Excess of weight and antropometric variables of cardiovascular risk in patients with polycystic ovary syndrome

Authors

DOI:

https://doi.org/10.33448/rsd-v10i4.14230

Keywords:

Polycystic Ovary Syndrome; Cardiovascular Diseases; Anthropometry; Obesity; Body mass index.

Abstract

Object: to evaluate the frequency of overweight in women with Polycystic Ovarian Syndrome (PCOS) and associations with cardiovascular risk. Methodology: a cross-sectional study with 44 women with a diagnosis of PCOS and age between 21 and 50 years. Anthropometric variables (Body Mass Index - BMI, Waist Circumference - CC, Waist-Hip Ratio - WHR and Waist-Stature Ratio - STt) were analyzed, sociodemographic variables (age, income, marital status, sedentary lifestyle, family history) and clinical variables presence of Melito Diabetes, Systemic Arterial Hypertension and / or Menstrual Irregularity). The statistical tests used for frequencies, associations and comparisons were: Chi-square, Fisher's exact, F (ANOVA) and Kruskal-Wallis, with a significance level of 5%. Results: the majority of the group presented obesity (52.2%) followed by overweight (25%), high STCh (72.7%), high STC (65.9%) and high STCh (68.2%), ≤ 0.001; without associated chronic pathologies; (21-39 years), non-white, single women residing in the interior of the state, with menstrual irregularity and sedentary lifestyle predominated. Conclusion: overweight was present in almost all of the sample, with all the anthropometric indices showing a high cardiovascular risk, with the RCEst and CC being higher than the BMI and WHR in the risk classification.

References

Abdullah, E., Idris, A., & Saparon, A. (2017). Papr reduction using scs-slm technique in stfbc mimo-ofdm. ARPN Journal of Engineering and Applied Sciences, 12(10), 3218-3221.

Alves, A. C., Valcarcel, B., Mäkinen, V. P., Morin-Papunen, L., Sebert, S., Kangas, A. J., Soininen, P., DAS, S., Iorio, M., & Coin, L. (2017). Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity. International Journal Of Obesity, 41(9), 1331-1340. http://dx.doi.org/10.1038/ijo.2017.126

Alves, R. F. S., & Faerstein, E. (2016). Desigualdade educacional na ocorrência de obesidade abdominal por gênero e cor/raça: estudo pró-saúde, 1999-2001 e 2011-2012. Cadernos de Saúde Pública, 32(2), e00077415. http://dx.doi.org/10.1590/0102-311x00077415

Anagnostis, P., Tarlatzis, B. C., & Kauffman, R. P. (2017). Polycystic ovarian syndrome (PCOS): long-term metabolic consequences. Metabolism, 86, 33-43. http://dx.doi.org/10.1016/j.metabol.2017.09.016

Associação Brasileira para Estudo da Obesidade e Síndrome Metabólica. (2016). Diretrizes brasileiras de obesidade. 1-188. https://abeso.org.br/wp content/uploads/2019/12/Diretrizes-Download-Diretrizes-Brasileiras-de-Obesidade-2016.pdf

Aziz, M., Sidelmann J. J., Faber, J., Wissing, M. L. M., Naver, K. V., Mikkelsen, A. L., Nilas, L., & Skouby, S. O. (2015). Polycystic ovary syndrome: cardiovascular risk factors according to specific phenotypes. Acta Obstet Gynecol Scand, 94(10), 1082-1089. http://dx.doi.org/10.1111/aogs.12706

Baldani, D. P., Skrgatic L., & Ougouag, R. (2015). Polycystic ovary syndrome: important underrecognised cardiometabolic risk factor in reproductive-Age women. International Journal Of Endocrinology, 1-17. http://dx.doi.org/10.1155/2015/786362

Boumosleh, J. M., Grundy, S. M., Phan J., Neeland, I. J., Chang, A., & Vega, G. L. (2017). Metabolic Concomitants of Obese and Nonobese Women With Features of Polycystic Ovarian Syndrome. Journal Of The Endocrine Society, 1(12), 1417-1427. http://dx.doi.org/10.1210/js.2017-00323

Delitala, A. P., Capobianco, G., Delitala, G., Cherchi, P. L., & Dessole, S. (2017). Polycystic ovary syndrome, adipose tissue and metabolic syndrome. Archives Of Gynecology And Obstetrics, 296(3), 405-419. http://dx.doi.org/10.1007/s00404-017-4429-2

Dias, J. A., Cândido, A. L., Oliveira, F. R., Azevedo, R. C. S., Rocha, A. L. L., & Reis, F. M. (2015). LAP (produto da acumulação lipídica) e síndrome metabólica em pacientes com síndrome dos ovários policísticos. Reprodução & Climatério, 30(3), 127-131. http://dx.doi.org/10.1016/j.recli.2015.11.005

Dumitrescu, R., Mehedintu, C., Briceag, I., Purcarea, V. L., & Hudita, D. (2015). The polycystic ovary syndrome: an update on metabolic and hormonal mechanisms. Journal of medicine and life, 8(2), 142-145.

Engmann, L., Jin, S., Sun, F., Legro, R. S., Polotsky, A. J., Hansen, K. R.; Coutifaris, C., Diamond, M. P., Eisenberg, E., & Zhang, H. (2017). Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype. American Journal Of Obstetrics And Gynecology, 216(5), 493.e1-493.e13. http://dx.doi.org/10.1016/j.ajog.2017.01.003

Escobar-Morreale, H. F. (2018). Polycystic ovary syndrome: definition, etiology, diagnosis and treatment. Nature Reviews Endocrinology, 14(5), 270-284.

http://dx.doi.org/10.1038/nrendo.2018.24

Federação Brasileira das Associações de Ginecologia e Obstetrícia. (2018). Síndrome dos ovários policísticos. Comissão Nacional de Ginecologia Endócrina, 4, 103. https://www.febrasgo.org.br/media/k2/attachments/18Z-ZSndromeZdosZovriosZpolicsticos.pdf

Ferreira, A. I. S., & SLOB, E. (2014). Avaliação do Perfil Nutricional dos Funcionários das Equipes Estratégia Saúde da Família e Núcleo de Apoio a Saúde da Família do Município de Pedralva – MG. Revista Ciências em Saúde, 4(3), 12-21. http://dx.doi.org/10.21876/rcsfmit.v4i3.223

Habib, L., Gois, M., Gilmar, J., Santos, C., Maria J., & Dias G. (2016). A importância da idade na síndrome metabólica em pacientes portadoras de ovários policísticos. International Journal of Nutrology, 9(2), 199-208.

Harris, H. R., Titus, L. J., Cramer, D. W., & Terry, K.L. (2017). Long and irregular menstrual cycles, polycystic ovary syndrome, and ovarian cancer risk in a population-based case-control study. International Journal Of Cancer, 140(2), 285-291. http://dx.doi.org/10.1002/ijc.30441

Hillman, J. K., Johnson, L. N. C., Limaye, M., Feldman, R. A., Sammel, M., & Dokras, A. (2014). Black women with polycystic ovary syndrome (PCOS) have increased risk for metabolic syndrome and cardiovascular disease compared with white women without PCOS. Fertility And Sterility, 101(2), 530-535. http://dx.doi.org/10.1016/j.fertnstert.2013.10.055

Jeanes, Y. M., & Reeves, S. (2017). Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges. Nutrition Research Reviews, 30(1), 97-105. http://dx.doi.org/10.1017/s0954422416000287

Joham, A. E., Boyle, J. A., Zoungas, S., & Teede, H. J. (2015). Hypertension in reproductive-aged women with polycystic ovary syndrome and association with obesity. American Journal Of Hypertension, 28(7), 847-851. http://dx.doi.org/10.1093/ajh/hpu251

Krentowska, A., Łebkowska, A., Jacewicz-Święcka, M., Hryniewicka, J., Leśniewska, M., Adamska, A., & Kowalska, I. (2021). Metabolic syndrome and the risk of cardiovascular complications in young patients with different phenotypes of polycystic ovary syndrome. Endocrine. http://dx.doi.org/10.1007/s12020-020-02596-8

Legro, R. S., Arslanian, S. A., Ehrmann, D. A., Hoeger, K. M., Murad, M. H., Pasquali, R., & Welt, C. K. (2013). Diagnosis and Treatment of Polycystic Ovary Syndrome: an endocrine society clinical practice guideline. The Journal Of Clinical Endocrinology & Metabolism, 98(12), 4565-4592. http://dx.doi.org/10.1210/jc.2013-2350

Lin, T., Li, S., Xu, H., Zhou, H., Feng, R., Liu, W., Sun, Y., & Ma, J. (2015). Gastrointestinal hormone secretion in women with polycystic ovary syndrome: an observational study. Human Reproduction, 30(11) 2639-2644. http://dx.doi.org/10.1093/humrep/dev231

Lizneva, D., Suturina, L., Walker, W., Brakta, S., Gavrilova-Jordan, L., & Azziz, R. (2016). Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertility And Sterility, 106(1), 6-15. http://dx.doi.org/10.1016/j.fertnstert.2016.05.003

Marques, P., Ferreira, F., Soares, A. P., Nunes, J., Sousa, S., Aguiar, A., & Calhaz, C.J. (2015). Significado cardiometabólico do excesso de peso/obesidade numa população de 263 mulheres inférteis com síndrome do ovário poliquístico. Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo, 10(1), 2-7.

https://doi.org/10.1016/j.rpedm.2014.12.003

Moraes, K. D., Araújo, A. P., Santos, A. F., Barbosa, J. M. A., & Martins, M. L. B. (2015). Correlação Entre O Índice De Massa Corporal E Indicadores Antropométricos De Risco Cardiovascular Em Mulheres. Revista de Pesquisa em Saúde, 16(3), 175-181.

Organización Mundial de la Salud. (2014). Informe sobre la situación mundial de las enfermedades no transmisibles. https://www.who.int/nmh/publications/ncd-status-report-2014/es/

Orio, F., Muscogiuri, G., Nese, C., Palomba, S., Savastano, S., Tafuri, D., Colarieti, G., Lasala, G., Colao, A., & Yildiz, B. O. (2016). Obesity, type 2 diabetes mellitus and cardiovascular disease risk: an uptodate in the management of polycystic ovary syndrome. European Journal Of Obstetrics & Gynecology And Reproductive Biology, 207, 214-219. http://dx.doi.org/10.1016/j.ejogrb.2016.08.026

Palomba, S., Santagni, S., Falbo, A., & Lasala, G. B. (2015). Complications and challenges associated with polycystic ovary syndrome: current perspectives. International Journal Of Women'S Health, 745-763. http://dx.doi.org/10.2147/ijwh.s70314

Ramoglu, S., Yoldemir, T., Atasayan, K., & Yavuz, D. G. (2017). Does cardiovascular risk vary according to the criteria for a diagnosis of polycystic ovary syndrome?. Journal Of Obstetrics And Gynaecology Research, 43(12), 1848-1854. http://dx.doi.org/10.1111/jog.13455

Rissanen, A. P. E., Koskela-Koivisto, T., Hägglund, H., Koponen, A. S., Aho, J. M., Pöyhönen-Alho, M., Tiitinen, A., Tikkanen, H. O., & Peltonen, J. E. (2016). Altered cardiorespiratory response to exercise in overweight and obese women with polycystic ovary syndrome. Physiological Reports, 4(4), 12719. http://dx.doi.org/10.14814/phy2.12719

Sanchez-Garrido, M. A., & Tena-Sempere, M. (2020). Metabolic dysfunction in polycystic ovary syndrome: pathogenic role of androgen excess and potential therapeutic strategies. Molecular metabolism, 35, 100937. http://dx.doi.org/10.1016/j.molmet.2020.01.001

Siqueira, A. S. E., Siqueira-Filho, A. G., & Land, M. G. P. (2017). Analysis of the Economic Impact of Cardiovascular Diseases in the Last Five Years in Brazil. Arquivos Brasileiros de Cardiologia, 109(1), 39-46. http://dx.doi.org/10.5935/abc.20170068

Sirmans, S. M., Pate, & K. A. (2013). Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clinical epidemiology, 6, 1-13.

https://doi.org/10.2147/CLEP.S37559

Sousa, R. M. L., Chein, M. B. C., Silva, D. S. M., Dutra, M. B., Navarro, P. A. A. S., Neto, J. A. F., & Brito, L. M. O. (2013). Perfil metabólico em mulheres de diferentes índices de massa corporal com síndrome dos ovários policísticos. Revista Brasileira de Ginecologia e Obstetrícia, 35(9), 413-420. http://dx.doi.org/10.1590/s0100-72032013000900006

Techatraisak, K., Wongmeerit, K., Dangrat, C., Wongwananuruk, T., & Indhavivadhana, S. Measures of body adiposity and visceral adiposity index as predictors of metabolic syndrome among Thai women with PCOS. (2016). Gynecological Endocrinology, 32(4), 276-280. http://dx.doi.org/10.3109/09513590.2015.1112785

Teede, H., Misso, M., Costello, M., Dokras, A., Laven, J., Moran, L., Piltonen, T., & Norman, R. (2018). International evidence based guideline for the assessment and management of polycystic ovary syndrome. The Australian National Health and Medical Research Council. https://www.monash.edu/__data/assets/pdf_file/0004/1412644/PCOS_Evidence-Based-Guidelines_20181009.pdf

Tosi, F., Sarra, D., Kaufman, J. M., Bonin, C., Moretta, R., Bonora, E., Zanolin, E., Moghetti, P. (2015). Total body fat and central fat mass independently predict insulin resistance but not hyperandrogenemia in women with polycystic ovary syndrome. The Journal Of Clinical Endocrinology & Metabolism, 100(2), 661-669. http://dx.doi.org/10.1210/jc.2014-2786

World Health Organization. (2000). Obesity: preventing and managing the global epidemic: Report of a World Health Organization consultation.

https://apps.who.int/iris/handle/10665/42330

Published

12/04/2021

How to Cite

COELHO, R. S.; SILVA, T. V. N. da .; NERIS , V. A. .; MAIO, R. .; CAVALCANTI, R. de A. S. .; BURGOS, M. G. P. de A. . Excess of weight and antropometric variables of cardiovascular risk in patients with polycystic ovary syndrome . Research, Society and Development, [S. l.], v. 10, n. 4, p. e34110414230, 2021. DOI: 10.33448/rsd-v10i4.14230. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/14230. Acesso em: 12 nov. 2024.

Issue

Section

Health Sciences