Use of Salvia officinalis as a phytotherapy agent in the control of Diabetes Mellitus
DOI:
https://doi.org/10.33448/rsd-v9i9.6930Keywords:
Salvia officinalis; Phytotherapy; Diabetes Mellitus.Abstract
The present study aimed to perform a literature review regarding the use of Salvia officinalis in the treatment of Diabetes Mellitus, in view of the importance of glycemic control for the systemic and oral health of patients with this disease. The literature review was prepared using the Google Scholar, PubMed and Scielo platforms as a research source. From the descriptors: “Phytotherapy”, “Salvia officinalis” and “Diabetes”, 31 articles published between 2010 and 2020 were selected. Diabetes mellitus stands out as an important cause of morbidity and mortality worldwide. Several researchers have investigated the effects of Salvia officinalis against diabetes, and its traditional use as an antidiabetic can be justified by the secondary metabolisms that are present in the preparations made from this plant. Studies indicate that S. officinalis can improve glycemic control and lipid profile, being useful in the treatment of diabetic and hyperlipidemic patients. In addition, no adverse effects have been reported. Salvia officinalis has stood out for its hypoglycemic action capacity, through the activity of its various constituents, showing itself capable of reducing fasting and postprandial blood glucose in several studies, in addition to decreasing glycosylated hemoglobin, total cholesterol , triglycerides and LDL, either alone or associated with other natural compounds.
References
Anjos Prado, M. A. S., Matsuok, J. T., & Giotto, A. C. (2018). Importância das Farmácias Vivas no âmbito da produção dos medicamentos fitoterápicos. Revista de Iniciação Científica e Extensão, 1(1), 32-37.
Behradmanesh, S., Derees, F., & Rafieian-Kopaei, M. (2013). Effect of Salvia officinalis on diabetic patients. Journal of renal injury prevention, 2(2), 51–54.
Ben Khedher, M. R., Hammami, M., Arch, J., Hislop, D. C., Eze, D., Wargent, E. T., Kępczyńska, M. A., & Zaibi, M. S. (2018). Preventive effects of Salvia officinalis leaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone. PeerJ, 6, e4166.
Bento, A. (2012). Como fazer uma revisão da literatura: Considerações teóricas e práticas. Revista JA (Associação Académica da Universidade da Madeira), 7(65), 42-44.
Brasil, M. D. S. (2020). Ministério da Saúde. Vigitel Brasil 2019: principais resultados. Boletim Epidemiológico, 51(16).
Christensen, K. B., Jørgensen, M., Kotowska, D., Petersen, R. K., Kristiansen, K., & Christensen, L. P. (2010). Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.). Journal of ethnopharmacology, 132(1), 127–133.
Corrêa, K., Gouvêa, G. R., Silva, M. A. V. D., Possobon, R. D. F., Barbosa, L. F. D. L. N., Pereira, A. C., ... & Cortellazzi, K. L. (2017). Qualidade de vida e características dos pacientes diabéticos. Ciência & Saúde Coletiva, 22, 921-930.
Cortez, N. D., Reis, I. A., Souza, D. A. S., Macedo, M. M. L., & Torres, H. C. (2015). Complicações e o tempo de diagnóstico do diabetes mellitus na atenção primária. Acta Paul Enferm. 28(3). 250-5.
Flor, L. S., & Campos, M. R. (2017). Prevalência de diabetes mellitus e fatores associados na população adulta brasileira: evidências de um inquérito de base populacional. Revista Brasileira de Epidemiologia, 20(1), 16–29.
Ghorbani, A., & Esmaeilizadeh, M. (2017). Pharmacological properties of Salvia officinalis and its components. Journal of traditional and complementary medicine, 7(4), 433–440.
Ghorbani, A., Shafiee-Nick, R., Rakhshandeh, H., & Borji, A. (2013). Antihyperlipidemic effect of a polyherbal mixture in streptozotocin-induced diabetic rats. Journal of lipids, 2013, 675759.
Hamidpour, M., Hamidpour, R., Hamidpour, S., & Shahlari, M. (2014). Chemistry, pharmacology, and medicinal property of sage (Salvia) to prevent and cure illnesses such as obesity, diabetes, depression, dementia, lupus, autism, heart disease, and cancer. Journal of traditional and complementary medicine, 4(2), 82-88.
Jayanthy, G., & Subramanian, S. (2014). Rosmarinic acid, a polyphenol, ameliorates hyperglycemia by regulating the key enzymes of carbohydrate metabolism in high fat diet – STZ induced experimental diabetes mellitus. Biomedicine & Preventive Nutrition. 431-437.
Khacheba, I., Djeridane, A., & Yousfi, M. (2014). Twenty traditional Algerian plants used in diabetes therapy as strong inhibitors of α-amylase activity. International Journal of Carbohydrate Chemistry, 2014.
Kianbakht, S., & Dabaghian, F. H. (2013). Improved glycemic control and lipid profile in hyperlipidemic type 2 diabetic patients consuming Salvia officinalis L. leaf extract: a randomized placebo. Controlled clinical trial. Complementary therapies in medicine, 21(5), 441–446.
Labolita, K. A., Santos, I. B., Balbino, V. C., Andrade, G. L., Araujo, I. C., & Fernandes, D. C. (2020). Assistência odontológica à pacientes diabéticos. Caderno de Graduação-Ciências Biológicas e da Saúde-UNIT-ALAGOAS, 6(1), 89.
Medeiros, I. C. (2018). Avaliação do conhecimento e uso de plantas medicinais e fitoterápicos por dentistas do seridó potiguar (Trabalho de conclusão de residência multiprofissional). Universidade Federal do Rio Grande do Norte, Currais Novos, RN, Brasil.
Melo Aleluia, C., de Cássia Procópio, V., Oliveira, M. T. G., Furtado, P. G. S., Giovannini, J. F. G., & de Mendonça, S. M. S. (2015). Fitoterápicos na odontologia. Revista de Odontologia da Universidade Cidade de São Paulo, 27(2), 126-134.
Moradabadi, L., Kouhsari, S. M., & Sani, M. F. (2013). Hypoglycemic Effects of Three Medicinal Plants in Experimental Diabetes: Inhibition of Rat Intestinal α-glucosidase and Enhanced Pancreatic Insulin and Cardiac Glut-4 mRNAs Expression. Iranian journal of 8pharmaceutical research: IJPR, 12(3), 387–397.
Neto, J. N. C., Beltrami, M., & Souza, I. F. A., de Andrade, J. M., da Silva, J. A. L., Quintela, K. L. (2012). O paciente diabético e suas implicações para conduta odontológica. Revista Dentística on line, (23).
Ogurtsova, K., da Rocha Fernandes, J. D., Huang, Y., Linnenkamp, U., Guariguata, L., Cho, N. H., ... Makaroff, L. E. (2017). Atlas de Diabetes da IDF: Estimativas globais para a prevalência de diabetes para 2015 e 2040. Diabetes Research and Clinical Practice, 128, 40-50.
Olokoba, A. B., Obateru, O. A. & Olokoba, L. B. (2012). Type 2 Diabetes Mellitus: A Review of Current Trends. Oman Medical Journal, 27(4), 269-273.
Paz, A. M., Pereira, D. C. T., de Souza Júnior, J. F. A., & Fonseca, F. L. D. M. A. (2017). Atendimento odontológico para pessoas com diabetes mellitus. Revista Científica da OARF, 1(2).
Pereira, A., Banegas-Luna, A. J., Peña-García, J., Pérez-Sánchez, H., & Apostolides, Z. (2019). Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening. Molecules (Basel, Switzerland), 24(22), 4030.
Pereira, A., den Haan, H., Peña-García, J., Moreno, M. M., Pérez-Sánchez, H., & Apostolides, Z. (2019). Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server. Molecules (Basel, Switzerland), 24(10), 2002.
Petermann, X. B., Machado, I. S., Pimentel, B. N., Miolo, S. B., Martins5, L. R., & Fedosse, E. (2015). Epidemiologia e cuidado para Diabetes Mellitus praticado na Atenção Primária à Saúde: uma revisão narrativa. Saúde (Santa Maria), 41(1), 49-56.
Salah, M. A., Hussein, M., Rana, I., & Khalid, L. B. (2016). Effect of Salvia officinalis L.(Sage) Aqueous extract on Liver and Testicular Function of Diabetic Albino Male Rats. Journal of University of Babylon, 24(2), 390-399.
Shafiee-Nick, R., Ghorbani, A., Vafaee, F., & Rakhshandeh, H. (2012). Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats. Advances in pharmacological sciences, 2012, 789796.
Souza, L. R. G. D. (2014). Prescrição de fitoterápicos por estudantes dos cursos de odontologia das universidades públicas do Rio Grande do Norte (Trabalho de conclusão de curso). Universidade Federal do Rio Grande do Norte, UFRN, Natal, RN, Brasil.
Viana, M. R., & Rodriguez T. T. (2010). Complicações cardiovasculares e renais no diabetes mellitus. Revista de Ciências Médicas e Biológicas. 10(3). 290-296.
Weinert, L. S., Silveiro, S. P., Oppermann, M. L., Salazar, C. C., Simionato, B. M., Siebeneichler, A., & Reichelt, A. J. (2011). Diabetes gestacional: um algoritmo de tratamento multidisciplinar. Arquivos Brasileiros de endocrinologia & metabologia, 55(7), 435-445.
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Copyright (c) 2020 Rafaela Oliveira Santos, Igor Natanyo de Freitas Silva, Alexandre José da Costa, Gabrielli Bezerra Sales, Janaina Barbosa de Alencar, Sérvulo da Costa Rodrigues Neto, Raline Mendonça dos Anjos, Maria Angélica Sátyro Gomes Alves, Aleson Pereira de Sousa, Abrahão Alves de Oliveira Filho
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