Analysis of proviral load levels in HTLV-1 carriers with different neurological impairment conditions

Authors

DOI:

https://doi.org/10.33448/rsd-v10i3.13264

Keywords:

HTLV-1; Tropical Spastic Paraparesis; Neurological disorders; Proviral load.

Abstract

Objectives: To analyze the levels of proviral load (CPV) in patients with HTLV-1 with different conditions of neurological impairment. Methodology: Cross-sectional study, conducted from March to October 2017, with 43 patients with HTLV-1, divided into three groups in decreasing order of neurological involvement, according to the updated proposal of the clinical diagnosis criteria for HAM / TSP: Defined for HAM / TSP (Group 1, n = 7); Probable / Possible for HAM / TSP (Group 2, n = 9); Without HAM / TSP (Group 3, n = 27). The ANOVA test (one criterion) was used to verify the difference between the groups' mean CPV (p-value≤0.05). Results: The groups presented the following average CPV values: G1 = 9.00 ± 11.18; G2 = 1.88 ± 3.92; G3 = 2.81 ± 4.03 copies / 106 PBMC. In the intergroup comparison, of the difference between the means of CPV, a significant difference was observed between groups 1 and 2 and between groups 1 and 3 (p <0.05); a significantly higher mean of CPV was not observed in the HTLV-1 infected groups with neurological impairment, compared to those infected without neurological impairment (p = 0.7063). Conclusion: CPV in patients with HTLV-1 seems to help the clinical evaluation of neurological impairment in the classification of classic cases of HAM/TSP, but it is not an important indicator of initial clinical conditions of HAM/TSP.

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Published

14/03/2021

How to Cite

ASSIS, I. M. de .; DOMINGUES , M. M. .; ALMEIDA, D. de S. .; COVRE, L. de S. C. .; LA-ROQUE, D. G. L. de .; SILVA, I. C. .; NOBRE, A. F. S. .; BORGES, M. da S. .; PEREIRA, C. C. C. .; SANTANA, B. B. .; VALLINOTO, A. C. R. .; SOUSA, M. S. de . Analysis of proviral load levels in HTLV-1 carriers with different neurological impairment conditions. Research, Society and Development, [S. l.], v. 10, n. 3, p. e22310313264, 2021. DOI: 10.33448/rsd-v10i3.13264. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/13264. Acesso em: 12 apr. 2021.

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Section

Health Sciences