Errors in the prescription, preparation, and administration of medicines in Pediatric and Neonatal Intensive Care Unit: systematic review
DOI:
https://doi.org/10.33448/rsd-v10i14.22315Keywords:
Hospital Pharmacy; Medication Errors; Neonatal Intensive Care Unit; Pediatric Intensive Care Unit; Patient safety.Abstract
Objective: To seek evidence on how to prevent potential medication errors in the prescription, preparation, and administration of medications for patients in the Pediatric and Neonatal Intensive Care Unit. Method: Systematic review and narrative synthesis. Results: 18 articles were selected with evidence on how to prevent potential medication errors in the prescription, preparation and administration of medications for patients in the Pediatric and Neonatal Intensive Care Unit. The studies are quite varied as to the methodology adopted. There are articles that made systematic, integrative, and narrative reviews, prospective and retrospective cohort studies, observational and economic analysis studies, most of them from European countries, not providing information on equity or subgroup analysis. Conclusion: There is evidence that structural and technological interventions; organizational and professional; regulatory and educational, and interdisciplinary and multifaceted, reduce prescription and preparation errors, drug interactions, adverse drug reactions, improving the quality of services and patient safety.
References
Ainscough, L. P., Ford, J. L, Morecroft, C. W., Peak, M., Turner, M. A., Nunn, A. J., & Roberts, M. (2017). Accuracy of intravenous and enteral preparations involving small volumes for pediatric use: a review. Eur J Hosp Pharm. 0:1-6. 10.1136/ejhpharm-2016-001117
Barreto, H. A. G., Sestren, B., Lacerda, R. B., & Soares, L. C. C. (2019). Standard concentration infusions of inotropic and vasoactive drugs in pediatric intensive care: a strategy for patient safety. Journal of Pharmacy and Pharmacology. 71(5):826-838. 10.1111/jphp.13065
Basagoiti, A., Fernández, A., Mendiola, S., Guerra, M. M. E., Loureiro, B., & Campino, A. (2019). Intravenous drug use in neonatal intensive care units. Eur J Hosp Pharm. 0:1-5. 10.1136/ejhpharm-2019-001939
Becker, G. C., Machado, F. R., & Bueno. D. (2016). Perfil de utilização de medicamentos em pacientes pediátricos em cuidados intensivos. Revista Brasileira de Farmácia Hospitalar. 7(2):42-47.
Brasil. (2021). Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos em Saúde. Departamento de Gestão e Incorporação de Tecnologias em Saúde. Diretrizes metodológicas: Elaboração de revisão sistemática e metanálise de ensaios clínicos randomizados. Brasília: Ministério da Saúde,. 93 p. http://bvsms.saude.gov.br/bvs/publicacoes/diretrizes_elaboracao_revisao_sistematica_meta-analise.pdf
Campino, A., Arranz, C., Unceta, M., Rueda, M., Sordo, B., Pascual, P., Lopez-de-Heredia, I., & Santesteban, E. (2016). Medicine preparation errors in ten Spanish neonatal intensive care units. Eur J Pediatr. 175:203-10. https://doi.org/10.1007/s00431-015-2615-4
Campino, A., Sordo, B., Pascual, P., Arranz, C., Santesteban, M. U., & Lopez-de-Heredia, I. (2017). Intravenous medicine preparation technique training programme for nurses in clinical áreas. Eur J Hosp Pharm. 0:1. 10.1136/ejhpharm-2016-000947
Costa, H. T., Leopoldino, R. W. D., Costa, T. X., Oliveira, A. G., & Martins, R.R. (2021) Drug--drug interactions in neonatal intensive care: A prospective cohort study. Pediatrics and Neonatology. 62:151-157. 10.1016/j.pedneo.2020.10.006
Custódio, I. L., Lima, F. E. T., Pascoal, L. M., Barbosa, L. P., Pinheiro, P. N. C., Barbosa, I. V., & Almeida, P.C. (2021). Treinamento para enfermagem sobre administração de medicamentos na pediatria: avaliação do comportamento observado e autorreferido. Rev. Bras. Enferm. 74 (04). https://doi.org/10.1590/0034-7167-2020-1188
Ewig, C. L. Y., Cheung, H. M., Kam, K. H., Wong, H. L., & Knoderer, C. A. (2017). Occurrence of Potential Adverse Drug Events from Prescribing Errors in a Pediatric Intensive and High Dependency Unit in Hong Kong: An Observational Study. Pediatr Drugs. 19, 347–355. https://doi.org/10.1007/s40272-017-0222-8
Flamein, F., Storme, L., Foinard, A. M., Perez, M., Décaudin, B., Masse, M., Genay, S., & Odou, P. (2017). Avoid Drug Incompatibilities: Clinical Context in Neonatal Intensive Care Unit (NICU). Pharm. Technol. Hosp. Pharm. 2(2):71-78. https://doi.org/10.1515/pthp-2017-0009
Guzzo, G. M., Magalhães, A. M. M., Moura, G. M. S. S., & Wegner, W. (2018). Segurança da terapia medicamentosa em neonatologia: olhar da enfermagem na perspectiva do pensamento ecológico restaurativo. Texto & Contexto - Enfermagem [online]. 27(3):e4500016.CISSN 1980-265X. https://doi.org/10.1590/0104-070720180004500016.
Hermanspann, T., Linden, E. V., schoberer, M., Orlikowsky, T., Marx, G., & Eisert, A. (2019). Evaluation to improve the quality of medication preparation and administration in pediatric and adult intensive care units. Drug, Healthcare and Patient Safety. Drug, Healthcare and Patient Safety. 2019:11. http://dx.doi.org/10.2147/DHPS.S184479
Howlett, M. M., Cleary, B. J., & Breatnach, C. V. (2018). Defining electronic-prescribing and infusion-related medication errors in pediatric intensive care – a Delphi study. BMC Medical Informatics and Decision Making. 18-130. https://doi.org/10.1186/s12911-018-0713-8
Leopoldino, R. W., Costa, H. T., Costa, T. X., Martins, R. R., & Oliveira, A.G. (2018). Potential drug incompatibilities in the neonatal intensive care unit: a network analysis approach. BMC Pharmacology and Toxicology. 19:83. https://doi.org/10.1186/s40360-018-0265-7
Marques, L. F., Marta, C. B., Silva, R. C. L., Peregrino, A. A. F., Silva, C. R. L., & Schutz, V. (2018). Custo-efetividade da utilização da central de mistura intravenosa em unidade de terapia intensiva neonatal. Cogitare enferm. 24: e60877, 2019. http://dx.doi.org/10.5380/ce.v24i0.60877
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G. (2009). The PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med. 6(7): e1000097. 10.1371/journal.pmed100009
Moreira, A.P. A., Carvalho, M. F., Silva, R. C. L., Marta, C. B., Fonseca, E. R., & Barbosa MTS. (2020). Erros de manuseio na bomba de infusão convencional e smart pump: revisão sistemática com metanálise. Rev Esc Enferm USP. 54:e03562 https://doi.org/10.1590/S1980-220X2018032603562
Nguyen, M. R., Mosel, C., & Grzeskowiak, L. E. (2018). Interventions to reduce medication errors in neonatal care: a systematic review. Ther Adv Drug Saf. 9(2):123-155. 10.1177/2042098617748868
Ni, Y., Lingren, T., Hall, E. S., Leonard, M., Melton, K., & Kirkendall, E. S. (2018). Designing and evaluating an automated system for real-time medication administration error detection in a neonatal intensive care unit. Journal of the American Medical Informatics Association: JAMIA, 25(5), 555–563. https://doi.org/10.1093/jamia/ocx156
Soler, O., & Barreto, J. O. M. (2019). Community-Level Pharmaceutical Interventions to reduce the risks of polypharmacy in the elderly: Overview of systematic reviews and economic evaluations. Frontiers in Pharmacology. 10:302. 10.3389/fphar.2019.0030
Pawluk, S., Jaam, M., Hazi, F., HAIL, M. S. A., Kassem, W. E., Khalifa, H., Thomas, B., & Rouf, P. A. (2016). A Description of medication errors reported by pharmacists in a neonatal intensive care unit. Int J Clin Pharm. DOI 10.1007/s11096-016-0399-x
Rishoej, R. M., Lai, N. H., Strzelec, S.M., Fritsdal, R. J., Allermann, B. S., Gramstrup, H. M., Thybo, C. H., Juel, K. L., Hallas, J., & Almarsdóttir, A. B. (2018). Qualitative exploration of practices to prevent medication errors in neonatal intensive care units: a focus group study. Ther Adv Drug Saf. 9(7):343-353. 10.1177/2042098618771541
Rostas, S. E. (2017). Medication Safety in the Neonatal Intensive Care Unit. The Journal of Perinatal & Neonatal Nursing. 10.1097/JPN.0000000000000230
Silva, R. C. L., Louro, T. Q., Peregrino, A. A. F., Silva, C. R. L., Marta, C. B., & Itria, A. (2019). Custo efetividade de bombas de infusão para a redução de erros em uma UTI Pediátrica. Revista Brasileira de Enfermagem. 72(3). https://doi.org/10.1590/0034-7167-2018-0526
Sutherlaland, A., Ashcroft, D. M., & Phipps, D. L. (2019). Exploring the human factors of prescribing errors in paediatric intensive care units. Arch Dis Child. 0:1-8. 10.1136/archdischild-2018-315981
Sutherland, A., Phipps, D. L., Tomlin, S., & Ashcroft, D. M. (2019). Mapping the prevalence and nature of drug related problems among hospitalised children in the United Kingdom: a systematic review. BMC Pediatrics. 19:486. https://doi.org/10.1186/s12887-019-1875-y
Willems, J., Hermans, E., Schelstraete, P., Depuydt, P., & Cock, P. (2020). Optimizing the Use of Antibiotic Agents in the Pediatric Intensive Care Unit: A Narrative Review. Pediatr Drugs. https://doi.org/10.1007/s40272-020-00426-y
World Health Organization (WHO). (2009). World Alliance for Patient Safety. The conceptual framework for the international classification for patient safety: final technical report [Internet]. Version 1.1. Genebra: WHO. Microsoft Word - The ICPS - Technical Report-Katthyana-proof.doc (who.int)
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Copyright (c) 2021 Haila Kelli dos Santos Vieira; Sâmella Benoliel Elmescany; Silvia Tavares Gonçalves; Thais Castro de Oliveira; Valéria Regina Cavalcante dos Santos; Orenzio Soler
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