Diabetes mellitus and its relationship with COVID-19: A current overview from a systematic review
DOI:
https://doi.org/10.33448/rsd-v10i15.22598Keywords:
Diabetes mellitus; COVID-19; Comorbidity.Abstract
Introduction: Currently, the occurrence of type 2 Diabetes Mellitus (DM2) is increasing gradually, which becomes a global concern. This concern is due to the fact that some studies suggest that diabetes is associated with an increased risk of developing severe forms of COVID-19. Objective: To conduct a systematic review of DM in relation to COVID-19. Methodology: This is a systematic literature review study using the PubMed (United States National Library of Medicine) and Science Direct databases with the descriptors “Diabetes mellitus”, “covid-19”, “risk factors / Diabetes mellitus”, “ covid-19 ”,“ comorbidity ”. The search was limited based on publication date (5 years' time: 2016-2021), species (humans), available languages (English, Spanish and Portuguese). Articles that were not part of the COVID-19 x Diabetes Mellitus theme were excluded from the research. Results and Discussion: During the study, it was possible to observe the strong correlation between the poor prognosis of COVID-19 and Diabetes type 1 and 2. Since diabetes immunocompromises the human body, it is understood that an infection secondary to COVID - 19 is more persistent and lethal. Conclusion: It is concluded that patients with diabetes who contract have a worse prognosis when compared to non-diabetic patients. These patients should receive greater attention from the health system, receiving preventive measures such as strict glycemic control. It is also urgent to show this population the importance of vaccination.
References
Abbas, H. M., Nassir, K. F., Al Khames Aga, Q. A., Al‐Gharawi, A. A., Rasheed, J. I., AL‐Obaidy, M. W., & Al Khames Aga, L. A. (2021). Presenting the characteristics, smoking versus diabetes, and outcome among patients hospitalized with COVID‐19. Journal of medical virology, 93(3), 1556-1567.
Akter, F., Mannan, A., Mehedi, H. H., Rob, M. A., Ahmed, S., Salauddin, A., & Hasan, M. M. (2020). Clinical characteristics and short term outcomes after recovery from COVID-19 in patients with and without diabetes in Bangladesh. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 14(6), 2031-2038.
Akbariqomi, M., Hosseini, M. S., Rashidiani, J., Sedighian, H., Biganeh, H., Heidari, R., & Kooshki, H. (2020). Clinical characteristics and outcome of hospitalized COVID-19 patients with diabetes: A single-center, retrospective study in Iran. diabetes research and clinical practice, 169, 108467.
Alam, M. R., Kabir, M. R., & Reza, S. (2021). Comorbidities might be a risk factor for the incidence of COVID-19: Evidence from a web- based survey. Preventive Medicine Reports, 21, 101319.
Al‐Salameh, A., Lanoix, J. P., Bennis, Y., Andrejak, C., Brochot, E., Deschasse, G., & Lalau, J. D. (2021). Characteristics and outcomes of COVID‐19 in hospitalized patients with and without diabetes. Diabetes/metabolism research and reviews, 37(3), e3388.
Alzaid, F., Julla, J. B., Diedisheim, M., Potier, C., Potier, L., Velho, G., & Gautier, J. F. (2020). Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID‐19 in type 2 diabetes. EMBO molecular medicine, 12(10), e13038.
Arango-Guerra, P., Moncayo-Viveros, J. G., Correa-Londoño, N., García-Roncallo, A., Ramírez-Escobar, L., Sánchez-Moreno, A. M., & Moreno-Bedoya, S. (2021). Crisis hiperglucémica concomitante con infección por SARS-CoV-2: una serie de casos. Acta Colombiana de Cuidado Intensivo.
Barron, E., Bakhai, C., Kar, P., Weaver, A., Bradley, D., Ismail, H., & Valabhji, J. (2020). Associations of type 1 and type 2 diabetes with COVID-19- related mortality in England: a whole-population study. The lancet Diabetes & endocrinology, 8(10), 813-822.
Bhatti, R., Khamis, A. H., Khatib, S., Shiraz, S., & Matfin, G. (2020). Clinical Characteristics and Outcomes of Patients With Diabetes Admitted for COVID- 19 Treatment in Dubai: Single-Centre Cross-Sectional Study. JMIR public health and surveillance, 6(4), e22471.
Chan, K. H., Thimmareddygari, D., Ramahi, A., Atallah, L., Baranetsky, N. G., & Slim, J. (2020). Clinical characteristics and outcome in patients with combined diabetic ketoacidosis and hyperosmolar hyperglycemic state associated with COVID- 19: a retrospective, hospital-based observational case series. Diabetes research and clinical practice, 166, 108279.
Chen, Q., Zheng, Z., Zhang, C., Zhang, X., Wu, H., Wang, J., & Zheng, C. (2020). Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. Infection, 48(4), 543-551.
Cheng, Y., Yue, L., Wang, Z., Zhang, J., & Xiang, G. (2021). Hyperglycemia associated with lymphopenia and disease severity of COVID-19 in type 2 diabetes mellitus. Journal of Diabetes and its Complications, 35(2), 107809.
Dyusupova, A., Faizova, R., Yurkovskaya, O., Belyaeva, T., Terekhova, T., Khismetova, A., & Glushkova, N. (2021). Clinical characteristics and risk factors for disease severity and mortality of COVID-19 patients with diabetes mellitus in Kazakhstan: A nationwide study. Heliyon, 7(3), e06561.
Ebinger, J. E., Achamallah, N., Ji, H., Claggett, B. L., Sun, N., Botting, P., & Cheng, S. (2020). Pre-existing traits associated with Covid- 19 illness severity. PloS one, 15(7), e0236240.
Escobedo-de la Peña, J., Pacheco, R. A. R., de Jesús Ascencio-Montiel, I., González-Figueroa, E., Fernández-Gárate, J. E., Medina-Gómez, O. S., & Borja- Aburto, V. H. (2020). Hypertension, diabetes and obesity, major risk factors for death in patients with COVID-19 in Mexico. Archives of Medical Research.
Fadini, G. P., Morieri, M. L., Boscari, F., Fioretto, P., Maran, A., Busetto, L., & Vettor, R. (2020). Newly- diagnosed diabetes and admission hyperglycemia predict COVID-19 severity by aggravating respiratory deterioration. Diabetes research and clinical practice, 168, 108374.
Fox, T., Ruddiman, K., Lo, K. B., Peterson, E., DeJoy, R., Salacup, G., & Patarroyo-Aponte, G. (2021). The relationship between diabetes and clinical outcomes in COVID-19: a single-center retrospective analysis. Acta Diabetologica, 58(1), 33-38.
Kim, M. K., Jeon, J. H., Kim, S. W., Moon, J. S., Cho, N. H., Han, E., & Lee, J. H. (2020). The clinical characteristics and outcomes of patients with moderate- to-severe coronavirus disease 2019 infection and diabetes in Daegu, South Korea. Diabetes & metabolism journal, 44(4), 602.
Lampasona, V., Secchi, M., Scavini, M., Bazzigaluppi, E., Brigatti, C., Marzinotto, I., & Piemonti, L. (2020). Antibody response to multiple antigens of SARS-CoV-2 in patients with diabetes: an observational cohort study. Diabetologia, 63(12), 2548-2558.
Liang, J. J., Liu, J., Chen, Y., Ye, B., Li, N., Wang, X., & Shao, J. (2020). Characteristics of laboratory findings of COVID-19 patients with comorbid diabetes mellitus. Diabetes research and clinical practice, 167, 108351.
Liu, Y., Lu, R., Wang, J., Cheng, Q., Zhang, R., Zhang, S., & Hong, T. (2021). Diabetes, even newly defined by HbA1c testing, is associated with an increased risk of in-hospital death in adults with COVID- 19. BMC Endocrine Disorders, 21(1), 1-10.
Liu, Z., Li, J., Huang, J., Guo, L., Gao, R., Luo, K., & Wu, X. (2020). Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan. Frontiers in endocrinology, 11, 478.
McGurnaghan, S. J., Weir, A., Bishop, J., Kennedy, S., Blackbourn, L. A., McAllister, D. A., & Health Protection Study Group. (2021). Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland. The Lancet Diabetes & Endocrinology, 9(2), 82-93.
Mishra, Y., Pathak, B. K., Mohakuda, S. S., Tilak, T. V. S. V. G. K., Sen, S., Harikrishnan, P., & Singh, A. R. (2020). Relation of D-dimer levels of COVID- 19 patients with diabetes mellitus. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 14(6), 1927-1930.
Mithal, A., Jevalikar, G., Sharma, R., Singh, A., Farooqui, K. J., Mahendru, S., & Budhiraja, S. (2021). High prevalence of diabetes and other comorbidities in hospitalized patients with COVID-19 in Delhi, India, and their association with outcomes. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 15(1), 169-175.
Mondal, S., DasGupta, R., Lodh, M., Gorai, R., Choudhury, B., Hazra, A. K., & Ganguly, A. (2021). Predictors of new- onset diabetic ketoacidosis in patients with moderate to severe COVID-19 receiving parenteral glucocorticoids: A prospective single- centre study among Indian type 2 diabetes patients. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 15(3), 795-801.
Odriozola, A., Ortega, L., Martinez, L., Odriozola, S., Torrens, A., Corroleu, D., & Malik, R. A. (2021). Widespread sensory neuropathy in diabetic patients hospitalized with severe COVID-19 infection. Diabetes research and clinical practice, 172, 108631.
O’Malley, G., Ebekozien, O., Desimone, M., Pinnaro, C. T., Roberts, A., Polsky, S., & Levy, C. J. (2021). COVID-19 Hospitalization in Adults with Type 1 Diabetes: Results from the T1D Exchange Multicenter Surveillance Study. The Journal of Clinical Endocrinology & Metabolism, 106(2), e936-e942.
Satman, I., Demirci, I., Haymana, C., Tasci, I., Salman, S., Ata, N., & Sonmez, A. (2021). Unexpectedly lower mortality rates in COVID- 19 patients with and without type 2 diabetes in Istanbul. Diabetes Research and Clinical Practice, 174, 108753.
Schlömmer, C., Dünser, M. W., Antlanger, M., Paar, C., Winkler, M., Meier, J., & Salzer, H. J. (2020). Fatal case of COVID-19 in a 27-year- old woman with diabetes mellitus. Wiener klinische Wochenschrift, 132(21), 695-696.
Shang, J., Wang, Q., Zhang, H., Wang, X., Wan, J., Yan, Y., & Lin, J. (2021). The relationship between diabetes mellitus and COVID-19 prognosis: a retrospective cohort study in Wuhan, China. The American journal of medicine, 134(1), e6-e14.
Sun, Y., Guan, X., Jia, L., Xing, N., Cheng, L., Liu, B., & He, K. (2021). Independent and combined effects of hypertension and diabetes on clinical outcomes in patients with COVID‐19: A retrospective cohort study of Huoshen Mountain Hospital and Guanggu Fangcang Shelter Hospital. The Journal of Clinical Hypertension, 23(2), 218-231.
Ushigome, E., Yamazaki, M., Hamaguchi, M., Ito, T., Matsubara, S., Tsuchido, Y., & Fukui, M. (2021). Usefulness and safety of remote continuous glucose monitoring for a severe COVID-19 patient with diabetes. DiabetesTechnology & Therapeutics, 23(1), 78-80.
Yan, Y., Yang, Y., Wang, F., Ren, H., Zhang, S., Shi, X., & Dong, K. (2020). Clinical characteristics and outcomes of patients with severe covid- 19 with diabetes. BMJ open diabetes research and care, 8(1), e001343.
Zhang, N., Wang, C., Zhu, F., Mao, H., Bai, P., Chen, L. L., & Zhou, M. (2020). Risk factors for poor outcomes of diabetes patients with COVID-19: a single- center, retrospective study in early outbreak in China. Frontiers in endocrinology, 11.
Zhang, Q., Wei, Y., Chen, M., Wan, Q., & Chen, X. (2020). Clinical analysis of risk factors for severe COVID-19 patients with type 2 diabetes. Journal of Diabetes and its Complications, 34(10)
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Copyright (c) 2021 Bianca Sampaio Lima; Maiza Carneiro Machado Frota; Sara Prado Ramos; José Lopes Pereira Júnior; Antonio de Pádua Rocha Nóbrega Neto
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