Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence
Keywords:Insanity; Neuroprotective drugs; Efficiency
AbstractThe present study had as objective to verify the effectiveness of the use of lithium in the treatment of Alzheimer's Disease. It is a review of the integrative type, using articles published in the years 2011 to 2014, available in PubMed, ScienceDirect and Scielo databases. Recent studies have shown that dietary supplementation with lithium prevented the increase of inflammatory mediators in the rat brain, leading to apparent therapeutic neuroprotective effects of lithium. It also leads to increased neurogenesis in the hippocampal gyrus and appears to increase gray matter, evidence that lithium has a neuroprotective action in the treatment of symptoms associated with Alzheimer's disease. It was observed that the use of lithium in the treatment of Alzheimer's disease has some positive effects, however, more detailed studies are needed.
ALMEIDA, M. C.; GOMES, C. M.; NASCIMENTO, L. F. Spatial distribution of deaths due to Alzheimer's disease in the state of São Paulo, Brazil. São Paulo Medical Journal, v. 132, n. 1, p. 199-204, 2014. Disponivel em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000400199. Acesso em: 17 out. 2018.
ÁLVAREZ-RUÍZ, Y.; CARRILLO-MORA, P. Amyloid beta 25-35 impairs reconsolidation of object recognition memory in rats and this effect is prevented by lithium carbonate. Neurosci Lett, v. 548, n. 26, p. 79-83, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/23774478. Acesso: 20 out.2018.
CERULLI, F. G. et al. Lítio crônico potencializa a sobrevivência de novas células induzida por enriquecimento ambiental no hipocampo de camundongos adultos. Rev Med, v. 92, n. 1, p. 78-80, 2013. Disponível em: http://www.revistas.usp.br/revistadc/article/view/69590. Acesso em: 16 out. 2018.
DINIZ, B. S.; TEIXEIRA, A. L. Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond. Neuromolecular Med, v. 13, n. 4, p. 217-222, 2011. Disponivel em: https://www.ncbi.nlm.nih.gov/pubmed/21898045. Acesso em: 18 out. 2018.
DOWNEY, D. Pharmacologic management of Alzheimer Desease. Journal of Neuroscience Nursing. v. 40, n. 1, p. 55-59, 2008. Disponivel em: https://www.medscape.com/viewarticle/571451. Acesso em: 20 out. 2018.
FORLENZA, O. V. et al. Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial. Br J Psychiatry, v. 198, n. 1, p. 351-356, 2011. Disponivel em: https://www.ncbi.nlm.nih.gov/pubmed/21525519. Acesso em: 17 out. 2018.
KAMADA, M.; MATTAR, A. G.; FONTANA, M. P. Uso do lítio no tratamento do Alzheimer. Rev Soc Bras Clin Med, v. 14, n. 1, p. 63-66, 2016. Disponivel em: http://docs.bvsalud.org/biblioref/2016/05/33/63-66.pdf. Acesso em: 17 out. 2018.
LEYHE, T. et al. Impairment of episodic and semantic autobiographical memory in patients with mild cognitive impairment and early Alzheimer’s disease. Neuropsychologia, v. 47, n. 12, p. 2464-2469, 2009. Disponivel em: https://www.ncbi.nlm.nih.gov/pubmed/19409401. Acesso em: 17 out. 2018.
MENDES, K. D. S.; SILVEIRA, R. C. C. P.; GALVÃO, C. M. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto Contexto Enferm, v. 17, n. 4, p. 758-764, 2008. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-07072008000400018. Acesso em: 17 out. 2018.
NERY, L. R. Caracterização de modelos de experimentação baseados na doença de alzheimer em zebrafish. Porto Alegre [tese]. Porto Alegre: Pontifícia Universidade Católica do Rio Grande do Sul; 2015.
RUDY, C. C. et al. The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer’s disease. Aging Dis, v. 6, n. 2, p. 131-148, 2015. Disponivel em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365957/. Acesso em: 20 out. 2018.
SCHOWE, N. M. Relação entre o Tratamento Crônico com Lítio e Papel do Sistema Colinérgico na Neuroinflamação. Dissertação (Pós-graduação em Farmacologia) Instituto de Ciências Biomédicas da Universidade de São Paulo, 2014. Disponível em: http://www.teses.usp.br/teses/disponiveis/42/42136/tde-11062014-145521/pt-br.php. Acesso em: 18 out. 2018.
TUNG, T. C.; MINATOGAWA-CHANG, T. M.; TAVEIRA, A. Novas perspectivas no uso do lítio. RBM Rev Bras Med, v. 71, n. 3, p. 4-26, 2014. Disponível em: http://www.moreirajr.com.br/revistas.asp?fase=r003&id_materia=5881. Acesso em: 18 out. 2018.
YANG, Z. et al. Meta-analysis of Ginkgo biloba extract for the treatment of Alzheimer’s disease. Neural Regeneration Research, v. 6, n. 15, p. 1125-1129, 2011. Disponivel em: https://www.ncbi.nlm.nih.gov/books/NBK80888/. Acesso em: 17 out. 2018.
ZHAO, L. et al. Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer’s disease mouse model. Neurobiol Aging, v. 35, n. 12, p. 2736-2745, 2014. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/25018109. Acesso em: 17 out. 2018.
WALLACE, J. Calcium dysregulation, and lithium treatment to forestall Alzheimer’s disease – a merging of hypotheses. Cell Calcium, v. 55, n. 3, p. 175-181, 2014. Disponivel em: https://www.ncbi.nlm.nih.gov/pubmed/24636273. Acesso em: 20 out. 2018.
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