Detection of thiamine deficiency by food record, lactate dosage and arterial blood gases in population samples in the City of Manaus - Amazonas

Authors

DOI:

https://doi.org/10.33448/rsd-v10i10.18579

Keywords:

Thiamine; Hypovitaminosis; Lactate levels; Blood gas analysis; Emergency.

Abstract

Thiamine (vitamin B1) is a water-soluble vitamin, an essential micronutrient, naturally occurring. Humans do not synthesize thiamine, its supply in the human body depends almost entirely on food intake. The lactate dosage is an indirect indicator of thiamine deficiency. This is a clinical study to evaluate the intake of thiamine in patients from the Emergency Room, its relation to the normal feed intake, and indirect measures of activity vitamin B1 according to serum lactate. In a cross-sectional study, 15 patients (GPS) underwent collection of blood lactate, arterial blood gases, usual food recall, verified the underlying disease, symptoms, nosographic data, medications, food intake and alcohol intake. The control group (CG), 22 individuals, was submitted by the usual food recall. From the GPS, the adequacy for dietary intake of thiamine did not show any significant difference with the CG. There was significant correlation between lactate and thiamine (r = -0.60) and between fat intake and thiamin (r = 0.72) but not total energy, carbohydrates and protein. The food intake of the participants (GPS and CG) equipped with a higher frequency of fish, chicken, flour and white rice. The data suggest a low intake of thiamine. These data may justify the availability of vitamins for hospital pharmacotherapeutic treatment and new, broader studies may support the hypothesis of thiamine supplementation in commonly consumed foods (eg flour), for the population of Manaus, associated with measures of guidance.

References

Andersen, L. W., Mackenhauer, J., Roberts, J. C., Berg, K. M., Cocchi, M. N., & Donnino, M. W. (2013). Etiology and therapeutic approach to elevated lactate levels. Mayo Clinic proceedings, 88(10), 1127–1140. https://doi.org/10.1016/j.mayocp.2013.06.012.

Cicarelli, D. D., Vieira, J. E., & Bensenor, F. E. M. (2007). Lactato como prognóstico de mortalidade e falência orgânica em pacientes com síndrome da resposta inflamatória sistêmica. Revista Brasileira de Anestesiologia, 57(6), 630-638. https://doi.org/10.1590/S0034-70942007000600005.

Correia, M. I., & Waitzberg, D. L. (2003). The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clinical nutrition (Edinburgh, Scotland), 22(3), 235–239. https://doi.org/10.1016/s0261-5614(02)00215-7.

Counts, J. P., Rivera, V. F., Kimmons, L. A., & Jones, G. M. (2019). Thiamine Use in Sepsis: B1 for Everyone? Critical care nursing quarterly, 42(3), 292–303. https://doi.org/10.1097/CNQ.0000000000000272

De Negreiros Nogueira Maduro, I. P., Lima Souza, S. P., Jorge Brandão, A. R., & Petruccelli Israel, K. C. (2020). Double-Blind Placebo Controlled Study of Thiamine and Cognitive Effect on Chronic Hemodialysis Patients. Annals of Chronic Diseases, 3(1), 1006.

Donnino, M. W., Carney, E., Cocchi, M. N., Barbash, I., Chase, M., Joyce, N., Chou, P. P., & Ngo, L. (2010). Thiamine deficiency in critically ill patients with sepsis. Journal of critical care, 25(4), 576–581. https://doi.org/10.1016/j.jcrc.2010.03.003.

Donnino, M. W., Miller, J., Garcia, A. J., Mckee, E., & Walsh, M. (2006). Distinctive acid-base pattern in Wernicke’s encephalopathy. Annals of Emergency Medicine, 50(6): 722-725. https://doi.org/10.1016/j.annemergmed.2006.10.022

Dounousi, E., Zikou, X., Koulouras, V., & Katopodis, K. (2015). Metabolic acidosis during parenteral nutrition: Pathophysiological mechanisms. Indian journal of critical care medicine: peer-reviewed, official publication of Indian Society of Critical Care Medicine, 19(5), 270–274. https://doi.org/10.4103/0972-5229.156473.

Frank L. L. (2015). Thiamin in Clinical Practice. JPEN. Journal of parenteral and enteral nutrition, 39(5), 503–520. https://doi.org/10.1177/0148607114565245.

Guyton, A. C., & Hall, J. E. (2006). Tratado de fisiologia humana. 11. ed. Rio de Janeiro: Elsevier, 2006.

Hajjar, L. A., Almeida, J. P., Fukushima, J. T., Rhodes, A., Vincent, J. L., Osawa, E. A., & Galas, F. R. (2013). High lactate levels are predictors of major complications after cardiac surgery. The Journal of thoracic and cardiovascular surgery, 146(2), 455–460. https://doi.org/10.1016/j.jtcvs.2013.02.003

Jermendy G. (2006). Evaluating thiamine deficiency in patients with diabetes. Diabetes & vascular disease research, 3(2), 120–121. https://doi.org/10.3132/dvdr.2006.014.

Kumar, V., Abbas, A., Fausto, N., Robbins, S., & Cotran, R. (2005). Bases patológicas das doenças. 7. ed. Rio de Janeiro: Elsevier.

Levy, M. M., Evans, L. E., & Rhodes, A. (2018). The Surviving Sepsis Campaign Bundle: 2018 update. Intensive care medicine, 44(6), 925–928. https://doi.org/10.1007/s00134-018-5085-0

Lima, L. F., Leite, H. P., & Taddei, J. A. (2011). Low blood thiamine concentrations in children upon admission to the intensive care unit: risk factors and prognostic significance. The American journal of clinical nutrition, 93(1), 57–61. https://doi.org/10.3945/ajcn.2009.29078.

Loma-Osorio, P., Peñafiel, P., Doltra, A., Sionis, A., & Bosch, X. (2011). Shoshin beriberi mimicking a high-risk non-ST-segment elevation acute coronary syndrome with cardiogenic shock: when the arteries are not guilty. The Journal of emergency medicine, 41(4), e73–e77. https://doi.org/10.1016/j.jemermed.2008.03.040

Lonsdale, D. (2018). Thiamin. Advances in Food and Nutrition Research, 83, 1-56. https://doi.org/10.1016/bs.afnr.2017.11.001.

Madl, C., Kranz, A., Liebisch, B., Traindl, O., Lenz, K., & Druml, W. (1993). Lactic acidosis in thiamine deficiency. Clinical nutrition (Edinburgh, Scotland), 12(2), 108–111. https://doi.org/10.1016/0261-5614(93)90060-h

Mallat, J., Lemyze, M., & Thevenin, D. (2016). Do not forget to give thiamine to your septic shock patient! Journal of thoracic disease, 8(6), 1062–1066. https://doi.org/10.21037/jtd.2016.04.32

Medeiros, L. R. F. B., Beltrão, B. A., Mourão, A. C. S. M. C., Aragão, N. L. P., Júnior, A. H. F., & Júnior, A. A. P. (2018). Protocolo de uso suplementar de tiamina em pacientes utilizando nutrição parenteral total no Hospital Walter Cantídio (HUWC). Revista de Medicina da UFC, 58(1), 80-83. https://doi.org/10.20513/2447-6595.2018v58n1p80-83.

Moskowitz, A., Graver, A., Giberson, T., Berg, K., Liu, X., Uber, A., Gautam, S., & Donnino, M. W. (2014). The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis. Journal of critical care, 29(1), 182.e5–182.e1.82E8. https://doi.org/10.1016/j.jcrc.2013.06.008

Ozawa, H., Homma, Y., Arisawa, H., Fukuuchi, F., & Handa, S. (2001). Severe metabolic acidosis and heart failure due to thiamine deficiency. Nutrition (Burbank, Los Angeles County, Calif.), 17(4), 351–352. https://doi.org/10.1016/s0899-9007(00)00588-8

Pacei, F., Tesone, A., Laudi, N., Laudi, E., Cretti, A., Pnini, S., Varesco, F., & Colombo, C. (2020). The Relevance of Thiamine Evaluation in a Practical Setting. Nutrients, 12(9), 2810. https://doi.org/10.3390/nu12092810.

Park, Y. J., Kim, D. H., Kim, S. C., Kim, T. Y., Kang, C., Lee, S. H., Jeong, J. H., Lee, S. B., & Lim, D. (2018). Serum lactate upon emergency department arrival as a predictor of 30-day in-hospital mortality in an unselected population. PloS one, 13(1), e0190519. https://doi.org/10.1371/journal.pone.0190519

Porto, C. C. (2005). Semiologia médica. 5. ed. Rio Ed Janeiro: Guanabara Koogan.

Preedy, V. R., Srirajaskanthan, R., & Patel, V. B. (2013) Handbook of Food Fortification and Health. 1st ed New York, NY: Humana Press.

Rindi, G., & Laforenza, U. (2000). Thiamine intestinal transport and related issues: recent aspects. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 224(4), 246–255. https://doi.org/10.1046/j.1525-1373.2000.22428.x

Sabogal, C. E. L., Rivera, A. F. C., & Higuera, A. Y. J. (2014). Lactato y déficit de bases en trauma: valor pronóstico. Revista Colombiana de Anestesiología, 42(1), 60–64. https://doi.org/10.1016/j.rca.2013.09.002.

Sequeira Lopes da Silva, J. T., Almaraz Velarde, R., Olgado Ferrero, F., Robles Marcos, M., Pérez Civantos, D., Ramírez Moreno, J. M., & Luengo Pérez, L. M. (2010) Wernicke’s encephalopathy induced by total parental nutrition. Nutrición Hospitalaria. 25(6):1034-1036. https://doi.org/10.3305/nh.2010.25.6.4937

Silva, J. H., Carvalho, B. B., Oeiras, C. R., Silva Junior, E. F., Abinader, E. O., Horstmann, H., & Maduro, I. P. N. N. (2011). Severe thiamine deficiency following bariatric surgery Case report. International Journal of Nutrology, 4(1), 20-22.

Thornalley, P. J., Babaei-Jadidi, R., Al Ali, H., Rabbani, N., Antonysunil, A., Larkin, J., Ahmed, A., Rayman, G., & Bodmer, C. W. (2007). High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia, 50(10), 2164–2170. https://doi.org/10.1007/s00125-007-0771-4.

Ward, M. J., Self, W. H., Singer, A., Lazar, D., & Pines, J. M. (2016). Cost-effectiveness analysis of early point-of-care lactate testing in the emergency department. Journal of critical care, 36, 69–75. https://doi.org/10.1016/j.jcrc.2016.06.031

Whitfield, KC, Bourassa, MW, Adamolekun, B., Bergeron, G., Bettendorff, L., Brown, KH, Cox, L., Fattal-Valevski, A., Fischer, PR, Frank, EL, Hiffler, L., Hlaing, LM, Jefferds, ME, Kapner, H., Kounnavong, S., Mousavi, M., Roth, DE, Tsaloglou, MN, Wieringa, F., & Combs, GF, Jr (2018). Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Annals of the New York Academy of Sciences, 1430(1), 3–43. https://doi.org/10.1111/nyas.13919

Published

07/08/2021

How to Cite

LIMA, J. P.; JUNGES FILHO, L. F.; PONTES, D. F.; MADURO, I. P. de N. N. Detection of thiamine deficiency by food record, lactate dosage and arterial blood gases in population samples in the City of Manaus - Amazonas. Research, Society and Development, [S. l.], v. 10, n. 10, p. e156101018579, 2021. DOI: 10.33448/rsd-v10i10.18579. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/18579. Acesso em: 25 apr. 2024.

Issue

Section

Health Sciences