Use of antimicrobials in patients with COVID-19 without prior evaluation of an associated bacterial infection

Authors

DOI:

https://doi.org/10.33448/rsd-v10i12.20410

Keywords:

SARS-CoV-2 infection; Anti-infective agents; Drug resistance bacterial.

Abstract

This paper aims to clarify and present discussions about the COVID-19 disease, its variants and prevention measures, as well as clarifying the excessive use of antimicrobials in the protocols of patients infected with it, as this practice can intensify an already existing public health problem, which is antimicrobial resistance. The methodology used in this research was a literature review on bacterial resistance due to the indiscriminate use of antimicrobials and the possible impacts caused in the COVID-19 pandemic, as well as the variants of worldwide concern, based on the Scientific Electronic Library Online databases - SCIELO, National Library of Medicine - PubMed, CAPES Journal Portal, Academic Google and National Health Surveillance Agency (ANVISA). Based on the literature presented here, it is concluded that COVID-19 is a disease caused by the acute respiratory syndrome (SARS-CoV-2) presenting a clinical spectrum ranging from asymptomatic infections to severe conditions. Several variants have emerged in several countries modifying the dynamics of transmissibility and potential immune flight from the disease, the Delta variant (B.1.617.2) being a greater threat to public health due to its high transmissibility. The misuse and excessive use of antimicrobials prescribed for the treatment of this disease can favor the emergence of superbugs and such resistance is a global problem. Therefore, the help of laboratory and clinical tests is essential to carry out a therapeutic intervention, observing the best options for each clinical case, since COVID-19 is a new disease and still under study.

References

Abdool Karim, S.{Citation}S., & de Oliveira, T. (2021). New SARS-CoV-2 Variants—Clinical, Public Health, and Vaccine Implications. The New England Journal of Medicine, 384(19), 1866–1868. https://doi.org/10.1056/NEJMc2100362

ANVISA. (2017). Diretriz Nacional para Elaboração de Programa de Gerenciamento do Uso de Antimicrobianos em Serviços de Saúde – NasceCME. http://nascecme.com.br/diretriz-nacional-para-elaboracao-de-programa-de-gerenciamento-do-uso-de-antimicrobianos-em-servicos-de-saude/

CDC. (2021, agosto 31). Coronavirus Disease 2019 (COVID-19). Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-info.html

Chen, Y., & Li, L. (2020). SARS-CoV-2: Virus dynamics and host response. The Lancet. Infectious Diseases, 20(5), 515–516. https://doi.org/10.1016/S1473-3099(20)30235-8

da Silva, J. B., Espinal, M., & Ramón-Pardo, P. (2020). Resistencia a los antimicrobianos: Tiempo para la acción. Revista Panamericana de Salud Pública, 44, e122. https://doi.org/10.26633/RPSP.2020.122

Ferraz, E. R., Ishii, S., Ciosak, S. I., Miyadahira, A. M. K., & Chaves, E. C. (1982). IATROGENIA: IMPLICAÇÕES PARA A ASSISTÊNCIA DE ENFERMAGEM. Revista da Escola de Enfermagem da USP, 16(2), 165–179. https://doi.org/10.1590/0080-6234198201600200165

Frampton, D., Rampling, T., Cross, A., Bailey, H., Heaney, J., Byott, M., Scott, R., Sconza, R., Price, J., Margaritis, M., Bergstrom, M., Spyer, M. J., Miralhes, P. B., Grant, P., Kirk, S., Valerio, C., Mangera, Z., Prabhahar, T., Moreno-Cuesta, J., … Nastouli, E. (2021). Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: A whole-genome sequencing and hospital-based cohort study. The Lancet Infectious Diseases, 21(9), 1246–1256. https://doi.org/10.1016/S1473-3099(21)00170-5

Gil, A. C. (2017). COMO ELABORAR PROJETOS DE PESQUISA - 6aED.(2017)—Antonio Carlos Gil—Livro (6 ed).

Lima, C. M. A. de O. (2020). Information about the new coronavirus disease (COVID-19). Radiologia Brasileira, 53(2), V–VI. https://doi.org/10.1590/0100-3984.2020.53.2e1

Luiz, L. da C., Bell, M. J. V., Rocha, R. A. da, Leal, N. L., & Anjos, V. de C. dos. (2018). Detection of Veterinary Antimicrobial Residues in Milk through Near-Infrared Absorption Spectroscopy. Journal of Spectroscopy, 2018, e5152832. https://doi.org/10.1155/2018/5152832

Luiz, L. D. C. (2019). Espectroscopia óptica para detecção de resíduos de antimicrobianos em leite. 96.

Miranda, C. D., Godoy, F. A., & Lee, M. R. (2018). Current Status of the Use of Antibiotics and the Antimicrobial Resistance in the Chilean Salmon Farms. Frontiers in Microbiology, 9, 1284. https://doi.org/10.3389/fmicb.2018.01284

Oliveira, M., Pereira, K. D. S., & Zamberlam, C. R. (2020). RESISTÊNCIA BACTERIANA PELO USO INDISCRIMINADO DE ANTIMICROBIANOS: UMA QUESTÃO DE SAÚDE PÚBLICA [Professional, Abeu - Centro Universitário (UNIABEU)]. https://doi.org/10.29327/4426668

Oliveira, W. K. de, Duarte, E., França, G. V. A. de, & Garcia, L. P. (2020). Como o Brasil pode deter a COVID-19. Epidemiologia e Serviços de Saúde, 29. https://doi.org/10.5123/S1679-49742020000200023

Oliveira Junior, I. S. (2016). Princípios da farmacologia básica em ciências biológicas e da saúde (2o ed). Rideel.

OPAS. (2020). Número recorde de países contribui com dados que revelam taxas preocupantes de resistência antimicrobiana—OPAS/OMS | Organização Pan-Americana da Saúde. https://www.paho.org/pt/noticias/1-6-2020-numero-recorde-paises-contribui-com-dados-que-revelam-taxas-preocupantes

OPAS. (2021, agosto 8). Atualização epidemiológica: Incremento de variante Delta e seu potencial impacto na região das Américas—8 de agosto de 2021—OPAS/OMS | Organização Pan-Americana da Saúde. https://www.paho.org/pt/documentos/atualizacao-epidemiologica-incremento-variante-delta-e-seu-potencial-impacto-na-regiao

Paumgartten, F. J. R., & Oliveira, A. C. A. X. de. (2020). Off label, compassionate and irrational use of medicines in Covid-19 pandemic, health consequences and ethical issues. Ciência & Saúde Coletiva, 25, 3413–3419. https://doi.org/10.1590/1413-81232020259.16792020

Pereira, C. G., Anjos, V., Luiz, L. da C., & Bell, M. J. V. (2020). Near And Mid Infrared Spectroscopy To Assess Milk Products Quality: A Review Of Recent Applications. Journal of Dairy Research & Technology, 3(1), 1–10. https://doi.org/10.24966/DRT-9315/100014

Planas, D., Veyer, D., Baidaliuk, A., Staropoli, I., Guivel-Benhassine, F., Rajah, M. M., Planchais, C., Porrot, F., Robillard, N., Puech, J., Prot, M., Gallais, F., Gantner, P., Velay, A., Le Guen, J., Kassis-Chikhani, N., Edriss, D., Belec, L., Seve, A., … Schwartz, O. (2021). Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization. Nature, 596(7871), 276–280. https://doi.org/10.1038/s41586-021-03777-9

Silva, M. O. da, & Aquino, S. (2018). Antimicrobial resistance: A review of the challenges in the search for new treatment alternatives. Revista de Epidemiologia e Controle de Infecção, 8(4), 472–482. https://doi.org/10.17058/reci.v8i4.11580

Souza, J. F. R. de, Marinho, C. L. C., & Guilam, M. C. R. (2008). Consumo de medicamentos e internet: Análise crítica de uma comunidade virtual. Revista da Associação Médica Brasileira, 54, 225–231. https://doi.org/10.1590/S0104-42302008000300015

Teixeira, B. C. (2019). PERFIL DA AUTOMEDICAÇÃO EM ESTUDANTES DE ENSINO SUPERIOR: IMPACTO NA RESISTÊNCIA BACTERIANA. 12, 67–78.

Teixeira, A. R., Figueiredo, A. F. C., & França, R. F. (2019). RESISTÊNCIA BACTERIANA RELACIONADA AO USO INDISCRIMINADO DE ANTIMICROBIANOS. Revista Saúde em Foco, 23.

Vellano, P. O., & Paiva, M. J. M. de. (2020). O uso de antimicrobiano na COVID-19 e as infecções: O que sabemos. Research, Society and Development, 9(9), e841997245–e841997245. https://doi.org/10.33448/rsd-v9i9.7245

Yadav, P. D., Sapkal, G. N., Ella, R., Sahay, R. R., Nyayanit, D. A., Patil, D. Y., Deshpande, G., Shete, A. M., Gupta, N., Mohan, V. K., Abraham, P., Panda, S., & Bhargava, B. (2021). Neutralization of Beta and Delta variant with sera of COVID-19 recovered cases and vaccinees of inactivated COVID-19 vaccine BBV152/Covaxin. Journal of Travel Medicine, taab104. https://doi.org/10.1093/jtm/taab104

Downloads

Published

19/09/2021

How to Cite

SILVA, D. D. M. da .; SANTOS, J. C. dos .; JESUS, L. C. de .; LUIZ, L. da C. .; BELL, M. J. V. .; BATISTA, R. T. .; ANJOS, V. de C. dos . Use of antimicrobials in patients with COVID-19 without prior evaluation of an associated bacterial infection. Research, Society and Development, [S. l.], v. 10, n. 12, p. e264101220410, 2021. DOI: 10.33448/rsd-v10i12.20410. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20410. Acesso em: 9 dec. 2022.

Issue

Section

Health Sciences