Scientific evidences about this steviosíde in mellitus Diabetes type 2 control: a review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i14.22051

Keywords:

Diabetes mellitus type II; Stevia; Steviosíde; Glycosides.

Abstract

The aim of the present article was to search for scientific evidence to evaluate the function and action of stevioside in     patients with mellitus diabetes type 2. This work is an integrative literature review, the sources were linked in the following databases: (Scielo), (PubMed), LILACS and Academic Google. It was chosen some selection for the present sample and criteria for original articles indexed from 2017 to 2021 were established. The choice of this period presented results to the criterion of temporality, in which the five-year selected period was considered, as these are more current publications, in English and Portuguese in the studies analyzed, it was evidenced that stevioside is a glycosidic compound with high sweetness, low caloric value, including the interaction with glimeripedine and metformin, which enhances glycemic reduction through antioxidant actions and improves the lipid profile. It highlighted the action in reducing glucose and total cholesterol levels, preventing oxidative damage and improving liver and kidney function, as well as reducing damage to internal organs through removing tissue collagen and contributing to normal cardiac functioning. It also demonstrates positive results in satiety, contributing to a delay in gastric emptying and being useful in the treatment of obesity, working in the inhibition of glucose absorption. According this database, it is concluded that stevioside has preventive and metabolic function, besides to promote pre-clinical and experimental studies, culminating in non-caloric, anti-diabetic and anti-hyperglycemic effects, with sensory, therapeutic and nutritional quality.

Author Biographies

Keila Cristiane Batista Bezerra, Centro Universitário Santo Agostinho

The aim of the present article was to search for scientific evidence to evaluate the function and action of stevioside in     patients with mellitus diabetes type 2. This work is an integrative literature review, the sources were linked in the following databases: (Scielo), (PubMed), LILACS and Academic Google. It was chosen some selection for the present sample and criteria for original articles indexed from 2017 to 2021 were established. The choice of this period presented results to the criterion of temporality, in which the five-year selected period was considered, as these are more current publications, in English and Portuguese in the studies analyzed, it was evidenced that stevioside is a glycosidic compound with high sweetness, low caloric value, including the interaction with glimeripedine and metformin, which enhances glycemic reduction through antioxidant actions and improves the lipid profile. It highlighted the action in reducing glucose and total cholesterol levels, preventing oxidative damage and improving liver and kidney function, as well as reducing damage to internal organs through removing tissue collagen and contributing to normal cardiac functioning. It also demonstrates positive results in satiety, contributing to a delay in gastric emptying and being useful in the treatment of obesity, working in the inhibition of glucose absorption. According this database, it is concluded that stevioside has preventive and metabolic function, besides to promote pre-clinical and experimental studies, culminating in non-caloric, anti-diabetic and anti-hyperglycemic effects, with sensory, therapeutic and nutritional quality.

Liejy Agnes dos Santos Raposo Landim, Centro Universitário Santo Agostinho

The aim of the present article was to search for scientific evidence to evaluate the function and action of stevioside in     patients with mellitus diabetes type 2. This work is an integrative literature review, the sources were linked in the following databases: (Scielo), (PubMed), LILACS and Academic Google. It was chosen some selection for the present sample and criteria for original articles indexed from 2017 to 2021 were established. The choice of this period presented results to the criterion of temporality, in which the five-year selected period was considered, as these are more current publications, in English and Portuguese in the studies analyzed, it was evidenced that stevioside is a glycosidic compound with high sweetness, low caloric value, including the interaction with glimeripedine and metformin, which enhances glycemic reduction through antioxidant actions and improves the lipid profile. It highlighted the action in reducing glucose and total cholesterol levels, preventing oxidative damage and improving liver and kidney function, as well as reducing damage to internal organs through removing tissue collagen and contributing to normal cardiac functioning. It also demonstrates positive results in satiety, contributing to a delay in gastric emptying and being useful in the treatment of obesity, working in the inhibition of glucose absorption. According this database, it is concluded that stevioside has preventive and metabolic function, besides to promote pre-clinical and experimental studies, culminating in non-caloric, anti-diabetic and anti-hyperglycemic effects, with sensory, therapeutic and nutritional quality.

References

Abdel-Aal, R. A., Abdel-Rahman, M. S. & Ali, L. A. (2019). Stevia improves the antihyperglycemic effect of metformin in streptozotocin-induced diabetic rats: a novel strategy in type 2 diabetes mellitus Bull. Pharm. Sci., Assiut University, 42 (4) 39-50.

Ahamad, U. & Ahmad, R. S. (2018). Anti-diabetic property of aqueous extract of Stevia Rebaudiana Bertoni leaves in Streptozotocin-induced diabetes in albino rats. BMC Complement Altern Med, 12 (18) 179-187.

Ali, A. M. et al. (2021). Producing and Quality Attributes of Low Calories Dark Chocolate Using Different Intense sweeteners and Wheat Fiber Isolate.American Journal of Food Science and Technology, 9 (1) 1-7.

Assi, A. et al. (2020). The Potential Efficacy of Stevia Extract, Glimepiride and Their Combination in Treating Diabetic Rats: A Novel Strategy in Therapy of Type 2 Diabetes Mellitus. Egyptian Journal of Basic and Clinical Pharmacology 10(15) 101455.doi :10.32527

Castro, I. B. et al. (2019). 9(2)133922193. Estratégias nutricionais no tratamento do diabetes mellitus: revisão bibliográfica. Research, Society and Development. 9 (2) 34-45.

Farhat, G., Berset, V., & Moure, A. L. (2019). Effects of Stevia Extract on Postprandial Glucose Response, Satiety and Energy Intake: A Three-Arm Crossover Trial. Nutrients, 11, 30-36.

Gao, J.et al. (2019). The Potential of Modulating the Reducing Sugar Released (and the Potential Glycemic Response) of Muffins Using a Combination of a Stevia Sweetener and Cocoa Powder †Foods; 8, 644.

Gu, W., et al. (2019). Glucuronídeo de esteviol, um metabólito dos glicosídeos de esteviol, potentemente estimula a secreção de insulina de ilhotas de camundongo isoladas: Estudos em vitro. Endocrinol Diab Metab 2(.4) 45-53.

Khiraoui, A. et al. (2017). Nutritional and biochemical properties of natural sweeteners of six cultivars of Stevia rebaudiana Bertoni leaves grown in Morocco. JMES, .8, (3) p. 1015-1022.

Kurek, J. M., Król, E. & Krejpcio, Z. A. (2021). Steviol Glycosides Supplementation Affects Lipid Metabolism in High-Fat Fed STZ-Induced Diabetic Rats Nutrients ,13. 112.

Rizwan, F., et al. (2018). Preliminary analysis of the effect of Stevia (Stevia rebaudiana) in patients with chronic kidney disease (stage I to stage III) Contemporary Clinical Trials Communications (12) p.17–25.

Rodrigues, M. A.et al. (2017). Cultivar Stevia Rebaudiana Bertoni em Bragança: orientações para a técnica cultural. Revista de Ciências Agrárias. 40, (12) 41-49.

Rotimi, S. O.et al. (2018). Steviosíde modulates oxidative damage in the liver and kidney of high fat/ low streptozocin diabetic rats. Heliyon; 31, (4) 78-87.

Ruiz, J. C. R., & Campos, M. R. S., (2020). Development of nopal pineapple marmalade formulated with aqueous stevia extract: effect on physical-chemical properties, α-amylase inhibition and glycemic response Nutr. Hosp. vol.36 no.5 Madrid set. /oct. 2019 Epub 24-Ene-2020.

Sari, F.R. et al. (2019). Ingestão diária de adoçante líquido de Stevia extrato de rebaudiana melhora diabetes mellitus crônicono rato induzido por spreptozotocina Eco. Env. & Cons; .25(3)1424-1428.

Scarton, J., et al. (2020). Mortalidade materna: causas e estratégias de prevenção. Research, Society and Devolopment, 9(5), e 67953081.https://doi.org/10.33448/rsd-9I5.3081

Silva, S. A. & Alves, S. H. S. (2019). Conhecimento do diabetes tipo 2 e relação com o comportamento de adesão ao tratamento Estudos Interdisciplinares em Psicologia, Londrina, 9 (2) 39-57.

SBD. Sociedade Brasileira de Diabetes. Diretrizes da Sociedade Brasileira de Diabetes: 2017-2018. Clannad; 2017.

Tonetto, I. F.A., Baptista, B.H.M. & Gomides, D.dos S. (2019). Quality of life of people with diabetes mellitus. Rev. esc. enferm. USP-São Paulo, 53 (31) 67-76.

Zhao, R. R. et al. (2020). Stevioside improved hyperglycemia-induced cardiac dysfunction by attenuating the development of fibrosis and promoting the degradation of established fibrosis. Journal of Functional Foods, 68, (3) 103-113.

Published

03/11/2021

How to Cite

SILVA, L. P. e .; BEZERRA, K. C. B. .; LANDIM, L. A. dos S. R. . Scientific evidences about this steviosíde in mellitus Diabetes type 2 control: a review. Research, Society and Development, [S. l.], v. 10, n. 14, p. e331101422051, 2021. DOI: 10.33448/rsd-v10i14.22051. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22051. Acesso em: 20 apr. 2024.

Issue

Section

Review Article