Advantages of using liposome-encapsulated antibiotics to fight infections caused by enterobacteria




Gram-negative bactéria; Bacterial resistance; Antimicrobials; Nanotechnology.


Introduction: The treatment of diseases caused by enterobacteria is an increasing challenge. This problem results from the inefficiency of antibiotics to fight pathogens or to stimulate phagocytosis of cells of the reticuloendothelial system, mainly against bacteria that install and multiply inside phagocytic cells. Some antibiotics are ineffective at entering cells or have their capacity reduced by the plasma membrane. Thus, the scientific community joins efforts seeking new therapeutic alternatives that overcome these limitations. Liposomes are lipid nanocarriers capable of encapsulating antibiotics, aiming at increasing the specificity of delivery, the concentration of compounds delivered to the site, maintaining the plasma concentration of drugs and protecting the active molecules. Thus, the objective of this review was to describe the main liposomal properties, emphasizing the advantages of using these lipid vesicles to administer antibiotics against infections caused by enterobacteria. Methodology: This is a bibliographic review through searches in national and international electronic databases, selecting articles from 2007 to 2020 using the descriptors: Gram-negative bacteria, bacterial resistance, antimicrobials and nanotechnology. Results: Cationic and furtive liposomes consisting mainly of cholesterol, PEG, phosphatidylcholine and carboxymethyl chitosan encapsulating drugs such as amoxicillin, ciprofloxacin, cloxacillin, vancomycin, azithromycin, amoxicillin, cefepime, gentamicin and cefotaxime have shown antibacterial activity. Liposomes encapsulating drugs such as chloramphenicol, azithromycin, gentamicin and polymyxin B showed greater antibiofilm efficiency compared to enterobacteria when compared to non-encapsulated drugs. Conclusion: The results showed that liposomes have significant therapeutic potential for the treatment of infections caused by enterobacteria.

Author Biographies

Júlio Eduardo Barbosa da Silva, Faculdade São Miguel

Graduando em Biomedicina no Centro Universitário São Miguel. Atualmente é integrante do grupo de pesquisa Microbiologia clínica e Novas Abordagens Terapêuticas (MicroNAT).

Jaqueline Barbosa de Souza, Universidade Federal de Pernambuco

Graduada em Ciências Farmacêuticas pelo Centro Universitário São Miguel. Mestranda pelo Programa de Pós-Graduação em Inovação Terapêutica (PPGIT) da Universidade Federal de Pernambuco (UFPE). Atualmente é integrante do grupo de pesquisa Microbiologia clínica e Novas Abordagens Terapêuticas (MicroNAT).

Daniel Charles dos Santos Macêdo, Universidade Federal de Pernambuco

Graduado em Ciências Farmacêuticas pela Universidade Federal de Pernambuco (UFPE). Mestre pelo Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal de Pernambuco (PPGCF/UFPE). Doutorado pelo PPGCF/UFPE. Atualmente é integrante do grupo de pesquisa Nanotecnologia, Biotecnologia e Cultura de Células (NANOBIOCEL) e do grupo Laboratório de Nanotecnologia Farmacêutica (LNFarm) da UFPE.

Luís André de Almeida Campos, Universidade Federal de Pernambuco

Graduado em Ciências Biológicas pelo Centro Acadêmico de Vitória da Universidade Federal de Pernambuco (CAV/UFPE). Mestre pelo Programa de Pós-graduação em Biologia Aplicada a Saúde da Universidade Federal de Pernambuco (PPGBAS/UFPE). Doutorando pelo Programa de Pós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco (PPGCB/UFPE). Atualmente, é integra os grupos de pesquisa Microbiologia clínica e Novas Abordagens Terapêuticas (MicroNAT) e do grupo Laboratório de Nanotecnologia Farmacêutica (LNFarm) da UFPE. 

Isabella Macário Ferro Cavalcanti, Universidade Federal de Pernambuco

Graduada em Biomedicina pela Universidade Federal de Pernambuco (UFPE). Especialista em Microbiologia Clínica pela Universidade de Pernambuco (UPE). Mestre pelo Programa de Pós-graduação em Inovação Terapêutica da UFPE (PPGIT/UFPE). Doutora pelo Programa de Pós-graduação em Ciências Biológicas da UFPE (PPGCB/UFPE). Professora Associada I das disciplinas de Microbiologia, Imunologia e Exames Laboratoriais no Centro Acadêmico de Vitória (CAV/UFPE). Membro permanente do Programa de Pós-Graduação de Mestrado Profissional em Ensino de Biologia em Rede Nacional (PROFBIO), conceito 4 da CAPES. Chefe e Pesquisadora do Setor de Microbiologia Clínica do Laboratório de Imunopatologia Keizo Asami da Universidade Federal de Pernambuco (LIKA/UFPE). Membro da Sociedade Brasileira de Microbiologia. Membro do Comitê Científico e Consultivo de Apoio às Ações de Combate ao COVID-19 - CAV/UFPE. Líder do grupo de pesquisa Microbiologia clínica e Novas Abordagens Terapêuticas (MicroNAT).


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How to Cite

SILVA, J. E. B. da .; SOUZA, J. B. de .; MACÊDO, D. C. dos S. .; CAMPOS, L. A. de A. .; CAVALCANTI, I. M. F. Advantages of using liposome-encapsulated antibiotics to fight infections caused by enterobacteria. Research, Society and Development, [S. l.], v. 10, n. 6, p. e15010615439, 2021. DOI: 10.33448/rsd-v10i6.15439. Disponível em: Acesso em: 15 jun. 2021.



Review Article