Worldwide panorama of technologies related to the use of ejiao through patent search
DOI:
https://doi.org/10.33448/rsd-v10i2.12428Keywords:
Donkey; Colla corii asini; Donkey-hide gelatin.Abstract
Colla corii asini or donkey-hide gelatin or ejiao is a gelatin obtained from the collagen of donkeys' skin, used for thousands of years for various purposes in traditional Chinese medicine. Demand for ejiao, mixed with herbs and other ingredients in Chinese medicine, has increased due to the economic rise of the Chinese population in general. The donkey skins from countries like Kyrgyzstan, Brazil and Mexico go to China to produce Ejiao. In this extractive chain, Africa is the most affected territory, both in the number of animals slaughtered and in the social and economic impact. This work is a prospective patent survey on innovations and discoveries in the therapeutic use of ejiao. The research was carried out on three patent bases and from these the total of 1837 documents on technologies that make use of ejiao were recovered. Analyzing the temporal trajectory of publications in the area, it is observed that inventions started in the 90s and reached their peak in 2015, however there was a relapse in the following years, the assumption is that the decline was caused by the population reduction of donkeys in China and in the supplier countries of other regions of the world, in addition to the non-existence of the donkey skin production chain.
References
Carneiro G. F., Lucena, J. E. C., & Barros, L. O. (2018). The current Situation and Trend of the Donkey Industry in South America. Journal of equine veterinary science; 65, 106-110.
Chen, B. F. (2011). Clinical observation on triple therapy of Ejiao and Weifuchun for chronic atrophic gastritis combined with peptic ulcer. International Journal of Clinical and Experimental Medicine; 10, 1622-1623.
Chen, D. Y., Wang, J. Z., & Liu, W. L. (1991). Analytical studies on amino acids and trace elements in donkey-hide gelatin. China journal of Chinese materia medica; 16(2), 83-84.
Chengbiao, L., & Qiusheng, T. (1991) The Effect of EJIAO on Cellular Immunological Function of Normal Mice. Pharmacology and Clinics of Chinese Materia Medica; 4.
Deng, W. L., Wu, H. Z., Xu, W., Zhang, Y. X., & Lu, M. (2011). Effective component of colla corri asini on blood anemia induced by cyclophosphamide in mice bone marrow microenviroment. Lishizhen. Medicine and Materia Medica Research; 22, 2542-2544.
Instituto Brasileiro de Geografia e Estatística (IBGE). Censo agro 2017.
Köhle, N. (2018). Feasting on the dunkey skin. In: Prosperity. Golley J. & Jaivin L. Acton ACT, Australia: ANU Press, pag. 176–181.
Li, N., Chen, XI., Li, X., Zhang, D., Chu, Z., & Feng, J. (2013). Clinical observation in treating cancer-related fatigue with Fufang Ejiao Jiang. China Journal of Traditional Chinese Medicine and Pharmacy. 28(2).
Liu, C. L. (1983). Ingredients of colla corii asini comparison analysis research. Chin Tradit Pat Med; 1, 36-37.
Liu, M., Tan, H., Zhang X., Liu, Z., Cheng, Y., & Wang, F. (2014). Hematopoietic effects and mechanisms of Fufang e׳jiao jiang on radiotherapy and chemotherapy-induced myelosuppressed mice. J Ethnopharmacol; 152(3), 575-84.
Liu, P. M., You, J. H., Xie, F. S., Cai, B. C., Xie, X. J., & Tian, S. S. (2005). Experimental research of donkey-hide gelatin on restraining tumor and prolonging survival time of tumor carrying mice. Chin Med Sci Heal; 2, 25-26.
Liu, T., Zhang, P., Ling, Y., Hu, G., Gu, J., Yang, H., Wei, J., Wang, A., & Jin, H. (2019). Protective Effect of Colla corii asini against Lung Injuries Induced by Intratracheal Instillation of Artificial Fine Particles in Rats. International Journal of Molecular Sciences; 20(1), 55.
Lv, P., Zhao, Y. J., Qi, F., Zhou, X. S., You, J. H., Qin, Y. F., & Zhang, Y. X. (2011). Authentication of equine DNA from highly processed donkey-hide glue (Colla corii asini) using sine element. J Food Drug Anal; 19, 123-130.
Asa
Nongxuan, M. A. O. (2016). The Anti-Fatigue Effect Of Compound Donkey-Hide Gelatine Mucilage On Free Combat Athletes. Journal Of Computational And Theoretical Nanoscience, 13(3), 2091 2095.
Ass
Pereira, A. S., et al. (2018). Metodologia da pesquisa científica. UFSM.
asa
Song, Y. M., Mao, G. N., Huang, X. S., & Dou, Y. M. (2011). Study on hemopoiesis and anti-fatigue effects of colla corri asini effervescent granules in mice. Prog Vet Med; 32, 83-86.
asa
Wang, D. L., Ru, W. W., Xu, Y. P., Zhang, J. L., He, X. X., Fan, G. H., Mao, B., Zhou, X., & Qin, Y. F. (2014). Chemical constituents and bioactivities of Colla corii asini. Drug Discoveries & Therapeutics; 8, 201–207.
asa
Wang, D., Liu, M., Cao, J., Chng, Y., Zhuo, C., Xu, H., Tian, S., Zhang, Y., Zhang, J., & Wang, F. 2012). Effect of Colla corii asini (E’jiao) on D-Galactose Induced Aging Mice. Biol. Pharm. Bull; 35, 2128–2132.
asa
Wu, H. Z., Yang, F., Cui, S. Y., Qin, Y. F., Liu, J. W., & Zhang, Y. X. (2007). Hematopoietic effect of fractions from the enzyme digested colla corii asini on mice with 5-fluorouracil induced anemia. Am J Chin Med. 35, 853-866.
asa
Ying, J., Xiao, B., Yang, W., Zeng, X., Guo, J., & Xiao, Y. (2011). Leukocytopoiesis-promoting Action Comparison of Effective Components from Caulis Spatholobi and Colla Corii Asini in Leukopenia Rats. Traditional Chinese Drug Research and Clinical Pharmacology; vol. 2.
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Copyright (c) 2021 Lucas Santana da Fonseca; Claudia Beatriz Lopes Almeida; Tobyas Maia Albuquerque Mariz ; Chiara Albano Araújo Oliveira; Pierre Barnabe Escodro
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