Relationship between vitamin C ingestion and antioxidant enzymes in obese women

Authors

DOI:

https://doi.org/10.33448/rsd-v10i3.13489

Keywords:

Vitamin C; Glutathione Peroxidase; Superoxide Dismutase; Obesity.

Abstract

The present study aimed to assess the relationship between dietary vitamin C intake and activity of antioxidant enzymes in obese women. This is a case-control study, involving 62 women, aged between 20 and 50 years, divided into two groups: control group (eutrophic women, n = 40) and case group (obese women, n = 22). The measures of weight and height were considered to calculate the body mass index, as well as the estimated intake of calories, macronutrients and vitamin C. In addition, blood samples were collected from the participants for further analysis of the erythrocyte activity of the enzymes glutathione peroxidase and superoxide dismutase. The data were analyzed using the statistical program SPSS for Windows 22.0. As for the results, a statistically significant difference was observed regarding the consumption of carbohydrates and lipids (p <0.05), being lower in the case group. Moreover, obese women ingested less vitamin C than the control group (p <0.05). The activity of the glutathione peroxidase enzyme was similar in the groups, however, reduced activity of the superoxide dismutase enzyme was observed in obese women (p <0.05). There was no correlation between the parameters of vitamin C and antioxidant enzymes in the groups. Wherefore, it is concluded that the intake of vitamin C did not seem to influence the activity of antioxidant enzymes.

References

Agarwal, S. et al. (2015). Comparison of prevalence of inadequate nutrient intake based on body weight status of adults in the United States: an analysis of NHANES 2001-2008. Journal of the American College of Nutrition, 34(2), 126-134.

Amirkhizi, F. et al. (2014). Impaired enzymatic antioxidante defense in erythrocytes of women with general and abdominal obesity. Obesity Research & Clinical Practice, 8(1), 26-34.

Anção, M. S. et al. (2002). Programa de apoio à nutrição Nutwin: versão 1.5. São Paulo: Departamento de Informática em Saúde, SPDM, Unifesp/EPM, 1 CD-ROM.

Brasil (2012). Ministério da Saúde. Conselho Nacional de Pesquisa com Seres Humanos. Resolução nº466, de 12 de dezembro de 2012. Diário Oficial da União, Brasília, DF.

Brasil (2011). Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Orientações para a coleta e análise de dados antropométricos em serviços de saúde: Norma Técnica do Sistema de Vigilância Alimentar e Nutricional – SISVAN. Brasília: Ministério da Saúde.

Brasil (2004). Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Vigilância alimentar e nutricional - Sisvan: Orientações básicas para a coleta, processamento, análise de dados e informação em serviços de saúde. Brasília:

Ministério da Saúde.

Carr, A. C. & Rowe, S. Factors affecting vitamin C status and prevalence of deficiency: a global health perspective. Nutrients, 12(7), 1-19.

Colak, E. et al. (2020). The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk. Journal of Medical Biochemistry, 39(3), 346-354.

Dennis, K. K.; Go, Y. & Jones, D. P. (2019). Redox systems biology of nutrition and oxidative stress. Journal of Nutrition, 149(4), 553-565.

Fisberg, R. M. et al. (2005). Inquéritos alimentares: métodos e bases científicas. São Paulo: Manole.

Ferraz, L. et al. (2020). Association between antioxidant vitamins and oxidative stress among patients with a complete hydatidiform mole. Clinics, 75(e1724), 1-6.

García, E. A. (2012). Obesidad, tejido adiposo y resistência a la insulina. Acta Bioquímica Clínica Latinoamericana, 46 (2), 183-194.

Goul, R. L. & Pazdro, R. (2019). Impacto f supplementary amino acids, micronutrientes, and overall diet on glutathione homeostasis. Nutrients, 11(5), 1-21.

Haubrock, J. et al. (2011). Estimating usual food intake distributions by using the multiple source method in the EPIC-Potsdam Calibration Study. Journal of Nutrition, 141(5), 914-20.

Hauck, A. K. et al. (2019). Adipose oxidative stress and protein carbonylation. Journal of Biological Chemistry, 294(4), 2019.

IOM (Institute of Medicine) (2006). Dietary reference intakes: the essential guide to nutrient requirements. Washington: National Academy Press.

Jaime, PC et al. (2003). Comparative study among two methods for energy adjustment for nutriente intake. Nutrire, 26, 11-18.

Kadkhoda, G. et al. (2020). Association of dietary intake of fruit and green vegetables with PTEN and p53 mRNA gene expression in visceral and subcutaneous adipose tissues of obese and non-obese adults. Gene, 733.

Laureano, G. H. C. et al. (2016). Comparison of the ISU, NCI, MSM, and SPADE Methods for Estimating Usual Intake: A Simulation Study of Nutrients Consumed Daily. Nutrients, 8(3), 166.

Lee, Y. Y. & Muda, W. A. M. W. (2019). Dietary intakes and obesity of Malaysian adults. Nutrition Research and Practice, 13(2), 159-168.

Manna, P. & Jain, S. K. (2015). Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies. Metabolic Syndrome and Related Disorders, 13(10), 423-444.

Maslov, L. N. et al. (2019). Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? Journal of Clinical & Translation Endrocrinology,15, 1-5.

Monacelli, F. et al. (2017). Vitamin C, aging and alzheimer’s disease. Nutrients, 9(7), 1-26.

MSM. (2011). Multiple Source Method (MSM) for estimating usual dietary intake from shortterm measurement data: user guide. EFCOVAL: Potsdam, pp.41.

Pearson, J. F. et al. (2017). Vitamin C status correlates with markers of metabolic and cognitive health in 50-yer-olds: findings of the CHALICE cohort study. Nutrients, 9(8), 1-15.

Pereira, A.S et al. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Recuperado de: https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.

Pol, A. V. D. et al. (2019). Treating oxidative stress in heart failure: past, present and future. European Journal of Heart Failure, 21(4), 425-435.

Rapa, S. F. et al. (2020). Inflammation and oxidativo stress in chronic kidney disease-potential therapeutic role of minerals, vitamins and plant-derived metabolites. International Journal of Molecular Sciences, 21(1), 1-26.

Rauber, F. et al. (2020). Ultra-processed food consumption and indicators of obesity in the United Kingdom population (2008-2016). Plos One, 15(5), 1-15.

Rendeiro, L. C. et al. (2018). Consumo alimentar e adequação nutricional de adultos com obesidade. Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 12(76, supl. 2), 996-1008.

Roh, H.; Cho, S. & So, W. (2017). Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise. Journal of Sport and Health Science, 6(2), 225-230.

Rowe, S. & Carr, A. C. (2020). Global vitamin C status and prevalence of deficiency: a cause for concern? Nutrients, 12(7), 1-20.

Schmatz, R. et al. (2017). Evaluation of the biochemical, inflammatory and oxidative profile of obese patients given clinical treatment and bariatric surgery. Clinica Chimica Acta, 465, 72-79.

Senoner, T. & Dichtl, W. (2019). Oxidative stress in cardiovascular diseases: still a therapeutic target. Nutrients, 11(9), 1-25.

Shim, J.; Oh, K. & Kim, H. C (2014). Dietary assessment methods in epidemiologic studies. Epidemiology and Health, 36, 1-8.

Sousa, T. G. V. et al. (2020). Ingestão dietética de magnésio e ferro e sua relação com estresse oxidativo em mulheres obesas. Research, Society and Development, 9(1), 1-16.

Souverein, O. W. et al. (2011). Comparing four methods to estimate usual intake distributions. European Journal of Clinical Nutrition, 65 (suppl. 1), S92-101.

Torkanlou, K. et al. (2016). Reduced sérum levels of zinc and superoxide dismutase in obese individuals. Annals of Nutrition & Metabolism, 69(1), 232-236.

Upadhyay, J. et al. (2017). Obesity as a disease. Medical Clinics of North America, 102(1), 13-33.

Wong, S. K; Chin, K. Y. & Ima-Nirwana, S. (2020). Vitamin C: a review on its role in the management of metabolic syndrome. International Journal of Medical Sciences, 17(11), 1625-1638.

World Health Organization. (2008). Obesity: preventing and managing the global epidemic – report of a WHO consultation. Geneva: World Health Organization.

World Health Organization. (2000). Obesity: Preventing and managing the global epidemic. Technical report series, 894, 9.

Willett, W. & Stampfer, M. J. (1986). Total energy intake: implications for epidemiologic analyses. American Journal of Epidemiology, 124(1), 4199-4239.

Wilson, R. et al. (2017). Inadequate Vitamin C status in prediabestes and type 2 diabetes mellitus: associations with glycaemic control, obesity, and smoking. Nutrients, 9(9), 1-15.

Published

21/03/2021

How to Cite

SILVA, L. D. da; SILVA, N. C. da; SANTOS, L. R. dos; SOARES, T. da C.; RÊGO, M. N. do; SILVA, M. C. L. da; FONTENELE, L. C.; POLTRONIERI, F.; MARREIRO, D. do N. Relationship between vitamin C ingestion and antioxidant enzymes in obese women. Research, Society and Development, [S. l.], v. 10, n. 3, p. e43810313489, 2021. DOI: 10.33448/rsd-v10i3.13489. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/13489. Acesso em: 26 dec. 2024.

Issue

Section

Health Sciences