ECMO treatment on patients with respiratory failure because of COVID-19 and improvement of the clinical condition
DOI:
https://doi.org/10.33448/rsd-v10i9.17758Keywords:
ECMO treatment; Extracorporeal membrane oxygenation; Respiratory failure; COVID-19; Clinic efficacy.Abstract
Extracorporeal membrane oxygenation (ECMO) has been widely used in patients with severe respiratory failure caused by the new coronavirus (COVID-19). In those people, the pulmonary interstice is occupied by cells and inflammatory substances, which impairs gas exchange and causes hypoxemia. The ECMO treatment consists of boosting the blood of the person through a cannula to an artificial membrane capable of oxygenating it, which is then able to return to the body. The present study aimed to identify, on patients with respiratory failure due to COVID-19, whether the ECMO treatment compared to standard therapy provides improvements in the clinical condition. A systematic review of the literature was conducted in May 2021. The research was done in two databases: PubMed and BVS. From the resulting articles, 7 were selected because they fit the research criteria. From the analysis of the results, it was found that ECMO treatment is able to reduce the mortality of patients with severe respiratory failure when compared to other treatments. When used, this resource proved to be able to reduce the amount of inflammatory substances and the storm of cytokines, thus enabling improvement in the oxygen supply to vital organs and avoiding lung injuries resulting from mechanical damage. In addition, when used in conjunction with medications, it showed a reduction in inflammation. Therefore, it was perceived that ECMO is a good alternative to patients, but not when used alone. It is necessary to supplement treatment with medications that relieves the symptoms.
References
Abrams, P., Khoury, S., & Grant, A. (2007). Evidence-based medicine overview of the main steps for developing and grading guideline recommendations. Prog Urol, 17(3), 681-4. https://pubmed.ncbi.nlm.nih.gov/17622102/
Dequin, P. F., Heming, N., Meziani, F., Plantefève, G., Voiriot, G., Badié, J., François, B., et al. (2020). Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA, 324(13), 1-9. https://jamanetwork.com/journals/jama/fullarticle/2770276
Dioh, W., Chabane, M., Tourette, C., Azbekyan, A., Morelot-Panzini, C., Hajjar Lins, L. A. M., Nair, G. B., et al. (2020) Testing the efficacy and safety of BIO101, for the prevention of respiratory deterioration, in patients with COVID-19 pneumonia (COVA study): a structured summary of a study protocol for a randomised controlled trial. BMC Trials, 22(42). https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04998-5
Dos Santos, S. M., Costa, D. D. N., Santos, F. S., Pereira, R. S., & Santos, E. S. (2016). Cuidado ao paciente em ECMO (Extracorporeal Membrane Oxygenation): um desafio para a enfermagem. Sempesq, 4(4), 64-68. https://eventos.set.edu.br/sempesq/article/view/4028
Grasselli, G., Zangrillo, A., Zanella, A., Antonelli, M., Cabrini, L., Castelli, A., Cereda D., et al. (2020). Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA, 323(16), 1574-1581. https://jamanetwork.com/journals/jama/fullarticle/2764365
Haiduc, A. A., Alom, S., Melamed, N., & Harky, A. (2020). Role of extracorporeal membrane oxygenation in COVID‐19: a systematic review. Journal of Cardiac Surgery, 35(10), 2679-2687. https://pubmed.ncbi.nlm.nih.gov/32717771/
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., et al. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395(10223), 497-506. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext
Jacobs, J. P., Stammers, A. H., Louis, J. S., Hayanga, J. W. A., Firstenberg, M. S., Mongero, L. B., Tesdahl E. A., et al. (2020). Extracorporeal membrane oxygenation in the treatment of severe pulmonary and cardiac compromise in COVID-19: experience with 32 patients. ASAIO J, 66, 722-730. https://pubmed.ncbi.nlm.nih.gov/32317557/
Kon, Z. N., Smith, D. E., Chang, S. H., Goldenberg, R. M., Angel, L. F., Carillo, J. A., Geraci, T. C., et al. (2020). Extracorporeal Membrane Oxygenation Support in Severe COVID-19. The Annals of Thoracic Surgery, 111(2), 537-543. https://pubmed.ncbi.nlm.nih.gov/32687823/
McInnes, M. D., Moher, D., Thombs, B. D., McGrath, T. A., Bossuyt, P. M., Clifford, T., & Willis, B. H. (2018). Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA statement. JAMA, 319(4), 388-396. https://pubmed.ncbi.nlm.nih.gov/29362800/
Munshi, L., Walkey, A., Goligher, E., Pham, T., Uleryk, E. M., & Fan E. (2019). Venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis. Lancet Respir Med, 7, 163-172. https://pubmed.ncbi.nlm.nih.gov/30642776/
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. Santa Maria, RS: UFSM, NTE. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1
Petersen, M. W., Meyhoff, T. S., Helleberg, M., Kjær, M. B. N., Granholm, A., Hjortsø, C. J. S., Jensen, T. S., et al. (2020). Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan. Acta Anestesiológico Scand, 64(9), 1365-1375. https://pubmed.ncbi.nlm.nih.gov/32779728/
Ribeiro, A. P. R. (2020). ECMO A Terapia Que Salva Vidas: Revisão Sistemática. Revista Multidisciplinar e Psicologia, 54(14), 341-356. https://idonline.emnuvens.com.br/id/article/view/2974
Rilinger, J., Kern, W. V., Duerschmied, D., Supady, A., Bode, C., Staudacher, D. L., & Wengenmayer, T. (2020). A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trial. Trials, 21, 470. https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04447-3
Roehrig, S., Hssain, A. A., Shallik, N. A. H., Elsaid, I. M. A., Mustafa, S. F., Smain, O. A. M., Molokhia, A. A., & Lance, M. D. (2020). Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial. Trials, 21(1), 781. https://pubmed.ncbi.nlm.nih.gov/32917259/
Romano, T. G., Mendes, P. V., Park, M., & Costa, E. L. V. (2017). Extracorporeal respiratory support in adult patients. Jornal Brasileiro de Pneumologia [online], 43(1), 60-70. https://www.scielo.br/j/jbpneu/a/xDMfv6JJQfTchN5Hw3QS7jb/abstract/?lang=pt
Shaefi, S., Brenner, S. K., Gupta, S., O’Gara, B. P., Krajewski, M. L., Charytan, D. M., Chaudhry, S. et al. (2021). Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19. Cuidados Intensivos Med, 47, 208-221. https://link.springer.com/article/10.1007/s00134-020-06331-9
Sousa, M. N. A., De Estrela, Y., De C. A., & Bezerra, A. L. D. (2020) Perfil epidemiológico de casos de coronavírus no Estado da Paraíba utilizando o Boletim Epidemiológico local. Informação em Pauta, 5(2), 91-106. http://www.periodicos.ufc.br/informacaoempauta/article/view/44288
Verdejo, C., Vergara-Merino, L., Meza, N., Pérez-Bracchiglione, J., Carvajal-Juliá, N., Madrid, E., Rada. G., & Reyes, M, X, R. (2020). Macrolides for the treatment of COVID-19: a living, systematic review. Medwave, 20(11). https://doi.org/10.5867/medwave.2020.11.8073
Wu, Z., & McGoogan J. M. (2020). Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA, 323 (13), 1239-1242. https://pubmed.ncbi.nlm.nih.gov/32091533/
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Virna Maria Lima Morais de Carvalho; Lana Beatriz de Oliveira Pinho Viana; Andrea Vaz Diniz; Maria Eduarda Minervino Almeida; Divane Hannah Nóbrega de Melo; Dayana Macário Martins; Tiago Bruno Carneiro de Farias; Milena Nunes Alves de Sousa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.