Association of the main hematological, biochemical and immunological parameters in critical and non-critical patients with COVID-19: a systematic review
Keywords:SARS-CoV-2; Laboratory; Biomarkers.
Introduction: COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, responsible for mainly affecting the lungs and triggering respiratory pathologies, as well as developing liver, neurological and gastrointestinal problems. The objective of this systematic review was to conduct a survey of studies with the main laboratory markers of patients with COVID-19 relating the abnormalities of these results to the clinical prediction of severe and non-severe patients. Methodology: This study was conducted following the methodological guidelines of a Systematic Review according to the PRISMA protocol, of which searches were carried out in the electronic databases PubMed, LILACS, EMBASE, Science, medRxiv, and bioRxiv, using the keywords- keys: "SARS-CoV-2" OR "COVID- 19" OR "Coronavirus" AND "Laboratory Parameters" AND "Exams" OR "Laboratory". Eligible articles published from January 2020 to May 20, 2020 were used, without language restrictions containing hematological, biochemical and immunological laboratory data. Results: According to this review, 16 eligible articles were selected. The main abnormalities were observed in critically ill patients with significant changes in some hematological, biochemical and immunological parameters, such as: ferritin, lymphocytes, D-Dimer, LDH, AST, PCR, Procalcitonin, TcnI and IL-6. Conclusion: The present study demonstrates the relevance of laboratory tests to assist healthcare professionals in carrying out necessary measures and appropriate therapeutic approaches for the treatment of patients infected with coronavirus.
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Copyright (c) 2020 Karolayne Silva Souza; Milena Roberta Freire da Silva; Sivoneide Maria da Silva; Maria Betânia Melo de Oliveira; Ana Vitória Araújo Lima; Rafael Artur de Queiroz Cavalcanti de Sá; Bárbara de Azevedo Ramos; Jaqueline dos Santos Silva; Graziele dos Santos ; Felicson Leonardo Oliveira Lima; Rodrigo Rege dos Santos Silva; Leandro Paes de Brito
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