Large-extension osteosarcoma with involvement of multiple maxillofacial structures: a rare case report

Authors

DOI:

https://doi.org/10.33448/rsd-v9i10.8461

Keywords:

Oral cavity; Head and Neck Neoplasms; Bone Neoplasm; Osteosarcoma.

Abstract

Background: Osteosarcoma is a malignant neoplasm that occurs most often in long bones, with the head and neck region being rarely affected, accounting for less than 1% of all cancers in this region. Objective: To report a rare case of a large-extension osteosarcoma with emphasis on its clinical and diagnostic aspects. Case presentation: A 43-year-old woman presenting an intraoral exophytic lesion with involvement of other maxillofacial structures, such as nostril, zygoma and orbit. Despite the initial clinical diagnosis of actinomycosis, an incisional biopsy confirmed the histopathological diagnosis of osteosarcoma, showing a wide morphological variety. Conclusion: This case highlights the importance of clinical and histopathological findings for the correct diagnosis of osteosarcoma. Moreover, it shows that, although surgical resection is the primary treatment for this neoplasia, depending on the extent of the tumor and its proximity to vital anatomical structures, the most appropriate conduct is not always feasible.

References

Chen, Y., Gokavarapu, S., Shen, Q., Liu, F., Cao, W., Ling, Y., & Ji, T. (2017). Chemotherapy in head and neck osteosarcoma: Adjuvant chemotherapy improves overall survival. Oral oncology, 73, 124-131.

Crowe, S., Cresswell, K., Robertson, A., Huby, G., Avery, A., & Sheikh, A. (2011). The case study approach. BMC medical research methodology, 11(1), 100.

de Arruda, J. A. A., de Oliveira Silva, L. V., de Oliveira, C. D. N. A., Schuch, L. F., Batista, A. C., Costa, N. L., ... & Sobral, A. P. V. (2017). A multicenter study of malignant oral and maxillofacial lesions in children and adolescents. Oral Oncology, 75, 39-45.

DeAngelis, A. F., Spinou, C., Tsui, A., Iseli, T., Desai, J., Wiesenfeld, D., & Chandu, A. (2012). Outcomes of patients with maxillofacial osteosarcoma: a review of 15 cases. Journal of oral and maxillofacial surgery, 70(3), 734-739.

de Carvalho, W. R. S., de Souza, L. L., Pontes, F. S. C., Uchôa, D. C. C., Corrêa, D. L., et al. (2020). A multicenter study of oral sarcomas in Brazil. Oral diseases, 26(1), 43-52.

Demicco, E. G., Deshpande, V., Nielsen, G. P., Kattapuram, S. V., & Rosenberg, A. E. (2010). Well-differentiated osteosarcoma of the jaw bones: a clinicopathologic study of 15 cases. The American journal of surgical pathology, 34(11), 1647-1655.

Jeong, H. I., Lee, M. J., Nam, W., Cha, I. H., & Kim, H. J. (2017). Osteosarcoma of the jaws in Koreans: analysis of 26 cases. Journal of the Korean Association of Oral and Maxillofacial Surgeons, 43(5), 312-317.

Kimura, Y., Tomihara, K., Tachinami, H., Imaue, S., Nakamori, K., Fujiwara, K., ... & Noguchi, M. (2017). Conventional osteosarcoma of the mandible successfully treated with radical surgery and adjuvant chemotherapy after responding poorly to neoadjuvant chemotherapy: a case report. Journal of Medical Case Reports, 11(1), 1-6.

Krishnamurthy, A., & Palaniappan, R. (2018). Osteosarcomas of the head and neck region: a case series with a review of literature. Journal of maxillofacial and oral surgery, 17(1), 38-43.

Laskar, S., Basu, A., Muckaden, M. A., D'Cruz, A., Pai, S., Jambhekar, N., ... & Shrivastava, S. K. (2008). Osteosarcoma of the head and neck region: lessons learned from a single‐institution experience of 50 patients. Head & Neck: Journal for the Sciences and Specialties of the Head and Neck, 30(8), 1020-1026.

Liang, L., Zhang, T., You, Y., He, Q., Fan, Y., & Liao, G. (2019). An individual patient data meta‐analysis on the effect of chemotherapy on survival in patients with craniofacial osteosarcoma. Head & neck, 41(6), 2016-2023.

Nissanka, E. H., Amaratunge, E. A. P. D., & Tilakaratne, W. M. (2007). Clinicopathological analysis of osteosarcoma of jaw bones. Oral diseases, 13(1), 82-87.

Paparella, M. L., Olvi, L. G., Brandizzi, D., Keszler, A., Santini‐Araujo, E., & Cabrini, R. L. (2013). Osteosarcoma of the jaw: an analysis of a series of 74 cases. Histopathology, 63(4), 551-557.

Thariat, J., Schouman, T., Brouchet, A., Sarini, J., Miller, R. C., Reychler, H., ... & Bompas, E. (2013). Osteosarcomas of the mandible: multidisciplinary management of a rare tumor of the young adult a cooperative study of the GSF-GETO, Rare Cancer Network, GETTEC/REFCOR and SFCE. Annals of oncology, 24(3), 824-831.

Yamamoto-Silva, F. P., SILVA, B. S. D. F., Batista, A. C., MENDONÇA, E. F. D., Pinto-Junior, D. D. S., & Estrela, C. (2017). Chondroblastic osteosarcoma mimicking periapical abscess. Journal of Applied Oral Science, 25(4), 455-461.

Yildiz, F. R., Avci, A., Dereci, O., Erol, B., Celasun, B., & Gunhan, O. (2014). Gnathic osteosarcomas, experience of four institutions from Turkey. International Journal of Clinical and Experimental Pathology, 7(6), 2800.

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Published

21/09/2020

How to Cite

GONÇALO, R. I. C.; MEDEIROS, C. K. S. .; CHAVES NETO, H. P.; SANTOS, J. L. de M. dos; GERMANO, A. R.; QUEIROZ, L. M. G. . Large-extension osteosarcoma with involvement of multiple maxillofacial structures: a rare case report. Research, Society and Development, [S. l.], v. 9, n. 10, p. e1519108461, 2020. DOI: 10.33448/rsd-v9i10.8461. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/8461. Acesso em: 14 nov. 2024.

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Section

Health Sciences