Cherubism - Clinical case report and narrative review
DOI:
https://doi.org/10.33448/rsd-v10i2.12085Keywords:
Cherubism; Pathology; Heredity.Abstract
Cherubism is described as a rare and benign hereditary bone disease, characterized by a bilateral volumetric increase in the maxillary bones, with a greater predilection for males in childhood. Clinically, it presents as a volumetric enlargement of the mandible and, maxilla, which is generally painless, firm on palpation and varies in relation to size and extension. Its differential diagnosis is the Brown Tumor of Hyperparathyroidism and the Central Lesion of Giant Cells. The diagnosis is based on the assessment of clinical characteristics together with complementary exams. The objective of this study was to carry out a brief review of the literature and report a clinical case of this pathology in a 9-year-old child with a family history of cherubism, assessed through imaging, histopathological and karyotype exams, which continues to be assisted by the oral and maxilofacial surgery team of the Faculdade de Odontologia de Araçatuba - FOA Unesp since the treatment of the cherubism still does not have a definitive protocol.
References
Beaman, F. D., Bancroft, L. W., Peterson, J. J., & Kransdorf, M. J. (2004). Imaging characteristics of cherubism. Am J Roentgenol. 182(4), 1051-1054.
Bianchi, S. D., Boccardi, A., Mela, F., et al. (1987). As aparições tomográficas computadorizadas do querubismo. Skeletal Radiol 16, 6-10.
Cardoso, J. A., Nogueira Neto, J. N., Ferreira. C. M., Arcadinos Leite, E., Gonçalves de Farias. (2012). Acometimento do querubismo em dois irmãos: relato de casos. RFO UPF 17(3), 342-346.
Cariati, P., Iglesias, F. M., Solís, J. F., Laseca, A. V., & Lara, I. M. (2017). Cherubism. A case report. ScienceDirect, 13(6), 352-53.
Chrcanovic, B. R., Guimarães, L. M., Gomes, C. C., & Gomez, R. S. (2020). Cherubism: a systematic literature review of clinical and molecular aspects. Int J Oral Maxillofac Surg, 10(1), 10-16.
Dias, A. R. M., & Guedes, A. M. L. (1999). Aspecto radiográfico do querubismo: relato de caso. Rev Bras Odontol, 56(3), 104-107.
Delanora, L. A., Baggio, A. M. P., Farah, G. J., & Faverai, L. P. Relationship between chemical dependents, blood pressure values and Dentist Surgeon performance. Research, Society and Development, [S. l.], 9(8), e847986203, 2020. 10.33448/rsd-v9i8.6203. https://rsdjournal.org/index.php/rsd/article/view/6203.
Fonseca, L. C., De Freitas, J. B., Maciel, P. H., & Cavalcanti, M. G. P. (2004). Temporal bone involvement in Cherubism: case report. Braz Dent J, 15(1), 75-78.
Li, C., Yu, S. Uma nova mutação no gene SH3BP2 causa querubismo: relato de caso. (2006). BMC Med Genet 7, 84.
López, H. M. L., Picco, D. M. I., & Lagunes, L. M. Querubismo, revisión de la literatura y reporte de un caso clínico. (2016). Rev Mex Cir Bucal Maxilofac, 12(3), 86-92.
Marçolla, A. S., Barroso, F. T., Simões, N. M., Valerio, C. S., Alves Cardoso, C. A., Silva, A. I. V., & Manzi, F. R. (2014). Diagnóstico tomográfico do querubismo: Relato de caso - Tomographic diagnosis of cherubism: casa report. Arquivo Brasileiro de Odontologia, 10(1), 40-45.
Oliveira, F. M. P., Cavasin Filho, J. C., Costa, C., & Dib, L. L. (2008). Cherubism: clinical, radiographic and therapeutic aspects. Rev Inst Ciênc Saúde, 26(2), 254-257.
Ozkan, Y., Varol, A., Turker, N., Aksakalli, N., & Basa, S. (2003). Clinical and radiological evaluation of cherubism: a sporadic case report and review of the literature. Intern Jour of Ped Otorhino. 67(9), 1005-1012.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Methodology of cientific research. Santa Maria: UAB / NTE / UFSM. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1&isAllowed=y
Tiziani, V., Reichenberger, E., Buzzo, C. L., Niazi, S., Fukai, N., Stiller, M., Peters, H., Salzano, F. M., Raposo do Amaral, C. M., & Olsen, B. R. (1999). The gene for cherubism maps to chromosome 4p16. Am J Hum Genet, 65(1), 158-166.
Ueki, Y., Tiziani,V., Santanna, C., Fukai, N., Maulik, C., Garfinkle, J., Ninomiya, C., do Amaral, C., Peters, H., Habal, M., Rhee-Morris, L., Doss, J. B., Kreiborg, S., Olsen, B. R., & Reichenberger, E. (2001). Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. Nat Genet. 28(2), 125-126.
Yalçin, S., Yalçin, F., Soydinç, M., Palanduz, S., Gunham, O. (1999). Gingival fibromatosis combined with cherubism and psychomotor retardation: a rare syndrome. J Periodontol, 70(2), 201-204.
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Copyright (c) 2021 Leonardo Alan Delanora; Ana Maira Pereira Baggio; Nathália Januario de Araujo; Idelmo Rangel Garcia-Junior; Sabrina Ferreira
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