 2020. For selection, the criteria were applied in the following order: (a) exploratory reading; (b) selective reading, (c) selection of material in accordance with the research objectives. Results: 789 files were found, of which 38 were selected for this article. Conclusion: The adoption of practices by the Hospital Infection Control team is very important, contributing to improvements in the quality of health care, thus increasing the safety of the entire team of professionals and patients.
References
Acioly, D. N. (2016). Avaliação da ocorrência de Enterococcus spp. resistentes à vancomicina em um hospital público de Fortaleza. Journal of Infection Control, 5(4). Recuperado de: http://jic-abih.com.br/index.php/jic/article/view/174.
Almeida, W. B., Machado, N. C. B., Rodrigues, A. P., Alves, I. A., Fontana, R. T., Monteiro, R. F. F., & Soares, N. V. (2019). Infecção hospitalar: controle e disseminação nas mãos dos profissionais de saúde de uma Unidade de Terapia Intensiva. Revista Eletrônica Acervo Saúde, 11(2), e130-e130. DOI: https://doi.org/10.25248/reas.e130.2019.
Arias, C. A., & Murray, B. E. (2012). The rise of the Enterococcus: beyond vancomycin resistance. Nature Reviews Microbiology, 10(4), 266-278. DOI: https://doi.org/10.1038/nrmicro2761.
Batistão, D. W. D. F., Gontijo-Filho, P. P., Conceição, N., Oliveira, A. G. D., & Ribas, R. M. (2012). Risk factors for vancomycin-resistant enterococci colonisation in critically ill patients. Memórias do Instituto Oswaldo Cruz, 107(1), 57-63. DOI: https://doi.org/10.1590/S0074-02762012000100008.
Billington, E. O., Phang, S. H., Gregson, D. B., Pitout, J. D. D., Ross, T., Church, D. L., & Parkins, M. D. (2014). Incidence, risk factors, and outcomes for Enterococcus spp. blood stream infections: a population-based study. International Journal of Infectious Diseases, 26, 76-82. DOI: https://doi.org/10.1016/j.ijid.2014.02.012.
Campos, P. A., et al. (2014) A sustained endemic outbreak of vancomycin-resistant Enterococcus faecium: A 30-month surveillance study. Scadinavian Journal of Infectious Diseases. 46(8), 547-554. DOI: https://doi.org/10.3109/00365548.2014.912348.
Correa, A. A., et al. (2015). Small hospitals matter: insights from the emergence and spread of vancomycin-resistant enterococci in 2 public in inner Brasil. Diagnostic Microbiology and Infections Disease. 82(3), 227-233. DOI: http://doi.org/10.1016/j.diagmicrobio.2015.03.026.
Da Silva, N. S., Muniz, V. D., Estofolete, C. F., Furtado, G. H. C., & Rubio, F. G. (2014). Identification of temporal clusters and risk factors of bacteremia by nosocomial vancomycin-resistant enterococci. American journal of infection control, 42(4), 389-392. DOI: https://doi.org/10.1016/j.ajic.2013.11.010.
Souza, M. A., Ribeiro, L. C. M., Primo, M. G. B., Sirico, S. C. A., Guilarde, A. O., & de Abreu Batista, L. J. (2012). Enterococo resistente à vancomicina em um hospital universitário no centro-oeste do Brasil. Revista de Patologia Tropical/Journal of Tropical Pathology, 41(2). Recuperado de: https://revistas.ufg.br/iptsp/article/download/19332/11232.
Drees, M., Snydman, D. R., Schmid, C. H., Barefoot, L., Hansjosten, K., Vue, P. M. ... & Golan, Y. (2008). Prior environmental contamination increases the risk of acquisition of vancomycin-resistant enterococci. Clinical infectious diseases, 46(5), 678-685. DOI: 10.1086/527394.
Ekwanzala, M. D., Dewar, J. B., Kamika, I., & Momba, M. N. B. (2020). Comparative genomics of vancomycin-resistant Enterococcus spp. revealed common resistome determinants from hospital wastewater to aquatic environments. Science of The Total Environment, 719, 137275. DOI: https://doi.org/10.1016/j.scitotenv.2020.137275.
Figueredo, R. A. M., Oliveira, J. T., Silva, A. M. T. C., & Ataides, F. S. (2017). Enterococcus resistente à vancomicina: uma preocupação em expansão no ambiente hospitalar. Journal of Infection Control, 6(1), 11-15. Recuperado de: http://jic-abih.com.br/ index.php/jic/article/view/160
Giroti, A. L. B., Ferreira, A. M., Rigotti, M. A., Sousa, Á. F. L. D., Frota, O. P., & Andrade, D. D. (2018). Programas de Controle de Infecção Hospitalar: avaliação de indicadores de estrutura e processo. Revista da Escola de Enfermagem da USP, 52. DOI: https://doi.org/10.1590/s1980-220x2017039903364.
Guimarães, D. O., Momesso, L. D. S., & Pupo, M. T. (2010). Antibióticos: importância terapêutica e perspectivas para a descoberta e desenvolvimento de novos agentes. Química Nova, 33(3), 667-679. DOI: http://dx.doi.org/10.1590/S0100-40422010000300035.
Jones, R. N., Guzman-Blanco, M., Gales, A. C., Gallegos, B., Castro, A. L. L., Martino, M. D. V., & Castanheira, M. (2013). Susceptibility rates in Latin American nations: report from a regional resistance surveillance program (2011). The Brazilian journal of infectious diseases, 17(6), 672-681. Recuperado de: https://doi.org/10.1016/j.bjid.2013.07.002
Merlo, T. P. (2013). Comparação genotípica e fenotípica de Enterococcus faecalis resistentes à vancomicina isolados nos anos de 2009 e 2011 em um hospital de Minas Gerais (Doctoral dissertation, Universidade de São Paulo). DOI: 10. 11606/D.76.2013.tde-19122013-171502.
Miller, W. R., Munita, J. M., & Arias, C. A. (2014). Mechanisms of antibiotic resistance in enterococci. Expert review of anti-infective therapy, 12(10), 1221-1236. DOI: https://dx.doi.org/10.1586%2F14787210.2014.956092.
Oliveira, A. C. D., & Damasceno, Q. S. (2010). Superfícies do ambiente hospitalar como possíveis reservatórios de bactérias resistentes: uma revisão. Revista da Escola de Enfermagem da USP, 44(4), 1118-1123. Recuperado de: https://www.scielo.br/pdf/reeusp/v44n4/38.pdf.
Oliveira, A. C. M. T. D. (2019). Análise de técnicas de diagnóstico de resistência à Vancomicina em amostras de Enterococcus provenientes de quadros de infecção da corrente sanguínea. Recuperado de: https:/ /app.uff.br/riuff/handle/1/13137.
Oliveira, A. C., & Bettcher, L. (2010). Aspectos epidemiológicos da ocorrência do Enterococcus resistente a Vancomicina. Revista da Escola de Enfermagem da USP, 44(3), 725-731. DOI: https://doi.org/10.1590/S0080-62342010000300025.
Oliveira, A. C., & Damasceno, Q. S. (2012). O papel do ambiente hospitalar na disseminação de bactérias resistentes. Rev Epidemiol Control Infect, 2(1), 28-31. Recuperado de: https://online.unisc.br/seer/index.php/epidemiologia/article/download/2625/1838.
Oliveira, H. M. D., Silva, C. P. R., & Lacerda, R. A. (2016). Policies for control and prevention of infections related to healthcare assistance in Brazil: a conceptual analysis. Revista da Escola de Enfermagem da USP, 50(3), 505-511. DOI: https://doi.org/10.1590/S0080-623420160000400018.
Palazzo, I. C. V., Pitondo-Silva, A., Levy, C. E., & da Costa Darini, A. L. (2011). Changes in vancomycin-resistant Enterococcus faecium causing outbreaks in Brazil. Journal of Hospital Infection, 79(1),70-74. DOI: https://doi.org/10.1016/j.jhin.2011.04.016.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. Recuperado de: https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.
Resende, M. etal. (2014). Emergence of Van A vancomycin-resistant Enterococcus faecium in a Hospital in Porto Alegre, South Brazil. The Journal of Infection in Developing Coutries. 8(2), 160-167. DOI:10.3855/jidc.4126.
Reyes, J., Panesso, D., Tran, T. T., Mishra, N. N., Cruz, M. R., Munita, J. M., & Garsin, D. (2015). A liaR deletion restores susceptibility to daptomycin and antimicrobial peptides in multidrug-resistant Enterococcus faecalis. The Journal of infectious diseases, 211(8), 1317-1325. DOI: https://doi.org/10.1093/infdis/jiu602.
Rosa, R. G., Schwarzbold, A. V., Santos, R. P. D., Turra, E. E., Machado, D. P., & Goldani, L. Z. (2014). Vancomycin-resistant Enterococcus faecium bacteremia in a tertiary care hospital: epidemiology, antimicrobial susceptibility, and outcome. BioMed research international. DOI: https://dx.doi.org/10.1155%2F2014%2F958469.
Rubin, I. M. C., Pedersen, M. S., Mollerup, S., Kaya, H., Petersen, A. M., Westh, H., & Pinholt, M. (2020). Association between vancomycin-resistant Enterococcus faecium colonization and subsequent infection: a retrospective WGS study. Journal of Antimicrobial Chemotherapy. DOI: https://doi.org/10.1093/jac/dkaa074.
Santana, A. M. (2019). Identificação, caracterização de resistência e patogenicidade de Enterococcus spp. Em amostras de doadoras do banco de leite humano do hospital Esaú matos em vitória da conquista, BA. Recuperado de: https://biocienciasims.ufba.br/sites/biocienciasims.ufba.br/files/luana_andrade_mendes_santana.pdf.
Santos, V. S. (2012). Diversidade microbiana, suscetibilidade a antibióticos e fatores de virulência em Enterococcus spp. Recuperado de: https://core.ac.uk/download/pdf/12427622.pdf.
Semedo-Lemsaddek T., Mato R. (2011) Pathogenesis and Virulence. In: Semedo-Lemsaddek T., Barreto-Crespo M. T., Tenreiro R. (Eds.) Enterococcus and Safety, Nova Science Publisher, New York. DOI: 10,1128 / aem.00687-09.
Terra, M. R., Da Silva, R. S. (2017). Vancomicina- Um antimicrobiano de importância nosocomial. Brazilian Jornal of Surgery and Clinical Research- BJSCR, 19 (3), 79-80. Recuperado de: https://www.mastereditora.com.br/download-2423.
Trabusli, L. R., Alterthum, F., Martinez, M. B., Campos, L. C., Gompertz, O. F., Gambale, W., Rácz, M. L. (2015). Microbiologia.
Yang, J., Jiang, Y., Guo, L., Ye, L., Ma, Y., & Luo, Y. (2016). Prevalence of diverse clones of vancomycin-resistant Enterococcus faecium ST78 in a Chinese hospital. Microbial Drug Resistance, 22(4), 294-300. DOI: https://doi.org/10.1089/mdr.2015.0069.
Zanella, R. C., et al. (1999). First confirmed case of a vancomycin-resistente Enterococcus faecium with Van A Phenotype from Brazil: isolation from a meningits case in São Paulo. Microbial Drug Resistance, 5, 159-161. DOI: 10.1089/mdr.1999.5.159.
Zanella, R. C., et al. (2003). Phenotypic an genotypie characterization of de VanA Enterococcus isolated the first nosocomial outbreak in Brasil. Microbial Drug Resistance. 9(3), 283-291. DOI: http://dx.doi.org/10.1089/107662903322286490.
Zanella, R. C., Brandileone, M. C. C., Bokermann, S., Almeida, S. C., Valdetaro, F., Vitório, F., & Pignatari, A. C. C. (2003). Phenotypic and genotypic characterization of VanA Enterococcus isolated during the first nosocomial outbreak in Brazil. Microbial Drug Resistance, 9(3), 283-291. DOI: http://dx.doi.org/10.1089/107662903322286490.
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