The effect of the use of melatonin in the treatment of intestinal inflammatory diseases: an integrative review

Authors

  • Rosenely Aline Pereira Ferreira União das Instituições de Serviços, Ensino e Pesquisa
  • Priscila de Sá Ramos União das Instituições de Serviços, Ensino e Pesquisa
  • Angela Alves Salvador União das Instituições de Serviços, Ensino e Pesquisa
  • Arthur Alves Negrão da Silva Faculdades Integradas do Vale do Ribeira
  • Francini Xavier Rossetti Faculdades Integradas do Vale do Ribeira
  • Gislene dos Anjos Tamasia Faculdades Integradas do Vale do Ribeira
  • Mariana Scudeller Vicentini União das Instituições de Serviços, Ensino e Pesquisa
  • Sergio Ricardo Brito Bello Centro Universitário Campos de Andrade

DOI:

https://doi.org/10.33448/rsd-v8i9.1263

Keywords:

Melatonin; Inflammatory Bowel Diseases; Colitis; Tryptophan; Serotonin; Antioxidant.

Abstract

Inflammatory Bowel Diseases (IBD) is characterized by inflammation of the gastrointestinal tract and the two most common types are Crohn's disease (DC) and ulcerative colitis (UC). Both diseases have relapsing immune function. In the extreme context, a melatonin (LMT), is triggered enzymatically from L-tryptophan, has been shown to be a versatile hormone favorable in the treatment of DII disease. Based on the main complications associated with an IBD, the objective of this review is to integrate the decision-making of the main clinical actors related to the use of MLT in the treatment of Crohn's disease (DC) and ulcerative colitis (RCU). For that, an integrative review was performed considering the bibliographies selected in the main databases. The MLT appears to play a significant role in GIT, with no gastrointestinal side effects, with free radical effects, local anti-inflammatory activity, and a moderation of visceral. Thus, it appears to be a promising alternative in the treatment of IBD.

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Published

14/06/2019

How to Cite

FERREIRA, R. A. P.; RAMOS, P. de S.; SALVADOR, A. A.; SILVA, A. A. N. da; ROSSETTI, F. X.; TAMASIA, G. dos A.; VICENTINI, M. S.; BELLO, S. R. B. The effect of the use of melatonin in the treatment of intestinal inflammatory diseases: an integrative review. Research, Society and Development, [S. l.], v. 8, n. 9, p. e17891263, 2019. DOI: 10.33448/rsd-v8i9.1263. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/1263. Acesso em: 26 sep. 2021.

Issue

Section

Health Sciences