Total phenolic content and antioxidant and anticholinesterase activities of medicinal plants from the State’s Cocó Park (Fortaleza-CE, Brazil)
DOI:
https://doi.org/10.33448/rsd-v10i5.14493Keywords:
Cocó State Park; Medicinal plants; Antioxidant activity; Anticholinesterase activity.Abstract
The State’s Cocó Park in the city of Fortaleza-CE present mainly a mangrove flora and include landscape and medicinal plants. The aim of this study is determining the total phenol content, antioxidant activity against the free radical DPPH and the inhibition of the enzyme acetylcholinesterase (AChE) in ethanolic extracts of 30 medicinal plants and thus assess which plants have potential against Alzheimer's Disease. The plants rich in phenolic compounds with amounts ranging from 297.46 ± 26.94 to 599.30 ± 17.08 mg GAE/g plant extract, which showed greater antioxidant activities (with IC50 against DPPH radical from 3.44 ± 0.16 to 3.73 ± 0.12 µg mL-1) and higher acetylcholinesterase inhibiting power (IC50 < 20 μg mL-1) were Anacardium occidentale, Ceiba pentandraLaguncularia racemosa, Mangifera indica, Myracrodrum urundeuva and Terminalia catappa. Then, these species and their constituents are recommended for more specific studies related to Alzheimer´s Disease.
References
Achkar, M. T., Novaes, G. M., Silva, M. J. D., & Vilegas, W. (2013). Propriedade antioxidante de compostos fenólicos: Importância na dieta e na conservação de alimentos. Revista da Universidade Vale do Rio Verde, 11(2), 398-406. http://dx.doi.org/10.5892/ruvrd.v11i2.398406
Agra, M. F., Silva, K. N., Basílio, I. J. L. D., Freitas, P. F., & Barbosa-Filho, J. M. (2008). Survey of medicinal plants used in the region Northeast of Brazil. Revista Brasileira de Farmacognosia, 18(3), 472-508. https://dx.doi.org/10.1590/S0102-695X2008000300023
Aja, P. M., Nwachukwu, N., Ibiam, U. A., Igwenyi, I. O., Offor, C. E., & Orji, U.O. (2014). Chemical constituents of Moringa oleifera leaves and seeds from Abakaliki, Nigeria. American Journal of Phytomedicine and Clinical Therapeutics, 2(3), 310-321. https://www.imedpub.com/articles/chemical-constituents-of-moringa-oleiferaleaves-and-seeds-from-abakaliki-nigeria.pdf
Akram, M., & Nawaz, A. (2017). Effects of medicinal plants on Alzheimer's disease and memory deficits. Neural Regeneration Research, 12(4), 660-670. http://dx.doi.org/10.4103/1673-5374.205108
Al-Barazie, R. M., Bashir, G. H., Qureshi, M. M., Mohamed, Y. A., Al-Sbiei, A., Tariq, S., Lammers, W. J., Al-Ramadi, B. K., & Fernandez-Cabezudo M. J. (2018). Cholinergic activation enhances resistance to oral Salmonella infection by modulating innate immune defense mechanisms at the intestinal barrier. Frontiers in immunology, 9(19), 551. https://doi.org/10.3389/fimmu.2018.00551
Araújo, C. R. M., Santos, V. L. A., & Gonsalves, A. A. (2016). Acetylcholinesterase - AChE: a pharmacological interesting enzyme. Revista Virtual de Química 8(6), 1818-1834. http://dx.doi.org/10.21577/1984-6835.20160122
Bandaranayake, W. M. (2002). Bioactivities, bioactive compounds and chemical constituents of mangrove plants. Wetlands Ecology and Management, 10(6), 421-452. http://dx.doi.org/10.1023/A:1021397624349
Barbosa, F. G., Lima, M. A. S., Braz-Filho, R. & Silveira, E. R. (2006). Iridoid and phenylethanoid glycosides from Lippia alba. Biochemical Systematics and Ecology, 34(11), 819-821. http://dx.doi.org/10.1016/j.bse.2006.06.006
Bigueti, B. C. P., Lellis, J. Z. & Dias, J. C. R. (2018). Essential nutrients in the prevention of Alzheimer's disease. Revista Ciências Nutricionais Online, 2(2), 18-25. https://www.unifafibe.com.br/revistasonline/arquivos/cienciasnutricionaisonline/sumario/62/13042018180525.pdf
Cartaxo-Furtado, N. A. D. E. O., Sampaio, T. O., Xavier, M. A., Medeiros, A. D. D. E. & Pereira, J. V. (2015). Phytochemical profile and determination of the antimicrobial activity of Syzygium cumini (L.) Skeels (Myrtaceae) against oral microorganisms. Revista Brasileira de Plantas Medicinais, 17(43), 1091-1096. https://dx.doi.org/10.1590/1983-084x/14_153
Castro, M. A. de, Bonilla, O. H., Pantoja, L. D. M., Mendes, R. M. S., Edson-Chaves, B. & Lucena, E. M. P. de (2021). Research, Society and Development, v. 10, n. 3, e8910313008. DOI: 10.33448/rsd-v10i3.13008.
Cochrane, C. B., Nair, P., Raveendran, K., Melnick, S. J., Resek, A. P., & Ramachandran, C. (2008). Anticancer effects of Annona glabra plant extracts in human leukemia cell lines. Anticancer Research, 28(1), 965-972. https://ar.iiarjournals.org/content/anticanres/28/2A/965.full.pdf
Cruz, M. P., Andrade, C. M. F., Silva, K. O., Souza, E. P., Yatsuda, R., & Marques, L. M. (2016). Antinoceptive and anti-inflammatory activities of the ethanolic extract, fractions and flavones isolated from Mimosa tenuiflora (Willd.) Poir (Leguminosae). Plos One, 11(3), e0150839. http://dx.doi.org/10.1371/journal.pone.0150839
Ellman, G. L., Courtney, K. D., Andres, V. J., & Featherstone, R. M. (1961). A new and rapid colorimetric of acetylcholinesterase determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2), 88–95. https://dx.doi.org/10.1016/0006-2952(61)90145-9
Falco, A., Cukierman, D. S., Hauser-Davis, R. A., & Rey, N. A. (2016). Alzheimer's disease: etiological hypotheses and treatment perspectives: Etiological hypotheses and treatment perspectives. Química Nova, 39(1), 63-80. http://dx.doi.org/10.5935/0100-4042.20150152
Fonseca Filho, I. C., Bomfim, B. L. S., Farias, J. C., Vieira, F. J., & Barros, R. F. M. (2017). Pau-d’arco-roxo (Handroanthus Impetiginosus (Mart. Ex Dc.) Mattos): Conhecimento e uso madeireiro em comunidades rurais do nordeste do Brasil. Gaia Scientia, 11(2), 57-70. https://dx.doi.org/10.22478/ufpb.1981-1268.2017v11n2.34878
França, F. V. (2017). Phytochemical study and antioxidant activity of ethanol extract from Genipa americana. Revista Mundi Saúde e Biológicas, 2(2), 1-12. http://dx.doi.org/10.21575/25254766msb2017vol2n2393
Freitas, R. F., Lima, P. R. A., Pimentel, M. A., & Queiroz, P. R. (2018). Phytochemical profile, microbiological assay and toxicity against saline artemia from Myracrodruon urundeuva. Biota Amazônia, 8(3), 24-27. http://dx.doi.org/10.18561/2179-5746/biotaamazonia.v8n3p24-27
Guarim Neto, G., Santana, S.R., & Silva, J. V. B. (2003). Botanical repertoire of “Pitombeira” (Talisia esculenta (A. St.-Hil.) Radlk. – Sapindaceae). Acta Amazônica, 33(2), 237-242. https://dx.doi.org/10.1590/1809-4392200332242
Guimarães, I. P., Coelho, M. F. B., Azevedo, & R. A. B. (2013). Pau Branco (Cordia oncocalyx Allemão) - Boraginaceae: Endemic tree of the Caatinga. Revista Verde de Agroecologia e Desenvolvimento Sustentável, 8(5), 31-39. https://www.gvaa.com.br/revista/index.php/RVADS/article/view/2114
Kobayashi, Y. T. S., Almeida, V. T., Bandeira, T., Alcântara, B. N., Silva, A. S. B., Barbosa, W. L. R., Silva, P. B., Monteiro, M. V. B., & Almeida, M. B. (2015). Phytochemical evaluation and healing potential of the ethanolic extract of the fruits of Jucá (Libidibia ferrea) in winstar rats. Brazilian Journal of Veterinary Research and Animal Science, 52(1), 34-40. https://dx.doi.org/10.11606/issn.1678-4456.v52i1p34-40
Kumar, C. S., Naresh, G., Sudheer, V., & Veldi, N. (2011). A short review on therapeutic uses of Couroupita guianensis Aubl. International Research Journal of Pharmaceutical and Applied Sciences, 1(1), 105-108. https://scienztech.org/irjpas/article/view/281/224
Kumbhare, M. R., Sivakumar, T., Udavant, P. B., Dhake, A. S., & Surana, A. R. (2012). In vitro antioxidant activity, phytochemical screening, cytotoxicity and total phenolic content in extracts of Caesalpinia pulcherrima (Caesalpiniaceae) pods. Pakistan Journal of Biological Sciences, 15(7), 325-332. https://dx.doi. org/10.3923/pjbs.2012.325.332
Loganayaki, N., Siddhuraju, P., & Manian, S. (2013). Antioxidant activity and free radical scavenging capacity of phenolic extracts from Helicteres isora L. and Ceiba pentandra L. Journal of Food Science and Technology, 50(4), 687-695. https://dx.doi.org/10.1007/s13197-011-0389-x
López, R. E. S., & Santos, B. C. (2015). Bauhinia forficata Link (Fabaceae). Revista Fitos, 9(3), 161-252. https://dx.doi.org/10.5935/2446-4775.20150018
Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 13, 757–772. https://dx.doi.org/10.2147/CIA.S158513
Matos, F. J. A. (2009). Introdução à fitoquímica experimental (3. ed.). Edições UFC.
Morais, S. M., Lima, K. S. B., Siqueira, S. M. C., Cavalcanti, E. S. B., Souza, M. S. T., Menezes, J. E. S. A., & Trevisan, M. T. S. (2013). Correlation between antiradical, anti-acetylcholinesterase activities and total phenol content of medicinal plant extracts from live pharmacies. Revista Brasileira de Plantas Medicinais, 15(4), 575-582. https://dx.doi.org/10.1590/S1516-05722013000400014
Orsi, P. R., Bonamin, F., Severi, J. A., Santos, R. C., Vilegas, W., Hiruma-Lima, C. A., & Stasi, L. C. D. (2012). Hymenaea stigonocarpa Mart. Ex Hayne: A Brazilian medicinal plant with gastric and duodenal anti-ulcer and antidiarrheal effects in experimental rodent models. Journal of Ethnopharmacology, 143(1), 81-90. https://dx.doi.org/10.1016/j.jep.2012.06.001
Palumbo, C. F. G., Gardin, N. E., & Nakamura, M. U. (2015). Erythrina mulungu Mart. Ex Benth and Erythrina velutina Willd. – Pharmacological aspects and anthroposophical perspective of Brazilian plants. Arte Médica Ampliada, 36(4), 152-161. http://abmanacional.com.br/wp-content/uploads/2017/06/36-4-Erythrina-mulungu-e-Erythrina-velutina.pdf
Parque Ecológico do rio Cocó. (2010) https://www.semace.ce.gov.br/2010/12/08/paque-ecologico-do-rio-coco/ Access 14/04/2021
Parvez, G. M. M. (2016). Pharmacological activities of mango (Mangifera indica): A review. Journal of Pharmacognosy and Phytochemistry, 5(3), 1-7. https://www.phytojournal.com/archives/2016/vol5issue3/PartA/5-2-21-518.pdf
Patel, S. S., Raghuwanshi, R., Masood, M., Acharya, A., & Jain, S. K. (2018). Medicinal plants with acetylcholinesterase inhibitory activity. Reviews in the Neurosciences, 29(5), 491-529. https://dx.doi.org/10.1515/revneuro-2017-0054
Penido, A. B., Morais, S. M., Ribeiro, A. B., Alves, D. R., Rodrigues, A. L. M., Santos, L. H., & Menezes, J. E. S. A. (2017). Medicinal plants from northeastern Brazil against Alzheimer’s disease. Evidence-Based Complementary and Alternative Medicine, 1, 1753673. https://dx.doi.org/10.1155/2017/1753673
Pereira, G. A., Araujo, N. M. P., Arruda, H. S., Farias, D. P., Molina, G., & Pastore, G. M. (2019). Phytochemicals and biological activities of Mutamba (Guazuma ulmifolia Lam.): A review. Food Research International, 126, 108713. https://dx.doi.org/10.1016/j.foodres.2019.108713
Phaniendra, A., Jestadi, D. B., & Periyasamy, L. (2014). Free radicals: Properties, sources, targets, and their implication in various diseases. Indian Journal of Clinical Biochemistry, 30(1), 11-26. https://dx.doi.org/10.1007/s12291-014-0446-0
Rodrigues, A., Guimarães, D., Konno, T., Tinoco, L., Barth, T., Aguiar, F., Lopes, N., Leal, I., Raimundo, J., & Muzitano, M. (2017). Phytochemical study of Tapirira guianensis leaves guided by vasodilatory and antioxidant activities. Molecules, 22(2), 304-316. https://dx.doi.org/10.3390/molecules22020304
Santos, T. C., Gomes, T. M., Pinto, B. A. S., Camara, A. L., & Paes, A. M. A. (2018). Naturally occurring acetylcholinesterase inhibitors and their potential use for Alzheimer's disease therapy. Frontiers in Pharmacology, 9, 1192. https://dx.doi.org/10.3389/fphar.2018.01192
Sharma, P., Patil, D., Patil, A. (2013). Crateva tapia Linn. - an important medicinal plant: A review of its traditional uses, phytochemistry and pharmacologiccal properties. International Journal of Pharmaceutical Sciences and Research, 4(2), 582-589. http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).582-89
Silva, A. E. S., & Almeida, S. S. M. S. (2013). Análise fitoquímica das cascas do caule do cajueiro (Anacardium occidentale L. – Anacardiaceae)
Estação Científica (Unifap), 3(2), 81-88. https://periodicos.unifap.br/index.php/estacao/article/view/1169/annav3n2.pdf
Silva, F. D. B., Sales, M. A. G., Sá, O. R. M., Santana, G. M., Deus, M. S. M., Sousa, J. M. C. E., Ferreira, P. M. P., & Peron, A. P. (2015). Cytotoxic, genotoxic and cytoprotective potential of aqueous extracts from Caesalpinia pyramidalis Tul., Caesalpinia ferrea Mart. and Caesalpinia pulcherrima Sw. Revista Brasileira de Biociências, 13(2), 101-109. http://www.ufrgs.br/seerbio/ojs/index.php/rbb/article/view/3252/1279
Silva, G. A., Brito, N. J. N., Santos, E. C. G., López, J. A., & Almeida, M. G. (2014). Spondias genus: botanical aspects, chemical composition and pharmacological potential. Revista de Biologia, Farmácia e Manejo Agrícola, 10(1), 27-41.
Silva, L. P., Angelis, C. D., Bonamin, F., Kushima, H., Mininel, F. J., Santos, L. C., Delella, F. K., Felisbino, S. L., Vilegas, W., & Rocha, L. R. M. (2015). Terminalia catappa L.: A medicinal plant from the caribbean pharmacopeia with anti-helicobacter pylori and antiulcer action in experimental rodent models. Journal of Ethnopharmacology, 15(159), 285-295. http://dx.doi.org/10.1016/j.jep.2014.11.025
Silva, M. L. C., Costa, R. S., Santana, A. S., & Koblitz, M. G. B. (2010). Phenolic compounds, carotenoids and antioxidant activity in plant products. Semina: Ciências Agrárias, 31(3), 669-682. http://dx.doi.org/10.5433/1679-0359.2010v31n3p669
Silva, T. C. L., Almeida, C. C. B. R., Veras Filho, J., Peixoto Sobrinho, T. J. S., Amorim, E. L. C., Costa, E. P., & Araújo, J. M. (2011). Antioxidant and antimicrobial activities of Ziziphus joazeiro Mart. (Rhamnaceae): Comparative evaluation between bark and leaves. Journal of Basic and Applied Pharmaceutical Sciences, 2(32), 193-199. https://rcfba.fcfar.unesp.br/index.php/ojs/article/view/344/342
Silva, A. F. L. da & Barros, L. A. A. (2021). Evaluation of practices for the use of medicinal plants in the City of Caxias-MA. Research, Society and Development, [S. l.], v. 10, n. 4, p. e10010413832, 2021. DOI: 10.33448/rsd-v10i4.13832.
Sousa, C. M. M., Silva, H. R., Vieira-Júnior, G. M., Ayres, M. C. C., Costa, C. L. S., Araújo, D. S., Cavalcanti, L. C. D., Barros, E. D. S., Araújo, P. B. M., Brandão, M. S., & Chaves, M. H. (2007). Total phenolics and antioxidant activity of five medicinal plants. Química Nova, 30(2), 351-355. https://dx.doi.org/10. 1590/S0100-40422007000200021
Sousa, É. N. C. & Santos, S. A. (2016). O processo de implantação do Parque Estadual do Cocó, Fortaleza (CE): conflitos e perspectivas. Revista de Geociências do Nordeste, 2, 781-790. https://periodicos.ufrn.br/revistadoregne/article/view/10526
Souza, D. O., Tintino, S. R., Figueiredo, F. G., Borges, M. C. M., Braga, M. F. B. M., Felipe, C. F. B., Costa, J. G. M., Coutinho, H. D. M., Menezes, I. R. A., & Kerntopf, M. R. (2014). Antibacterial and modulating activity of Cecropia pachystachya Trécul on the action of aminoglycosides. Revista Cubana de Plantas Medicinales, 19(1), 121-132. https://www.medigraphic.com/pdfs/revcubplamed/cpm-2014/cpm143a.pdf
Souza, R. K. D., Mendonça, A. C. A. M., & Silva, M. A. P. (2013). Ethnobotanical, phytochemical and pharmacological aspects of Rubiaceae species in Brazil. Revista Cubana de Plantas Medicinales, 18(1), 140-156. https://www.medigraphic.com/pdfs/revcubplamed/cpm-2013/cpm131p.pdf
Souza, R. O. S., Assreuy, A. M. S., Madeira, J. C., Chagas, F. D. S., Parreiras, L. A., Santos, G. R. C., Mourão, P. A. S., & Pereira, M. G. (2015). Purified polysaccharides of Geoffroea spinosa barks have anticoagulant and antithrombotic activities devoid of hemorrhagic risks. Carbohydrate Polymers, 124, 208-215. https://dx.doi.org/10.1016/j.carbpol.2015.01.069
Tabet, N. (2006). Acetylcholinesterase inhibitors for Alzheimer’s disease: Anti-inflammatories in acetylcholine clothing. Age and Ageing, 35(4), 336-338. https://dx.doi.org/10.1093/ageing/afl 027
Trevisan, M. T. S., Macedo, F. V. V., Van De Meent, M. H. M., Rhee I. K., & Verpoorte, R. (2003). Seleção de plantas com atividade anticolinesterase para tratamento da doença de Alzheimer. Química Nova. 26(3), 301-304. https://dx.doi.org/10.1590/S0100-40422003000300002
Tungmunnithum, D., Thongboonyou, A., Pholboon, A., & Yangsabai, A. (2018). Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: An overview. Medicines, 5(3), 93. https://dx.doi.org/10.3390/medicines5030093
Valente, T., Hidalgo, J., Bolea, I., Ramirez, B., Anglès, N., Reguant, J., Morelló, J., Gutiérrez, C., & Boada, M. (2009). A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain. Journal of Alzheimer's Disease, 18(4), 849-865. https://dx.doi.org/10.3233/JAD-2009-1188
Yepez, B., Espinosa, M., López, S., & Bolaños, G. (2002). Producing antioxidant fractions from herbaceous matrices by supercritical fluid extraction. Fluid Phase Equilibria, 194(197), 879-884. https://dx.doi.org/10.1016/S0378-3812(01)00707-5
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Selene Maia de Morais; Francisco Flávio da Silva Lopes; Gilson Araújo Fontenele; Marcus Vinícius Ferreira da Silva; Victor Borges Fernandes; Daniela Ribeiro Alves
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
