Evaluation of the clinical evolution of patients with Multidrug Resistant Tuberculosis
DOI:
https://doi.org/10.33448/rsd-v9i10.8615Keywords:
Multidrug resistant tuberculosis; Public health; Amazon.Abstract
Objective: To assess the clinical evolution of patients with Multiple Drug-Resistant Tuberculosis treated in a referral center in the Amazon region, between the years 2010 to 2014. Methods: Cross-sectional, descriptive and quantitative approach research, through the collection of patient data attended at Hospital Universitário de Belém do Pará, between the years 2010 and 2014. Results: There was a predominance of males and a faixa age most affected was in the most productive phase (18 to 55 years old), secondary to teaching 94.1% were present in two cases, or time of diagnosis and initiation of treatment from 1 to 10 days appeared in the majority, how many years profile of drug resistance prevailing with rifampicin, isoniazid and streptomycin and most associated comorbidities foi or diabetes. Conclusion: There is a great complexity surrounding the aspects related to the treatment of Tuberculous Resistant to Multiple Medications, and that these factors contribute to the maintenance of two high teaching indices, as well as a scarcity of technologies such as rapid diagnosis of the teaching and availability of more alternatives of most effective treatment. The limiting factor of the investigation is due to the fact that it is a matter of medical records, there is no pattern of records in some, with little information.
References
Almeida, M. G. de, Barbosa, D. R. M., & Almeida, D. F. S. (2013). Epidemiologia e distribuição espacial de casos notificados de Tuberculose Resistente a Múltiplos Medicamentos (TB-MR) no Brasil, 2008-2012. Revista de epidemiologia e controle de infecção, 3 (4).
Coelho, A. G. V., Zamarioli, L. A., Telles, M. A., Ferrazoli, L., & Waldman, E. A. (2012). A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, São Paulo, Brazil. Mem. Inst. Oswaldo Cruz [Internet], 107(6), 760-766.
Coelho, A. G. V. (2014). Tuberculose multirresistente e extensivamente resistente em área metropolitana de elevada incidência – município de Santos (SP). São Paulo: Faculdade de Medicina, Universidade de São Paulo.
Esperón, J. M. T. (2017). Pesquisa Quantitativa na Ciência da Enfermagem. Rev.Anna Nery, 21(1), e20170027.
Ferreira, K. R. (2014). A adesão ao tratamento no caso da tuberculose multirresistente. Escola de Enfermagem da Universidade de São Paulo, 281.
Filho, M. P. S., Luna, I. T., Silva, K. L., & Pinheiro, P. N. C. (2012). Pacientes vivendo com HIV/ AIDS e coinfecção tuberculose: dificuldades associadas à adesão ou ao abandono do tratamento. Rev Gaúcha Enferm. 33(2):139-145.
Magee, M. J., Bloss, E., Shin, S., Contreras, C., Huaman, H. A., Ticona, J. C., Bayona, J., Bonilla, C., Yagui, M., Jave, O., & Cegielski, J. P. (2013). Clinical characteristics, drug resistance, and treatment outcomes among tuberculosis patients with diabetes in Peru. International Journal of Infectious Diseases. 17 (6), e404–e412.
Mahfuza, R., Milton, A. H., Hall, J., Oldmeadow, C., Islam, M. A., Husain, A., Akhanda, M. W., & Siddiquea, B. N. (2014). Development of Multidrug Resistant Tuberculosis in Bangladesh: A Case-Control Study on Risk Factors. Plos One, 9(8), e105214.
Micheletti, V. C., Moreira, J. S., Ribeiro, M. O., Kritski, A. L., Braga, J. U. Drug-resistant tuberculosis in subjectsincluded in the Second National Surveyon Antituberculosis Drug Resistance in Porto Alegre, Brazil. 2014; 40(2), 155-163.
Migliori, G. B., Sotgiu, G., Gandhi, N. R., Falzon, D., DeRiemer, K., Centis, R., Hollm-Delgado, M. G., Palmero, D., Pérez-Guzmán, C., Vargas, M. H., D'Ambrosio, L., Spanevello, A., Bauer, M., Edward Chan, E. D., & Schaaf, H. S. (2013). Drug resistance beyond extensively drug-resistant tuberculosis: individual patient data meta-analysis. Eur Respir J, 42(1):169- 79.
Migliori, G. B., Sotgiu, G., D'Ambrosio, L., Centis, R., Lange, C., Bothamley, G., Cirillo, D. M., & Lorenzo, S. (2012). TB and MDR/XDR-TB in European Union and European Economic Area countries: managed or mismanaged?. European Respiratory Journal, 39 (3) 619-625.
Pereira, A. S., et al. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Recuperado de ,https://repositorio.ufsm.br/bitstream/handle/1/15 824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1
Rangaka, M. X., Cavalcante, S. C., Marais, B. J., Thim, S., Martinson, N. A., Swaminathan, S., & Chaisson, R. E. (2015). Control of tuberculosis seeds: diagnosis and treatment of tuberculosis infection. Lancet (Londres, Inglaterra), 386(10010), 2344-2353.
Resende, L. S. O., & Santos-Neto, E. T. (2015). Fatores de risco associados às reações adversas a medicamentos antituberculos. J Bras Pneumol, 41(1), 77-89.
Rocha, D. S., & Adorno, R. C. F. (2012). Dropouts or discontinuity of the treatment of tuberculosis in Rio Branco. Acre. Saude soc, 21(1), 232-245.
Trujillo, A. M. (2016). Epidemiologia: história, tipos e métodos. Revista Simbiótica [Internet], 3(1), 1-27. Disponível em: http://periodicos.ufes.br/simbiotica/article/view/14.
Yuen, C. M., Amanullah, F., Dharmadhikari, A., Nardell, E. A., Seddon, J. A., & Vasilyeva, I. (2015). Turning off the tap: stopping tuberculosis transmission through active case-finding and prompt effective treatment. The Lancet, 386 (10010), 2334-2343.
Zumla, A. I., Gillespie, S. H., Hoelscher, M., Philips, P. P., Cole, S. T., Abubakar, I., McHugh, T. D., Schito, M., Maeurer, M., & Nunn, A. J. (2014). New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects. The Lancet, 14(4), 327–340.
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Copyright (c) 2020 Paula Sousa da Silva Rocha; Dayara de Nazaré Rosa de Carvalho; Dandara de Fátima Ribeiro Bendelaque; Felipe Costa Soares; Rafael Everton Assunção Ribeiro da Costa; Marcela Raíssa Asevedo Dergan; Rogéria de Sousa Rodrigues; Jucilene Luz Neves; Ana Carolina Marinho Pinheiro; Thais Neves de Souza; Susi dos Santos Barreto de Souza; Kathleen Heloisa Pinheiro Costa Neves; Ivonete Vieira Pereira Peixoto; Armando Sequeira Penela; Marcieni Ataíde Andrade; Marcos Valério Santos da Silva
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