Relationship between exposure to the pesticide Rotenone and the development of motor and non-motor symptoms of Parkinson's disease

Authors

DOI:

https://doi.org/10.33448/rsd-v9i9.7917

Keywords:

Pesticides; Nervous system diseases; Gastrointestinal tract; Parkinson disease.

Abstract

Introduction: Parkinson's disease (PD) is known for its debilitating motor symptoms and the dependence that its progression causes. Although classic, this condition still does not have its causal factors fully elucidated and, therefore, the prediction sometimes becomes ineffective. In the search for a better understanding of the disease, researchers found an intimate relationship between their symptoms and populations that had contact with the pesticide rotenone, widely used in agricultural processes and that can be an auxiliary factor in the development of the disease in the agricultural population. Objective: To elucidate, based on the literature, the interrelation of Parkinson's Disease with rotenone. Methodology: Integrative literature review that used the descriptors: “Parkinson Disease”, “Rotenone”, “Synucleins”, “Gastrointestinal Tract”, “Vagus Nerve” and “Microbiota” in the databases: PubMed, ScienceDirect, SCIELO, and BVS where 13 documents were selected for analysis that elucidated in their text the relationship between the disease and the substance studied. Results: The works portray an intimate relationship between exposure to rotenone and non-motor symptoms of Parkinson's disease. Also, these symptoms mainly affect signs in the gastrointestinal tract, which sometimes can help in the prediction of the disease long before the manifestation of classic symptoms. Final Considerations: Rotenone has a well-elucidated relationship in the development of Parkinson's disease, besides, this relationship allows a better understanding of the connection between the brain and the gastrointestinal tract through the vagus nerve. Thus, such findings can serve as a basis for a better understanding and prevention of the diagnosis and treatment of PD.

References

Arnhold, M., Dening, Y., Chopin, M., Arévalo, E., Schwarz, M., & Reichmann, H. et al. (2016). Changes in the sympathetic innervation of the gut in rotenone treated mice as possible early biomarker for Parkinson’s disease. Clinical Autonomic Research, 26(3), 211-222. https://doi.org/10.1007/s10286-016-0358-6

Baizabal-Carvallo, J., & Alonso-Juarez, M. (2020). The Link between Gut Dysbiosis and Neuroinflammation in Parkinson’s Disease. Neuroscience, 432, 160-173. https://doi.org/10.1016/j.neuroscience.2020.02.030

Bu, J., Qiao, X., He, Y., & Liu, J. (2019). Colonic electrical stimulation improves colonic transit in rotenone-induced Parkinson's disease model through affecting enteric neurons. Life Sciences, 231, 116581. https://doi.org/10.1016/j.lfs.2019.116581

Dantas, É., & Ramalho, D. (2020). O uso de diferentes metodologias no ensino de microbiologia: Uma revisão sistemática de literatura. Research, Society And Development, 9(8), e665986396. https://doi.org/10.33448/rsd-v9i8.6396

Drolet, R., Cannon, J., Montero, L., & Greenamyre, J. (2009). Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiology Of Disease, 36(1), 96-102. https://doi.org/10.1016/j.nbd.2009.06.017

Johnson, M., Stringer, A., & Bobrovskaya, L. (2018). Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson’s disease. Neurotoxicology, 65, 174-185. https://doi.org/10.1016/j.neuro.2018.02.013

Kim, S., Kwon, S., Kam, T., Panicker, N., Karuppagounder, S., & Lee, S. et al. (2019). Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease. Neuron, 103(4), 627-641.e7. https://doi.org/10.1016/j.neuron.2019.05.035

Klingelhoefer, L., & Reichmann, H. (2015). Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors. Nature Reviews Neurology, 11(11), 625-636. https://doi.org/10.1038/nrneurol.2015.197

Klingelhoefer, L., & Reichmann, H. (2017). The Gut and Nonmotor Symptoms in Parkinson's Disease. International Review Of Neurobiology, 787-809. https://doi.org/10.1016/bs.irn.2017.05.027

Koutzoumis, D., Vergara, M., Pino, J., Buddendorff, J., Khoshbouei, H., Mandel, R., & Torres, G. (2020). Alterations of the gut microbiota with antibiotics protects dopamine neuron loss and improve motor deficits in a pharmacological rodent model of Parkinson's disease. Experimental Neurology, 325, 113159. https://doi.org/10.1016/j.expneurol.2019.113159

Martinez, E., Young, A., Patankar, Y., Berwin, B., Wang, L., & von Herrmann, K. et al. (2017). Editor’s Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice. Toxicological Sciences, 159(1), 64-75. https://doi.org/10.1093/toxsci/kfx117

Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., & Petticrew, M. et al. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4(1). https://doi.org/10.1186/2046-4053-4-1

Pan-Montojo, F., & Funk, R. (2010). Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System. Journal Of Visualized Experiments, (44). https://doi.org/10.3791/2123

Pan-Montojo, F., Anichtchik, O., Dening, Y., Knels, L., Pursche, S., & Jung, R. et al. (2010). Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice. Plos ONE, 5(1), e8762. https://doi.org/10.1371/journal.pone.0008762

Pan-Montojo, F., Schwarz, M., Winkler, C., Arnhold, M., O'Sullivan, G., & Pal, A. et al. (2012). Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Scientific Reports, 2(1). https://doi.org/10.1038/srep00898

Perez-Pardo, P., Dodiya, H., Broersen, L., Douna, H., van Wijk, N., & Lopes da Silva, S. et al. (2017). Gut–brain and brain–gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet. Nutritional Neuroscience, 21(6), 391-402. https://doi.org/10.1080/1028415x.2017.1294555

Perez-Pardo, P., Dodiya, H., Engen, P., Naqib, A., Forsyth, C., & Green, S. et al. (2018). Gut bacterial composition in a mouse model of Parkinson’s disease. Beneficial Microbes, 9(5), 799-814. https://doi.org/10.3920/bm2017.0202

Sharma, S., Awasthi, A., & Singh, S. (2019). Altered gut microbiota and intestinal permeability in Parkinson’s disease: Pathological highlight to management. Neuroscience Letters, 712, 134516. https://doi.org/10.1016/j.neulet.2019.134516

Spielman, L., Gibson, D., & Klegeris, A. (2018). Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases. Neurochemistry International, 120, 149-163. https://doi.org/10.1016/j.neuint.2018.08.005

Tanner, C., Kamel, F., Ross, G., Hoppin, J., Goldman, S., & Korell, M. et al. (2011). Rotenone, Paraquat, and Parkinson’s Disease. Environmental Health Perspectives, 119(6), 866-872. https://doi.org/10.1289/ehp.1002839

Tasselli, M., Chaumette, T., Paillusson, S., Monnet, Y., Lafoux, A., & Huchet-Cadiou, C. et al. (2013). Effects of oral administration of rotenone on gastrointestinal functions in mice. Neurogastroenterology & Motility, 25(3), e183-e193. https://doi.org/10.1111/nmo.12070

Published

04/09/2020

How to Cite

Oliveira, J. K. S. de, Carvalho, J. M. de, Silva, C. A., Lima, M. B. de, Cavalcante, P. M. F., & Paiva, D. F. F. (2020). Relationship between exposure to the pesticide Rotenone and the development of motor and non-motor symptoms of Parkinson’s disease. Research, Society and Development, 9(9), e706997917. https://doi.org/10.33448/rsd-v9i9.7917

Issue

Section

Health Sciences