The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis
DOI:
https://doi.org/10.33448/rsd-v10i14.22262Keywords:
Parkinson disease; Levodopa; Vital Capacity; Total lung capacity; Lung volume measurements; Tidal volume.Abstract
There is no consensus in the literature about the influence of levodopa on respiratory disorders, which are the main cause of death in Parkinson’s disease patients. Thus, the aim of this study was to conduct a systematic review and meta-analysis to assess the influence of levodopa on lung function in patients with Parkinson’s disease. A systematic search was performed in the MEDLINE-PubMed, Lilacs, IEEE Xplore Digital Library and Cochrane Library databases, until July 2020. Eligibility, screening, data extraction and quality assessment of the studies found were conducted independently by a minimum of two reviewers. The meta-analysis was made using RevMan 5, using standardized difference of means (SDM) with the random effects model and 95% confidence interval. The presence of heterogeneity was evaluated through the percentage of i². In total, 78 studies were identified; of these,7 were included in the review and meta-analysis after considering the inclusion and exclusion criteria. By comparing the 'on' and 'off' levodopa states, in the outcomes of interest found in the included studies, the following results were obtained in the meta-analysis: FVC (SMD of 0.12, p = 0.41); FEV1 (SMD of 0.10, p = 0.47); PEF (SMD of -0.00, p = 0.99); FEV1/FVC (SMD 0.04, p = 0.76). The conducted study suggested that there was no influence of levodopa treatment on any of the pulmonary variables assessed in patients with Parkinson’s disease.
References
Bogaard, J. M., Hovestadt, A., Meerwaldt, J., v. d. Meché, F. G. A., & Stigt, J. (1989). Maximal expiratory and inspiratory flow-volume curves in parkinson’s disease. American Review of Respiratory Disease, 139(3), 610–614. https://doi.org/10.1164/ajrccm/139.3.610
David, S., & Edwards, C. W. (2019). Forced expiratory volume.
David, S., & Sharma, S. (2019). Vital Capacity.
Deng, H., Wang, P., & Jankovic, J. (2018). The genetics of Parkinson disease. Ageing Research Reviews, 42, 72–85. https://doi.org/10.1016/j.arr.2017.12.007
DeVrieze, B. W., Modi, P., & Giwa, A. O. (2017). Peak Flow Rate Measurement.
Duarte, A. A. D. O., Pereira, C. A. D. C., & Rodrigues, S. C. S. (2007). Validation of new brazilian predicted values for forced spirometry in caucasians and comparison with predicted values obtained using other reference equations. Jornal Brasileiro de Pneumologia, 33, 527-535.
Herer, B., Arnulf, I., & Housset, B. (2001). Effects of levodopa on pulmonary function in parkinson’s disease. Chest, 119(2), 387–393. https://doi.org/10.1378/chest.119.2.387
Higgins, J. P., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., & Welch, V. A. (Eds.). (2019). Cochrane handbook for systematic reviews of interventions. John Wiley & Sons.
Hovestadt, A., Bogaard, J. M., Meerwaldt, J. D., van der Meché, F. G., & Stigt, J. (1989). Pulmonary function in Parkinson’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 52(3), 329–333. https://doi.org/10.1136/jnnp.52.3.329
Kalia, L. V., & Lang, A. E. (2016). Evolving basic, pathological and clinical concepts in PD. Nature Reviews Neurology, 12(2), 65–66. https://doi.org/10.1038/nrneurol.2015.249
Lamb, K., Theodore, D., & Bhutta, B. S. (2020). Spirometry. StatPearls [Internet].
L-dopa for parkinsonism. (1968). New England Journal of Medicine, 278(11), 630–630. https://doi.org/10.1056/NEJM196803142781127
LeWitt, P. A., Pahwa, R., Sedkov, A., Corbin, A., Batycky, R., & Murck, H. (2018). Pulmonary safety and tolerability of inhaled levodopa (CVT-301) administered to patients with parkinson’s disease. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 31(3), 155–161. https://doi.org/10.1089/jamp.2016.1354
Lim, A., Leow, L., Huckabee, M.-L., Frampton, C., & Anderson, T. (2008). A pilot study of respiration and swallowing integration in parkinson’s disease: “On” and “off” levodopa. Dysphagia, 23(1), 76–81. https://doi.org/10.1007/s00455-007-9100-9
Lorenzi, F. G. (2005). II Consenso Brasileiro sobre Doença Pulmonar Obstrutiva Crônica-DPOC. J bras pneumol, 30(5).
McGuinness, L. A., & Higgins, J. P. T. (2020). Risk‐of‐bias VISualization (Robvis): An R package and Shiny web app for visualizing risk‐of‐bias assessments. Research Synthesis Methods, 12(1), 55–61. https://doi.org/10.1002/jrsm.1411
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group. (2009). Preferred reporting items for systematic reviews and meta-analyses: The prisma statement. PLoS Medicine, 6(7), e1000097. https://doi.org/10.1371/journal.pmed.1000097
Moola, S., Munn, Z., Tufanaru, C., Aromataris, E., Sears, K., Sfetc, R., Currie, M., Lisy, K., Qureshi, R., Mattis, P., & Mu, P.-F. (2020). Chapter 7: Systematic reviews of etiology and risk. In E. Aromataris & Z. Munn (Orgs.), JBI Manual for Evidence Synthesis. JBI. https://doi.org/10.46658/JBIMES-20-08
Pal, P. K., Sathyaprabha, T. N., Tuhina, P., & Thennarasu, K. (2007). Pattern of subclinical pulmonary dysfunctions in Parkinson’s disease and the effect of levodopa. Movement Disorders, 22(3), 420–424. https://doi.org/10.1002/mds.21330
Parkinson, J. (1817). An essay on the shaking palsey. Sherwood, Neely and Jones.
Review Manager (RevMan) [Computer program]. Version 5.4, The Cochrane Collaboration, 2020.
Sathyaprabha, T. N., Kapavarapu, P. K., Pall, P. K., Thennarasu, K., & Raju, T. R. (2005). Pulmonary functions in Parkinson’s disease. The Indian Journal of Chest Diseases & Allied Sciences, 47(4), 251–257.
Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., Cates, C. J., Cheng, H.-Y., Corbett, M. S., Eldridge, S. M., Emberson, J. R., Hernán, M. A., Hopewell, S., Hróbjartsson, A., Junqueira, D. R., Jüni, P., Kirkham, J. J., Lasserson, T., Li, T., … Higgins, J. P. T. (2019). RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ, l4898. https://doi.org/10.1136/bmj.l4898
Tambasco, N., Murgia, N., Nigro, P., Paoletti, F. P., Romoli, M., Brahimi, E., Filidei, M., Simoni, S., Muzi, G., & Calabresi, P. (2018). Levodopa-responsive breathing discomfort in Parkinson’s disease patients. Journal of Neural Transmission, 125(7), 1033–1036. https://doi.org/10.1007/s00702-018-1890-4
Templeman, L., & Roberts, F. (2020). Effectiveness of expiratory muscle strength training on expiratory strength, pulmonary function and cough in the adult population: a systematic review. Physiotherapy, 106, 43-51.
Torsney, K., & Forsyth, D. (2017). Respiratory dysfunction in Parkinson’s disease. Journal of the Royal College of Physicians of Edinburgh, 47(1), 35–39. https://doi.org/10.4997/JRCPE.2017.108
Weiner, P., Inzelberg, R., Davidovich, A., Nisipeanu, P., Magadle, R., Berar-Yanay, N., & Carasso, R. L. (2002). Respiratory muscle performance and the perception of dyspnea in parkinson’s disease. Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques, 29(1), 68–72. https://doi.org/10.1017/S031716710000175X
Wells, G. A., Shea, B., O’Connell, D., Peterson, J., Welch, V., Losos, M., & Tugwell, P. (2000). The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Francisco José Silva Ferreira; Paulo Eduardo Gonçalves; Alice Santos Lima; Diogo Costa Garção
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
