Association of the main hematological, biochemical and immunological parameters in critical and non-critical patients with COVID-19: a systematic review




SARS-CoV-2; Laboratory; Biomarkers.


Introduction: COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, responsible for mainly affecting the lungs and triggering respiratory pathologies, as well as developing liver, neurological and gastrointestinal problems. The objective of this systematic review was to conduct a survey of studies with the main laboratory markers of patients with COVID-19 relating the abnormalities of these results to the clinical prediction of severe and non-severe patients. Methodology: This study was conducted following the methodological guidelines of a Systematic Review according to the PRISMA protocol, of which searches were carried out in the electronic databases PubMed, LILACS, EMBASE, Science, medRxiv, and bioRxiv, using the keywords- keys: "SARS-CoV-2" OR "COVID- 19" OR "Coronavirus" AND "Laboratory Parameters" AND "Exams" OR "Laboratory". Eligible articles published from January 2020 to May 20, 2020 were used, without language restrictions containing hematological, biochemical and immunological laboratory data. Results: According to this review, 16 eligible articles were selected. The main abnormalities were observed in critically ill patients with significant changes in some hematological, biochemical and immunological parameters, such as: ferritin, lymphocytes, D-Dimer, LDH, AST, PCR, Procalcitonin, TcnI and IL-6. Conclusion: The present study demonstrates the relevance of laboratory tests to assist healthcare professionals in carrying out necessary measures and appropriate therapeutic approaches for the treatment of patients infected with coronavirus.


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How to Cite

Souza, K. S. ., Silva, M. R. F. da ., Silva, S. M. da ., Oliveira, M. B. M. de ., Lima, A. V. A. ., Sá, R. A. de Q. C. de ., Ramos, B. de A. ., Silva, J. dos S. ., Santos , G. dos ., Lima, F. L. O. ., Silva, R. R. dos S. ., & Brito, L. P. de . (2020). Association of the main hematological, biochemical and immunological parameters in critical and non-critical patients with COVID-19: a systematic review. Research, Society and Development, 9(11), e2619118955.



Review Article