Heart failure associated with anemia: Use of intravenous iron compared to placebo
DOI:
https://doi.org/10.33448/rsd-v10i9.17732Keywords:
Iron deficiency; Iron deficiency anemia; Cardiac insufficiency.; Iron deficiency; Iron deficiency anemia; Cardiac insufficiency.Abstract
Heart failure (HF) is a syndrome in which the heart has its capacity to fill or eject the ventricles decreased. Iron deficiency is commonly associated with HF and has been shown to be a factor of worse prognosis. The aim of this study is to evaluate patients affected by heart failure for intravenous iron supplementation compared to non-supplementation (or placebo). In this systematic review, a bibliographic search was conducted in the electronic databases Virtual Health Library, Capes Journal Portal and SciSearch. The Health Sciences Descriptors (DeCS) Heart Failure, Iron deficiency anemia and Iron Deficiency were used. The GRADE System was used to evaluate the quality of evidence of the articles analyzed, and 11 Randomized Clinical Studies covering 5 nationalities were included. Symptomatic patients diagnosed with HF associated with Ironpriva Anemia showed improvements in primary outcomes on the global self-assessment scale and in the New York Heart Association (NYHA) functional class when receiving intravenous iron replacement when compared to those receiving placebo. In addition, there were no significant improvements in patients regarding oral iron treatment. Thus, it is concluded that anemia has important repercussions for patients affected by HF, being related to a worse prognosis. Therefore, intravenous iron supplementation is necessary to improve symptoms and quality of life, and should be monitored by specialists due to the possible adverse reactions that may appear.
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Copyright (c) 2021 Caroline Melo de Sousa; Heloisa da Silva Araújo; Lais Pinheiro Frutuoso; Maria Cândida Alencar da Silveira; Germana Lacerda Linhares; Milena Nunes Alves de Sousa; Tiago Bruno Carneiro de Farias
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