Quality of life measurement instruments applied to kidney transplanted individuals





Kidney Transplatation; Quiz; Quality of life.


The objective of this research was to identify in the literature the instruments applied to measure the quality of life (QOL) in kidney transplant patients. This is a literature review carried out in the Pubmed, Science direct databases and in the Virtual Health Library (VHL) portal that identified publications that used Patient-Reported Outcome Measures (MRRP) in kidney transplantation. The corpus of analysis of this research was obtained by 23 articles, which presented different instruments for assessing QoL in kidney transplant recipients. It was possible to observe a low bibliographic production on this theme, with an average of 1.5 publications per year, considering the sample interval (1996-2021). The SF-36 was the predominant questionnaire among the analyzed studies, with the others having a generic approach with characteristics that diverged between the evaluator and the research objectives. Finally, this study pointed to the need for further research to assess the application of more specific instruments for this population so that the real needs of kidney transplant recipients are captured, contributing to patient-centered care.


Adeeb, H., Ullah, I., Zeb, M., & Haq, M. (2021). Clinical factors and comorbidities affecting health-related quality of life in postrenal transplant patients. Porto Biomedical Journal, 6(3), e131. https://doi.org/10.1097/j.pbj.0000000000000131

Agochukwu, N. Q., Wittmann, D., Boileau, N. R., Dunn, R. L., Montie, J., Kim, T., Miller, D. C., Peabody, J., & Carlozzi, N. E. (2020). Reply to K.P. Weinfurt et al. Journal of Clinical Oncology, 38(6), 654–655. https://doi.org/10.1200/JCO.19.02642

Alvares, J., Cesar, C. C., Acurcio, F. de A., Andrade, E. I. G., & Cherchiglia, M. L. (2012). Quality of life of patients in renal replacement therapy in Brazil: Comparison of treatment modalities. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 21(6), 983–991. https://doi.org/10.1007/s11136-011-0013-6

Baker, R. J., Mark, P. B., Patel, R. K., Stevens, K. K., & Palmer, N. (2017). Renal association clinical practice guideline in post-operative care in the kidney transplant recipient. BMC Nephrology, 18(1), 174. https://doi.org/10.1186/s12882-017-0553-2

Barotfi, S., Molnar, M. Zs., Almasi, C., Kovacs, A. Zs., Remport, A., Szeifert, L., Szentkiralyi, A., Vamos, E., Zoller, R., Eremenco, S., Novak, M., & Mucsi, I. (2006). Validation of the Kidney Disease Quality of Life-Short Form questionnaire in kidney transplant patients. Journal of Psychosomatic Research, 60(5), 495–504. https://doi.org/10.1016/j.jpsychores.2005.09.009

Cetingok, M., Winsett, R. P., & Hathaway, D. K. (2004). A comparative study of quality of life among the age groups of kidney transplant recipients. Progress in Transplantation (Aliso Viejo, Calif.), 14(1), 33–38. https://doi.org/10.7182/prtr.14.1.g5612w70x8331k61

Czyżewski, Ł., Frelik, P., Wyzgał, J., & Szarpak, Ł. (2018). Evaluation of Quality of Life and Severity of Depression, Anxiety, and Stress in Patients After Kidney Transplantation. Transplantation Proceedings, 50(6), 1733–1737. https://doi.org/10.1016/j.transproceed.2018.04.026

Dobbels, F., Wong, S., Min, Y., Sam, J., & Kalsekar, A. (2014). Beneficial effect of belatacept on health-related quality of life and perceived side effects: Results from the BENEFIT and BENEFIT-EXT trials. Transplantation, 98(9), 960–968. https://doi.org/10.1097/TP.0000000000000159

Flechner, S. M. (2016). Optimizing immunosuppression: Who can do more with less? Transplant International: Official Journal of the European Society for Organ Transplantation, 29(1), 20–22. https://doi.org/10.1111/tri.12676

Flythe, J. E., Powell, J. D., Poulton, C. J., Westreich, K. D., Handler, L., Reeve, B. B., & Carey, T. S. (2015). Patient-Reported Outcome Instruments for Physical Symptoms Among Patients Receiving Maintenance Dialysis: A Systematic Review. American Journal of Kidney Diseases, 66(6), 1033–1046. https://doi.org/10.1053/j.ajkd.2015.05.020

Franke, G. H., Yücetin, L., Yaman, H., Reimer, J., & Demirbas, A. (2006). Disease-Specific Quality of Life in Turkish Patients After Successful Kidney Transplantation. Transplantation Proceedings, 38(2), 457–459. https://doi.org/10.1016/j.transproceed.2005.12.110

Gibbons, A., Bayfield, J., Cinnirella, M., Draper, H., Johnson, R. J., Oniscu, G. C., Ravanan, R., Tomson, C., Roderick, P., Metcalfe, W., Forsythe, J. L. R., Dudley, C., Watson, C. J. E., Bradley, J. A., & Bradley, C. (2021). Changes in quality of life (QoL) and other patient-reported outcome measures (PROMs) in living-donor and deceased-donor kidney transplant recipients and those awaiting transplantation in the UK ATTOM programme: A longitudinal cohort questionnaire survey with additional qualitative interviews. BMJ Open, 11(4), e047263. https://doi.org/10.1136/bmjopen-2020-047263

Graziadei, I. (2014). [Intensive care treatment before and after liver transplantation]. Medizinische Klinik, Intensivmedizin Und Notfallmedizin, 109(6), 411–417. https://doi.org/10.1007/s00063-014-0364-1

Johnson, C. D., Wicks, M. N., Milstead, J., Hartwig, M., & Hathaway, D. K. (1998). Racial and gender differences in quality of life following kidney transplantation. Image--the Journal of Nursing Scholarship, 30(2), 125–130. https://doi.org/10.1111/j.1547-5069.1998.tb01266.x

Ju, A., Josephson, M. A., Butt, Z., Jowsey-Gregoire, S., Tan, J., Taylor, Q., Fowler, K., Dobbels, F., Caskey, F., Jha, V., Locke, J., Knoll, G., Ahn, C., Hanson, C. S., Sautenet, B., Manera, K., Craig, J. C., Howell, M., Rutherford, C., … Patients and family members. (2019). Establishing a Core Outcome Measure for Life Participation: A Standardized Outcomes in Nephrology-kidney Transplantation Consensus Workshop Report. Transplantation, 103(6), 1199–1205. https://doi.org/10.1097/TP.0000000000002476

Kamran, F., & Fife-Schaw, C. (2012). Psychosocial versus clinical factors influencing QoL among renal transplant recipients. International Journal of Research Studies in Psychology, 2. https://doi.org/10.5861/ijrsp.2012.159

Kizilisik, A. T., Feurer, I. D., VanBuren, D. H., Wise, P., Van Buren, D., Hopkins, J., Ray, J., Nylander, W., Shaffer, D., Helderman, J. H., Langone, A. J., Speroff, T., & Pinson, C. W. (2003). Effects of diabetes and cadaveric organs on functional performance and health-related quality of life after kidney transplantation. The American Journal of Surgery, 186(5), 535–539. https://doi.org/10.1016/j.amjsurg.2003.07.013

Kong, I. L. L., & Molassiotis, A. (1999). Quality of life, coping and concerns in Chinese patients after renal transplantation. International Journal of Nursing Studies, 36(4), 313–322. https://doi.org/10.1016/S0020-7489(99)00025-5

Kurtin, P. S., Davies, A. R., Meyer, K. B., DeGiacomo, J. M., & Kantz, M. E. (1992). Patient-Based Health Status Measures in Outpatient Dialysis: Early Experiences in Developing an Outcomes Assessment Program. Medical Care, 30(5), MS136–MS149.

Laupacis, A., Keown, P., Pus, N., Krueger, H., Ferguson, B., Wong, C., & Muirhead, N. (1996). A study of the quality of life and cost-utility of renal transplantation. Kidney International, 50(1), 235–242. https://doi.org/10.1038/ki.1996.307

Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ (Clinical Research Ed.), 339, b2700. https://doi.org/10.1136/bmj.b2700

Lim, M. A., Kohli, J., & Bloom, R. D. (2017). Immunosuppression for kidney transplantation: Where are we now and where are we going? Transplantation Reviews (Orlando, Fla.), 31(1), 10–17. https://doi.org/10.1016/j.trre.2016.10.006

Mitsui, Y., Araki, M., Maruyama, Y., Yoshinaga, K., Sadahira, T., Wada, K., Tanabe, K., Kitagawa, M., Kobayashi, Y., Watanabe, M., Watanabe, T., & Nasu, Y. (2020). Quality of Life and Mental Satisfaction Improve Slowly in Preemptive Kidney Transplantation Compared With Nonpreemptive Kidney Transplantation. Transplantation Proceedings, 52(3), 740–747. https://doi.org/10.1016/j.transproceed.2020.01.042

Monica, 1776 Main Street Santa, & California 90401-3208. ([s.d.]). 36-Item Short Form Survey Instrument (SF-36). Recuperado 2 de setembro de 2021, de https://www.rand.org/health-care/surveys_tools/mos/36-item-short-form/survey-instrument.html

Muehrer, R. J., & Becker, B. N. (2005). Life after transplantation: New transitions in quality of life and psychological distress. Seminars in Dialysis, 18(2), 124–131. https://doi.org/10.1111/j.1525-139X.2005.18214.x

Ponton, P., Rupolo, G. P., Marchini, F., Feltrin, A., Perin, N., Mazzoldi, M. A., Giacon, B., Baldan, N., & Rigotti, P. (2001). Quality-of-life change after kidney transplantation. Transplantation Proceedings, 33(1), 1887–1889. https://doi.org/10.1016/S0041-1345(00)02737-8

See, S. B., Aubert, O., Loupy, A., Veras, Y., Lebreton, X., Gao, B., Legendre, C., Anglicheau, D., & Zorn, E. (2018). Post-Transplant Natural Antibodies Associate with Kidney Allograft Injury and Reduced Long-Term Survival. Journal of the American Society of Nephrology: JASN, 29(6), 1761–1770. https://doi.org/10.1681/ASN.2017111157

Sesso, R., Rodrigues-Neto, J. F., & Ferraz, M. B. (2003). Impact of socioeconomic status on the quality of life of ESRD patients. American Journal of Kidney Diseases, 41(1), 186–195. https://doi.org/10.1053/ajkd.2003.50003

Shah, V. S., Ananth, A., Sohal, G. K., Bertges-Yost, W., Eshelman, A., Parasuraman, R. K., & Venkat, K. K. (2006). Quality of Life and Psychosocial Factors in Renal Transplant Recipients. Transplantation Proceedings, 38(5), 1283–1285. https://doi.org/10.1016/j.transproceed.2006.03.027

Sharp, L. A. (1995). Organ transplantation as a transformative experience: Anthropological insights into the restructuring of the self. Medical Anthropology Quarterly, 9(3), 357–389. https://doi.org/10.1525/maq.1995.9.3.02a00050

Soares, C. B., Hoga, L. A. K., Peduzzi, M., Sangaleti, C., Yonekura, T., & Silva, D. R. A. D. (2014). Integrative Review: Concepts and Methods Used In Nursing. Revista Da Escola de Enfermagem Da USP, 48(2), 335–345. https://doi.org/10.1590/S0080-6234201400002000020

Tang, E., Ekundayo, O., Peipert, J. D., Edwards, N., Bansal, A., Richardson, C., Bartlett, S. J., Howell, D., Li, M., Cella, D., Novak, M., & Mucsi, I. (2019). Validation of the Patient-Reported Outcomes Measurement Information System (PROMIS)-57 and -29 item short forms among kidney transplant recipients. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 28(3), 815–827. https://doi.org/10.1007/s11136-018-2058-2

The World Health Organization Quality of Life assessment (WHOQOL): Position paper from the World Health Organization. (1995). Social Science & Medicine (1982), 41(10), 1403–1409. https://doi.org/10.1016/0277-9536(95)00112-k

Tsarpali, V., Midtvedt, K., Lønning, K., Bernklev, T., Lippe, N. von der, Reisæter, A. V., Brunborg, C., & Heldal, K. (2021). Health-Related Quality of Life in Older Kidney Transplant Recipients: A National Cohort Study of Short- and Longer-Term Outcomes. Kidney Medicine. https://doi.org/10.1016/j.xkme.2021.05.007

Urstad, K. H., Øyen, O., Andersen, M. H., Moum, T., & Wahl, A. K. (2012). The effect of an educational intervention for renal recipients: A randomized controlled trial. Clinical Transplantation, 26(3), E246-253. https://doi.org/10.1111/j.1399-0012.2012.01666.x

Verberne, W. R., Das-Gupta, Z., Allegretti, A. S., Bart, H. A. J., van Biesen, W., García-García, G., Gibbons, E., Parra, E., Hemmelder, M. H., Jager, K. J., Ketteler, M., Roberts, C., Al Rohani, M., Salt, M. J., Stopper, A., Terkivatan, T., Tuttle, K. R., Yang, C.-W., Wheeler, D. C., & Bos, W. J. W. (2019). Development of an International Standard Set of Value-Based Outcome Measures for Patients With Chronic Kidney Disease: A Report of the International Consortium for Health Outcomes Measurement (ICHOM) CKD Working Group. American Journal of Kidney Diseases, 73(3), 372–384. https://doi.org/10.1053/j.ajkd.2018.10.007

Villeneuve, C., Rousseau, A., Rerolle, J.-P., Couzi, L., Kamar, N., Essig, M., Etienne, I., Westeel, P.-F., Büchler, M., Esposito, L., Thierry, A., Marquet, P., & Monchaud, C. (2020). Adherence profiles in kidney transplant patients: Causes and consequences. Patient Education and Counseling, 103(1), 189–198. https://doi.org/10.1016/j.pec.2019.08.002

Von der Lippe, N., Waldum, B., Brekke, F. B., Amro, A. A. G., Reisæter, A. V., & Os, I. (2014). From dialysis to transplantation: A 5-year longitudinal study on self-reported quality of life. BMC Nephrology, 15, 191. https://doi.org/10.1186/1471-2369-15-191

Ware, J. E., Richardson, M. M., Meyer, K. B., & Gandek, B. (2019). Improving CKD-Specific Patient-Reported Measures of Health-Related Quality of Life. Journal of the American Society of Nephrology: JASN, 30(4), 664–677. https://doi.org/10.1681/ASN.2018080814

Wasson, J., Keller, A., Rubenstein, L., Hays, R., Nelson, E., Johnson, D., & Project, T. D. P. C. C. (1992). Benefits and Obstacles of Health Status Assessment in Ambulatory Settings: The Clinician’s Point of View. Medical Care, 30(5), MS42–MS49.

Wolfe, R. A., Ashby, V. B., Milford, E. L., Ojo, A. O., Ettenger, R. E., Agodoa, L. Y., Held, P. J., & Port, F. K. (1999). Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. The New England Journal of Medicine, 341(23), 1725–1730. https://doi.org/10.1056/NEJM199912023412303

Wu, A. W., & Predmore, Z. S. (2019a). Patient-Reported Outcomes: Toward Better Measurement of Patient-Centered Care in CKD. Journal of the American Society of Nephrology, 30(4), 523–525. https://doi.org/10.1681/ASN.2019020169

Wu, A. W., & Predmore, Z. S. (2019b). Patient-Reported Outcomes: Toward Better Measurement of Patient-Centered Care in CKD. Journal of the American Society of Nephrology, 30(4), 523–525. https://doi.org/10.1681/ASN.2019020169

Wu, A. W., Snyder, C., Clancy, C. M., & Steinwachs, D. M. (2010). Adding The Patient Perspective To Comparative Effectiveness Research. Health Affairs, 29(10), 1863–1871. https://doi.org/10.1377/hlthaff.2010.0660

XXVI No 4—Anual. ([s.d.]). ABTO. Recuperado 2 de setembro de 2021, de https://site.abto.org.br/publicacao/xxvi-no-4-anual/

Yapa, H. E., Purtell, L., Chambers, S., & Bonner, A. (2020). The Relationship Between Chronic Kidney Disease, Symptoms and Health-Related Quality of Life: A Systematic Review. Journal of Renal Care, 46(2), 74–84. https://doi.org/10.1111/jorc.12303

Yildirim, A. (2006). The Importance of Patient Satisfaction and Health-Related Quality of Life After Renal Transplantation. Transplantation Proceedings, 38(9), 2831–2834. https://doi.org/10.1016/j.transproceed.2006.08.162

Zaydfudim, V., Feurer, I. D., Moore, D. R., Moore, D. E., Pinson, C. W., & Shaffer, D. (2010). Pre-transplant Overweight and Obesity Do Not Affect Physical Quality of Life after Kidney Transplantation. Journal of the American College of Surgeons, 210(3), 336–344. https://doi.org/10.1016/j.jamcollsurg.2009.11.009

Zhao, L., Yan, J., Yang, G.-L., & Liu, Y. (2017). A Study on Adherence to Follow-up, Quality of Life, and Associated Factors Among Renal Transplant Recipients in China. Transplantation Proceedings, 49(6), 1285–1290. https://doi.org/10.1016/j.transproceed.2017.03.086



How to Cite

FARIAS, M. T. D. .; ARAKAKI, E. .; SOUZA, D. G.; ALMEIDA, I. F. B. de; ROZA, B. de A.; BOHOMOL, E. .; MACHADO, R. C. Quality of life measurement instruments applied to kidney transplanted individuals. Research, Society and Development, [S. l.], v. 10, n. 13, p. e337101321548, 2021. DOI: 10.33448/rsd-v10i13.21548. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/21548. Acesso em: 4 dec. 2021.



Health Sciences