Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case report
DOI:
https://doi.org/10.33448/rsd-v9i9.7234Keywords:
Dogs; Ozonetherapy; Ehrlichiosis; Adjuvant therapy.Abstract
The aim of this paper is to describe the platelet increase in a dog with persistent thrombocytopenia, when it was subjected to adjuvant ozone therapy, correlating the effects of this gas on metabolism and its cellular mobilization. Thrombocytopenia is characterized by hematological changes, with a reduction in the number of platelets in the blood. There are several diseases related to thrombocytopenia, among them we can mention hemoparasitosis, where thrombocytopenia appears as a result of megakaryocytic hypoplasia, or due to immune causes, related to the presence of antiplatelet antibodies, which cause accelerated destruction of platelets by macrophages of the phagocytic mononuclear system. Several therapies can be instituted, according to their underlying cause. However, there are few descriptions of the association of adjuvant therapies, such as the use of ozone as a therapeutic form. Ozone (O3) has been shown to be promising in medicinal use, being used in the treatment of several diseases, including those of a hematological nature, requiring further studies for its validation and scientific proof. A 10-month-old canine patient was seen with suspected hemoparasitosis, with a history of contact with ectoparasites and lack of appetite. The clinical signs observed were pale mucous membranes and epistaxis. Treatment was instituted, using doxycycline-based antibiotics, for a period of 28 days, in addition to blood transfusion and use of erythropoietin, but without success. In view of this situation, we opted for the institution of adjuvant ozone therapy, through the infusion of ozonated saline solution, intravenously. After 15 days of association, the patient improved his persistent thrombocytopenia, evidenced after new tests, as well as clinical improvement of the signs previously presented.
References
ABOZ (2020). Associação Brasileira de Ozonioterapia. Recuperado de https://www.aboz.org.br/veterinaria/.
Anzolin, P. A. & Bertol, C. D. (2018). Ozone therapy as an integrating therapeutic in osteoartrosis treatment: a systematic review. Brazilian Journal Pain, 1(2),171-175.
Bacal, N. S., Guerra, C. C. C., Rosenfeld, L. G. M., Hamerschlak, N., Lazaro, R. J., Takiri, I, Y., Ioshida, M. R., Nozawa, S. T., Kanayama, R. H. & Guerra, J. C. C. (2011). Plaquetopenias: diagnóstico usando citometria de fluxo e anticorpos antiplaquetas, Einstein, 9(2),130-134.
Bocci, V. A. (2018). Scientific and medical aspects of ozone therapy. State of the art. Archives Medical Research, 37(4),425-435.
Bocci, V., Zanardi, I. & Travagli, V. (2011). Oxygen/ozone as medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects. Medical Gas Research, 1(1), 6-15.
Cheville, N. F. (2009). Introdução à patologia veterinária. São Paulo: Manole, 3°ed. 344p.
Elvis, A. M. & Ekta, J. S. (2011). Ozone therapy: a clinical review. Journal National Science Biological Medicine, 2(1),66-70.
Garcia, C. A., Berbert, R. P., Rodrigues, G. M., Nascimento, F. G. O., Cipriano, L. F. & Violatti, I. C. A. (2010). The use of ozonated major autohemotherapy in canine ehrlichiosis’ treatment: case report. Revista CENIC. Ciências Biológicas, 41(1),1-7, 2010.
Gough, A. (2009). Achados Laboratoriais. In: Gough, A. Diagnóstico diferencial na medicina veterinária, São Paulo: Roca, 1º edição, 312-314.
Haddad, M. A., Souza, M. V., Hincapie, J. J., Ribeiro Junior, J. I. & Benjamin, L. A. (2009). Comportamento de componentes bioquímicos do sangue em eqüinos submetidos à ozonioterapia. Arquivo Brasileiro Medicina Veterinária e Zootecnia, 61(3), 539-546.
Haddad, M. A. (2006). Dissertação. Efeitos da ozonioterapia sobre parâmetros clínicos, hematológicos, e da bioquímica sanguínea em eqüinos. Universidade Federal de Viçosa, 134p.
Hernández, O. & González, R. (2001). Ozonoterapia En Úlceras flebostáticasin: Revista Cubana de Cirugía, 40(2), 123-129.
Jericó, M. M., Neto, J. P. A. & Kogika, M. M. (2019). Tratado de medicina interna de cães e gatos. Rio de Janeiro: Roca, 508p.
Kahn, C. M. & Line, S. (2013). Manual Merck de Veterinária. São Paulo: Roca, (10a ed.), 824-828.
Kienle, G. S. & Kiene, H. (2011). Como escrever um relato de caso. Arte Médica Ampliada, 31(2),1-4.
Kornad, H. (2020). Ozônio medicinal. Ozone clinic. Recuperado de http://www.ozonio.med.br/.
León-Fernandez, O. S., Viebahn-Haensler, R., Cabreja, G. L., Espinosa, I. S., Matos, Y. H. & Roche, L. D. (2016). Medical ozone increases methotrexate clinical response and improves cellular redox balance in patients with rheumatoid arthritis. Eurpean Journal of Pharmacology, 789(1), 313-318.
Matos Neto, A., et al. (2012). Ozonioterapia no tratamento de ferida infectada - relato de caso. Journal Brasileiro de Ciência Animal, 5(10), suppl.10-12.
Morette, D. F. (2011). Trabalho de Conclusão de Curso (Bacharelado em Medicina Veterinária) - Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu. Principais aplicações terapêuticas da ozonioterapia, 1-19.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. p. Recuperado de https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1
Sangioni, L. A. & Botton, S. A. (2017). Riquétsias In: Monteiro, S. G. Parasitologia na Medicina Veterinária. Rio de Janeiro: Roca, (2a ed.), 167-178.
Shen, L., Yuan, T., Chen, S., Xie, X. & Zhang, C. (2017). The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. Journal of Orthophedy Surgery Research, 12(16), 1-12.
Souza, D. M. B., et al. (2012). Elriquiose transmitida aos cães pelo carrapato marrom (Rhipicephalus sanguineus). Ciência. Veterinária tropical. 15(30), 21-31.
Villegas-Perez, S. L., Ojeda-Chia, L. M., Rodriguez-Vivas, R. I., Esteve-Gasen, M. D., Perez, A. A. & Modarelli, L. J. (2019). Ehrlichia canis in dogs of Mexico: Prevalence, incidence, co-infectiom and factors associated. Comparative Immunology, Microbiology and Infectious Diseases. 67(1), 1-6.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Bruna Pereira Gonçalves; Larissa Magalhães de Castro; Helena Gomes Ferreira Pinto; Mário dos Santos Filho
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
