Vitamin D in COVID-19 patients: current overview
DOI:
https://doi.org/10.33448/rsd-v10i13.21167Keywords:
25OHD; Cholecalciferol; Ergocalciferol; SARS-CoV-2; Coronaviruses ; COVID-19.Abstract
The search for therapeutic resources that add to the vaccine and are able to prevent and/or treat COVID-19 suggests vitamin D. Vitamin D is known to play several extra-skeletal roles in the body, particularly in the immune system. This review aims to address the current attributions and perspectives for the use of vitamin D in patients with COVID-19. The search was performed using the Medline (PubMed) database, between May and July 2021, regarding the physiological and immunological roles of vitamin D in respiratory infections, as well as its mechanisms of action, concerning COVID- 19. The results suggest a possible association between serum 25(OH)D concentrations and the clinical setting of COVID-19 (mortality, systemic inflammation, illness severity, mechanical ventilation requirement or admission to the ICU), although the studies found differ in the design, sample size and outcomes, mitigating an accurate between-trial comparison. Therefore, further studies with a well-defined design evaluating the role of vitamin D in the prevention and/or treatment of COVID-19 is still necessary.
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Copyright (c) 2021 Ana Beatriz Bessa de Albuquerque; Alan Lins Fernandes; Bruna Zavarize Reis
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