The use of botulinum toxin in pregnant and lactating women: literature review




Botulinum Toxin; Pregnant; Lactation.


It’s perceived that currently the search for professionals who perform facial harmonization is growing more and more, and consequently the use of botulinum toxin as well, which is leading to a very present theme in studies and research among dentists, but a factor interesting that we realize is that there is a shortage in production in its use in pregnant women and from this we decided to carry out a research that aims to evaluate the studies in relation to the use of botulinum toxin in pregnant women and lactating women, for this we decided to do a literature review , where among the articles found, 30 articles were used that had a more relevant character for the production of this research, which made us realize that due to the botulinum toxin being one of the most used materials, it is necessary that there is a greater collection of academic productions in its application in pregnant and lactating women, in order to avoid possible damage to the mother and fetus.


Aguilar-Rebolledo, F., Hernández-Sánchez, J., Rayo-Mares, D., Fonseca, F. S., García-Muñoz, L., Ruiz-Ponce, J., & Garrido-Ramírez, E. (2001). Toxina botulínica como tratamiento de la espasticidad y distonía en la parálisis cerebral infantil. Gaceta Médica de México, 137(5), 403-411. Disponível em:

Aranda, M. A., Herranz, A., Del Val, J., Bellido, S., & García-Ruiz, P. (2012). Botulinum toxin A during pregnancy, still a debate. European journal of neurology, 19(8), e81. Doi: 10.1111/j.1468-1331.2012.03775.x

Araújo, L. F., Silva, M. S. (2020). O uso de toxina botulínica em gestantes e lactantes: revisão de literatura. Maceió, Centro Universitário Tiradentes, (14).

Aoki, K. R. (1995). Pharmacology of BOTOX^(! R)(Botulinum toxin type A) purified neurotoxin complex: local versus systemic muscle activity measurements in mice. Eur J Neurol, 2, 3-9. Disponível em:

Barbosa, C. M. R., & de Albergaria Barbosa, J. R. (2017). Toxina Botulínica em odontologia. Elsevier Brasil. Disponível em:,+C.%3B+BARBOSA,+J.+Toxina+Botul%C3%ADnica+em+Odontologia.+Elsevier:+S%C3%A3o+Paulo.+2017.&ots=9vsX20a0US&sig=B9INU8A6DWsxni6RJxc1XgAf77k#v=onepage&q=BARBOSA%2C%20C.%3B%20BARBOSA%2C%20J.%20Toxina%20Botul%C3%ADnica%20em%20Odontologia.%20Elsevier%3A%20S%C3%A3o%20Paulo.%202017.&f=false

Benedetto, A. V. (1999). The cosmetic uses of botulinum toxin type A. International journal of dermatology, 38(9), 641-655. Doi: 10.1046/j.1365-4362.1999.00722.x

Brandt, F. S., & Boker, A. (2004). Botulinum toxin for the treatment of neck lines and neck bands. Dermatologic clinics, 22(2), 159-166. Doi: 10.1016/s0733-8635(03)00021-4

Newman, W. J., Davis, T. L., Padaliya, B. B., Covington, C. D., Gill, C. E., Abramovitch, A. I., & Charles, P. D. (2005). Erratum: Botulinum toxin type a therapy during pregnancy. Mov Disord 2004; 19 (11): 1384–1385. Movement Disorders: Official Journal of the Movement Disorder Society, 20(1), 121-121. Doi: 10.1002/mds.20338

Colhado, O. C. G., Boeing, M., & Ortega, L. B. (2019). Toxina botulínica no tratamento da dor. Brazilian Journal of Anesthesiology, 59(3), 366-381. Doi: 10.1590/S0034-70942009000300013

Contarino, M. (2017). Clinical Practice: Evidence-Based Recommendations for the Treatment of Cervical Dystonia with Botulinum Toxin. Frontiers in Neurology., 8(35), p. 1-8. Disponível em:

Dover, J., Kaminer, M., Kenneth, A. (2002) Atlas of Cosmetic Surgery. W.B. Sanders Company: EUA, (535). Disponível em:,+j.%3B+kaminer,+m.%3B+kenneth+a.&ots=Qoxc-1pjqL&sig=4eJVyOISTL08TycGAqk3RaKu4y8#v=onepage&q=dover%2C%20j.%3B%20kaminer%2C%20m.%3B%20kenneth%20a.&f=false

Garcia, A., & Fulton Jr, J. E. (1996). Cosmetic denervation of the muscles of facial expression with botulinum toxin A dose‐response study. Dermatologic surgery, 22(1), 39-43. Doi: 10.1111/j.1524-4725.1996.tb00569.

Guerrissi, J. O. (2000). Intraoperative injection of botulinum toxin A into orbicularis oculi muscle for the treatment of crow’s feet. Plastic and reconstructive surgery, 105(6), 2219-2225.KLEIN, AW. Dilution and storage of botulinum toxin. Dermatol. Surg., 24(11), p. 1179-1180. 1998. Disponível em:

Lang, A. (2004). History and Uses of BOTOX®(Botulinum Toxin Type A). Professional Case Management, 9(2), 109-112. Disponível em:

Lanzl, I., & Merté, R. L. (2007). Faltenbehandlung durch Botulinumtoxin. Der Ophthalmologe, 104(9), 777-782. Disponível em:

Müller, J., Wenning, G. K., Wissel, J., Seppi, K., & Poewe, W. (2002). Botulinum toxin treatment in atypical parkinsonian disorders associated with disabling focal dystonia. Journal of neurology, 249(3), 300-304. Disponível em:

Ohishi, I. W. A. O. (1984). Oral toxicities of Clostridium botulinum type A and B toxins from different strains. Infection and immunity, 43(2), 487-490. Disponível em:

Pedron, I. G. (2014). A utilização da toxina botulínica em Odontologia. Revista da Associacao Paulista de Cirurgioes Dentistas, 68(3), 244-245. Disponível em:

Quagliato, E., Bang, G., Botelho, L. (2009) Associação Brasileira de Medicina Física e Reabilitação, Espasticidade: Tratamento Medicamentoso. Projecto de Diretrizes. 1, p. 1-17. Disponível em:

Robinson, A. Y., & Grogan, P. M. (2014). OnabotulinumtoxinA successfully used as migraine prophylaxis during pregnancy: a case report. Military medicine, 179(6), e703-e704. Doi: 10.7205/MILMED-D-13-00477

de Mello Sposito, M. M. (2004). Toxina botulínica tipo A-propriedades farmacológicas e uso clínico. Revista Acta Fisiï¿ ½trica, 11, S7-S44. Disponível em:

Trivedi, M. K., Kroumpouzos, G., & Murase, J. E. (2017). A review of the safety of cosmetic procedures during pregnancy and lactation. International Journal of Women's Dermatology, 3(1), 6-10. Doi: 10.1016/j.ijwd.2017.01.005

Wataganara, T., Leelakusolvong, S., Sunsaneevithayakul, P., & Vantanasiri, C. (2009). Treatment of severe achalasia during pregnancy with esophagoscopic injection of botulinum toxin A: a case report. Journal of Perinatology, 29(9), 637-639. Disponível em:

Wiegand, H., Erdmann, G., & Wellhöner, H. H. (1976). 125I-labelled botulinum A neurotoxin: pharmacokinetics in cats after intramuscular injection. Naunyn-Schmiedeberg's archives of pharmacology, 292(2), 161-165. Doi:



How to Cite

CRUZ, A. Ítalo .; LIMA, J. M. C. S. R. .; ARAÚJO, L. F. .; SILVA, M. S. .; LIMA, P. C. C. S. R. .; FERREIRA, R. V. de V. L. . The use of botulinum toxin in pregnant and lactating women: literature review. Research, Society and Development, [S. l.], v. 9, n. 11, p. e89791110471, 2020. DOI: 10.33448/rsd-v9i11.10471. Disponível em: Acesso em: 22 feb. 2024.



Health Sciences