Relationship between Cognition, levels of PTX-3, MBL and their polymorphisms: A systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i10.9215

Keywords:

Cognition; Genotype; Immunity; Polymorphism, Single Nucleotide; Central Nervous System; Cognition Disorders.

Abstract

Introduction: Studies have suggested that pentraxin 3 (PTX3) and Mannose Binding Lectin (MBL) may interfere with cognitive processes. Objective: Identify data reported in the literature involving cognition, PTX3 and MBL. Materials and Methods: The research was done in five databases and the selection of studies was performed in two stages. The first involved review of titles and abstracts. Then the full articles were read and those that did not meet the eligibility criteria were excluded. Results: A total of 3,097 titles and abstracts were selected, but 3,089 were excluded. Finally, 8 articles were included in the review. The articles pointed out that high levels of PTX-3 could be predictors of cognitive impairment while high levels of MBL could have a protective effect on cognition. Conclusion: The current studies are still contradictory and inconclusive, but they lead us to reflect on possible genetic influences of innate immunity in the Central Nervous System. Further research involving the effects of PTX-3 and MBL and its variants on cognition are necessary.

References

Arora, M.; Munoz, E. & Tenner, A.J. (2001). Identification of a site on mannan-binding lectin critical for enhancement of phagocytosis. J Biol Chem, 276, 43087-43094. doi:10.1074/jbc.M105455200

Auriti, C.; Prencipe, G.; Caravale, B.; Coletti, M.F.; Ronchetti, M.P.; Piersigilli, F.; Azzari, C. & Di Ciommo, V.M. (2014). MBL2 gene polymorphisms increase the risk of adverse neurological outcome in preterm infants: a preliminary prospective study. Pediatr Res, 76(5), 464-469. doi:10.1038/pr.2014.118

Boos, G.L.; Soares, L.F. & Oliveira Filho, G.R. (2005). Postoperative cognitive dysfunction: prevalence and associated factors. Rev Bras Anestesiol, 55, 517-524. doi:10.1590/s0034-70942005000500006

Carmo, R.F.; Aroucha, D.; Vasconcelos, L.R.S.; Pereira, L.M.M.B.; Moura, P. & Cavalcanti, M.S.M. (2016). Genetic variation in PTX3 and plasma levels associated with hepatocellular carcinoma in patients with HCV. J Viral Hepat, 23, 116–122. doi:10.1111/jvh.12472

Chi, G.C.; Fitzpatrick, A.L.; Sharma, M.; Jenny, N.S.; Lopez, O.L. & DeKosky, S.T. (2016). Inflammatory biomarkers predict domain-specific cognitive decline in older adults. J Gerontol A Biol Sci Med Sci, 72, 796-803. doi:10.1093/gerona/glw155

Dufek, M.; Hamanová, M.; Lokaj, J.; Goldemund, D.; Rektorová, I.; Michálková, Z.; Sheardová, K. & Rektor, I. (2009). Serum inflammatory biomarkers in Parkinson’s disease, Parkinsonism. Relat Disord, 15, 318–320. doi:10.1016/j.parkreldis.2008.05.014

Eisen, S.; Dzwonek, A. & Klein, N.J. (2008). Mannose-Binding Lectin in HIV Infection. Future Virol, 3, 225–233. doi:10.2217/17460794.3.3.225

Fornai, F.; Carrizzo, A.; Forte, M.; Ambrosio, M.; Damato, A.; Ferrucci, M.; Biagioni, F.; Busceti, C.; Puca, A.A. & Vecchione, C. (2016). The inflammatory protein Pentraxin 3 in cardiovascular disease. Immun Ageing, 13, 25. doi:10.1186/s12979-016-0080-1

Fossati, G.; Pozzi, D.; Canzi, A.; Mirabella, F.; Valentino, S.; Morini, R.; Ghirardini, E.; Filipello, F.; Moretti, M.; Gotti, C.; Annis, D.S.; Mosher, D.F.; Garlanda, C.; Bottazzi, B.; Taraboletti, G.; Mantovani, A.; Matteoli, M. & Menna, E. (2019). Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and b1-integrin. Embo J, 3, 38. doi: 10.15252/embj.201899529

He, X.; Han, B. & Liu, M. (2007). Long pentraxin 3 in pulmonary infection and acute lung injury. Am J Physiol Lung Cell Mol Physiol, 292, L1039-L1049. doi:10.1152/ajplung.00490.2006

Hedden, T. (2007). Imaging Cognition in the Aging Human Brain. In Riddle, D.R. (Ed.), Brain Aging: Models, Methods, and Mechanisms (pp. 01-38). Boca Raton: CRC Press/Taylor & Francis.

Heyer, E.J.; Kellner, C.P.; Malone, H.R.; Bruce, S.S.; Mergeche, J.L.; Ward, J.T. & Connolly, E.S. Jr. (2013). Complement polymorphisms and cognitive dysfunction after carotid endarterectomy. J Neurosurg, 119, 648-654. doi:10.3171/2013.4.JNS1368

Holtzer, R.; Friedman, R.; Lipton, R.B.; Katz, M.; Xue, X. & Verghese, J. (2007). The relationship between specific cognitive functions and falls in aging. Neuropsychology, 21, 540-548. doi:10.1037/0894-4105.21.5.540

Inforzato, A.; Doni, A.; Barajon, I.; Leone, R.; Garlanda, C.; Bottazzi, B. & Mantovani, A. (2013). PTX3 as a paradigm for the interaction of pentraxins with the Complement system. Semin Immunol, 25, 79-85. doi:10.1016/j.smim.2013.05.002

Jack, D.L.; Klein, N.J. & Turner, M.W. (2001). Mannose‐binding lectin: targeting the microbial world for complement attack and opsonophagocytosis. Immunol Rev, 180, 86-99. doi:10.1034/j.1600-065x.2001.1800108.x

Jylhävä, J.; Haarala, A.; Kähönen, M.; Lehtimäki, T.; Jula, A.; Moilanen, L.; Kesäniemi, Y.A.; Nieminen, M.S. & Hurme, M. (2011). Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey. Clin Exp Immunol, 164, 211-217. doi:10.1111/j.1365-2249.2011.04354.x

Ko, C.Y.; Chang, L.H.; Lee, Y.C.; Sterneck, E.; Cheng, C.P.; Chen, S.H.; Huang, A.M.; Tseng, J.T. & Wang, J.M. (2012). CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. Neurobiol Aging, 33, 422.e11-25. doi:10.1016/j.neurobiolaging.2010.09.017

Konopka, G.; Bomar, J.M.; Winden, K.; Coppola, G.; Jonsson, Z.O.; Gao, F.; Peng, S.; Preuss, T.M.; Wohlschlegel, J.A. & Geschwind, D.H. (2009). Human-specific transcriptional regulation of CNS development genes by FOXP2. Nature, 462 213-217. doi:10.1038/nature08549

Lee, H.W.; Choi, J. & Suk, K. (2011). Increases of pentraxin 3 plasma levels in patients with Parkinson's disease. Mov Disord, 26, 2364-2370. doi:10.1002/mds.23871

Miller, L.M.; Jenny, N.S. Rawlings, A.M.; Arnold, A.M.; Fitzpatrick, A.L.; Lopez, O.L. & Odden, M.C. (2019). Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci, 75(8), 1523-1529. doi:10.1093/gerona/glz217

Moher, D.; Liberati, A.; Tetzlaff, J.; Altman; D.G. & PRISMA Group. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PloSMed, 6(7), 1–6. doi:10.1371/journal.pmed.1000097

Mukamel, Z.; Konopka, G.; Wexler, E.; Osborn, G.E.; Dong, H.; Bergman, M.Y.; Levitt, P. & Geschwind, D.H. (2011). Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk. J Neurosci, 31(32), 11437-11442. doi:10.1523/JNEUROSCI.0181-11.2011

Muller, B.; Peri, G.; Doni, A.; Torri, V.; Landmann, R.; Bottazzi, B. & Mantovani, A. (2001). Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients. Crit Care Med, 29, 1404-1407. doi:10.1097/00003246-200107000-00017

Najmabadi, H.; Hu, H.; Garshasbi, M.; Zemojtel, T.; Abedini, S.S.; Chen, W.; Hosseini, M.; Behjati, F.; Haas, S.; Jamali, P.; Zecha, A.; Mohseni, M.; Püttmann, L.; Vahid, L.N.; Jensen, C.; Moheb, L.A.; Bienek, M.; Larti, F.; Mueller, I.; Weissmann, R.; Darvish, H.; Wrogemann, K.; Hadavi, V.; Lipkowitz, B.; Esmaeeli-Nieh, S.; Wieczorek, D.; Kariminejad, R.; Firouzabadi, S.G.; Cohen, M.; Fattahi, Z.; Rost, I.; Mojahedi, F.; Hertzberg, C.; Dehghan, A.; Rajab, A.; Banavandi, M.J.; Hoffer, J.; Falah, M.; Musante, L.; Kalscheuer, V.; Ullmann, R.; Kuss, A.W.; Tzschach, A.; Kahrizi, K. & Ropers, H.H. (2011). Deep sequencing reveals 50 novel genes for recessive cognitive disorders. Nature, 478 (7367), 57-63. doi:10.1038/nature10423

Nijstad, B.A.; De Dreu, C.K.; Rietzschel, E.F. & Baas, M. (2010). The dual pathway to creativity model: Creative ideation as a function of flexibility and persistence. Eur Rev Soc Psychol, 21, 34-77. doi:10.1080/10463281003765323

Osera, C.; Pascale, A.; Amadio, M.; Venturini, L.; Govoni, S.; & Ricevuti, G. (2012). Pentraxins and Alzheimer's disease: at the interface between biomarkers and pharmacological targets. Ageing Res Rev, 11, 189-198. doi:10.1016/j.arr.2011.12.004

Parlak, A.; Aydogan, U.; Iyisoy, A.; Dikililer, M.A.; Kut, A.; Cakır, E. & Sağlam, K. (2012). Elevated pentraxin-3 levels are related to blood pressure levels in hypertensive patients: an observational study. Anadolu Kardiyol Derg, 12(4), 298-304. doi:10.5152/akd.2012.092

Rajkovic, I.; Denes, A.; Allan, S.M. & Pinteaux, E. (2016). Emerging roles of the acute phase protein pentraxin-3 during central nervous system disorders. J Neuroimmunol, 292, 27–33. doi:10.1016/j.jneuroim.2015.12.007

Sharma, M.; Fitzpatrick, A.L.; Arnold, A.M.; Chi, G.; Lopez, O.L.; Jenny, N.S. & Dekosky, S.T. (2016). Inflammatory Biomarkers and Cognitive Decline: The Ginkgo Evaluation of Memory Study. J Am Geriatr Soc, 64(6), 1171-1177. doi:10.1111/jgs.14140

Shatil, E. (2013). Does combined cognitive training and physical activity training enhance cognitive abilities more than either alone? A four-condition randomized controlled trial among healthy older adults. Front aging neurosci, 26, 8. doi:10.3389/fnagi.2013.00008

Shindo, A.; Maki, T.; Mandeville, E.T.; Liang, A.C.; Egawa, N.; Itoh, K.; Itoh, N.; Borlongan, M.; Holder, J.C.; Chuang, T.T.; McNeish, J.D.; Tomimoto, H.; Lok, J.; Lo, E.H. & Arai, K. (2016). Astrocyte-Derived Pentraxin 3 Supports Blood-Brain Barrier Integrity Under Acute Phase of Stroke. Stroke, 47(4), 1094-100. doi: 10.1161/STROKEAHA.115.012133

Singh, K.K.; Lieser, A.; Ruan, P.K.; Fenton, T. & Spector, S.A. (2008). An age-dependent association of mannose-binding lectin-2 genetic variants on HIV-1–related disease in children. J Allergy Clin Immunol, 122, 173-180. doi:10.1016/j.jaci.2008.05.025

Spector, S.A.; Singh, K.K.; Gupta, S.; Cystique, L.A.; Jin, H.; Letendre, S.; Schrier, R.; Wu, Z.; Hong, K.X.; Yu, X.; Shi, C.; Heaton, R.K. & HNRC Group. (2010). APOE epsilon4 and MBL-2 O/O Genotypes are Associated with Neurocognitive Impairment in HIV-Infected Plasma Donors from Anhui Province, China. AIDS, 24 (10), 1471-1479. doi:10.1097/QAD.0b013e328339e25c

Thouvenot, E.; Lafon-Cazal, M.; Demettre, E.; Jouin, P.; Bockaert, J. & Marin, P. (2006). The proteomic analysis of mouse choroid plexus secretome reveals a high protein secretion capacity of choroidal epithelial cells. Proteomics, 6, 5941-5952. doi:10.1002/pmic.200600096

Yano, Y.; Matsuda, S.; Hatakeyama, K.; Sato, Y.; Imamura, T.; Shimada, K.; Kodama, T.; Kario, K. & Asada, Y. (2010). Plasma Pentraxin 3, butnot High-sensitivity C-reactiveProtein, is a Useful Inflammatory Biomarker for Predicting Cognitive Impairment in Elderly Hypertensive Patients. J Gerontol A Biol Sci Med Sci, 65, 547-552. doi:10.1093/gerona/glq030

Zanier, E.R.; Brandi, G.; Peri, G.; Longhi, L.; Zoerle, T.; Tettamanti, M.; Garlanda, C.; Sigurtà, A.; Valaperta, S.; Mantovani, A.; De Simoni, M.G. & Stocchetti, N. (2011). Cerebrospinal fluid pentraxin 3 early after subarachnoid hemorrhage is associated with vasospasm. Intensive Care Med, 37, 302-309. doi:10.1007/s00134-010-2075-2

Downloads

Published

23/10/2020

How to Cite

CARVALHO, T. L.; BELMONT, T. F. de M.; SILVA, A. S. da; Ó, K. P. do; SILVA, L. de L. S. e; LIMA, E. A. de; VASCONCELOS, L. R. S.; MOURA, P. M. M. F. de; CORREIA, C. da C. Relationship between Cognition, levels of PTX-3, MBL and their polymorphisms: A systematic review. Research, Society and Development, [S. l.], v. 9, n. 10, p. e8749109215, 2020. DOI: 10.33448/rsd-v9i10.9215. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/9215. Acesso em: 4 nov. 2024.

Issue

Section

Review Article