Vaccine development for cryptosporidiosis: Systematic review




Cryptosporidium spp.; Coccicidiosis; Immunizatio; Zoonosis.


Cryptosporidium spp. are opportunistic parasites with zoonotic potential transmitted by ingestion of contaminated water and food, the infection consists of severe diarrhea leading to the death of babies and immunocompromised individuals. In the veterinary, it can generate economic losses due to the death of calves, these animals being a possible source of transmission of the parasite. Nitazoxanide and halofuginone are the only drugs approved for treatment in humans and calves respectively, however there are restrictions on their use. There is still no vaccine against cryptosporidiosis in humans or animals and its development is a great challenge. Our objective with the present work was to write a systematic review of the literature addressing the progress of studies on vaccines against cryptosporidiosis. The recommended guidelines for RSL were used, with the aid of the StArt software (State of the Art through Systematic Rewiews). The research took place in the databases: Lilacs, PubMed, Scielo, Science Direct, Scopus, Embase and Medline. In 30% of the selected articles, the calves were the study animal and in 50% the mice; 40% of the studies were with vaccines derived from recombinant proteins and 30% of the research was aimed at inhibiting the parasite from entering cells and activating the host's protective immunity. So far, a vaccine with no proven efficacy or an ideal cost-benefit has been developed. Many candidate antigenic targets for a vaccine have been characterized, in addition to elucidating the immunogenicity mechanism of Cryptosporidium spp. in the infected individual. However, another antigenic targets for a vaccine can be searched in future studies.

Author Biographies

Débora Regina Romualdo da Silva, São Paulo State University (Unesp), School of Veterinary Medicine, Araçatuba

Graduated in Biological Sciences Degree (2018) and Bachelor (2019) from Universidade
Paulista- UNIP. Specialist in Laboratory Surveillance and Public Health (2019), by Instituto
Adolfo Lutz de Araçatuba. Master in Animal Science, (2020) from the Faculty of Veterinary
Medicine, FMVA Unesp - Araçatuba. She is currently a doctoral student in Animal Science, at
the Faculty of Veterinary Medicine - FMVA - Unesp - Araçatuba.

Talita Carolina Bragança de Oliveira, São Paulo State University (Unesp), School of Veterinary Medicine, Araçatuba

Graduated from the Veterinary Medicine course at Universidade Estadual Paulista Júlio de
Mesquita Filho (UNESP), Araçatuba campus. He has a master's degree in Animal Science, with
an emphasis on Preventive Veterinary Medicine and Animal Health, by the same institution.
He was part of the research team related to rural settlements in the region, together with
APTA and ITESP. He is currently a member of the research team at the University of Warwick,
England, working in public health and epidemiology as well as zoonoses. She is a
Veterinary Physician at the Family Health Support Center of the Municipality of Araçatuba.

Bárbara Braga Ferreira Marta, São Paulo State University (Unesp), School of Veterinary Medicine, Araçatuba

Graduated in Biomedicine from Universidade Paulista - UNIP, Araçatuba - SP (2014),
with specialization in Microbiology from Universidade do Oeste Paulista - UNOESTE (2017).
He is currently Technical Director I of the Nucleus of Chemical and Bromatological Sciences
of the Regional Laboratory Center of Araçatuba - Adolfo Lutz Institute and master's student
of the Postgraduate Program in Animal Science at the Faculty of Veterinary Medicine, UNESP,


Carolina Beatriz Baptista, São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal

Egresado de la carrera de Medicina Veterinaria de Unisalesiano - Araçatuba (2016)
Actualmente tiene una maestría en Ciencia Animal, con énfasis en Medicina Veterinaria
Preventiva y Sanidad Animal, de la Universidade Estadual Paulista Júlio de Mesquita Filho
(UNESP), campus de Araçatuba.

Maria Cecília Zonetti Bottaro, São Paulo State University (Unesp), School of Veterinary Medicine, Araçatuba

Graduated in Veterinary Medicine from Universidade Estadual Paulista Júlio de
Mesquita Filho (2017). Has experience in Veterinary Medicine, with emphasis on
Animal Clinic and Surgery. Currently holds a master's degree in Animal Science, with
an emphasis on Preventive Veterinary Medicine and Animal Health, from Universidade Estadual
Paulista Júlio de Mesquita Filho (UNESP), Araçatuba.

Katia Denise Saraiva Bresciani , São Paulo State University (Unesp), School of Veterinary Medicine, Araçatuba

Veterinary Medicine Course at the Faculty of Veterinary Medicine and Animal Science (FMVZ) -
UNESP - Botucatu, São Paulo, Brazil (1992); Master in Animal Pathology (1997) and PhD in
Preventive Veterinary Medicine (2003) at the Faculty of Agricultural and Veterinary Sciences
(FCAV) - UNESP - Jaboticabal, SP, Brazil; Post-Doctorate in Parasitology at the Botucatu
Biosciences Institute (2006); Post-Doctorate in Scientific Writing at the Institute of
Education of the University of Lisbon, Portugal and the BiocIências Institute of Botucatu
(2013-2014); Scientific Reviewer of twelve journals. Professional Master Coach by the
Latin American Society of Coaching. Free Teaching in the Discipline of Parasitic Diseases
of Animals at the Faculty of Veterinary Medicine (FMVA), UNESP, Araçatuba, SP since 2011.
Leader of the research group: "Parasitology and Parasitic Diseases of Animals" and
participant in the groups: "Epidemiology and disease control domestic animal parasites
"and" Etiopathogenesis, Epidemiology and Control of Animal Coccidiosis ". Professor of the
Postgraduate Program in Animal Science, Concentration in Preventive Veterinary Medicine
and Animal Production at FMVA, UNESP, Araçatuba, SP and in the Postgraduate Course in
Veterinary Medicine, Concentration in Preventive Veterinary Medicine at FCAV, UNESP,
Jaboticabal, SP. Research Productivity Scholarship PQ2


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How to Cite

SILVA, D. R. R. da .; OLIVEIRA, T. C. B. de .; MARTA, B. B. F. .; BAPTISTA, C. B.; BOTTARO, M. C. Z. .; BRESCIANI , K. D. S. . Vaccine development for cryptosporidiosis: Systematic review. Research, Society and Development, [S. l.], v. 10, n. 6, p. e18910615540, 2021. DOI: 10.33448/rsd-v10i6.15540. Disponível em: Acesso em: 22 jul. 2024.



Review Article