Ozone therapy in the treatment of recurrent herpes labialis: a clinical case report
DOI:
https://doi.org/10.33448/rsd-v9i10.8418Keywords:
Herpes labialis; Ozone; Recurrence; Case report.Abstract
Herpes is one of the infectious diseases that grows the most worldwide, with 500,000 new cases every year. It is presented as a painful vesicular eruption, forming crusts that cause esthetic deformation and psychosocial distress. It is usually a self-limiting and recurrent disease with no cure available. This study aims to report an case in the literature of unusual treatment of a recurrent herpes simplex labialis with ozone therapy. A search for scientific articles was performed in the Pubmed, SciELO, and Embase databases for scientific basis and construction of the clinical case report. Female patient, 20 years old, with history of multiple recurrences of herpes labialis lesions, attended the clinical service with small perilabial vesicles after signs of itching and burning. Considering the previous history and lesion characteristics, a treatment was established for herpes labialis with ozone injection around the lesion associated with the topical use of ozonized sunflower oil. The clinical aspect of the lesion and related symptoms improved in a shorter period than the previous episodes. Ozone therapy was effective in this case of recurrent herpes labialis and further studies are required to create a clinical treatment protocol.
References
Akintoye, S. O., & Greenberg, M. S. (2005). Recurrent aphthous stomatitis. Dent Clin North Am, 49(1), 31–47, vii–viii. https://doi.org/10.1016/j.cden.2004.08.001
Arain, N., Paravastu, S. C., & Arain, M. A. (2015). Effectiveness of topical corticosteroids in addition to antiviral therapy in the management of recurrent herpes labialis: A systematic review and meta-analysis. BMC Infect Dis, 15, 82. https://doi.org/10.1186/s12879-015-0824-0
Azarpazhooh, A., & Limeback, H. (2008). The application of ozone in dentistry: A systematic review of literature. Journal of Dentistry, 36(2), 104–116. https://doi.org/10.1016/j.jdent.2007.11.008
Balasubramaniam, R., Kuperstein, A. S., & Stoopler, E. T. (2014). Update on oral herpes virus infections. Dent Clin North Am, 58(2), 265–280. https://doi.org/10.1016/j.cden.2013.12.001
Birkmann, A., & Zimmermann, H. (2016). HSV antivirals—Current and future treatment options. Curr Opin Virol, 18, 9–13. https://doi.org/10.1016/j.coviro.2016.01.013
Bocci, V. A. (2006). Scientific and medical aspects of ozone therapy. State of the art. Archives of Medical Research, 37(4), 425–435. https://doi.org/10.1016/j.arcmed.2005.08.006
Campos, D. da S., Morais, J. P., Tim, C. R., Gomes, J. C., & Assis, L. (2020). Implicações sobre o uso do ozônio (O3) no tratamento coadjuvante do COVID-19. Research, Society and Development, 9(9), e579997508–e579997508. https://doi.org/10.33448/rsd-v9i9.7508
Chattopadhyay, A., & Shetty, K. V. (2011). Recurrent aphthous stomatitis. Otolaryngol Clin North Am, 44(1), 79–88, v. https://doi.org/10.1016/j.otc.2010.09.003
Chi, C. C., Wang, S. H., Delamere, F. M., Wojnarowska, F., Peters, M. C., & Kanjirath, P. P. (2015). Interventions for prevention of herpes simplex labialis (cold sores on the lips). Cochrane Database Syst Rev, 8, CD010095. https://doi.org/10.1002/14651858.CD010095.pub2
Evans, T. G., Bernstein, D. I., Raborn, G. W., Harmenberg, J., Kowalski, J., & Spruance, S. L. (2002). Double-blind, randomized, placebo-controlled study of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis. Antimicrob Agents Chemother, 46(6), 1870–1874. https://doi.org/10.1128/aac.46.6.1870-1874.2002
Fatahzadeh, M., & Schwartz, R. A. (2013). Oral Kaposi’s sarcoma: A review and update. Int J Dermatol, 52(6), 666–672. https://doi.org/10.1111/j.1365-4632.2012.05758.x
Gagnier, J. J., Kienle, G., Altman, D. G., Moher, D., Sox, H., Riley, D., & CARE Group. (2013). The CARE guidelines: Consensus-based clinical case reporting guideline development. BMJ Case Reports, 2013. https://doi.org/10.1136/bcr-2013-201554
Harmenberg, J., Oberg, B., & Spruance, S. (2010). Prevention of ulcerative lesions by episodic treatment of recurrent herpes labialis: A literature review. Acta Derm Venereol, 90(2), 122–130. https://doi.org/10.2340/00015555-0806
Hull, C. M., Harmenberg, J., Arlander, E., Aoki, F., Bring, J., Darpö, B., Levin, M. J., Tyring, S., Spruance, S. L., & Group, M.-609 S. (2011). Early treatment of cold sores with topical ME-609 decreases the frequency of ulcerative lesions: A randomized, double-blind, placebo-controlled, patient-initiated clinical trial. J Am Acad Dermatol, 64(4), 696.e1-11. https://doi.org/10.1016/j.jaad.2010.08.012
Hull, C., McKeough, M., Sebastian, K., Kriesel, J., & Spruance, S. (2009). Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: A patient-initiated, double-blind, placebo-controlled pilot trial. J Eur Acad Dermatol Venereol, 23(3), 263–267. https://doi.org/10.1111/j.1468-3083.2008.03047.x
James, C., Harfouche, M., Welton, N. J., Turner, K. M., Abu-Raddad, L. J., Gottlieb, S. L., & Looker, K. J. (2020). Herpes simplex virus: Global infection prevalence and incidence estimates, 2016. Bull World Health Organ, 98(5), 315–329. https://doi.org/10.2471/BLT.19.237149
Jenson, H. B. (2011). Epstein-Barr virus. Pediatr Rev, 32(9), 375–383; quiz 384. https://doi.org/10.1542/pir.32-9-375
Naik, S. V., K, R., Kohli, S., Zohabhasan, S., & Bhatia, S. (2016). Ozone- A Biological Therapy in Dentistry- Reality or Myth????? The Open Dentistry Journal, 10, 196–206. https://doi.org/10.2174/1874210601610010196
Nogales, C. G., Ferrari, P. H., Kantorovich, E. O., & Lage-Marques, J. L. (2008). Ozone therapy in medicine and dentistry. The Journal of Contemporary Dental Practice, 9(4), 75–84.
Raborn, G. W., & Grace, M. G. (2003). Recurrent herpes simplex labialis: Selected therapeutic options. J Can Dent Assoc, 69(8), 498–503.
Saglam, E., Alinca, S. B., Celik, T. Z., Hacisalihoglu, U. P., Dogan, M. A., Saglam, E., Alinca, S. B., Celik, T. Z., Hacisalihoglu, U. P., & Dogan, M. A. (2020). Evaluation of the effect of topical and systemic ozone application in periodontitis: An experimental study in rats. Journal of Applied Oral Science, 28. https://doi.org/10.1590/1678-7757-2019-0140
Semprini, A., Singer, J., Shortt, N., Braithwaite, I., Beasley, R., & Network, P. R. (2017). Protocol for a randomised controlled trial of 90% kanuka honey versus 5% aciclovir for the treatment of herpes simplex labialis in the community setting. BMJ Open, 7(8), e017766. https://doi.org/10.1136/bmjopen-2017-017766
Spruance, S. L., & Kriesel, J. D. (2002). Treatment of herpes simplex labialis. Herpes, 9(3), 64–69.
Spruance, S. L., & McKeough, M. B. (2000). Combination treatment with famciclovir and a topical corticosteroid gel versus famciclovir alone for experimental ultraviolet radiation-induced herpes simplex labialis: A pilot study. The Journal of Infectious Diseases, 181(6), 1906–1910. https://doi.org/10.1086/315528
Spruance, S. L., Overall, J. C., Kern, E. R., Krueger, G. G., Pliam, V., & Miller, W. (1977). The natural history of recurrent herpes simplex labialis: Implications for antiviral therapy. N Engl J Med, 297(2), 69–75. https://doi.org/10.1056/NEJM197707142970201
Stoopler, E. T., & Greenberg, M. S. (2003). Update on herpesvirus infections. Dent Clin North Am, 47(3), 517–532. https://doi.org/10.1016/s0011-8532(03)00018-1
Stübinger, S., Sader, R., & Filippi, A. (2006). The use of ozone in dentistry and maxillofacial surgery: A review. Quintessence Int, 37(5), 353–359.
Suh, Y., Patel, S., Kaitlyn, R., Gandhi, J., Joshi, G., Smith, N. L., & Khan, S. A. (2019). Clinical utility of ozone therapy in dental and oral medicine. Med Gas Res, 9(3), 163–167. https://doi.org/10.4103/2045-9912.266997
Valdenassi, L., Franzini, M., Ricevuti, G., Rinaldi, L., Galoforo, A. C., & Tirelli, U. (2020). Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19. Eur Rev Med Pharmacol Sci, 24(8), 4059–4061. https://doi.org/10.26355/eurrev_202004_20976
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Lia Dietrich; Marcelo Dias Moreira de Assis Costa; Thaynná Alves Dias Teodoro; Luiz Renato Paranhos; Gisele Rodrigues da Silva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
