Influence of viral infection in the healing process of periapical lesions: a narrative review
DOI:
https://doi.org/10.33448/rsd-v10i3.13134Keywords:
Apical periodontitis; Cytomegalovirus; Epstein-Barr Virus; Herpes Simplex; HIV; Oral health.Abstract
Background: Endodontic treatment aims to eliminate microorganisms and their toxic products, allowing the reestablishment of the host defenses and consequently, the healing of periapical tissues. However, numerous factors can affect periapical healing, such as the filling materials, the presence of microorganisms, systemic factors and, more recently, viral infections have been associated with the worsening of periapical lesions. Objective: To discuss the relationship between the main viral infections and the manifestations of apical periodontitis and how these infections can influence the repair of periapical tissues. Conclusion: The literature does not establish a cause-effect relationship between the presence of viruses in the periapical tissues and the increase in pathogenicity of the apical periodontitis. However, further studies should be conducted to affirm the viral potential in periapical tissues, since the literature shows an immune response in apical periodontitis triggered by viruses in the lytic phase, similar to that observed in other pathogens, which can exacerbate the inflammatory response, increase bone resorption and also interfere in the healing of periapical tissues.
References
Alley, B. S., Buchanan, T. H., & Eleazer, P. D. (2008). Comparison of the success of root canal therapy in HIV/AIDS patients and non-infected controls. General Dentistry, 56(2), 155-157. Recuperado de https://www.researchgate.net/publication/5504826_Comparison_of_the_success_of_root_canal_therapy_in _HIVAIDS_patients_and_non-infected_controls
Aminoshariae, A., Kulild, J. C., Mickel, A., & Fouad, A. F. (2017). Association between systemic diseases and endodontic outcome: a systematic review. Journal of Endodontics, 43(4), 514-519. doi: https://doi.org/10.1016/j.joen.2016.11.008
Bate, S. L., Dollard, S. C., & Cannon, M. J. (2010). Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988–2004. Clinical Infectious Diseases, 50(11), 1439-1447. doi: https://doi.org/10.1086/652438
Chen, C., Feng, P., & Slots, J. (2020). Herpesvirus‐bacteria synergistic interaction in periodontitis. Periodontology 2000, 82(1), 42-64. doi: https://doi.org/10.1111/prd.12311
Cohen, J. I. (2000). Epstein–Barr virus infection. New England Journal of Medicine, 343(7), 481-492. doi: 10.1056/NEJM200008173430707
Contreras, A., Zadeh, H. H., Nowzari, H., & Slots, J. (1999). Herpesvirus infection of inflammatory cells in human periodontitis. Oral Microbiology and Immunology, 14(4), 206-212. doi: https://doi.org/10.1034/j.1399-302X.1999.140402.x
Cooper, H. (1993). Root canal treatment on patients with HIV infection. International Endodontic Journal, 26(6), 369-371. doi: https://doi.org/10.1111/j.1365-2591.1993.tb00771.x
De Brito, L. C. N., Teles, F. R., Teles, R. P., Nogueira, P. M., Vieira, L. Q., & Ribeiro Sobrinho, A. P. (2015). Immunological profile of periapical endodontic infections from HIV− and HIV+ patients. International Endodontic Journal, 48(6), 533-541. doi: https://doi.org/10.1111/iej.12345
Dioverti, M. V., & Razonable, R. R. (2016). Cytomegalovirus. Microbiology Spectrum, 4(4), 10.1128/microbiolspec.DMIH2-0022-2015. doi: https://doi.org/10.1128/microbiolspec.DMIH2-0022-2015
Dupont, L., & Reeves, M. B. (2016). Cytomegalovirus latency and reactivation: recent insights into an age old problem. Reviews in Medical Virology, 26(2), 75-89. doi: https://doi.org/10.1002/rmv.1862
Elkins, D. A., Torabinejad, M., Schmidt, R. E., Rossi, J. J., & Kettering, J. D. (1994). Polymerase chain reaction detection of human immunodeficiency virus DNA in human periradicular lesions. Journal of Endodontics, 20(8), 386-388. doi: https://doi.org/10.1016/S0099-2399(06)80296-7
Epstein, M. A. (1964). Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet, 1(7335), 702–703. doi: https://doi.org/10.1016/S0140-6736(64)91524-7
Ferreira, D. C., Paiva, S. S., Carmo, F. L., Rôças, I. N., Rosado, A. S., Santos, K. R., & Siqueira Jr, J. F. (2011). Identification of herpesviruses types 1 to 8 and human papillomavirus in acute apical abscesses. Journal of Endodontics, 37(1), 10-16. doi: https://doi.org/10.1016/j.joen.2010.09.009
Glick, M., Trope, M., Bagasra, O., & Pliskin, M. E. (1991). Human immunodeficiency virus infection of fibroblasts of dental pulp in seropositive patients. Oral Surgery, Oral Medicine, and Oral Pathology, 71(6), 733-736. doi: https://doi.org/10.1016/0030-4220(91)90284-J
Gomes, B. P. F. D. A., & Herrera, D. R. (2018). Etiologic role of root canal infection in apical periodontitis and its relationship with clinical symptomatology. Brazilian Oral Research, 32(suppl 1), e69. doi: http://dx.doi.org/10.1590/1807-3107bor-2018.vol32.0069
Green, M., & Michaels, M. G. (2013). Epstein–Barr virus infection and posttransplant lymphoproliferative disorder. American Journal of Transplantation, 13(s3), 41-54. doi: https://doi.org/10.1111/ajt.12004
Guilherme, B. P., Ferreira, D. C., Rôças, I. N., Provenzano, J. C., Santos, K. R., & Siqueira Jr, J. F. (2011). Herpesvirus carriage in saliva and posttreatment apical periodontitis: searching for association. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 112(5), 678-683. doi: https://doi.org/10.1016/j.tripleo.2011.05.003
Guimarães, F., Pavelski, M. D., Dallazen, E., de Souza Santos, A. M., Delanora, L. A., Silva, W. P. P., ... & Magro Filho, O. (2021). Como identificar uma manifestação oral de Herpes-Zoster?. Research, Society and Development, 10(2), e31610212617-e31610212617. doi: https://doi.org/10.33448/rsd-v10i2.12617
Hernádi, K., Szalmás, A., Mogyorósi, R., Czompa, L., Veress, G., Csoma, E., ... & Kónya, J. (2010). Prevalence and activity of Epstein-Barr virus and human cytomegalovirus in symptomatic and asymptomatic apical periodontitis lesions. Journal of Endodontics, 36(9), 1485-1489. doi: https://doi.org/10.1016/j.joen.2010.06.008
Himi, K., Takeichi, O., Imai, K., Hatori, K., Tamura, T., & Ogiso, B. (2020). Epstein–Barr virus reactivation by persistent apical periodontal pathogens. International Endodontic Journal, 53(4), 492-505. doi: https://doi.org/10.1111/iej.13255
Holland, R., Gomes Filho, J. E., Cintra, L. T. A., Queiroz, Í. O. D. A., & Estrela, C. (2017). Factors affecting the periapical healing process of endodontically treated teeth. Journal of Applied Oral Science, 25(5), 465-476. doi: https://doi.org/10.1590/1678-7757-2016-0464
Jakovljevic, A., & Andric, M. (2014). Human cytomegalovirus and Epstein-Barr virus in etiopathogenesis of apical periodontitis: a systematic review. Journal of Endodontics, 40(1), 6-15. doi: https://doi.org/10.1016/j.joen.2013.10.001
Jakovljevic, A., Andric, M., Knezevic, A., Soldatovic, I., Nikolic, N., Karalic, D., & Milasin, J. (2015). Human cytomegalovirus and Epstein-Barr virus genotypes in apical periodontitis lesions. Journal of Endodontics, 41(11), 1847-1851. doi: https://doi.org/10.1016/j.joen.2015.08.027
Jakovljevic, A., Andric, M., Nikolic, N., Coric, V., Krezovic, S., Carkic, J., ... & Milasin, J. (2018). Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein–Barr virus. International Endodontic Journal, 51(6), 593-604. doi: https://doi.org/10.1111/iej.12886
Jakovljevic, A., Nikolic, N., Carkic, J., Beljic‐Ivanovic, K., Soldatovic, I., Miletic, M., ... & Milasin, J. (2020). Association of polymorphisms in TNF‐α, IL‐1β, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection? International Endodontic Journal, 53(7), 895-904. doi: https://doi.org/10.1111/iej.13298
Jangra, S., Yuen, K. S., Botelho, M. G., & Jin, D. Y. (2019). Epstein–Barr virus and innate immunity: Friends or foes?. Microorganisms, 7(6), 183. doi: https://doi.org/10.3390/microorganisms7060183
Jones, J. F., Shurin, S., Abramowsky, C., Tubbs, R. R., Sciotto, C. G., Wahl, R., ... & Sklar, J. (1988). T-cell lymphomas containing Epstein–Barr viral DNA in patients with chronic Epstein–Barr virus infections. New England Journal of Medicine, 318(12), 733-741. doi: 10.1056/NEJM198803243181203
Kivity, S., Arango, M. T., Ehrenfeld, M., Tehori, O., Shoenfeld, Y., Anaya, J. M., & Agmon-Levin, N. (2014). Infection and autoimmunity in Sjogren's syndrome: a clinical study and comprehensive review. Journal of Autoimmunity, 51, 17-22. doi: https://doi.org/10.1016/j.jaut.2014.02.008
Köche, J. C. (2016). Fundamentos de metodologia científica. [e-book]. Petrópolis. Ed. Vozes. Recuperado de http://www.brunovivas.com/wp-content/uploads/sites/10/2018/07/K%C3%B6che-Jos%C3%A9-Carlos0D0AFundamentos-de-metodologia-cient%C3%ADfica-_-teoria-da0D0Aci%C3%AAncia-e-inicia%C3%A7%C3%A3o-%C3%A0-pesquisa.pdf
Lanzieri, T. M., Kruszon-Moran, D., Amin, M. M., Bialek, S. R., Cannon, M. J., Carroll, M. D., & Dollard, S. C. (2015). Seroprevalence of cytomegalovirus among children 1 to 5 years of age in the United States from the National Health and Nutrition Examination Survey of 2011 to 2012. Clinical and Vaccine Immunology, 22(2), 245-247. doi: 10.1128/CVI.00697-14
Levine, D. F., Witherspoon, D. E., Gutmann, J. L., & Iacopino, A. M. (2001). Interleukin-1β production in periradicular lesions in a human immunodeficiency virus/acquired immune deficiency syndrome model compared with a noninfected host. Journal of Endodontics, 27(8), 499-502. doi: https://doi.org/10.1097/00004770-200108000-00001
Li, H., Chen, V., Chen, Y., Baumgartner, J. C., & Machida, C. A. (2009). Herpesviruses in endodontic pathoses: association of Epstein-Barr virus with irreversible pulpitis and apical periodontitis. Journal of Endodontics, 35(1), 23-29. doi: https://doi.org/10.1016/j.joen.2008.09.017
Ludke, M. & Andre, M. E . D. A. (2013). Pesquisa em educação: abordagens qualitativas. São Paulo. Ed. EPU.
Luzuriaga, K., & Sullivan, J. L. (2010). Infectious mononucleosis. The New England Journal of Medicine, 362(21), 1993–2000. doi: https://doi.org/10.1056/NEJMcp1001116
Márton, I. J., & Kiss, C. (2014). Overlapping protective and destructive regulatory pathways in apical periodontitis. Journal of Endodontics, 40(2), 155-163. doi: https://doi.org/10.1016/j.joen.2013.10.036
Mochanko, K., Fejes, M., Breazavscek, D. M., Suarez, A., & Bachmann, A. E. (1979). The relation between epstein‐barr virus antibodies and clinical symptomatology and immunodeficiency in patients with Hodgkin's disease. Cancer, 44(6), 2065-2070. doi: https://doi.org/10.1002/1097-0142(197912)44:6<2065::AID-CNCR2820440617>3.0.CO;2-G
Mogensen, T. H., & Paludan, S. R. (2001). Molecular pathways in virus-induced cytokine production. Microbiology and molecular biology reviews: MMBR, 65(1), 131–150. doi: https://doi.org/10.1128/MMBR.65.1.131-150.2001
Mosca, F., Pugni, L., Barbi, M., & Binda, S. (2001). Transmission of cytomegalovirus. The Lancet, 357(9270), 1800. doi: https://doi.org/10.1016/S0140-6736(00)04914-X
Nair, P. R. (2004). Pathogenesis of apical periodontitis and the causes of endodontic failures. Critical Reviews in Oral Biology & Medicine, 15(6), 348-381. doi: https://doi.org/10.1177/154411130401500604
Nowalk, A., & Green, M. (2016). Epstein-Barr Virus. Microbiology Spectrum, 4(3), 10.1128/microbiolspec.DMIH2-0011-2015. doi: https://doi.org/10.1128/microbiolspec.DMIH2-0011-2015
Ozbek, S. M., Ozbek, A., & Demiray, T. (2016). Prevalence of several herpesviruses and human papillomavirus in acute apical abscesses. International Endodontic Journal, 49(6), 519-525. doi: https://doi.org/10.1111/iej.12482
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Recuperado em 27 abril, 2020, de:
Plachter, B., Sinzger, C., & Jahn, G. (1996). Cell types involved in replication and distribution of human cytomegalovirus. Advances in Virus Research, 46, 195-261. doi: https://doi.org/10.1016/S0065-3527(08)60073-1
Quesnell, B. T., Alves, M., Hawkinson Jr, R. W., Johnson, B. R., Wenckus, C. S., & BeGole, E. A. (2005). The effect of human immunodeficiency virus on endodontic treatment outcome. Journal of Endodontics, 31(9), 633-636. doi: https://doi.org/10.1097/01.don.0000157985.88883.81
Ricucci, D., Lin, L. M., & Spångberg, L. S. (2009). Wound healing of apical tissues after root canal therapy: a long-term clinical, radiographic, and histopathologic observation study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 108(4), 609-621. doi: https://doi.org/10.1016/j.tripleo.2009.05.028
Sabeti, M., Daneshmand, A., Simon, J. H., & Slots, J. (2009). Cytomegalovirus‐infected inflammatory cells in dental periapical lesions. Oral Microbiology and Immunology, 24(5), 434-436. doi: https://doi.org/10.1111/j.1399-302X.2009.00540.x
Sabeti, M., Kermani, V., Sabeti, S., & Simon, J. H. (2012). Significance of human cytomegalovirus and Epstein-Barr virus in inducing cytokine expression in periapical lesions. Journal of Endodontics, 38(1), 47-50. doi: https://doi.org/10.1016/j.joen.2011.09.026
Sabeti, M., Simon, J. H., Nowzari, H., & Slots, J. (2003a). Cytomegalovirus and Epstein-Barr virus active infection in periapical lesions of teeth with intact crowns. Journal of Endodontics, 29(5), 321-323. doi: https://doi.org/10.1097/00004770-200305000-00002
Sabeti, M., Valles, Y., Nowzari, H., Simon, J. H., Kermani‐Arab, V., & Slots, J. (2003b). Cytomegalovirus and Epstein–Barr virus DNA transcription in endodontic symptomatic lesions. Oral Microbiology and Immunology, 18(2), 104-108. doi: https://doi.org/10.1034/j.1399-302X.2003.00055.x
Sawada, S., Takei, M., Inomata, H., Nozaki, T., & Shiraiwa, H. (2007). What is after cytokine-blocking therapy, a novel therapeutic target—synovial Epstein-Barr virus for rheumatoid arthritis. Autoimmunity Reviews, 6(3), 126-130. doi: https://doi.org/10.1016/j.autrev.2006.08.014
Saygun, I., Yapar, M., Özdemir, A., Kubar, A., & Slots, J. (2004). Human cytomegalovirus and Epstein‐Barr virus type 1 in periodontal abscesses. Oral Microbiology and Immunology, 19(2), 83-87. doi: https://doi.org/10.1046/j.0902-0055.2002.00118.x
Shindell, E. (1962). Studies on the possible presence of a virus in subacute and chronic periapical granulomas. Oral surgery, Oral Medicine, and Oral Pathology, 15(11), 1382-1384. doi: https://doi.org/10.1016/0030-4220(62)90359-6
Siqueira Jr, J. F., & Rôças, I. N. (2008). Clinical implications and microbiology of bacterial persistence after treatment procedures. Journal of Endodontics, 34(11), 1291-1301. doi: https://doi.org/10.1016/j.joen.2008.07.028
Slots, J. (2005). Herpesviruses in periodontal diseases. Periodontology 2000, 38(1), 33-62. doi: https://doi.org/10.1111/j.1600-0757.2005.00109.x
Slots J. (2010). Herpesviral-bacterial interactions in periodontal diseases. Periodontology 2000, 52(1), 117–140. doi: https://doi.org/10.1111/j.1600-0757.2009.00308.x
Slots, J., Sabeti, M., & Simon, J. H. (2003). Herpesviruses in periapical pathosis: an etiopathogenic relationship? Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 96(3), 327–331. doi: https://doi.org/10.1016/s1079-2104(03)00352-4
Suchina, J. A., Levine, D., Flaitz, C. M., Nichols, C. M., & Hicks, M. J. (2006). Retrospective clinical and radiologic evaluation of nonsurgical endodontic treatment in human immunodeficiency virus (HIV) infection. The Journal of Contemporary Dental Practice, 7(1), 1–8. doi: 10.5005/jcdp-7-1-1
Tabtieng, T., & Gaglia, M. M. (2018). Emerging proviral roles of caspases during lytic replication of gammaherpesviruses. Journal of Virology, 92(19). doi: 10.1128/JVI.01011-17
Tootla, S., & Owen, C. P. (2012). A comparison of endodontic treatment outcomes between HIV-positive and HIV-negative patients. SADJ: Journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 67(7), 322–325. doi: https://journals.co.za/doi/10.10520/EJC143613
Vigueras, S. H., Zúniga, M. D., Jané-Salas, E., Navarrete, L. S., Segura-Egea, J. J., Velasco-Ortega, E., & López-López, J. (2016). Viruses in pulp and periapical inflammation: a review. Odontology, 104(2), 184-191. doi: 10.1007/s10266-015-0200-y
Yazdi, K. A., Sabeti, M., Jabalameli, F., Eman eini, M., Kolahdouzan, S. A., & Slots, J. (2008). Relationship between human cytomegalovirus transcription and symptomatic apical periodontitis in Iran. Oral Microbiology and Immunology, 23(6), 510-514. doi: https://doi.org/10.1111/j.1399-302X.2008.00471.x
Yildirim, S., Yapar, M., Kubar, A., & Slots, J. (2006). Human cytomegalovirus, Epstein‐Barr virus and bone resorption‐inducing cytokines in periapical lesions of deciduous teeth. Oral Microbiology and Immunology, 21(2), 107-111. doi: https://doi.org/10.1111/j.1399-302X.2006.00268.x
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Copyright (c) 2021 Caroline Loureiro; Marcelo Augusto Seron; Gabriela Pacheco de Almeida Braga; Cristiane Cantiga da Silva; Rogério Castilho Jacinto; Gustavo Sivieri-Araujo; Cristiane Duque; Luciano Tavares Angelo Cintra; João Eduardo Gomes-Filho
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