Plasma selenium and its relation to cardiovascular risk parameters in obese women
DOI:
https://doi.org/10.33448/rsd-v8i12.1734Keywords:
Nutritional deficiencies; Chronic diseases; Lipid MetabolismAbstract
The present study aims to evaluate the relationship between selenium plasma concentration and cardiovascular risk in obese women. This is a case-control study, involving 67 women, aged between 20 and 50 years, and divided into two groups: control group (eutrophic women, n = 42) and case group (obese women n = 25). Plasma selenium and lipid profile (total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol) were analyzed. Data were analyzed using the SPSS for Windows 22.0 statistical program. The project was approved by the Research Ethics Committee of the Federal University of Piauí, under opinion number 2.014.100. Regarding the results, lower concentrations of plasma selenium were observed for the obese group, with a statistically significant difference between the groups (p <0.001). At the same time, higher concentrations of total cholesterol, HDL-cholesterol, LDL-cholesterol, and Castelli I and II indices were found among obese women compared with eutrophic women, with a statistically significant difference (p <0.05). For the result of the correlation analysis between the variables, it was found that there was a moderate negative correlation between plasma selenium, total cholesterol and LDL-cholesterol (p <0.05). Before the results obtained, the study shows the likely influence of selenium on lipid profile parameters and, consequently, on the reduction of cardiovascular risk, such as the inverse relationship evidenced between plasma mineral concentration, total cholesterol and LDL-cholesterol.References
Alasfar, F.; Ben- Nakhi, M.; Khoursheed, M.; Kehinde, E. O. & Alsaleh, M. (2011). Selenium is significantly depleted among morbidly obese female patients seeking bariatric surgery. Obes Surg. 21(11), 1710-1713.
Azab, S. F. A.; Saleh, S. H.; Elsaeed, W. F.; Elshafie, M.A.; Laila M Sherief, L. M. & Esh, A. M. H. (2014). Serum trace elements in obese Egyptian children: a case-control study. Ital J Pediatr. 20(40)20.
Bahmani, F., Kia, M., Soleimani, A., Mohammadi, A.A. & Asemi Z (2016). The effects of selenium supplementation on biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy: a randomised, double-blind, placebo-controlled trial. Br J Nutr.; 116(7):1222-1228.
Barroso, T. A.; Marins, L. B.; Alves, R.; Gonçalves, A. C. S.; Barroso, S. G. & Rocha, G. S. (2017). Associação Entre a Obesidade Central e a Incidência de Doenças e Fatores de Risco Cardiovascular. Int. J. Cardiovasc. Sci. Rio de Janeiro, 30(5), 416-424.
Błażewicz, A., Klatka, M., Astel, A., Korona-Glowniak, I., Dolliver, W., Szwerc, W., Kocjan, R. (2015) Serum and urinary selenium levels in obese children: a cross-sectional study. J Trace Elem Med Biol. 29:116-22.
Bleys J., Navas-Acien A., Stranges S., Menke A., Miller E. & Guallar E. (2008). Serum selenium and serum lipids in us adults. Am J Clin Nutr. 88(2).
Brasil. Ministério da Saúde. (2012) Resolução nº466/12. Conselho Nacional de Pesquisa com Seres Humanos. Diário Oficial da União. Brasília.
Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. (2004). Vigilância alimentar e nutricional - Sisvan: Orientações básicas para a coleta, processamento, análise de dados e informação em serviços de saúde. Brasília: Ministério da Saúde.
Brasil. (2018). Vigitel Brasil: vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico. Brasília.
Carvalho, C. A. de; Fonseca, P.; C.; Barbosa, J. B.; Machado, S. P.; Santos, A. M. dos & Silva, A. A. M. da. (2015). Associação entre fatores de risco cardiovascular e indicadores antropométricos de obesidade em universitários de São Luís, Maranhão, Brasil. Ciênc. saúde coletiva, Rio de Janeiro. 20(2), 479-490.
Castelli, W.P.; Abbot, W.D. & Mcnamara, P.M. (1983). Summary estimates of cholesterol used to predict coronary heart disease. Circulation, 67, 730-4.
Cobayashi, F., Oliveira, F.L.C, Escrivão, M.A.M.S, Silveira, D. & Taddei, J.A.A.C. (2010). Obesidade e fatores de risco cardiovascular em adolescentes de escolas públicas. Arq. Bras. Cardiol., São Paulo, 95(2), 200-206.
Cominetti, C.; Bortoli, M.C.; Garrido, A.B. & Cozzolino, S.M. (2012). Brazil nut consumption improves selenium status and glutathione peroxidase activity and reduces atherogenic risk in obese women. Nutrition Research, 32, 403-407.
Cruz, K. J. C.; Oliveira, A. R. S.; Morais, J. B. S.; Severo, J. S.; Beserra, J. B.; Santos, L. R.; Colli, C.; Almendra, B. J. S. & Marreiro, D. N. (2018). Relationship between magnesium status and cardiovascular risk in obese women. Nutrition Clinique et Métabolisme. 32(1), 22-26.
Damms-Machado, A.; Weser, G. & Bischoff, S. C. (2012). Micronutrient deficiency in obese subjects undergoing low calorie diet. Nutr J. 11, 34.
Dhingra, S. & Bansal, M.P. (2006). Modulation of hypercholesterolemia-induced alterations in apolipoprotein B and HMG-CoA reductase expression by selenium supplementation. Chem Biol Interact. 161, 49–56.
Faghihi, T., Radfar, M., Barmal, M., Amini, P., Qorbani, M., Abdollahi, M., Larijani, B. (2014). A randomized, placebo-controlled trial of selenium supplementation in patients with type 2 diabetes: effects on glucose homeostasis, oxidative stress, and lipid profile. Am J Ther. 21(6):491-5.
Faludi, A.A.; Izar, M.C.O.; Saraiva, J.F.K.; Chacra, A.P.M.; Bianco, H.T.; Afiune Neto, A. et al. (2017). Atualização da diretriz brasileira de dislipidemias e prevenção da aterosclerose. Arq Bras Cardiol, 109(2), 1-76.
Feitosa, M. M. (2016). Estado nutricional relativo ao selênio e sua relação com marcadores do estresse oxidativo em mulheres obesas. Dissertação de mestrado. Teresina, PI.
Harrington, C.F., Walter, A., Nelms, S., Taylor, A. (2014) Removal of the gadolinium interference from the measurement of selenium in human serum by use of collision cell quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS). Ann Clin Biochem. 51(Pt 3):386-91.
Gazolla, F. M.; Bordallo, M. A. N.; Madeira, I. R.; Carvalho, C. N. M.; Collett-Solberg, P. F. & Bordallo, A. P. N. (2014). Fatores de risco cardiovasculares em crianças obesas. Rev. Hospital Universitário Pedro Ernesto.13(1).
Haun, D.R., Pitanga, F.I.G. & Lessa, I. (2009). Razão cintura/estatura comparado a outros indicadores antropométricos de obesidade como preditor de risco coronariano elevado. Rev Assoc Med Bras, 55(6).
Instituto Adolfo Lutz. (1985). Normas analíticas do Instituto Adolfo Lutz. 3. ed. São Paulo,1, 1-533.
Ju, W.; Ji, M.; Li, X.; Wu, L.; Fu, X.; Yang, X. & Gao, X. (2017). Relationship between higher serum selenium level and adverse blood lipid profile, Clinical Nutrition. 37(5), 1512-1517.
Laclaustra, M.; Stranges, S.; Navas-Acien, A.; Ordovas, J.M. & Guallar, E. (2010). Serum selenium and serum lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Atherosclerosis. 210(64).
Lay, S. L., Simard, G.; Martinez, M. C. & Andriantsitohaina, R. (2014). Oxidative stress and metabolic pathologies: from an adipocentric point of view. Oxid Med Cell Longev. 2014, 01-18.
Martitz, J.; Becker, N. P.; Renko, K.; Stoedter, M.; Hybsier, S. & Schomburg, L. (2015). Gene-specific regulation of hepatic selenoprotein expression by interleukin-6. Metallomics. 7(11). 1515-21..
Nolasco, M. P. B. (1995). Diagnóstico Clínico e Laboratorial – Composição Corporal. In: FISBERG, M. Obesidade na Infância e adolescência. São Paulo: Fundação BYK, 28-35.
Ouchi N.; Parker J.; Lugus J. & Walsh K. (2011). Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 11(2), 85-97.
Picon, P. X.; Leitão, C. B.; Gerchman, F.; Azevedo, M. J.; Silveiro, S. P.; Gross, J. L. & Canani, L. H. (2007) Medida da cintura e razão cintura/quadril e identificação de situações de risco cardiovascular: estudo multicêntrico em pacientes com diabetes melito tipo 2. Arq Bras Endocrinol Metab, 51(3)443-49.
Revoredo, C. M. S.; Aguiar, H. D. S. P.; Lima, S. M. T.; Saffnauer, E. S.; Almondes, K. G. S.; Holanda, A. O. N.; Araújo, C. G. B.; Nogueira, N. N. & Marreiro, D. N. (2016). Status do Zinco e sua Relação com Biomarcadores de Risco Cardiovascular. International Journal of Cardiovascular Sciences. 29 (5) 355-361.
Sant Anna Junior, M.; Carneiro, J.R.I.; Carvalhal, R. F.; Torres, D.F.M.; Cruz, G.G.; Quaresma, J. C. V.; Lugon, J. R. & Guimarães, F. S. (2015). Disfunção Autonômica Cardiovascular em Pacientes com Obesidade Mórbida. Arq. Bras. Cardiol. São Paulo, 105(6), 580-587.
Savini, I.; Catani, M. V.; Evangelista, D.; Gasperi, V & Avigliano, L. (2013). Obesity-associated oxidative stress: strategies finalized to improve redox state. Int J Mol Sci. 14(05), 10497-538,.
Su, L.; Gao, S.; Unverzagt, F.W; Cheng, Y.; Hake, A.M; Xin, P.; Chen, C.; Liu, J.; Ma, F.; Bian, J.; Li, P. & Jin, Y. (2015). Selenium Level and Dyslipidemia in Rural Elderly Chinese. PLoS One. 10(9).
Thomson, C. D. (2004). Assessment of requirements for selenium and adequacy of selenium status: a review. Eur J Clin Nutr., 58(3) 391-402.
World Health Organization. (2000). Obesity: Preventing and managing the global epidemic. Technical report series, Geneva, (894), 9.
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